LOCUS       NM_001546               3873 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens inhibitor of DNA binding 4 (ID4), mRNA.
ACCESSION   NM_001546
VERSION     NM_001546.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3873)
  AUTHORS   Choi,J.H., Park,J.D., Choi,S.H., Ko,E.S., Jang,H.J. and Park,K.S.
  TITLE     ELK3-ID4 axis governs the metastatic features of triple negative
            breast cancer
  JOURNAL   Oncol Res 32 (1), 127-138 (2023)
   PUBMED   38188675
  REMARK    GeneRIF: ELK3-ID4 axis governs the metastatic features of triple
            negative breast cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3873)
  AUTHORS   Qin,W., Zhang,J., Rong,R., Zhang,L., Gao,H., Liu,C., Ren,Q.,
            Zheng,G., Wang,J., Meng,L., Qiao,S., Qian,R., Zhou,C., Wang,H. and
            Zhang,Y.
  TITLE     Osteoglycin (OGN) promotes tumorigenesis of pancreatic cancer cell
            via targeting ID4
  JOURNAL   Tissue Cell 78, 101867 (2022)
   PUBMED   35908351
  REMARK    GeneRIF: Osteoglycin (OGN) promotes tumorigenesis of pancreatic
            cancer cell via targeting ID4.
REFERENCE   3  (bases 1 to 3873)
  AUTHORS   Feng,Y., Wang,X., Huang,C., Zhang,D., Liu,T., Zhang,C., Zhang,Y.,
            Ji,D., Tang,J. and Sun,Y.
  TITLE     Upregulated circTMEM59 Inhibits Cell Growth and Metastasis by
            miR-668-3p/ID4 Axis in Colorectal Cancer
  JOURNAL   Oxid Med Cell Longev 2022, 7242124 (2022)
   PUBMED   35656024
  REMARK    GeneRIF: Upregulated circTMEM59 Inhibits Cell Growth and Metastasis
            by miR-668-3p/ID4 Axis in Colorectal Cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3873)
  AUTHORS   Nasif,D., Real,S., Roque,M. and Branham,M.T.
  TITLE     CDC42 as an epigenetic regulator of ID4 in triple-negative breast
            tumors
  JOURNAL   Breast Cancer 29 (3), 562-573 (2022)
   PUBMED   35094293
  REMARK    GeneRIF: CDC42 as an epigenetic regulator of ID4 in triple-negative
            breast tumors.
REFERENCE   5  (bases 1 to 3873)
  AUTHORS   Zhu,K., Lin,J., Chen,S. and Xu,Q.
  TITLE     miR-9-5p Promotes Lung Adenocarcinoma Cell Proliferation, Migration
            and Invasion by Targeting ID4
  JOURNAL   Technol Cancer Res Treat 20, 15330338211048592 (2021)
   PUBMED   34723712
  REMARK    GeneRIF: miR-9-5p Promotes Lung Adenocarcinoma Cell Proliferation,
            Migration and Invasion by Targeting ID4.
REFERENCE   6  (bases 1 to 3873)
  AUTHORS   Lasorella,A., Benezra,R. and Iavarone,A.
  TITLE     The ID proteins: master regulators of cancer stem cells and tumour
            aggressiveness
  JOURNAL   Nat Rev Cancer 14 (2), 77-91 (2014)
   PUBMED   24442143
  REMARK    Review article
REFERENCE   7  (bases 1 to 3873)
  AUTHORS   Rigolet,M., Rich,T., Gross-Morand,M.S., Molina-Gomes,D.,
            Viegas-Pequignot,E. and Junien,C.
  TITLE     cDNA cloning, tissue distribution and chromosomal localization of
            the human ID4 gene
  JOURNAL   DNA Res 5 (5), 309-313 (1998)
   PUBMED   9872455
REFERENCE   8  (bases 1 to 3873)
  AUTHORS   Stewart,H.J., Zoidl,G., Rossner,M., Brennan,A., Zoidl,C.,
            Nave,K.A., Mirsky,R. and Jessen,K.R.
  TITLE     Helix-loop-helix proteins in Schwann cells: a study of regulation
            and subcellular localization of Ids, REB, and E12/47 during
            embryonic and postnatal development
  JOURNAL   J Neurosci Res 50 (5), 684-701 (1997)
   PUBMED   9418957
REFERENCE   9  (bases 1 to 3873)
  AUTHORS   Loveys,D.A., Streiff,M.B. and Kato,G.J.
  TITLE     E2A basic-helix-loop-helix transcription factors are negatively
            regulated by serum growth factors and by the Id3 protein
  JOURNAL   Nucleic Acids Res 24 (14), 2813-2820 (1996)
   PUBMED   8759016
REFERENCE   10 (bases 1 to 3873)
  AUTHORS   Pagliuca,A., Bartoli,P.C., Saccone,S., Della Valle,G. and Lania,L.
  TITLE     Molecular cloning of ID4, a novel dominant negative
            helix-loop-helix human gene on chromosome 6p21.3-p22
  JOURNAL   Genomics 27 (1), 200-203 (1995)
   PUBMED   7665172
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB461864.1, BC014941.1,
            AL022726.1 and AI692586.1.
            
            On Nov 24, 2018 this sequence version replaced NM_001546.3.
            
            Summary: This gene encodes a member of the inhibitor of DNA binding
            (ID) protein family. The encoded protein lacks DNA binding ability,
            and instead regulates gene expression through binding to and
            inhibiting basic helix-loop-helix transcription factors. This
            protein has been implicated in the regulation of diverse cellular
            processes that play a role in development and tumorigenesis.
            [provided by RefSeq, Aug 2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.9507.1,
                                           SRR1803614.153180.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378700.8/ ENSP00000367972.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                DB461864.1         1-16
            17-2300             BC014941.1         1-2284
            2301-3863           AL022726.1         68195-69757         c
            3864-3873           AI692586.1         19-28               c
FEATURES             Location/Qualifiers
     source          1..3873
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.3"
     gene            1..3873
                     /gene="ID4"
                     /gene_synonym="bHLHb27; IDB4"
                     /note="inhibitor of DNA binding 4"
                     /db_xref="GeneID:3400"
                     /db_xref="HGNC:HGNC:5363"
                     /db_xref="MIM:600581"
     exon            1..826
                     /gene="ID4"
                     /gene_synonym="bHLHb27; IDB4"
                     /inference="alignment:Splign:2.1.0"
     CDS             386..871
                     /gene="ID4"
                     /gene_synonym="bHLHb27; IDB4"
                     /note="class B basic helix-loop-helix protein 27;
                     inhibitor of differentiation 4; inhibitor of DNA binding
                     4, dominant negative helix-loop-helix protein; inhibitor
                     of DNA binding 4, HLH protein"
                     /codon_start=1
                     /product="DNA-binding protein inhibitor ID-4"
                     /protein_id="NP_001537.1"
                     /db_xref="CCDS:CCDS4544.1"
                     /db_xref="GeneID:3400"
                     /db_xref="HGNC:HGNC:5363"
                     /db_xref="MIM:600581"
                     /translation="MKAVSPVRPSGRKAPSGCGGGELALRCLAEHGHSLGGSAAAAAA
                     AAAARCKAAEAAADEPALCLQCDMNDCYSRLRRLVPTIPPNKKVSKVEILQHVIDYIL
                     DLQLALETHPALLRQPPPPAPPHHPAGTCPAAPPRTPLTALNTDPAGAVNKQGDSILC
                     R"
     exon            827..885
                     /gene="ID4"
                     /gene_synonym="bHLHb27; IDB4"
                     /inference="alignment:Splign:2.1.0"
     exon            886..3873
                     /gene="ID4"
                     /gene_synonym="bHLHb27; IDB4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2335..2340
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ID4"
                     /gene_synonym="bHLHb27; IDB4"
                     /note="hexamer: ATTAAA"
     polyA_site      2360
                     /gene="ID4"
                     /gene_synonym="bHLHb27; IDB4"
                     /note="major polyA site"
     regulatory      3852..3857
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ID4"
                     /gene_synonym="bHLHb27; IDB4"
                     /note="hexamer: AATAAA"
     polyA_site      3873
                     /gene="ID4"
                     /gene_synonym="bHLHb27; IDB4"
ORIGIN      
        1 gagagcgtag tggaggaggc gcggttgtga gtagtaccgg gagtggggtg atcccgggct
       61 aggggagcgc ggcggccgcg atcgggctta gtcggagctc cgaagggagt gactaggaca
      121 cccgggtggg ctacttttct tccggtgctt ttgctttttt tttcctttgg gctcgggctg
      181 agtgtcgccc actgagcaaa gattccctcg taaaacccag agcgaccctc ccgtcaattg
      241 ttgggctcgg gagtgtcgcg gtgccccgag cgcgccgggc gcggaggcaa agggagcgga
      301 gccggccgcg gacggggccc ggagcttgcc tgcctccctc gctcgcccca gcgggttcgc
      361 tcgcgtagag cgcagggcgc gcgcgatgaa ggcggtgagc ccggtgcgcc cctcgggccg
      421 caaggcgccg tcgggctgcg gcggcgggga gctggcgctg cgctgcctgg ccgagcacgg
      481 ccacagcctg ggtggctccg cagccgcggc ggcggcggcg gcggcagcgc gctgtaaggc
      541 ggccgaggcg gcggccgacg agccggcgct gtgcctgcag tgcgatatga acgactgcta
      601 tagccgcctg cggaggctgg tgcccaccat cccgcccaac aagaaagtca gcaaagtgga
      661 gatcctgcag cacgttatcg actacatcct ggacctgcag ctggcgctgg agacgcaccc
      721 ggccctgctg aggcagccac caccgcccgc gccgccacac cacccggccg ggacctgtcc
      781 agccgcgccg ccgcggaccc cgctcactgc gctcaacacc gacccggccg gcgcggtgaa
      841 caagcagggc gacagcattc tgtgccgctg agccgcgctg tccaggtgtg cggccgcctg
      901 agcccgagcc aggagcacta gagagggagg gggaagagca gaagttagag aaaaaaagcc
      961 accggaggaa aggaaaaaac atcggccaac ctagaaacgt tttcattcgt cattccaaga
     1021 gagagagagg aaagaaaaat acaactttca ttctttcttt gcacgttcat aaacattcta
     1081 catacgtatt ctcttttgtc tcttcattta taactgctgt gaattgtaca tttctgtgtt
     1141 ttttggaggt gcagttaaac ttttaagctt aagtgtgaca ggactgataa atagaagatc
     1201 aagagtagat ccgactttag aagcctactt tgtgaccaag gagctcaatt tttgttttga
     1261 agctttacta atctaccaga gcattgtaga tatttttttt ttacatctat tgtttaaaat
     1321 agatgattat aacggggcag agaactttct tttctctgca agaatgttac atattgtata
     1381 gataaatgag tgacatttca taccatgtat atatagagat gttctataag tgtgagaaag
     1441 tatatgcttt aatagatact gtaattataa gatattttta attaaatatt tttttgtaaa
     1501 tattatgtgt gtgttttttt ttaatctatg ggaatatttc ttttggaaaa tcatttttca
     1561 gctcaattac agagctcttg atatcttgaa tgtcttttct gtttggcctg gctcttaatt
     1621 tgcttttgtt ttgcccagta tagactcgga agtaacagtt atagctagtg gtcttgcatg
     1681 attgcatgag atgtttaatc acaaattaaa cttgttctga gtccattcaa atgtgttttt
     1741 ttaaatgtag attgaaatct ttgtatttga agcatacatg ttgaaaatac accttatcag
     1801 tttttaagta cagggtttta tagtgtaata tatacagagt aagtgtttgt ttttgttttt
     1861 caactgaggt caaaatggat tctgaatgat tttgcatatg ggatgaggaa atgcttggat
     1921 ccttaaggag tttacgaaat ctgctgtttt atcaaagtga aaaaaaattg cttattactc
     1981 ttcattttac actaaagctt aatgtcacta agtttcatgt ctgtacagat tatttaaatc
     2041 atggaaatga aaaaaatgtt ctctgcttgc taccaaagga caaactcttg gaaatgaaca
     2101 ctttctgctt tccttcctcc aaagaattaa taggcaacag tgggagaaaa aaaaggcata
     2161 atggcaaatc cttcaagcag ggataaaagt cgatcttcaa acattaactt aagcagacca
     2221 aaaattctga tgaccgcatc tagattattt ttttataaaa atgattttca ctatagctat
     2281 gttacgctaa gctactgtcc aatctcttgt gatgtgtaac ttttacatgt gaatattaaa
     2341 gtagatttct ctgtcttgta ctgtgatttc tggtctcatt tctttaaaac cttactctta
     2401 tttttctttt aaggctcttt tttctcctta aggaaggtaa tattttctag gttagatagg
     2461 actatcaggg tttgtgaaca ttatgcattt aatgttatgg gtactttaca cacaagttag
     2521 atggaatttt tagagtgaaa gaattaagta ggatttaatt gggtgctttg taaatagtca
     2581 actgtgtgta taacgtggtc tgtttgattt ttaaaaggaa aggatttgtt tcagattata
     2641 caagaataaa agtattatag acccaaggga cttcttatga ggtcaaattc agatatttat
     2701 atgaatatga aataccatgg tccctagtag tcagttgaag tggcaatgtc taaacagaaa
     2761 tgaacaaaac taatgctagc aggttaaaat caatcaaaat gtttaaaaat tgattctgtc
     2821 ctcagcatgt tatttcctca gctctgataa tttactggtc ttgagtattt tgagaatttg
     2881 atgttgaacg ttataaagtc aaagaactgc ttgtttagat gaggtttatt tttatttttg
     2941 atattattca ttcttgtcac acatcaagaa gaaaacacta gagtgctgct ggaattccaa
     3001 atctgaagaa ttctaacgac tgcattcttt gttattaaaa agggcacaat ccttcctttt
     3061 tatttggcag tttaatttca gtaggaagca tgtcacatgt gcactgttgg ttagaattat
     3121 gcatctgtca tgcctgactg ctgaacccta cctaagcctt ttggcgcagt ttaaaactta
     3181 tactggtgga ctgtgaacct caaaacaaat gggtattttt gggttttgag gatagatgtt
     3241 actccttaaa gtttgtattt ggggcatgaa aaactactga aagaagaaaa gtgctacaga
     3301 tactacattt caaagagttg gcattttccc tttggccact caagcagcat ttgatgtatc
     3361 taaagaaaca aagtcattgt ttatttttta aaaaattata tgcagttgta caagatacta
     3421 cattccattg aaatgttggc tatgtcctaa ccaggcaacc agataacaaa aacattttga
     3481 gtcttttatc taggtagttc taattattca gctacttagt ttaacaaagg aaaatatcct
     3541 gacttctctc atttcatttg tagacttttc attgtatagg cacaaccaaa gagtcagact
     3601 ggtttaaaac tccagaagga aaaaaagtat cccacacagt ggatgttgtt tctaagaatg
     3661 ctacaaaatc ctgacatctc agacatctca atgttaaagg aagaaaaaaa ataccttttc
     3721 atttcaaaga actaatatac tttgatattg tgtaaacctt actcaagttt attgtcaagc
     3781 tttaactgcc tttttagaac tttttaaaat ttcgagccca caaatctatt gtattagttg
     3841 ccttctataa caataaatct tcactgagca aaa
//
