LOCUS       NM_033261               1356 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens isopentenyl-diphosphate delta isomerase 2 (IDI2),
            mRNA.
ACCESSION   NM_033261
VERSION     NM_033261.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1356)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1356)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   3  (bases 1 to 1356)
  AUTHORS   Nakamura,K., Mori,F., Tanji,K., Miki,Y., Yamada,M., Kakita,A.,
            Takahashi,H., Utsumi,J., Sasaki,H. and Wakabayashi,K.
  TITLE     Isopentenyl diphosphate isomerase, a cholesterol synthesizing
            enzyme, is localized in Lewy bodies
  JOURNAL   Neuropathology 35 (5), 432-440 (2015)
   PUBMED   25950736
  REMARK    GeneRIF: The present findings suggest that IDI1 and IDI2 may be
            associated with the production of cholesterol metabolites in
            neurons, leading to alpha-synuclein aggregation during the process
            of Lewy body formation.
REFERENCE   4  (bases 1 to 1356)
  AUTHORS   Kato,T., Emi,M., Sato,H., Arawaka,S., Wada,M., Kawanami,T.,
            Katagiri,T., Tsuburaya,K., Toyoshima,I., Tanaka,F., Sobue,G. and
            Matsubara,K.
  TITLE     Segmental copy-number gain within the region of isopentenyl
            diphosphate isomerase genes in sporadic amyotrophic lateral
            sclerosis
  JOURNAL   Biochem Biophys Res Commun 402 (2), 438-442 (2010)
   PUBMED   20955688
  REMARK    GeneRIF: Within the 40-kb region on 10p15.3 subtelomere, which
            harbours two genes encoding isopentenyl diphosphate isomerase 1
            (IDI1) and IDI2, there was found a segmental copy-number gain in a
            large proportion of sporadic amyotrophic lateral sclerosis
            patients.
REFERENCE   5  (bases 1 to 1356)
  AUTHORS   Clizbe,D.B., Owens,M.L., Masuda,K.R., Shackelford,J.E. and
            Krisans,S.K.
  TITLE     IDI2, a second isopentenyl diphosphate isomerase in mammals
  JOURNAL   J Biol Chem 282 (9), 6668-6676 (2007)
   PUBMED   17202134
  REMARK    GeneRIF: Enzyme kinetic analysis; both isozymes IDI1 and IDI2 are
            localized to the peroxisome by a PTS1-dependent pathway; data
            suggest that IDI2 is regulated independently from IDI1, by a
            mechanism that may involve PPARalpha
REFERENCE   6  (bases 1 to 1356)
  AUTHORS   Breitling,R., Laubner,D., Clizbe,D., Adamski,J. and Krisans,S.K.
  TITLE     Isopentenyl-diphosphate isomerases in human and mouse: evolutionary
            analysis of a mammalian gene duplication
  JOURNAL   J Mol Evol 57 (3), 282-291 (2003)
   PUBMED   14629038
  REMARK    GeneRIF: IDI2 is expressed at high levels only in skeletal muscle,
            where it may be involved in the specialized production of isoprenyl
            diphosphates for the posttranslational modification of proteins.
REFERENCE   7  (bases 1 to 1356)
  AUTHORS   Hahn,F.M., Xuan,J.W., Chambers,A.F. and Poulter,C.D.
  TITLE     Human isopentenyl diphosphate: dimethylallyl diphosphate isomerase:
            overproduction, purification, and characterization
  JOURNAL   Arch Biochem Biophys 332 (1), 30-34 (1996)
   PUBMED   8806705
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC022536.13.
            
            On Nov 23, 2018 this sequence version replaced NM_033261.2.
            
            Summary: The protein encoded by this gene catalyzes the conversion
            of isopentenyl diphosphate to dimethylallyl diphosphate, which is a
            precursor for the synthesis of cholesterol and other isoprenoids.
            This gene, which is a product of an ancestral gene duplication
            event, encodes a protein that may be involved in the aggregation of
            alpha-synuclein in the cerebral cortex of patients with Lewy body
            disease. In addition, segmental copy number gains in this locus
            have been associated with sporadic amyotrophic lateral sclerosis.
            [provided by RefSeq, Jul 2016].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK056950.1, BC017778.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2158800, SAMEA2162946
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000277517.2/ ENSP00000277517.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                AC022536.13        97803-97846
            45-207              AC022536.13        98918-99080
            208-300             AC022536.13        100887-100979
            301-431             AC022536.13        102765-102895
            432-1356            AC022536.13        103828-104752
FEATURES             Location/Qualifiers
     source          1..1356
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p15.3"
     gene            1..1356
                     /gene="IDI2"
                     /gene_synonym="IPPI2"
                     /note="isopentenyl-diphosphate delta isomerase 2"
                     /db_xref="GeneID:91734"
                     /db_xref="HGNC:HGNC:23487"
                     /db_xref="MIM:615389"
     exon            1..44
                     /gene="IDI2"
                     /gene_synonym="IPPI2"
                     /inference="alignment:Splign:2.1.0"
     exon            45..207
                     /gene="IDI2"
                     /gene_synonym="IPPI2"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..749
                     /gene="IDI2"
                     /gene_synonym="IPPI2"
                     /EC_number="5.3.3.2"
                     /note="diphosphate dimethylallyl diphosphate isomerase 2;
                     IPP isomerase 2; isopentenyl pyrophosphate isomerase 2"
                     /codon_start=1
                     /product="isopentenyl-diphosphate delta-isomerase 2"
                     /protein_id="NP_150286.1"
                     /db_xref="CCDS:CCDS7055.1"
                     /db_xref="GeneID:91734"
                     /db_xref="HGNC:HGNC:23487"
                     /db_xref="MIM:615389"
                     /translation="MSDINLDWVDRRQLQRLEEMLIVVDENDKVIGADTKRNCHLNEN
                     IEKGLLHRAFSVVLFNTKNRILIQQRSDTKVTFPGYFTDSCSSHPLYNPAELEEKDAI
                     GVRRAAQRRLQAELGIPGEQISPEDIVFMTIYHHKAKSDRIWGEHEICYLLLVRKNVT
                     LNPDPSETKSILYLSQEELWELLEREARGEVKVTPWLRTIAERFLYRWWPHLDDVTPF
                     VELHKIHRV"
     exon            208..300
                     /gene="IDI2"
                     /gene_synonym="IPPI2"
                     /inference="alignment:Splign:2.1.0"
     exon            301..431
                     /gene="IDI2"
                     /gene_synonym="IPPI2"
                     /inference="alignment:Splign:2.1.0"
     exon            432..1356
                     /gene="IDI2"
                     /gene_synonym="IPPI2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1333..1338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IDI2"
                     /gene_synonym="IPPI2"
                     /note="hexamer: AATAAA"
     polyA_site      1356
                     /gene="IDI2"
                     /gene_synonym="IPPI2"
                     /note="major polyA site"
ORIGIN      
        1 gagttccaca tctgataccc aggagtctcc agcttccaag agaggtcggg tcacagccag
       61 cagctatgtc tgacataaat cttgactggg ttgacaggcg tcagttgcag cgcttggagg
      121 aaatgctgat tgttgtggat gagaatgata aggttattgg tgccgacacc aagaggaatt
      181 gccatctgaa cgaaaacatt gagaaagggc tgctgcaccg agccttcagc gttgtcttgt
      241 ttaacaccaa gaatcgaatc ctgatacagc agaggtcgga cacgaaagtc acgtttcctg
      301 ggtattttac cgactcctgt agtagccacc cattatacaa cccagcagaa ctggaagaaa
      361 aggatgccat cggagtgagg agggcagccc agaggcgtct gcaagcagag ctgggaattc
      421 ctggggagca gatttctcca gaggacattg tgttcatgac aatctatcac cacaaggcaa
      481 aatcagacag aatttgggga gagcatgaaa tttgttacct tctgcttgtg aggaaaaacg
      541 tcactctgaa cccggatccc agtgaaacga aaagcatcct ctacctgtcc caggaggagc
      601 tgtgggagct gctggagagg gaggcgaggg gtgaagtcaa agtcaccccc tggctaagaa
      661 ccattgccga gaggtttctg taccggtggt ggcctcacct ggatgacgtg accccgtttg
      721 tggagcttca caaaatacac agagtgtgag aggcagggag gtcgagtcag ccatgtgtaa
      781 tgccctcagt gcaggcagac gcaccattga ggcaatgata caccctctcc aaaaaacagg
      841 gcaaaagggg cacttgattg cccatcatgt ataaatcact atttcaacct tttcatcaac
      901 tttgtcatat cttcattttc ccttttcctt atttccatat ttctcatctg cctggttgca
      961 gggaggaaat ttaacatttc ctttgtccca atttccattt tataagcact tgtttgatta
     1021 acagcagctg atcctgaaag tcttggggag atcttgagag tcctgaagca ggcggactag
     1081 cctggctgga ccatgaggct gtctccccac agctttatcc aagcctccaa ggtcaggatg
     1141 ggatctctgt atcatgtttt tctttttaaa tcacttattt cagagtgcaa cacaaggctg
     1201 catttttaaa aaaaagacac attcaatctt gcatcctaat acaagcagta cggaagatgc
     1261 gtatggtctc agccaagtga ctcgacgttt atccacttct gttcatttga tcgtttcagt
     1321 aatatgctta caaataaaga catacttgct ttaaaa
//
