LOCUS       NM_002166               1299 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens inhibitor of DNA binding 2 (ID2), mRNA.
ACCESSION   NM_002166
VERSION     NM_002166.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1299)
  AUTHORS   Vazquez-Cabrera,G., Skandik,M., Roncier,N., Real Oualit,F., Cruz De
            Los Santos,M., Baleviciute,A., Cheray,M. and Joseph,B.
  TITLE     ID2-ETS2 axis regulates the transcriptional acquisition of
            pro-tumoral microglia phenotype in glioma
  JOURNAL   Cell Death Dis 15 (7), 512 (2024)
   PUBMED   39019900
  REMARK    GeneRIF: ID2-ETS2 axis regulates the transcriptional acquisition of
            pro-tumoral microglia phenotype in glioma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1299)
  AUTHORS   Deng,Z., Xu,M., Ding,Z., Kong,J., Liu,J., Zhang,Z. and Cao,P.
  TITLE     ID2 promotes tumor progression and metastasis in thyroid cancer
  JOURNAL   Endocrine 84 (3), 1051-1063 (2024)
   PUBMED   38195969
  REMARK    GeneRIF: ID2 promotes tumor progression and metastasis in thyroid
            cancer.
REFERENCE   3  (bases 1 to 1299)
  AUTHORS   Elfiky,A.A.
  TITLE     Prediction of the binding location between the nuclear inhibitor of
            DNA binding and differentiation 2 (ID2) and HSPA5
  JOURNAL   Pathol Res Pract 255, 155217 (2024)
   PUBMED   38422912
  REMARK    GeneRIF: Prediction of the binding location between the nuclear
            inhibitor of DNA binding and differentiation 2 (ID2) and HSPA5.
REFERENCE   4  (bases 1 to 1299)
  AUTHORS   Han,M., Guo,Y., Li,Y., Zeng,Q., Zhu,W. and Jiang,J.
  TITLE     SMURF2 facilitates ubiquitin-mediated degradation of ID2 to
            attenuate lung cancer cell proliferation
  JOURNAL   Int J Biol Sci 19 (11), 3324-3340 (2023)
   PUBMED   37497010
  REMARK    GeneRIF: SMURF2 facilitates ubiquitin-mediated degradation of ID2
            to attenuate lung cancer cell proliferation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1299)
  AUTHORS   Lasorella,A., Iavarone,A. and Israel,M.A.
  TITLE     Id2 specifically alters regulation of the cell cycle by tumor
            suppressor proteins
  JOURNAL   Mol Cell Biol 16 (6), 2570-2578 (1996)
   PUBMED   8649364
REFERENCE   6  (bases 1 to 1299)
  AUTHORS   Mathew,S., Chen,W., Murty,V.V., Benezra,R. and Chaganti,R.S.
  TITLE     Chromosomal assignment of human ID1 and ID2 genes
  JOURNAL   Genomics 30 (2), 385-387 (1995)
   PUBMED   8586447
REFERENCE   7  (bases 1 to 1299)
  AUTHORS   Iavarone,A., Garg,P., Lasorella,A., Hsu,J. and Israel,M.A.
  TITLE     The helix-loop-helix protein Id-2 enhances cell proliferation and
            binds to the retinoblastoma protein
  JOURNAL   Genes Dev 8 (11), 1270-1284 (1994)
   PUBMED   7926730
REFERENCE   8  (bases 1 to 1299)
  AUTHORS   Hara,E., Yamaguchi,T., Nojima,H., Ide,T., Campisi,J., Okayama,H.
            and Oda,K.
  TITLE     Id-related genes encoding helix-loop-helix proteins are required
            for G1 progression and are repressed in senescent human fibroblasts
  JOURNAL   J Biol Chem 269 (3), 2139-2145 (1994)
   PUBMED   8294468
REFERENCE   9  (bases 1 to 1299)
  AUTHORS   Kurabayashi,M., Jeyaseelan,R. and Kedes,L.
  TITLE     Two distinct cDNA sequences encoding the human helix-loop-helix
            protein Id2
  JOURNAL   Gene 133 (2), 305-306 (1993)
   PUBMED   8224921
REFERENCE   10 (bases 1 to 1299)
  AUTHORS   Biggs,J., Murphy,E.V. and Israel,M.A.
  TITLE     A human Id-like helix-loop-helix protein expressed during early
            development
  JOURNAL   Proc Natl Acad Sci U S A 89 (4), 1512-1516 (1992)
   PUBMED   1741406
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011747.8.
            
            On Nov 26, 2018 this sequence version replaced NM_002166.4.
            
            Summary: The protein encoded by this gene belongs to the inhibitor
            of DNA binding family, members of which are transcriptional
            regulators that contain a helix-loop-helix (HLH) domain but not a
            basic domain. Members of the inhibitor of DNA binding family
            inhibit the functions of basic helix-loop-helix transcription
            factors in a dominant-negative manner by suppressing their
            heterodimerization partners through the HLH domains. This protein
            may play a role in negatively regulating cell differentiation. A
            pseudogene of this gene is located on chromosome 3. [provided by
            RefSeq, Aug 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.165011.1,
                                           SRR3476690.248816.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396290.2/ ENSP00000379585.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-458               AC011747.8         133701-134158
            459-522             AC011747.8         134488-134551
            523-1299            AC011747.8         135330-136106
FEATURES             Location/Qualifiers
     source          1..1299
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p25.1"
     gene            1..1299
                     /gene="ID2"
                     /gene_synonym="bHLHb26; GIG8; ID2A; ID2H"
                     /note="inhibitor of DNA binding 2"
                     /db_xref="GeneID:3398"
                     /db_xref="HGNC:HGNC:5361"
                     /db_xref="MIM:600386"
     exon            1..458
                     /gene="ID2"
                     /gene_synonym="bHLHb26; GIG8; ID2A; ID2H"
                     /inference="alignment:Splign:2.1.0"
     exon            459..522
                     /gene="ID2"
                     /gene_synonym="bHLHb26; GIG8; ID2A; ID2H"
                     /inference="alignment:Splign:2.1.0"
     exon            523..1299
                     /gene="ID2"
                     /gene_synonym="bHLHb26; GIG8; ID2A; ID2H"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1133..1138
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ID2"
                     /gene_synonym="bHLHb26; GIG8; ID2A; ID2H"
                     /note="hexamer: AATAAA"
     polyA_site      1156
                     /gene="ID2"
                     /gene_synonym="bHLHb26; GIG8; ID2A; ID2H"
                     /note="major polyA site"
     regulatory      1270..1275
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ID2"
                     /gene_synonym="bHLHb26; GIG8; ID2A; ID2H"
                     /note="hexamer: AATAAA"
     polyA_site      1299
                     /gene="ID2"
                     /gene_synonym="bHLHb26; GIG8; ID2A; ID2H"
ORIGIN      
        1 attctgagcc gagcccggtg ccaagcgcag ctagctcagc aggcggcagc ggcggcctga
       61 gcttcagggc agccagctcc ctcccggtct cgccttccct cgcggtcagc atgaaagcct
      121 tcagtcccgt gaggtccgtt aggaaaaaca gcctgtcgga ccacagcctg ggcatctccc
      181 ggagcaaaac ccctgtggac gacccgatga gcctgctata caacatgaac gactgctact
      241 ccaagctcaa ggagctggtg cccagcatcc cccagaacaa gaaggtgagc aagatggaaa
      301 tcctgcagca cgtcatcgac tacatcttgg acctgcagat cgccctggac tcgcatccca
      361 ctattgtcag cctgcatcac cagagacccg ggcagaacca ggcgtccagg acgccgctga
      421 ccaccctcaa cacggatatc agcatcctgt ccttgcaggc ttctgaattc ccttctgagt
      481 taatgtcaaa tgacagcaaa gcactgtgtg gctgaataag cggtgttcat gatttctttt
      541 attctttgca caacaacaac aacaacaaat tcacggaatc ttttaagtgc tgaacttatt
      601 tttcaaccat ttcacaagga ggacaagttg aatggacctt tttaaaaaga aaaaaaaaat
      661 ggaaggaaaa ctaagaatga tcatcttccc agggtgttct cttacttgga ctgtgatatt
      721 cgttatttat gaaaaagact tttaaatgcc ctttctgcag ttggaaggtt ttctttatat
      781 actattccca ccatggggag cgaaaacgtt aaaatcacaa ggaattgccc aatctaagca
      841 gactttgcct tttttcaaag gtggagcgtg aataccagaa ggatccagta ttcagtcact
      901 taaatgaagt cttttggtca gaaattacct ttttgacaca agcctactga atgctgtgta
      961 tatatttata tataaatata tctatttgag tgaaaccttg tgaactcttt aattagagtt
     1021 ttcttgtata gtggcagaga tgtctatttc tgcattcaaa agtgtaatga tgtacttatt
     1081 catgctaaac tttttataaa agtttagttg taaacttaac ccttttatac aaaataaatc
     1141 aagtgtgttt attgaatggt gattgcctgc tttatttcag aggaccagtg ctttgatttt
     1201 tattatgcta tgttataact gaacccaaat aaatacaagt tcaaatttat gtagactgta
     1261 taagattata ataaaacatg tctgaagtca atacctgaa
//
