LOCUS       NM_002167                950 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens inhibitor of DNA binding 3 (ID3), mRNA.
ACCESSION   NM_002167
VERSION     NM_002167.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 950)
  AUTHORS   Nagasaka,M., Miyajima,C., Inoue,Y., Hashiguchi,S., Suzuki,Y.,
            Morishita,D., Aoki,H., Toriuchi,K., Katayama,R., Aoyama,M. and
            Hayashi,H.
  TITLE     ID3 is a novel target gene of p53 and modulates lung cancer cell
            metastasis
  JOURNAL   Biochem Biophys Res Commun 708, 149789 (2024)
   PUBMED   38513475
  REMARK    GeneRIF: ID3 is a novel target gene of p53 and modulates lung
            cancer cell metastasis.
REFERENCE   2  (bases 1 to 950)
  AUTHORS   Yeh,C.Y., Cai,H.Y., Kuo,H.H., Lin,Y.Y., He,Z.J., Cheng,H.C.,
            Yang,C.J., Huang,C.F. and Chang,Y.C.
  TITLE     ALDOA coordinates PDE3A through the beta-catenin/ID3 axis to
            stimulate cancer metastasis and M2 polarization in lung cancer with
            EGFR mutations
  JOURNAL   Biochem Biophys Res Commun 696, 149489 (2024)
   PUBMED   38244313
  REMARK    GeneRIF: ALDOA coordinates PDE3A through the beta-catenin/ID3 axis
            to stimulate cancer metastasis and M2 polarization in lung cancer
            with EGFR mutations.
REFERENCE   3  (bases 1 to 950)
  AUTHORS   Deng,Z., Loyher,P.L., Lazarov,T., Li,L., Shen,Z., Bhinder,B.,
            Yang,H., Zhong,Y., Alberdi,A., Massague,J., Sun,J.C., Benezra,R.,
            Glass,C.K., Elemento,O., Iacobuzio-Donahue,C.A. and Geissmann,F.
  TITLE     The nuclear factor ID3 endows macrophages with a potent anti-tumour
            activity
  JOURNAL   Nature 626 (8000), 864-873 (2024)
   PUBMED   38326607
  REMARK    GeneRIF: The nuclear factor ID3 endows macrophages with a potent
            anti-tumour activity.
REFERENCE   4  (bases 1 to 950)
  AUTHORS   Wang,Y., He,S., Calendo,G., Bui,T., Tian,Y., Lee,C.Y., Zhou,Y.,
            Zhao,X., Abraham,C., Mo,W., Chen,M., Sanders-Braggs,R., Madzo,J.,
            Issa,J.P., Hexner,E.O., Wiest,D.L., Reshef,R., Xue,H.H. and
            Zhang,Y.
  TITLE     Tissue-infiltrating alloreactive T cells require Id3 to deflect
            PD-1-mediated immune suppression during GVHD
  JOURNAL   Blood 143 (2), 166-177 (2024)
   PUBMED   37871574
  REMARK    GeneRIF: Tissue-infiltrating alloreactive T cells require Id3 to
            deflect PD-1-mediated immune suppression during GVHD.
REFERENCE   5  (bases 1 to 950)
  AUTHORS   Lu,D., Cai,H., Li,Y., Chang,W., Liu,X., Dai,Q., Yu,W., Chen,W.,
            Qiao,G., Xie,H., Xiao,X. and Li,Z.
  TITLE     Investigating the ID3/SLC22A4 as immune-related signatures in
            ischemic stroke
  JOURNAL   Aging (Albany NY) 15 (24), 14803-14829 (2023)
   PUBMED   38112574
  REMARK    GeneRIF: Investigating the ID3/SLC22A4 as immune-related signatures
            in ischemic stroke.
REFERENCE   6  (bases 1 to 950)
  AUTHORS   White,P.S., Maris,J.M., Beltinger,C., Sulman,E., Marshall,H.N.,
            Fujimori,M., Kaufman,B.A., Biegel,J.A., Allen,C., Hilliard,C.,
            Valentine,M.B., Look,A.T., Enomoto,H., Sakiyama,S. and Brodeur,G.M.
  TITLE     A region of consistent deletion in neuroblastoma maps within human
            chromosome 1p36.2-36.3
  JOURNAL   Proc Natl Acad Sci U S A 92 (12), 5520-5524 (1995)
   PUBMED   7777541
REFERENCE   7  (bases 1 to 950)
  AUTHORS   Deed,R.W., Hirose,T., Mitchell,E.L., Santibanez-Koref,M.F. and
            Norton,J.D.
  TITLE     Structural organisation and chromosomal mapping of the human Id-3
            gene
  JOURNAL   Gene 151 (1-2), 309-314 (1994)
   PUBMED   7828896
REFERENCE   8  (bases 1 to 950)
  AUTHORS   Kato,S., Sekine,S., Oh,S.W., Kim,N.S., Umezawa,Y., Abe,N.,
            Yokoyama-Kobayashi,M. and Aoki,T.
  TITLE     Construction of a human full-length cDNA bank
  JOURNAL   Gene 150 (2), 243-250 (1994)
   PUBMED   7821789
REFERENCE   9  (bases 1 to 950)
  AUTHORS   Deed,R.W., Bianchi,S.M., Atherton,G.T., Johnston,D.,
            Santibanez-Koref,M., Murphy,J.J. and Norton,J.D.
  TITLE     An immediate early human gene encodes an Id-like helix-loop-helix
            protein and is regulated by protein kinase C activation in diverse
            cell types
  JOURNAL   Oncogene 8 (3), 599-607 (1993)
   PUBMED   8437843
REFERENCE   10 (bases 1 to 950)
  AUTHORS   Ellmeier,W., Aguzzi,A., Kleiner,E., Kurzbauer,R. and Weith,A.
  TITLE     Mutually exclusive expression of a helix-loop-helix gene and N-myc
            in human neuroblastomas and in normal development
  JOURNAL   EMBO J 11 (7), 2563-2571 (1992)
   PUBMED   1628620
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC003107.1 and AL021154.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002167.4.
            
            Summary: The protein encoded by this gene is a helix-loop-helix
            (HLH) protein that can form heterodimers with other HLH proteins.
            However, the encoded protein lacks a basic DNA-binding domain and
            therefore inhibits the DNA binding of any HLH protein with which it
            interacts. [provided by RefSeq, Aug 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.174333.1,
                                           SRR5189655.132403.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374561.6/ ENSP00000363689.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-387               BC003107.1         12-398
            388-388             AL021154.1         108771-108771       c
            389-705             BC003107.1         400-716
            706-706             AL021154.1         107934-107934       c
            707-946             BC003107.1         718-957
            947-950             AL021154.1         107690-107693       c
FEATURES             Location/Qualifiers
     source          1..950
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.12"
     gene            1..950
                     /gene="ID3"
                     /gene_synonym="bHLHb25; HEIR-1"
                     /note="inhibitor of DNA binding 3"
                     /db_xref="GeneID:3399"
                     /db_xref="HGNC:HGNC:5362"
                     /db_xref="MIM:600277"
     exon            1..375
                     /gene="ID3"
                     /gene_synonym="bHLHb25; HEIR-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..435
                     /gene="ID3"
                     /gene_synonym="bHLHb25; HEIR-1"
                     /note="helix-loop-helix protein HEIR-1; ID-like protein
                     inhibitor HLH 1R21; class B basic helix-loop-helix protein
                     25; inhibitor of differentiation 3; inhibitor of DNA
                     binding 3, dominant negative helix-loop-helix protein;
                     inhibitor of DNA binding 3, HLH protein"
                     /codon_start=1
                     /product="DNA-binding protein inhibitor ID-3"
                     /protein_id="NP_002158.3"
                     /db_xref="CCDS:CCDS237.1"
                     /db_xref="GeneID:3399"
                     /db_xref="HGNC:HGNC:5362"
                     /db_xref="MIM:600277"
                     /translation="MKALSPVRGCYEAVCCLSERSLAIARGRGKGPAAEEPLSLLDDM
                     NHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVLAEPAPGPPDGPHLPIQTA
                     ELTPELVISNDKRSFCH"
     exon            376..460
                     /gene="ID3"
                     /gene_synonym="bHLHb25; HEIR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            461..950
                     /gene="ID3"
                     /gene_synonym="bHLHb25; HEIR-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      924..929
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ID3"
                     /gene_synonym="bHLHb25; HEIR-1"
                     /note="hexamer: AATAAA"
     polyA_site      950
                     /gene="ID3"
                     /gene_synonym="bHLHb25; HEIR-1"
                     /note="major polyA site"
ORIGIN      
        1 gcgttgcagg tcactgtagc gggacttctt ttggttttct ttctctttgg ggcacctctg
       61 gactcactcc ccagcatgaa ggcgctgagc ccggtgcgcg gctgctacga ggcggtgtgc
      121 tgcctgtcgg aacgcagtct ggccatcgcc cggggccgag ggaagggccc ggcagctgag
      181 gagccgctga gcttgctgga cgacatgaac cactgctact cccgcctgcg ggaactggta
      241 cccggagtcc cgagaggcac tcagcttagc caggtggaaa tcctacagcg cgtcatcgac
      301 tacattctcg acctgcaggt agtcctggcc gagccagccc ctggaccccc tgatggcccc
      361 caccttccca tccagacagc cgagctcact ccggaacttg tcatctccaa cgacaaaagg
      421 agcttttgcc actgactcgg ccgtgtcctg acacctccag aacgcaggtg ctggcgcccg
      481 ttctgcctgg gaccccggga acctctcctg ccggaagccg gacggcaggg atgggcccca
      541 acttcgccct gcccacttga cttcaccaaa tcccttcctg gagactaaac ctggtgctca
      601 ggagcgaagg actgtgaact tgtggcctga agagccagag ctagctctgg ccaccagctg
      661 ggcgacgtca ccctgctccc accccacccc caagttctaa ggtctcttca gagcgtggag
      721 gtgtggaagg agtggctgct ctccaaacta tgccaaggcg gcggcagagc tggtcttctg
      781 gtctccttgg agaaaggttc tgttgccctg atttatgaac tctataatag agtatatagg
      841 ttttgtacct tttttacagg aaggtgactt tctgtaacaa tgcgatgtat attaaacttt
      901 ttataaaagt taacattttg cataataaac gatttttaaa cacttgtgta
//
