LOCUS       NM_001001551             936 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens IDNK gluconokinase (IDNK), transcript variant 1, mRNA.
ACCESSION   NM_001001551 XM_497063
VERSION     NM_001001551.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 936)
  AUTHORS   Rohatgi,N., Guethmundsson,S. and Rolfsson,O.
  TITLE     Kinetic analysis of gluconate phosphorylation by human
            gluconokinase using isothermal titration calorimetry
  JOURNAL   FEBS Lett 589 (23), 3548-3555 (2015)
   PUBMED   26505675
REFERENCE   2  (bases 1 to 936)
  AUTHORS   Rohatgi,N., Nielsen,T.K., Bjorn,S.P., Axelsson,I., Paglia,G.,
            Voldborg,B.G., Palsson,B.O. and Rolfsson,O.
  TITLE     Biochemical characterization of human gluconokinase and the
            proposed metabolic impact of gluconic acid as determined by
            constraint based metabolic network analysis
  JOURNAL   PLoS One 9 (6), e98760 (2014)
   PUBMED   24896608
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 936)
  AUTHORS   Rolfsson,O., Paglia,G., Magnusdottir,M., Palsson,B.O. and Thiele,I.
  TITLE     Inferring the metabolism of human orphan metabolites from their
            metabolic network context affirms human gluconokinase activity
  JOURNAL   Biochem J 449 (2), 427-435 (2013)
   PUBMED   23067238
  REMARK    GeneRIF: Data show that C9orf103 encodes a functional
            gluconokinase.
REFERENCE   4  (bases 1 to 936)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC036421.1 and AY615889.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001001551.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.20673.1,
                                           SRR5189664.18512.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376419.5/ ENSP00000365601.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                BC036421.1         98-126
            30-936              AY615889.1         15-921
FEATURES             Location/Qualifiers
     source          1..936
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.32"
     gene            1..936
                     /gene="IDNK"
                     /gene_synonym="bA522I20.2; C9orf103; hGntK"
                     /note="IDNK gluconokinase"
                     /db_xref="GeneID:414328"
                     /db_xref="HGNC:HGNC:31367"
                     /db_xref="MIM:611343"
     exon            1..79
                     /gene="IDNK"
                     /gene_synonym="bA522I20.2; C9orf103; hGntK"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..593
                     /gene="IDNK"
                     /gene_synonym="bA522I20.2; C9orf103; hGntK"
                     /EC_number="2.7.1.12"
                     /note="isoform 1 is encoded by transcript variant 1;
                     gluconokinase-like protein; probable gluconokinase;
                     glucokinase-like protein; gluconate kinase; idnK,
                     gluconokinase homolog"
                     /codon_start=1
                     /product="probable gluconokinase isoform 1"
                     /protein_id="NP_001001551.2"
                     /db_xref="CCDS:CCDS35048.2"
                     /db_xref="GeneID:414328"
                     /db_xref="HGNC:HGNC:31367"
                     /db_xref="MIM:611343"
                     /translation="MAAPGALLVMGVSGSGKSTVGALLASELGWKFYDADDYHPEENR
                     RKMGKGIPLNDQDRIPWLCNLHDILLRDVASGQRVVLACSALKKTYRDILTQGKDGVA
                     LKCEESGKEAKQAEMQLLVVHLSGSFEVISGRLLKREGHFMPPELLQSQFETLEPPAA
                     PENFIQISVDKNVSEIIATIMETLKMK"
     exon            80..110
                     /gene="IDNK"
                     /gene_synonym="bA522I20.2; C9orf103; hGntK"
                     /inference="alignment:Splign:2.1.0"
     exon            111..197
                     /gene="IDNK"
                     /gene_synonym="bA522I20.2; C9orf103; hGntK"
                     /inference="alignment:Splign:2.1.0"
     exon            198..241
                     /gene="IDNK"
                     /gene_synonym="bA522I20.2; C9orf103; hGntK"
                     /inference="alignment:Splign:2.1.0"
     exon            242..936
                     /gene="IDNK"
                     /gene_synonym="bA522I20.2; C9orf103; hGntK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      916..921
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IDNK"
                     /gene_synonym="bA522I20.2; C9orf103; hGntK"
                     /note="hexamer: AATAAA"
     polyA_site      936
                     /gene="IDNK"
                     /gene_synonym="bA522I20.2; C9orf103; hGntK"
                     /note="major polyA site"
ORIGIN      
        1 aggcgacggg aaggagccga gcttgggtta tggcggcgcc gggcgcgctg ctggtgatgg
       61 gcgtgagcgg ctcggggaaa tccaccgtgg gcgccctgct ggcatctgag ctgggatgga
      121 aattctatga tgctgatgat tatcacccgg aggaaaatcg aaggaagatg ggaaaaggca
      181 taccgctcaa tgaccaggac cggattccat ggctctgtaa cttgcatgac attttactaa
      241 gagatgtagc ctcgggacag cgtgtggttc tagcctgttc agccctgaag aaaacgtaca
      301 gagacatatt aacacaagga aaagatggtg tagctctgaa gtgtgaggag tcgggaaagg
      361 aagcaaagca ggctgagatg cagctcctgg tggtccatct gagcgggtcg tttgaggtca
      421 tctctggacg cttactcaaa agagagggac attttatgcc ccctgaatta ttgcagtccc
      481 agtttgagac tctggagccc ccagcagctc cagaaaactt tatccaaata agtgtggaca
      541 aaaatgtttc agagataatt gctacaatta tggaaaccct aaaaatgaaa tgacaatgat
      601 tttgtatcag tggtccaaac agaactaagc ataaatcatt gtgccatccc aaacctcgtt
      661 ccagccgcct tgcccatact agattctaaa tgtttctaaa ggcaaacccc aatgtgtcaa
      721 gacagacttg tttaggtgta attttaggaa ttatgctggt tcatcaggaa gcagaggggg
      781 agttttaaaa gtcaagctta aattgaagtt taaattcatc tataaccaaa tcaaatgatc
      841 agaggaaatt ctgtaatcaa tgctggaaat cgttacattg tttagaacat tcttgctcat
      901 gcctgtattt gcacaaataa atgaaacttc gctgtc
//
