LOCUS       NM_003897               1237 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens immediate early response 3 (IER3), mRNA.
ACCESSION   NM_003897
VERSION     NM_003897.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1237)
  AUTHORS   Ke,S., Zhang,X., Xiang,X., Lu,Y. and An,H.
  TITLE     IER3 (IEX-1) dysregulation serves as a potential prognostic factor
            in acute myeloid leukemia patients
  JOURNAL   Int J Lab Hematol 44 (2), 342-348 (2022)
   PUBMED   34729939
  REMARK    GeneRIF: IER3 (IEX-1) dysregulation serves as a potential
            prognostic factor in acute myeloid leukemia patients.
REFERENCE   2  (bases 1 to 1237)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1237)
  AUTHORS   Gao,J., Liu,L., Li,G., Cai,M., Tan,C., Han,X. and Han,L.
  TITLE     LncRNA GAS5 confers the radio sensitivity of cervical cancer cells
            via regulating miR-106b/IER3 axis
  JOURNAL   Int J Biol Macromol 126, 994-1001 (2019)
   PUBMED   30579899
  REMARK    GeneRIF: Overexpression of GAS5 enhanced the sensitivity of
            cervical cancer cells to radiation treatment via up-regulating IER3
            through miR-106b.
REFERENCE   4  (bases 1 to 1237)
  AUTHORS   Ye,J., Zhang,Y., Cai,Z., Jiang,M., Li,B., Chen,G., Zeng,Y.,
            Liang,Y., Wu,S., Wang,Z., He,H., Zhong,W. and Wu,C.L.
  TITLE     Increased expression of immediate early response gene 3 protein
            promotes aggressive progression and predicts poor prognosis in
            human bladder cancer
  JOURNAL   BMC Urol 18 (1), 82 (2018)
   PUBMED   30249226
  REMARK    GeneRIF: Our findings suggest for the first time that the increased
            expression of IER3 protein may promote the aggressive progression
            of BCa. Importantly, IER3 may be a potential prognostic marker for
            BCa patients.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1237)
  AUTHORS   Jin,H., Won,M., Shin,E., Kim,H.M., Lee,K. and Bae,J.
  TITLE     EGR2 is a gonadotropin-induced survival factor that controls the
            expression of IER3 in ovarian granulosa cells
  JOURNAL   Biochem Biophys Res Commun 482 (4), 877-882 (2017)
   PUBMED   27890615
  REMARK    GeneRIF: Analysis of consensus EGR-binding elements (EBEs) showed
            that the immediate early response 3 gene (IER3) is a novel
            transcriptional target gene of EGR2 as confirmed by the luciferase
            assay, electrophoretic mobility-shift assay (EMSA), chromatin
            immunoprecipitation (ChIP), and western blot analysis.
REFERENCE   6  (bases 1 to 1237)
  AUTHORS   Wu,M.X., Ao,Z., Prasad,K.V., Wu,R. and Schlossman,S.F.
  TITLE     IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell
            survival
  JOURNAL   Science 281 (5379), 998-1001 (1998)
   PUBMED   9703517
REFERENCE   7  (bases 1 to 1237)
  AUTHORS   Pietzsch,A., Buchler,C. and Schmitz,G.
  TITLE     Genomic organization, promoter cloning, and chromosomal
            localization of the Dif-2 gene
  JOURNAL   Biochem Biophys Res Commun 245 (3), 651-657 (1998)
   PUBMED   9588170
REFERENCE   8  (bases 1 to 1237)
  AUTHORS   Pietzsch,A., Buchler,C., Aslanidis,C. and Schmitz,G.
  TITLE     Identification and characterization of a novel monocyte/macrophage
            differentiation-dependent gene that is responsive to
            lipopolysaccharide, ceramide, and lysophosphatidylcholine
  JOURNAL   Biochem Biophys Res Commun 235 (1), 4-9 (1997)
   PUBMED   9196025
REFERENCE   9  (bases 1 to 1237)
  AUTHORS   Schafer,H., Trauzold,A., Siegel,E.G., Folsch,U.R. and Schmidt,W.E.
  TITLE     PRG1: a novel early-response gene transcriptionally induced by
            pituitary adenylate cyclase activating polypeptide in a pancreatic
            carcinoma cell line
  JOURNAL   Cancer Res 56 (11), 2641-2648 (1996)
   PUBMED   8653710
REFERENCE   10 (bases 1 to 1237)
  AUTHORS   Kondratyev,A.D., Chung,K.N. and Jung,M.O.
  TITLE     Identification and characterization of a radiation-inducible
            glycosylated human early-response gene
  JOURNAL   Cancer Res 56 (7), 1498-1502 (1996)
   PUBMED   8603392
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA893782.1, BC000844.2 and
            BM915952.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003897.3.
            
            Summary: This gene functions in the protection of cells from Fas-
            or tumor necrosis factor type alpha-induced apoptosis. Partially
            degraded and unspliced transcripts are found after virus infection
            in vitro, but these transcripts are not found in vivo and do not
            generate a valid protein. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC000844.2, BC005080.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000259874.6/ ENSP00000259874.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DA893782.1         5-17
            14-407              BC000844.2         1-394
            408-775             BM915952.1         416-783
            776-1237            BC000844.2         763-1224
FEATURES             Location/Qualifiers
     source          1..1237
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..1237
                     /gene="IER3"
                     /gene_synonym="DIF-2; DIF2; GLY96; IEX-1; IEX-1L; IEX1;
                     PRG1"
                     /note="immediate early response 3"
                     /db_xref="GeneID:8870"
                     /db_xref="HGNC:HGNC:5392"
                     /db_xref="MIM:602996"
     exon            1..239
                     /gene="IER3"
                     /gene_synonym="DIF-2; DIF2; GLY96; IEX-1; IEX-1L; IEX1;
                     PRG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..500
                     /gene="IER3"
                     /gene_synonym="DIF-2; DIF2; GLY96; IEX-1; IEX-1L; IEX1;
                     PRG1"
                     /note="immediately early gene X-1; gly96, mouse, homolog
                     of; anti-death protein; expressed in pancreatic carcinoma;
                     protein DIF-2; immediate early protein GLY96;
                     PACAP-responsive gene 1 protein; immediate early response
                     3 protein; differentiation-dependent gene 2 protein"
                     /codon_start=1
                     /product="radiation-inducible immediate-early gene IEX-1"
                     /protein_id="NP_003888.2"
                     /db_xref="CCDS:CCDS4689.1"
                     /db_xref="GeneID:8870"
                     /db_xref="HGNC:HGNC:5392"
                     /db_xref="MIM:602996"
                     /translation="MCHSRSCHPTMTILQAPTPAPSTIPGPRRGSGPEIFTFDPLPEP
                     AAAPAGRPSASRGHRKRSRRVLYPRVVRRQLPVEEPNPAKRLLFLLLTIVFCQILMAE
                     EGVPAPLPPEDAPNAASLAPTPVSAVLEPFNLTSEPSDYALDLSTFLQQHPAAF"
     exon            240..1237
                     /gene="IER3"
                     /gene_synonym="DIF-2; DIF2; GLY96; IEX-1; IEX-1L; IEX1;
                     PRG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1214..1219
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IER3"
                     /gene_synonym="DIF-2; DIF2; GLY96; IEX-1; IEX-1L; IEX1;
                     PRG1"
                     /note="hexamer: AATAAA"
     polyA_site      1237
                     /gene="IER3"
                     /gene_synonym="DIF-2; DIF2; GLY96; IEX-1; IEX-1L; IEX1;
                     PRG1"
                     /note="major polyA site"
ORIGIN      
        1 acttggcctt acactccgct cggctcacca tgtgtcactc tcgcagctgc cacccgacca
       61 tgaccatcct gcaggccccg accccggccc cctccaccat cccgggaccc cggcggggct
      121 ccggtcctga gatcttcacc ttcgaccctc tcccggagcc cgcagcggcc cctgccgggc
      181 gccccagcgc ctctcgcggg caccgaaagc gcagccgcag ggttctctac cctcgagtgg
      241 tccggcgcca gctgccagtc gaggaaccga acccagccaa aaggcttctc tttctgctgc
      301 tcaccatcgt cttctgccag atcctgatgg ctgaagaggg tgtgccggcg cccctgcctc
      361 cagaggacgc ccctaacgcc gcatccctgg cgcccacccc tgtgtccgcc gtcctcgagc
      421 cctttaatct gacttcggag ccctcggact acgctctgga cctcagcact ttcctccagc
      481 aacacccggc cgccttctaa ctgtgactcc ccgcactccc caaaaagaat ccgaaaaacc
      541 acaaagaaac accaggcgta cctggtgcgc gagagcgtat ccccaactgg gacttccgag
      601 gcaacttgaa ctcagaacac tacagcggag acgccacccg gtgcttgagg cgggaccgag
      661 gcgcacagag accgaggcgc atagagaccg aggcacagcc cagctggggc taggcccggt
      721 gggaaggaga gcgtcgttaa tttatttctt attgctccta attaatattt atatgtattt
      781 atgtacgtcc tcctaggtga tggagatgtg tacgtaatat ttattttaac ttatgcaagg
      841 gtgtgagatg ttccccctgc tgtaaatgca ggtctcttgg tatttattga gctttgtggg
      901 actggtggaa gcaggacacc tggaactgcg gcaaagtagg agaagaaatg gggaggactc
      961 gggtggggga ggacgtcccg gctgggatga agtctggtgg tgggtcgtaa gtttaggagg
     1021 tgactgcatc ctccagcatc tcaactccgt ctgtctactg tgtgagactt cggcggacca
     1081 ttaggaatga gatccgtgag atccttccat cttcttgaag tcgcctttag ggtggctgcg
     1141 aggtagaggg ttgggggttg gtgggctgtc acggagcgac tgtcgagatc gcctagtatg
     1201 ttctgtgaac acaaataaaa ttgatttact gtctgca
//
