LOCUS       NM_002165                983 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens inhibitor of DNA binding 1 (ID1), transcript variant
            1, mRNA.
ACCESSION   NM_002165
VERSION     NM_002165.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 983)
  AUTHORS   Shang,S., Yang,C., Chen,F., Xiang,R.S., Zhang,H., Dai,S.Y., Liu,J.,
            Lv,X.X., Zhang,C., Liu,X.T., Zhang,Q., Lu,S.B., Song,J.W., Yu,J.J.,
            Zhou,J.C., Zhang,X.W., Cui,B., Li,P.P., Zhu,S.T., Zhang,H.Z. and
            Hua,F.
  TITLE     ID1 expressing macrophages support cancer cell stemness and limit
            CD8+ T cell infiltration in colorectal cancer
  JOURNAL   Nat Commun 14 (1), 7661 (2023)
   PUBMED   37996458
  REMARK    GeneRIF: ID1 expressing macrophages support cancer cell stemness
            and limit CD8[+] T cell infiltration in colorectal cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 983)
  AUTHORS   Nguyen,A., Sung,Y., Lee,S.H., Martin,C.E., Srikanth,S., Chen,W.,
            Kang,M.K., Kim,R.H., Park,N.H., Gwack,Y., Kim,Y. and Shin,K.H.
  TITLE     Orai3 Calcium Channel Contributes to Oral/Oropharyngeal Cancer
            Stemness through the Elevation of ID1 Expression
  JOURNAL   Cells 12 (18), 2225 (2023)
   PUBMED   37759448
  REMARK    GeneRIF: Orai3 Calcium Channel Contributes to Oral/Oropharyngeal
            Cancer Stemness through the Elevation of ID1 Expression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 983)
  AUTHORS   Fei,M.Y., Wang,Y., Chang,B.H., Xue,K., Dong,F., Huang,D., Li,X.Y.,
            Li,Z.J., Hu,C.L., Liu,P., Wu,J.C., Yu,P.C., Hong,M.H., Chen,S.B.,
            Xu,C.H., Chen,B.Y., Jiang,Y.L., Liu,N., Zhao,C., Jin,J.C., Hou,D.,
            Chen,X.C., Ren,Y.Y., Deng,C.H., Zhang,J.Y., Zong,L.J., Wang,R.J.,
            Gao,F.F., Liu,H., Zhang,Q.L., Wu,L.Y., Yan,J., Shen,S., Chang,C.K.,
            Sun,X.J. and Wang,L.
  TITLE     The non-cell-autonomous function of ID1 promotes AML progression
            via ANGPTL7 from the microenvironment
  JOURNAL   Blood 142 (10), 903-917 (2023)
   PUBMED   37319434
  REMARK    GeneRIF: The non-cell-autonomous function of ID1 promotes AML
            progression via ANGPTL7 from the microenvironment.
REFERENCE   4  (bases 1 to 983)
  AUTHORS   Ma,J., Wen,X., Xu,Z., Xia,P., Jin,Y., Lin,J. and Qian,J.
  TITLE     Abnormal regulation of miR-29b-ID1 signaling is involved in the
            process of decitabine resistance in leukemia cells
  JOURNAL   Cell Cycle 22 (10), 1215-1231 (2023)
   PUBMED   37032592
  REMARK    GeneRIF: Abnormal regulation of miR-29b-ID1 signaling is involved
            in the process of decitabine resistance in leukemia cells.
REFERENCE   5  (bases 1 to 983)
  AUTHORS   Tang,Y., Zhang,S., Li,J., Wu,C. and Fan,Q.
  TITLE     ID1 marks the tumorigenesis of pancreatic ductal adenocarcinoma in
            mouse and human
  JOURNAL   Sci Rep 12 (1), 13555 (2022)
   PUBMED   35941362
  REMARK    GeneRIF: ID1 marks the tumorigenesis of pancreatic ductal
            adenocarcinoma in mouse and human.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 983)
  AUTHORS   Mathew,S., Chen,W., Murty,V.V., Benezra,R. and Chaganti,R.S.
  TITLE     Chromosomal assignment of human ID1 and ID2 genes
  JOURNAL   Genomics 30 (2), 385-387 (1995)
   PUBMED   8586447
REFERENCE   7  (bases 1 to 983)
  AUTHORS   Zhu,W., Dahmen,J., Bulfone,A., Rigolet,M., Hernandez,M.C.,
            Kuo,W.L., Puelles,L., Rubenstein,J.L. and Israel,M.A.
  TITLE     Id gene expression during development and molecular cloning of the
            human Id-1 gene
  JOURNAL   Brain Res Mol Brain Res 30 (2), 312-326 (1995)
   PUBMED   7637581
REFERENCE   8  (bases 1 to 983)
  AUTHORS   Pagliuca,A., Bartoli,P.C., Saccone,S., Della Valle,G. and Lania,L.
  TITLE     Molecular cloning of ID4, a novel dominant negative
            helix-loop-helix human gene on chromosome 6p21.3-p22
  JOURNAL   Genomics 27 (1), 200-203 (1995)
   PUBMED   7665172
REFERENCE   9  (bases 1 to 983)
  AUTHORS   Deed,R.W., Jasiok,M. and Norton,J.D.
  TITLE     Nucleotide sequence of the cDNA encoding human helix-loop-helix
            Id-1 protein: identification of functionally conserved residues
            common to Id proteins
  JOURNAL   Biochim Biophys Acta 1219 (1), 160-162 (1994)
   PUBMED   8086456
REFERENCE   10 (bases 1 to 983)
  AUTHORS   Hara,E., Yamaguchi,T., Nojima,H., Ide,T., Campisi,J., Okayama,H.
            and Oda,K.
  TITLE     Id-related genes encoding helix-loop-helix proteins are required
            for G1 progression and are repressed in senescent human fibroblasts
  JOURNAL   J Biol Chem 269 (3), 2139-2145 (1994)
   PUBMED   8294468
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA839689.1, BC012420.1 and
            AI304595.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002165.3.
            
            Summary: The protein encoded by this gene is a helix-loop-helix
            (HLH) protein that can form heterodimers with members of the basic
            HLH family of transcription factors. The encoded protein has no DNA
            binding activity and therefore can inhibit the DNA binding and
            transcriptional activation ability of basic HLH proteins with which
            it interacts. This protein may play a role in cell growth,
            senescence, and differentiation. Two transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform (a,
            also called ID-1H).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.26681.1, BM809372.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376112.4/ ENSP00000365280.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-542               DA839689.1         7-548
            543-962             BC012420.1         530-949
            963-983             AI304595.1         12-32               c
FEATURES             Location/Qualifiers
     source          1..983
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.21"
     gene            1..983
                     /gene="ID1"
                     /gene_synonym="bHLHb24; ID"
                     /note="inhibitor of DNA binding 1"
                     /db_xref="GeneID:3397"
                     /db_xref="HGNC:HGNC:5360"
                     /db_xref="MIM:600349"
     exon            1..525
                     /gene="ID1"
                     /gene_synonym="bHLHb24; ID"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..567
                     /gene="ID1"
                     /gene_synonym="bHLHb24; ID"
                     /note="isoform a is encoded by transcript variant 1;
                     inhibitor of differentiation 1; dJ857M17.1.2 (inhibitor of
                     DNA binding 1, dominant negative helix-loop-helix
                     protein); class B basic helix-loop-helix protein 24;
                     inhibitor of DNA binding 1, HLH protein"
                     /codon_start=1
                     /product="DNA-binding protein inhibitor ID-1 isoform a"
                     /protein_id="NP_002156.2"
                     /db_xref="CCDS:CCDS13185.1"
                     /db_xref="GeneID:3397"
                     /db_xref="HGNC:HGNC:5360"
                     /db_xref="MIM:600349"
                     /translation="MKVASGSTATAAAGPSCALKAGKTASGAGEVVRCLSEQSVAISR
                     CAGGAGARLPALLDEQQVNVLLYDMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYI
                     RDLQLELNSESEVGTPGGRGLPVRAPLSTLNGEISALTAEAACVPADDRILCR"
     exon            526..983
                     /gene="ID1"
                     /gene_synonym="bHLHb24; ID"
                     /inference="alignment:Splign:2.1.0"
     regulatory      960..965
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ID1"
                     /gene_synonym="bHLHb24; ID"
                     /note="hexamer: ATTAAA"
     polyA_site      983
                     /gene="ID1"
                     /gene_synonym="bHLHb24; ID"
                     /note="major polyA site"
ORIGIN      
        1 attccacgtt cttaactgtt ccattttccg tatctgcttc gggcttccac ctcatttttt
       61 tcgctttgcc cattctgttt cagccagtcg ccaagaatca tgaaagtcgc cagtggcagc
      121 accgccaccg ccgccgcggg ccccagctgc gcgctgaagg ccggcaagac agcgagcggt
      181 gcgggcgagg tggtgcgctg tctgtctgag cagagcgtgg ccatctcgcg ctgcgccggg
      241 ggcgccgggg cgcgcctgcc tgccctgctg gacgagcagc aggtaaacgt gctgctctac
      301 gacatgaacg gctgttactc acgcctcaag gagctggtgc ccaccctgcc ccagaaccgc
      361 aaggtgagca aggtggagat tctccagcac gtcatcgact acatcaggga ccttcagttg
      421 gagctgaact cggaatccga agttggaacc cccgggggcc gagggctgcc ggtccgggct
      481 ccgctcagca ccctcaacgg cgagatcagc gccctgacgg ccgaggcggc atgcgttcct
      541 gcggacgatc gcatcttgtg tcgctgaagc gcctccccca gggaccggcg gaccccagcc
      601 atccaggggg caagaggaat tacgtgctct gtgggtctcc cccaacgcgc ctcgccggat
      661 ctgagggaga acaagaccga tcggcggcca ctgcgccctt aactgcatcc agcctggggc
      721 tgaggctgag gcactggcga ggagagggcg ctcctctctg cacacctact agtcaccaga
      781 gactttaggg ggtgggattc cactcgtgtg tttctatttt ttgaaaagca gacattttaa
      841 aaaatggtca cgtttggtgc ttctcagatt tctgaggaaa ttgctttgta ttgtatatta
      901 caatgatcac cgactgaaaa tattgtttta caatagttct gtggggctgt ttttttgtta
      961 ttaaacaaat aatttagatg gtg
//
