LOCUS       NM_194294               2599 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens indoleamine 2,3-dioxygenase 2 (IDO2), transcript
            variant 1, mRNA.
ACCESSION   NM_194294 XM_095645
VERSION     NM_194294.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2599)
  AUTHORS   Guo,L., Zaharie,S.D., Marceline van Furth,A., van der Wel,N.N.,
            Grootemaat,A.E., Zhang,L., Bugiani,M., Kruger,M., van der Kuip,M.
            and Lutter,R.
  TITLE     Marked IDO2 expression and activity related to autophagy and
            apoptosis in brain tissue of fatal tuberculous meningitis
  JOURNAL   Tuberculosis (Edinb) 146, 102495 (2024)
   PUBMED   38460493
  REMARK    GeneRIF: Marked IDO2 expression and activity related to autophagy
            and apoptosis in brain tissue of fatal tuberculous meningitis.
REFERENCE   2  (bases 1 to 2599)
  AUTHORS   Suvieri,C., De Marchis,F., Mandarano,M., Ambrosino,S., Rossini,S.,
            Mondanelli,G., Gargaro,M., Panfili,E., Orabona,C., Pallotta,M.T.,
            Belladonna,M.L. and Volpi,C.
  TITLE     Membrane Localization and Phosphorylation of Indoleamine
            2,3-Dioxygenase 2 (IDO2) in A549 Human Lung Adenocarcinoma Cells:
            First Steps in Exploring Its Signaling Function
  JOURNAL   Int J Mol Sci 24 (22), 16236 (2023)
   PUBMED   38003426
  REMARK    GeneRIF: Membrane Localization and Phosphorylation of Indoleamine
            2,3-Dioxygenase 2 (IDO2) in A549 Human Lung Adenocarcinoma Cells:
            First Steps in Exploring Its Signaling Function.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2599)
  AUTHORS   Guo,L., Appelman,B., Mooij-Kalverda,K., Houtkooper,R.H., van
            Weeghel,M., Vaz,F.M., Dijkhuis,A., Dekker,T., Smids,B.S.,
            Duitman,J.W., Bugiani,M., Brinkman,P., Sikkens,J.J., Lavell,H.A.A.,
            Wust,R.C.I., van Vugt,M. and Lutter,R.
  CONSRTM   Amsterdam UMC COVID-19 Biobank study Group
  TITLE     Prolonged indoleamine 2,3-dioxygenase-2 activity and associated
            cellular stress in post-acute sequelae of SARS-CoV-2 infection
  JOURNAL   EBioMedicine 94, 104729 (2023)
   PUBMED   37506544
  REMARK    GeneRIF: Prolonged indoleamine 2,3-dioxygenase-2 activity and
            associated cellular stress in post-acute sequelae of SARS-CoV-2
            infection.
REFERENCE   4  (bases 1 to 2599)
  AUTHORS   Kado,S.Y., Bein,K., Castaneda,A.R., Pouraryan,A.A., Garrity,N.,
            Ishihara,Y., Rossi,A., Haarmann-Stemmann,T., Sweeney,C.A. and
            Vogel,C.F.A.
  TITLE     Regulation of IDO2 by the Aryl Hydrocarbon Receptor (AhR) in Breast
            Cancer
  JOURNAL   Cells 12 (10), 1433 (2023)
   PUBMED   37408267
  REMARK    GeneRIF: Regulation of IDO2 by the Aryl Hydrocarbon Receptor (AhR)
            in Breast Cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2599)
  AUTHORS   Gu,P., Ling,B., Ma,W., Zhang,J., Zhang,W., Zeng,Y., Liu,Y., Chi,J.,
            Ruan,X., Zheng,X., Wei,S. and Gao,M.
  TITLE     Indoleamine 2,3-dioxygenase 2 immunohistochemical expression in
            medullary thyroid carcinoma: implications in prognosis and
            immunomodulatory effects
  JOURNAL   BMC Cancer 22 (1), 1116 (2022)
   PUBMED   36319978
  REMARK    GeneRIF: Indoleamine 2,3-dioxygenase 2 immunohistochemical
            expression in medullary thyroid carcinoma: implications in
            prognosis and immunomodulatory effects.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2599)
  AUTHORS   Huttunen,R., Syrjanen,J., Aittoniemi,J., Oja,S.S., Raitala,A.,
            Laine,J., Pertovaara,M., Vuento,R., Huhtala,H. and Hurme,M.
  TITLE     High activity of indoleamine 2,3 dioxygenase enzyme predicts
            disease severity and case fatality in bacteremic patients
  JOURNAL   Shock 33 (2), 149-154 (2010)
   PUBMED   19487973
  REMARK    GeneRIF: High activity of indoleamine 2,3 dioxygenase enzyme
            predicts disease severity and case fatality in bacteremic patients.
REFERENCE   7  (bases 1 to 2599)
  AUTHORS   Witkiewicz,A.K., Costantino,C.L., Metz,R., Muller,A.J.,
            Prendergast,G.C., Yeo,C.J. and Brody,J.R.
  TITLE     Genotyping and expression analysis of IDO2 in human pancreatic
            cancer: a novel, active target
  JOURNAL   J Am Coll Surg 208 (5), 781-7 (2009)
   PUBMED   19476837
  REMARK    GeneRIF: First study to report IDO2 expression in pancreatic ductal
            adenocarcinoma indicating that IDO2 genetic polymorphisms do not
            negate interferon-gamma-inducible protein expression.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 2599)
  AUTHORS   Metz,R., Duhadaway,J.B., Kamasani,U., Laury-Kleintop,L.,
            Muller,A.J. and Prendergast,G.C.
  TITLE     Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical
            target of the antitumor indoleamine 2,3-dioxygenase inhibitory
            compound D-1-methyl-tryptophan
  JOURNAL   Cancer Res 67 (15), 7082-7087 (2007)
   PUBMED   17671174
  REMARK    GeneRIF: IDO2 encodes a novel IDO-related tryptophan catabolic
            enzyme that is preferentially inhibited by D-1-methyl-tryptophan
            (D-1MT).  IDO2 may have a distinct role in immune tolerance. Two
            common human genetic polymorphisms ablate IDO2 enzyme activity.
REFERENCE   9  (bases 1 to 2599)
  AUTHORS   Ball,H.J., Sanchez-Perez,A., Weiser,S., Austin,C.J., Astelbauer,F.,
            Miu,J., McQuillan,J.A., Stocker,R., Jermiin,L.S. and Hunt,N.H.
  TITLE     Characterization of an indoleamine 2,3-dioxygenase-like protein
            found in humans and mice
  JOURNAL   Gene 396 (1), 203-213 (2007)
   PUBMED   17499941
  REMARK    GeneRIF: This article describes the evolutionary relationships
            between the INDO and INDOL1 genes. The INDOL1 protein has a
            distinct expression pattern compared to INDO and both have the
            ability to catabolise tryptophan.
            Erratum:[Gene. 2010 Oct 1;465(1-2):66]
REFERENCE   10 (bases 1 to 2599)
  AUTHORS   Murray,M.F.
  TITLE     The human indoleamine 2,3-dioxygenase gene and related human genes
  JOURNAL   Curr Drug Metab 8 (3), 197-200 (2007)
   PUBMED   17430106
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007991.7 and AC087518.5.
            
            On Jun 11, 2021 this sequence version replaced NM_194294.4.
            
            Summary: Along with the enzymes encoded by the INDO (MIM 147435)
            and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene
            metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007
            [PubMed 17499941]).[supplied by OMIM, Feb 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: EF052681.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA2149398, SAMEA2153307 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            inferred exon combination        :: based on alignments, homology
            MANE Ensembl match               :: ENST00000502986.4/
                                                ENSP00000443432.2
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression,
                                                longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-568               AC007991.7         74728-75295
            569-684             AC007991.7         89226-89341
            685-780             AC007991.7         103685-103780
            781-900             AC007991.7         119144-119263
            901-1019            AC007991.7         122729-122847
            1020-1034           AC007991.7         125585-125599
            1035-1134           AC007991.7         127948-128047
            1135-1252           AC007991.7         129798-129915
            1253-1304           AC007991.7         145404-145455
            1305-1453           AC087518.5         62394-62542
            1454-2599           AC087518.5         64076-65221
FEATURES             Location/Qualifiers
     source          1..2599
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p11.21"
     gene            1..2599
                     /gene="IDO2"
                     /gene_synonym="INDOL1"
                     /note="indoleamine 2,3-dioxygenase 2"
                     /db_xref="GeneID:169355"
                     /db_xref="HGNC:HGNC:27269"
                     /db_xref="MIM:612129"
     exon            1..568
                     /gene="IDO2"
                     /gene_synonym="INDOL1"
                     /inference="alignment:Splign:2.1.0"
     exon            569..684
                     /gene="IDO2"
                     /gene_synonym="INDOL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             586..1809
                     /gene="IDO2"
                     /gene_synonym="INDOL1"
                     /EC_number="1.13.11.52"
                     /note="indoleamine-pyrrole 2,3 dioxygenase-like 1;
                     indoleamine 2,3-dioxygenase-like 1 protein; indoleamine
                     2,3-dioxygenase-like protein 1; indoleamine-pyrrole
                     2,3-dioxygenase-like protein 1"
                     /codon_start=1
                     /product="indoleamine 2,3-dioxygenase 2"
                     /protein_id="NP_919270.3"
                     /db_xref="CCDS:CCDS6114.3"
                     /db_xref="GeneID:169355"
                     /db_xref="HGNC:HGNC:27269"
                     /db_xref="MIM:612129"
                     /translation="MEPHRPNVKTAVPLSLESYHISEEYGFLLPDSLKELPDHYRPWM
                     EIANKLPQLIDAHQLQAHVDKMPLLSCQFLKGHREQRLAHLVLSFLTMGYVWQEGEAQ
                     PAEVLPRNLALPFVEVSRNLGLPPILVHSDLVLTNWTKKDPDGFLEIGNLETIISFPG
                     GESLHGFILVTALVEKEAVPGIKALVQATNAILQPNQEALLQALQRLRLSIQDITKTL
                     GQMHDYVDPDIFYAGIRIFLSGWKDNPAMPAGLMYEGVSQEPLKYSGGSAAQSTVLHA
                     FDEFLGIRHSKESGDFLYRMRDYMPPSHKAFIEDIHSAPSLRDYILSSGQDHLLTAYN
                     QCVQALAELRSYHITMVTKYLITAAAKAKHGKPNHLPGPPQALKDRGTGGTAVMSFLK
                     SVRDKTLESILHPRG"
     exon            685..780
                     /gene="IDO2"
                     /gene_synonym="INDOL1"
                     /inference="alignment:Splign:2.1.0"
     exon            781..900
                     /gene="IDO2"
                     /gene_synonym="INDOL1"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1019
                     /gene="IDO2"
                     /gene_synonym="INDOL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1034
                     /gene="IDO2"
                     /gene_synonym="INDOL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1134
                     /gene="IDO2"
                     /gene_synonym="INDOL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1252
                     /gene="IDO2"
                     /gene_synonym="INDOL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1304
                     /gene="IDO2"
                     /gene_synonym="INDOL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1453
                     /gene="IDO2"
                     /gene_synonym="INDOL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..2599
                     /gene="IDO2"
                     /gene_synonym="INDOL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2576..2581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IDO2"
                     /gene_synonym="INDOL1"
                     /note="hexamer: AATAAA"
     polyA_site      2599
                     /gene="IDO2"
                     /gene_synonym="INDOL1"
                     /note="major polyA site"
ORIGIN      
        1 gaagactcat ttttgtcttc attactgcta tgtggagcaa gggcccaagc ttttaaaaac
       61 aagagctcag agacatggcc ctggccttgg aagatgccct agagacgctg aggtggttgt
      121 acttttgcca taggagtggc agccagagaa ctgagcccaa tgaatgcaaa ggctggtgcc
      181 tggaaatatt gtgactttgc cacagaaaga agatggagaa ttttaaagtt ggaaatctgc
      241 ctggtaaggg atcatttgct ggtgtctgca aagttgagtc catacacact ggtttggaaa
      301 tttcagtcca gatgatagtt aagaaagcag taagaataca gagagtccac aatgagatga
      361 aaatgcactg ccagttgaaa catcctccta cactggagct ttataaatat tttaaagaca
      421 aggattggat tagatttgac attagaaatg taccataata cagaaggcaa tggacaccta
      481 aagaacagaa tgaaaacctt cttaggaaat gaagcttgac acttcaccca ccaggccacc
      541 acaagaatgt tgcattttca ttattatgat acttcaaaca aaataatgga gccccacaga
      601 ccgaatgtga agacagcagt gccattgtct ttggaaagct atcacatatc tgaagagtat
      661 ggctttcttc ttccagattc tctgaaagaa cttccagatc attataggcc ttggatggaa
      721 attgccaaca aacttcctca attgattgat gctcaccagc ttcaagctca tgtggacaag
      781 atgcccctgc tgagctgcca gttcctgaag ggtcaccggg agcagcgcct ggcccacctg
      841 gtcctgagct tcctcaccat gggttatgtc tggcaggaag gagaggcgca gcctgcagag
      901 gtcctgccaa ggaatcttgc ccttccattt gtcgaagtct ccaggaactt ggggctccct
      961 cctatcctgg tccactcaga cttggtgctg acgaactgga ccaaaaaaga tccagacgga
     1021 ttcctggaaa ttgggaacct ggagaccatc atctcatttc ctgggggaga gagcctgcat
     1081 ggttttatac tggtgactgc tttggtagag aaagaagcag tgcctgggat aaaggctctt
     1141 gttcaggcca cgaatgctat cttgcagccc aaccaggagg ccctgctcca agccctgcag
     1201 cgactgagac tgtctattca ggacatcacc aaaaccttag gacagatgca tgattatgta
     1261 gatccagaca tattttatgc aggcatccgg atctttctct ctggatggaa agacaaccca
     1321 gcaatgcctg cagggctgat gtatgaagga gtttcccaag agcccctgaa atactccggc
     1381 gggagtgcag ctcagagcac agtgcttcat gcctttgatg agttcttagg cattcgtcat
     1441 agcaaggaaa gtggtgactt tctgtacaga atgagggatt acatgcctcc ttcccataag
     1501 gccttcatag aagacatcca ctcagcacct tccctgaggg actacatcct gtcatctgga
     1561 caggaccact tgctgacagc ttataaccag tgtgtgcagg ccctggcaga gctgcggagc
     1621 tatcacatca ccatggtcac caaatacctc atcacagctg cagccaaggc aaagcatggg
     1681 aagccaaacc atctcccagg gcctcctcag gctttaaaag acaggggcac aggtggaacc
     1741 gcagttatga gctttcttaa gagtgtcagg gataagacct tggagtcaat ccttcaccca
     1801 cgtggttagg aggctgccct ctccccagca atgcagagcc cccatggagg gcaggtgggc
     1861 ctggagaatg agggtcaggg ttctgcctgg gatcatccag gaaggatctc agccctattc
     1921 atgtttctgc tctacagagc actatattct ccttgttgag agctgttggc ttcacaaagg
     1981 agagttgatg tggccaagcc tttccctccc tacctgatca ctgcttaacg gcatgtataa
     2041 tggatacttc ctcatgcaga acccccagag gagtgactgt atgccattct ctttgccaag
     2101 taatagaaaa ccaatctaaa tgtcaaaaat cagataaaat tgcctgggga tacattactt
     2161 gttgattttc ttaaaaaaca aattcactta acaattcatt aagttcatac tgagcactgc
     2221 ctccaagatt aaaaccagga tttctgtggt cccagaccag ccctcttctc cctgaatgtg
     2281 ttgagttggt ggcaggaggt tggaaatgct ccagtggaga tgggaagata gaggatgctg
     2341 acaataagga cttggaagtc actagtgtga aaatgagcag ttaatgatat gggaacggat
     2401 gagactttcc acgtggtacc tagatttgca aattctattg taatgccttt atttttagaa
     2461 gaattattct ctcttcttac tctgaaaatc tgtatttgta aaatgaatga atggatccta
     2521 tataagtaaa taagaaaact gggaataagt agtaaatcaa tgtgtttagt gtgcaaataa
     2581 atgtaaatgc ttttattga
//
