LOCUS       NM_004907               2110 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens immediate early response 2 (IER2), mRNA.
ACCESSION   NM_004907
VERSION     NM_004907.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2110)
  AUTHORS   Zhang,T.L., Zheng,B.W., Xia,C., Wu,P.F., Zheng,B.Y., Jiang,L.X.,
            Li,J., Lv,G.H., Zhou,H., Huang,W. and Zou,M.X.
  TITLE     Hypoxic Upregulation of IER2 Increases Paracrine GMFG Signaling of
            Endoplasmic Reticulum Stress-CAF to Promote Chordoma Progression
            via Targeting ITGB1
  JOURNAL   Adv Sci (Weinh) 11 (40), e2405421 (2024)
   PUBMED   39207055
  REMARK    GeneRIF: Hypoxic Upregulation of IER2 Increases Paracrine GMFG
            Signaling of Endoplasmic Reticulum Stress-CAF to Promote Chordoma
            Progression via Targeting ITGB1.
REFERENCE   2  (bases 1 to 2110)
  AUTHORS   Doi,K., Takeuchi,H. and Sakurai,H.
  TITLE     PP2A-B55 and its adapter proteins IER2 and IER5 regulate the
            activity of RB family proteins and the expression of cell
            cycle-related genes
  JOURNAL   FEBS J 290 (3), 745-762 (2023)
   PUBMED   36047562
  REMARK    GeneRIF: PP2A-B55 and its adapter proteins IER2 and IER5 regulate
            the activity of RB family proteins and the expression of cell
            cycle-related genes.
REFERENCE   3  (bases 1 to 2110)
  AUTHORS   Wang,C. and Jiang,H.
  TITLE     Long Non-Coding RNA PCAT19 Regulates the Malignant Progression of
            Bladder Cancer through the miR-335-5p/IER2 Axis
  JOURNAL   Crit Rev Eukaryot Gene Expr 32 (8), 81-94 (2022)
   PUBMED   36017918
  REMARK    GeneRIF: Long Non-Coding RNA PCAT19 Regulates the Malignant
            Progression of Bladder Cancer through the miR-335-5p/IER2 Axis.
REFERENCE   4  (bases 1 to 2110)
  AUTHORS   Kyjacova,L., Saup,R., Ronsch,K., Wallbaum,S., Dukowic-Schulze,S.,
            Foss,A., Scherer,S.D., Rothley,M., Neeb,A., Grau,N., Thiele,W.,
            Thaler,S., Cremers,N., Sticht,C., Gretz,N., Garvalov,B.K.,
            Utikal,J. and Sleeman,J.P.
  TITLE     IER2-induced senescence drives melanoma invasion through
            osteopontin
  JOURNAL   Oncogene 40 (47), 6494-6512 (2021)
   PUBMED   34611309
  REMARK    GeneRIF: IER2-induced senescence drives melanoma invasion through
            osteopontin.
REFERENCE   5  (bases 1 to 2110)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2110)
  AUTHORS   Wu,W., Zhang,X., Lv,H., Liao,Y., Zhang,W., Cheng,H., Deng,Z.,
            Shen,J., Yuan,Q., Zhang,Y. and Shen,W.
  TITLE     Identification of immediate early response protein 2 as a regulator
            of angiogenesis through the modulation of endothelial cell motility
            and adhesion
  JOURNAL   Int J Mol Med 36 (4), 1104-1110 (2015)
   PUBMED   26260137
  REMARK    GeneRIF: results from western blot analysis showed that the
            activity of the focal adhesion kinase (FAK) can be regulated by
            IER2.
REFERENCE   7  (bases 1 to 2110)
  AUTHORS   Neeb,A., Wallbaum,S., Novac,N., Dukovic-Schulze,S., Scholl,I.,
            Schreiber,C., Schlag,P., Moll,J., Stein,U. and Sleeman,J.P.
  TITLE     The immediate early gene Ier2 promotes tumor cell motility and
            metastasis, and predicts poor survival of colorectal cancer
            patients
  JOURNAL   Oncogene 31 (33), 3796-3806 (2012)
   PUBMED   22120713
  REMARK    GeneRIF: ectopic Ier2 expression promoted the motility and
            invasiveness of poorly metastatic 1AS pancreatic tumor cells in
            vitro
REFERENCE   8  (bases 1 to 2110)
  AUTHORS   Takaya,T., Kasatani,K., Noguchi,S. and Nikawa,J.
  TITLE     Functional analyses of immediate early gene ETR101 expressed in
            yeast
  JOURNAL   Biosci Biotechnol Biochem 73 (7), 1653-1660 (2009)
   PUBMED   19584537
  REMARK    GeneRIF: the functioning of ETR101 as a transcriptional activator
            for the gene ISYNA1
REFERENCE   9  (bases 1 to 2110)
  AUTHORS   Scott,J.L., Dunn,S.M., Zeng,T., Baker,E., Sutherland,G.R. and
            Burns,G.F.
  TITLE     Phorbol ester-induced transcription of an immediate-early response
            gene by human T cells is inhibited by co-treatment with calcium
            ionophore
  JOURNAL   J Cell Biochem 54 (2), 135-144 (1994)
   PUBMED   8175888
REFERENCE   10 (bases 1 to 2110)
  AUTHORS   Shimizu,N., Ohta,M., Fujiwara,C., Sagara,J., Mochizuki,N., Oda,T.
            and Utiyama,H.
  TITLE     Expression of a novel immediate early gene during
            12-O-tetradecanoylphorbol-13-acetate-induced macrophagic
            differentiation of HL-60 cells
  JOURNAL   J Biol Chem 266 (19), 12157-12161 (1991)
   PUBMED   2061303
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011446.6 and BC072432.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004907.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072432.1, AL554053.3 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000292433.4/ ENSP00000292433.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AC011446.6         21368-21424
            58-2107             BC072432.1         1-2050
            2108-2110           AC011446.6         25866-25868
FEATURES             Location/Qualifiers
     source          1..2110
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.13"
     gene            1..2110
                     /gene="IER2"
                     /gene_synonym="CHX1; ETR101"
                     /note="immediate early response 2"
                     /db_xref="GeneID:9592"
                     /db_xref="HGNC:HGNC:28871"
                     /db_xref="MIM:620036"
     exon            1..142
                     /gene="IER2"
                     /gene_synonym="CHX1; ETR101"
                     /inference="alignment:Splign:2.1.0"
     exon            143..2110
                     /gene="IER2"
                     /gene_synonym="CHX1; ETR101"
                     /inference="alignment:Splign:2.1.0"
     CDS             386..1057
                     /gene="IER2"
                     /gene_synonym="CHX1; ETR101"
                     /note="chxI protein homolog"
                     /codon_start=1
                     /product="immediate early response gene 2 protein"
                     /protein_id="NP_004898.2"
                     /db_xref="CCDS:CCDS12295.1"
                     /db_xref="GeneID:9592"
                     /db_xref="HGNC:HGNC:28871"
                     /db_xref="MIM:620036"
                     /translation="MEVQKEAQRIMTLSVWKMYHSRMQRGGLRLHRSLQLSLVMRSAR
                     ELYLSAKVEALEPEVSLPAALPSDPRLHPPREAESTAETATPDGEHPFPEPMDTQEAP
                     TAEETSACCAPRPAKVSRKRRSSSLSDGGDAGLVPSKKARLEEKEEEEGASSEVADRL
                     QPPPAQAEGAFPNLARVLQRRFSGLLNCSPAAPPTAPPACEAKPACRPADSMLNVLVR
                     AVVAF"
     regulatory      2084..2089
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IER2"
                     /gene_synonym="CHX1; ETR101"
                     /note="hexamer: AATAAA"
     polyA_site      2110
                     /gene="IER2"
                     /gene_synonym="CHX1; ETR101"
                     /note="major polyA site"
ORIGIN      
        1 agccctctcg tgccgcaccg tagggggcgg tgtcggagtt ctgtctgggc ctattcgggt
       61 ccgagttcgg aatttcggtt caaggcccag ttcctcggat tgttcctgcg caacttcagt
      121 ttcccttcca ggcacgggca atgagtgttt ggccgcgacg agttggaaag cccggatgcg
      181 tccttcggtt gggcggggtg tctcagtgac gtcactgggg gtataaaagg gcctgggtgg
      241 cgggcgcctg ggcagagcgt cctagcagtg tcactgcgtg ggttggtttg tgtagagagg
      301 cgtgagcgag cccgttgtcc ggagtgcacc tgctgcctgt tctgtccctc ccgggagccc
      361 ccgccgctgt cgccgtcgag tcgccatgga agtgcagaaa gaggcacagc gcatcatgac
      421 cctgtcggtg tggaagatgt atcactcccg catgcagcgc ggtggcctgc ggctgcaccg
      481 gagtctgcag ctgtcgctgg tcatgcgcag cgcccgggag ctctacctct cggccaaggt
      541 ggaggccctc gagcccgagg tgtcgttgcc ggccgccctc ccctctgacc ctcgcctgca
      601 cccgccccga gaagccgagt ccacggccga gacagcgacc cccgacggtg agcacccgtt
      661 tccggagcca atggacacgc aggaggcgcc gacagccgag gagacctccg cctgctgtgc
      721 cccgcgcccc gccaaagtca gccgcaaacg acgcagcagc agcctgagcg acggcgggga
      781 cgctggactg gtcccgagca agaaagcccg tctggaagaa aaggaagaag aggagggagc
      841 gtcatccgaa gtcgccgatc gcctgcagcc ccctccggcg caagcggagg gcgcctttcc
      901 caacctggcc cgcgtcctgc agaggcgctt ctccggcctc ctgaactgca gccccgcggc
      961 ccctccgacg gcgccgcccg cgtgcgaggc aaagcccgct tgccgcccgg cggacagcat
     1021 gctcaacgtg ctcgtgcggg ccgtggtggc cttctgagga ccccgagcgg cgctgccgga
     1081 gcccagagcg cgcgtcgaac cgtcggcccg agggcgcaga cctgaggcga ggccaccccc
     1141 ctccatcctg ggggaagcgc ccgcgaaaac cgtggagaga agccgccgcc cgggctgctg
     1201 agaggcccgg agagggactc tgtccccggg gagccatcgc cttcagtgtg cagggacggc
     1261 accgaggagt ctgagccggg ggcgcgggcg ccttccgcag agacctgcgc ccacaggtgc
     1321 tgtcttagtg gactgggacg tgaacctttc gctctccttc tggactggga gaagggaggc
     1381 ttgggtgttg tgttttttgt tttgtttgtt tgtttgtttt taaagatctc ctcagggtcg
     1441 gacttcattt tgtactgtgg gctgtgctgg ccctttcaag gtttttcaag agttggtttt
     1501 gcgtttccaa cctcggagaa ttccaggcac tccccttccc cctccgctga catacttgta
     1561 taagcggtca tcgttgcgtc atggggcagg cgtggggagc ttcctgtcgc cttgcgtggg
     1621 tgtggggcct gggaggaggt cctggggcgt gcacccgccc tgggcagtgg ggaggagagt
     1681 ggcctgagtt acttcacccc cgcgtgctgc tggttaatgt cccgcgtctc tgcaccttcg
     1741 ggtgggagcg gggactgatc tactttcaca ttctcaagtt tttctcatct gcattagagg
     1801 tgcccagtag gttcccaggt tccagcgtgc ccctccctca gacacacgga cacaatcagc
     1861 cgagaagttc ctggtctgaa tcacgagaat gtggaggggt ggggggtgtc agtggaaagg
     1921 cataaggctg agctgagacc agttgctggt gaaactgggc caatctgggg aggggaacat
     1981 ccttgccagg gagtttctga gggtctgctt tgtttacctt tcgtgcggtg gattcttttt
     2041 aactccgtct acctggcgtt ttgttagaaa tgtcagatag gaaaataaaa accatttgag
     2101 taaaaaagcc
//
