LOCUS       NM_015259               7078 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens inducible T cell costimulator ligand (ICOSLG),
            transcript variant 1, mRNA.
ACCESSION   NM_015259
VERSION     NM_015259.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7078)
  AUTHORS   Zong,L., Zheng,Y., Yu,X., Dai,X., Huang,R., Yan,G., Xu,Y. and
            Zheng,M.
  TITLE     ICOS-ICOSL pathway enhances NKT-like cell antiviral function in
            pregnant women with COVID-19
  JOURNAL   Int J Med Sci 21 (10), 1890-1902 (2024)
   PUBMED   39113896
  REMARK    GeneRIF: ICOS-ICOSL pathway enhances NKT-like cell antiviral
            function in pregnant women with COVID-19.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7078)
  AUTHORS   Leopizzi,M., Mundo,L., Messina,E., Campolo,F., Lazzi,S.,
            Angeloni,A., Marchese,C., Leoncini,L., Giordano,C., Slack,F.,
            Trivedi,P. and Anastasiadou,E.
  TITLE     Epstein-Barr virus-encoded EBNA2 downregulates ICOSL by inducing
            miR-24 in B-cell lymphoma
  JOURNAL   Blood 143 (5), 429-443 (2024)
   PUBMED   37847858
  REMARK    GeneRIF: Epstein-Barr virus-encoded EBNA2 downregulates ICOSL by
            inducing miR-24 in B-cell lymphoma.
REFERENCE   3  (bases 1 to 7078)
  AUTHORS   Zhang,L. and Gao,Y.
  TITLE     ICOSLG acts as an oncogene to promote glycolysis, proliferation,
            migration, and invasion in gastric cancer cells
  JOURNAL   Arch Biochem Biophys 752, 109841 (2024)
   PUBMED   38081339
  REMARK    GeneRIF: ICOSLG acts as an oncogene to promote glycolysis,
            proliferation, migration, and invasion in gastric cancer cells.
REFERENCE   4  (bases 1 to 7078)
  AUTHORS   Provera,A., Ramavath,N.N., Gadipudi,L.L., Gigliotti,C.L.,
            Boggio,E., Vecchio,C., Stoppa,I., Rolla,R., Boldorini,R.,
            Pirisi,M., Smirne,C., Albano,E., Dianzani,U. and Sutti,S.
  TITLE     Role of the co-stimulatory molecule inducible T-cell co-stimulator
            ligand (ICOSL) in the progression of experimental metabolic
            dysfunction-associated steatohepatitis
  JOURNAL   Front Immunol 14, 1290391 (2023)
   PUBMED   38077334
  REMARK    GeneRIF: Role of the co-stimulatory molecule inducible T-cell
            co-stimulator ligand (ICOSL) in the progression of experimental
            metabolic dysfunction-associated steatohepatitis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7078)
  AUTHORS   Zhan,X.K., Liu,X.K., Zhang,S. and Chen,H.
  TITLE     Expression and prognosis of inducible T-cell co-stimulator and its
            ligand in Chinese stage I-III lung adenocarcinoma patients
  JOURNAL   Animal Model Exp Med 6 (5), 464-473 (2023)
   PUBMED   37850501
  REMARK    GeneRIF: Expression and prognosis of inducible T-cell co-stimulator
            and its ligand in Chinese stage I-III lung adenocarcinoma patients.
REFERENCE   6  (bases 1 to 7078)
  AUTHORS   Ling,V., Wu,P.W., Miyashiro,J.S., Marusic,S., Finnerty,H.F. and
            Collins,M.
  TITLE     Differential expression of inducible costimulator-ligand splice
            variants: lymphoid regulation of mouse GL50-B and human GL50
            molecules
  JOURNAL   J Immunol 166 (12), 7300-7308 (2001)
   PUBMED   11390480
REFERENCE   7  (bases 1 to 7078)
  AUTHORS   Wang,S., Zhu,G., Chapoval,A.I., Dong,H., Tamada,K., Ni,J. and
            Chen,L.
  TITLE     Costimulation of T cells by B7-H2, a B7-like molecule that binds
            ICOS
  JOURNAL   Blood 96 (8), 2808-2813 (2000)
   PUBMED   11023515
REFERENCE   8  (bases 1 to 7078)
  AUTHORS   Yoshinaga,S.K., Zhang,M., Pistillo,J., Horan,T., Khare,S.D.,
            Miner,K., Sonnenberg,M., Boone,T., Brankow,D., Dai,T., Delaney,J.,
            Han,H., Hui,A., Kohno,T., Manoukian,R., Whoriskey,J.S. and
            Coccia,M.A.
  TITLE     Characterization of a new human B7-related protein: B7RP-1 is the
            ligand to the co-stimulatory protein ICOS
  JOURNAL   Int Immunol 12 (10), 1439-1447 (2000)
   PUBMED   11007762
REFERENCE   9  (bases 1 to 7078)
  AUTHORS   Aicher,A., Hayden-Ledbetter,M., Brady,W.A., Pezzutto,A.,
            Richter,G., Magaletti,D., Buckwalter,S., Ledbetter,J.A. and
            Clark,E.A.
  TITLE     Characterization of human inducible costimulator ligand expression
            and function
  JOURNAL   J Immunol 164 (9), 4689-4696 (2000)
   PUBMED   10779774
REFERENCE   10 (bases 1 to 7078)
  AUTHORS   Ling,V., Wu,P.W., Finnerty,H.F., Bean,K.M., Spaulding,V.,
            Fouser,L.A., Leonard,J.P., Hunter,S.E., Zollner,R., Thomas,J.L.,
            Miyashiro,J.S., Jacobs,K.A. and Collins,M.
  TITLE     Cutting edge: identification of GL50, a novel B7-like protein that
            functionally binds to ICOS receptor
  JOURNAL   J Immunol 164 (4), 1653-1657 (2000)
   PUBMED   10657606
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK314369.1, AP001058.1 and BQ005303.1.
            
            On Jun 2, 2019 this sequence version replaced NM_015259.5.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.155469.1,
                                           SRR1803611.197220.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000407780.8/ ENSP00000384432.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1035              AK314369.1         24-1058
            1036-3230           AP001058.1         22523-24717         c
            3231-3242           BQ005303.1         18-29               c
            3243-7078           AP001058.1         18675-22510         c
FEATURES             Location/Qualifiers
     source          1..7078
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..7078
                     /gene="ICOSLG"
                     /gene_synonym="B7-H2; B7h; B7H2; B7RP-1; B7RP1; CD275;
                     GL50; ICOS-L; ICOSL; IMD119; LICOS"
                     /note="inducible T cell costimulator ligand"
                     /db_xref="GeneID:23308"
                     /db_xref="HGNC:HGNC:17087"
                     /db_xref="MIM:605717"
     exon            1..140
                     /gene="ICOSLG"
                     /gene_synonym="B7-H2; B7h; B7H2; B7RP-1; B7RP1; CD275;
                     GL50; ICOS-L; ICOSL; IMD119; LICOS"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..1035
                     /gene="ICOSLG"
                     /gene_synonym="B7-H2; B7h; B7H2; B7RP-1; B7RP1; CD275;
                     GL50; ICOS-L; ICOSL; IMD119; LICOS"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; B7 homologue 2; transmembrane protein B7-H2
                     ICOS ligand; B7 homolog 2; B7-like protein Gl50;
                     B7-related protein 1"
                     /codon_start=1
                     /product="ICOS ligand isoform a precursor"
                     /protein_id="NP_056074.1"
                     /db_xref="CCDS:CCDS42952.1"
                     /db_xref="GeneID:23308"
                     /db_xref="HGNC:HGNC:17087"
                     /db_xref="MIM:605717"
                     /translation="MRLGSPGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSR
                     FDLNDVYVYWQTSESKTVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFN
                     VTPQDEQKFHCLVLSQSLGFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTS
                     INGYPRPNVYWINKTDNSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIE
                     NVLLQQNLTVGSQTGNDIGERDKITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWV
                     CRDRCLQHSYAGAWAVSPETELTGHV"
     exon            141..181
                     /gene="ICOSLG"
                     /gene_synonym="B7-H2; B7h; B7H2; B7RP-1; B7RP1; CD275;
                     GL50; ICOS-L; ICOSL; IMD119; LICOS"
                     /inference="alignment:Splign:2.1.0"
     exon            182..532
                     /gene="ICOSLG"
                     /gene_synonym="B7-H2; B7h; B7H2; B7RP-1; B7RP1; CD275;
                     GL50; ICOS-L; ICOSL; IMD119; LICOS"
                     /inference="alignment:Splign:2.1.0"
     exon            533..823
                     /gene="ICOSLG"
                     /gene_synonym="B7-H2; B7h; B7H2; B7RP-1; B7RP1; CD275;
                     GL50; ICOS-L; ICOSL; IMD119; LICOS"
                     /inference="alignment:Splign:2.1.0"
     exon            824..988
                     /gene="ICOSLG"
                     /gene_synonym="B7-H2; B7h; B7H2; B7RP-1; B7RP1; CD275;
                     GL50; ICOS-L; ICOSL; IMD119; LICOS"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1024
                     /gene="ICOSLG"
                     /gene_synonym="B7-H2; B7h; B7H2; B7RP-1; B7RP1; CD275;
                     GL50; ICOS-L; ICOSL; IMD119; LICOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..7078
                     /gene="ICOSLG"
                     /gene_synonym="B7-H2; B7h; B7H2; B7RP-1; B7RP1; CD275;
                     GL50; ICOS-L; ICOSL; IMD119; LICOS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7049..7054
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ICOSLG"
                     /gene_synonym="B7-H2; B7h; B7H2; B7RP-1; B7RP1; CD275;
                     GL50; ICOS-L; ICOSL; IMD119; LICOS"
                     /note="hexamer: AATAAA"
     polyA_site      7078
                     /gene="ICOSLG"
                     /gene_synonym="B7-H2; B7h; B7H2; B7RP-1; B7RP1; CD275;
                     GL50; ICOS-L; ICOSL; IMD119; LICOS"
                     /note="major polyA site"
ORIGIN      
        1 gcagttagag ccgatctccc gcgccccgag gttgctcctc tccgaggtct cccgcggccc
       61 aagttctccg cgccccgagg tctccgcgcc ccgaggtctc cgcggcccga ggtctccgcc
      121 cgcaccatgc ggctgggcag tcctggactg ctcttcctgc tcttcagcag ccttcgagct
      181 gatactcagg agaaggaagt cagagcgatg gtaggcagcg acgtggagct cagctgcgct
      241 tgccctgaag gaagccgttt tgatttaaat gatgtttacg tatattggca aaccagtgag
      301 tcgaaaaccg tggtgaccta ccacatccca cagaacagct ccttggaaaa cgtggacagc
      361 cgctaccgga accgagccct gatgtcaccg gccggcatgc tgcggggcga cttctccctg
      421 cgcttgttca acgtcacccc ccaggacgag cagaagtttc actgcctggt gttgagccaa
      481 tccctgggat tccaggaggt tttgagcgtt gaggttacac tgcatgtggc agcaaacttc
      541 agcgtgcccg tcgtcagcgc cccccacagc ccctcccagg atgagctcac cttcacgtgt
      601 acatccataa acggctaccc caggcccaac gtgtactgga tcaataagac ggacaacagc
      661 ctgctggacc aggctctgca gaatgacacc gtcttcttga acatgcgggg cttgtatgac
      721 gtggtcagcg tgctgaggat cgcacggacc cccagcgtga acattggctg ctgcatagag
      781 aacgtgcttc tgcagcagaa cctgactgtc ggcagccaga caggaaatga catcggagag
      841 agagacaaga tcacagagaa tccagtcagt accggcgaga aaaacgcggc cacgtggagc
      901 atcctggctg tcctgtgcct gcttgtggtc gtggcggtgg ccataggctg ggtgtgcagg
      961 gaccgatgcc tccaacacag ctatgcaggt gcctgggctg tgagtccgga gacagagctc
     1021 actggccacg tttgaccgga gctcaccgcc cagagcgtgg acagggcttc cgtgagacgc
     1081 caccgtgaga ggccaggtgg cagcttgagc atggactccc agactgcagg ggagcacttg
     1141 gggcagcccc cagaaggacc actgctggat cccagggaga acctgctggc gttggctgtg
     1201 atcctggaat gaggcccttt caaaagcgtc atccacacca aaggcaaatg tccccaagtg
     1261 agtgggctcc ccgctgtcac tgccagtcac ccacaggaag ggactggtga tgggctgtct
     1321 ctacccggag cgtgcgggat tcagcaccag gctcttccca gtaccccaga cccactgtgg
     1381 gtcttcccgt gggatgcggg atcctgagac cgaagggtgt ttggtttaaa aagaagactg
     1441 ggcgtccgct cttccaggac ggcctctgtg ctgctggggt cacgcgaggc tgtttgcagg
     1501 ggacacggtc acaggagctc ttctgccctg aacgctccca acctgcctcc cgcccggaag
     1561 ccacaggacc cactcatgtg tgtgcccaca agtgtagtta gccgtccaca ccgaggagcc
     1621 cccggaagtc cccactgggc ttcagtgtcc tctgccacat tccctgggag gaacaatgtc
     1681 cctcggctgt tccggtgaaa agttgagcca cctttggaag acgcacgggt ggagtttgcc
     1741 agaagaaagg ctgtgccagg gccgtgtttg gctacagggg ctgccggggc tcttggctct
     1801 gcagcgagaa agacacagcc cagcagggct ggagacgccc atgtccagca ggcgcaggcc
     1861 tggcaacacg gtccccagag tcctgagcag cagttaggtg catggagagg gtatcacctg
     1921 gtggccacag tcccccttct cacctcagca atgatcccca aagtgagagg tggctccccc
     1981 ggcccccacc accctcagca gccccacccc actcaaccct gagggtcccc agggtcctga
     2041 tgaagacctc cgaccccagc gccaggctcc tcggagccca acagtcccaa gggggcagga
     2101 gacggggtgg tccagtgctg aggggtacag ccctgggccc tgaccagccc cggcacctgc
     2161 catgctggtt cccggaatga atcagctgct gactgtctcc agaagggctg gaaaggatgc
     2221 tgccaggtga cccgaggtgc actcgcccca gggagatgga gtagacagcc tggcctggcc
     2281 ctcgggacac attgtctgcc ccggggctat gggcaaatgc ccctccttct tacttcccag
     2341 aatcccctga cattcccagg gtcagccagg acctgttaca gccctggtca cttggaactg
     2401 acagctgtgt gaggcctgca cttctcagac ccagacttag aacaaaagga ggagtgagga
     2461 ctcaaggcta caatgaggtt ccagtacttg ttacaagaaa ttggttttct gcaaaaaaag
     2521 tccctacctg agcctttagg tgaatgtggg atccactccc gcttttaaca tgaaagcatt
     2581 agaagatgtg tggtgtttat aaaagaacag ttgtcatcac cgggcattga ttggcaggga
     2641 caaggagctg cttgggtgtg gaaagttggg gcgttggaaa gtgggctgtg gtgcccattt
     2701 gcagtgactg tgaagtgact ccaggacgga cctgcggggg cacccagagg tcctaagccc
     2761 caggactgag ggtcgtgcat caccactcgg gtgtcccggg aggtgccctg ggcccgggga
     2821 cctcacaggc aggacggcga cactaatgca gggagaggga gtctggcccc agcttttcct
     2881 atcagaggcg attttccttc accaggggat gggcaggaaa gaggcagggg ccccagaagc
     2941 ttctgtccct catgcctgag ggcacggggg acacttggag gctgctgtca ccactgtgcg
     3001 tccaaggcca tgctctctgc gggtcagtgc ctgagtctcg cctccctgct ggtccctgaa
     3061 gccccctcag aagccctgcc tgtcacgtcg gcatttgtga gacctaccct gtaacgcctg
     3121 cccctctcag cccaacatca gcttcctctt tctcccttgc tgtagacagg ctggattcca
     3181 gtgttgggac agccatctcc agaaacctga cttaagagag taagatgcaa atcgtgcctg
     3241 tatccagtgg ctttggtggg tgcagggagt cttgggcaca gccagctcag ctgtctgtgg
     3301 tatgagcagg aacaggtgcc actcctgctc aggggaccct gccctacacc aggctgttcc
     3361 gtccccctgg aggacatggg gccaggtctg gaggcatttt gggttgtcac agctgggggc
     3421 tgttcctcgg cttcagcggg tggaagcctc agatgctgtt caacatcttc tggacacggg
     3481 aggccccgac agagagaagc gtccacccgc aagtccacag tctgaggtct cccctcagag
     3541 accctgccct gcacacccac ctccagccaa aggtcctgcc tgccccaggg ctcaggggaa
     3601 ccttgccggt ctgtggaaca ggagagggga ctctcgccag ctgcaccacc ctgcacgtag
     3661 taggtgtgcg gtaaacatcc accagggagg ctccagtcaa ggctggcaga tggggcggtc
     3721 catccctagg gcaggtgaca gaagggaaaa ggctgcctgc tggcccccga gccaggtagc
     3781 acatgcttgt gcctcagttt cccctcctgt aaagtgaggc gctggatcca ggttctgtct
     3841 actgggctct gcagcttgga cgctcctaag accaagcgac ccaccctggg gagggcagct
     3901 atggctttgg aatagctgtc caggcccggg tgcctccaag acggccacca caccctgcct
     3961 gtgctgcagg ggtgcagggg taaggggcaa gactccagag gcctcctctc tgcatctcct
     4021 tgtcttcagt ggccggaggt gaggcctgag ctcaggggag gggcttctgc cacgaaccct
     4081 atggcggggc acagcacact tttcccaggg aggacccctg ggccccctgc attatcccca
     4141 gcggagtgtg gggtcacctt ccaagagcga cattgagaag ctccagctct aggagtgtgc
     4201 agactcttaa ccaggcaggc ccaggccctg gggcacacaa aggcggggcc tgctctcccc
     4261 agctgcccct gccaatgggg gctggactgt cctaccctcc tcccttctac ctccccactg
     4321 tcttccctct ccactgtcac cactgcctcc ctcttccact gtcctccatg cactgccctc
     4381 cctccacctt cccccacccc caccactccc catgctgtcc ccaggctccc cccgctctcc
     4441 cccctcccca ctgtccccct ccccatgctg tacccagctc accccgctct cccctctccc
     4501 cactgtcccc cctcccactc cccatgctgt ccccagctca ccctacatgg acttggcgat
     4561 gtccttccat ggctcaccgg tctgaatttc catgatgagc cgggcctgca gctttgctcc
     4621 cctatccctg cccaggctgc agctgtccat gcagggagcg agctccagca cctgcggagt
     4681 ccttccgtgg gggcctctcc gtgccacagc agccagggac ctcaggtgcc tgtgcatgac
     4741 accaccgccc atcctcatcc tgagccagcc tctcaggatc aggacttggt ttggcggcgt
     4801 taaccttaga gcctgcaagg ggcttcctcc tggtgggtct ggccgtagcc tggggaggcc
     4861 acagctccag gccactccag acctcccttc ctctgggcct tccatgtggt ggcaaccacc
     4921 gcagctgtaa gggagggaaa atggagcgtt tgttctcggg ctgggctggg gtctggggga
     4981 agccatgggc gtgaagactg gagtattatt tgatggagaa gcggccactc ctggagaccg
     5041 gcggcaaaca cagaagcaca gcgtggaagg tgctggtgtc agcccacacg ggtgatgggg
     5101 tcagactcag gagtcacact caggagtcac caggctcaaa gggcccaggc accgcaagtc
     5161 ctgctcagcc ccagacacaa tgcattcctg ttgccctcgc cctcagccag gccccacgca
     5221 ggccagggag cactggcaaa gcttggcaac cctctggggg ccagccttca tccaggccga
     5281 aggtggtcag tggcccacca tggcccaggt agaaaactca cggattaaga tttcatgccc
     5341 gactccaaag gcaagagact ttattatttt attttttttg agccagagta tcgctctgtc
     5401 acctaggctg gagtgcaatc tctgctcatt gcaacatctg cctcccgaac tcaagcaatt
     5461 ctgcctcagc ctcccaagta gctgggatta caggtgtgcg ccaccatgcc caggtaattg
     5521 tatttttagt agagacaggg tttcaccatg ttggtcaggc tggtttcaaa ctcctgacct
     5581 caaatgatct gcccacctcg acctcccaaa gtgctgggat tacaggtgcg agccaccgca
     5641 cctggctacc agacacttca gagttacagg ttagtttttc tttttctttt attttttttt
     5701 ttttggcgga ggtgcagggg gagttaaaca aacaaacaaa ataaacaggc cgggtgcggt
     5761 ggctcatgcc tgtaatccca gcactttagg aggcctaggt gggtggatca cgagatcagg
     5821 ggttcaagac cagcctggcc gagatggtaa aaccccgtct ccactaaaaa tacaaaaatt
     5881 ggccaggcac ggtggctcac acctgtaatc ccagtacttt gggaggctga ggtgggcaga
     5941 tcacctgagg tcaggagttc aagaccaacc tgaccaacat ggagaaaccc catctctact
     6001 aaaaatacaa aattagccag gtgtggtggt gcatgcctgt aattccagct actcgggagg
     6061 ctgaggcagg agaattgctt gaacccagga ggcagaggtt gcagtgggcc aagatggcgc
     6121 cattgcactc cagcctggga acaagagcga aactctgact aaaaaagaaa gaaagaaaga
     6181 aaaaaattag ttgggcacgg tggcaggcgc ctgtaatccc aggtactcag gaggctgagg
     6241 caggagaatt gcttgaaccc gggaggcaga ggtcgcagtg agccgagatt gcaccactgc
     6301 cctccagcct gggtgacaga gcaagactcc gtctcaaaaa aaaaaaaaaa aaaaattgga
     6361 tacattgtaa tacctcaaat acttgtaagt gaagcacccc agttcccata gagctgccgc
     6421 actcagaggc ttctgtaacc tgcctgctcc cagcattcta tttagggtct ggtatgtcca
     6481 gaatttgcag acacagcaat tcctgcagca gcagtgcacc atgtggaagg ggccccatga
     6541 ccagcccact gtgagctcac acgtgatgac tgaggcttct tcacacagca gggctctggg
     6601 tgtgataccc agggcacacg cgtttgcaca ggcacaggcc acacaagttc tcacatgctc
     6661 agccccataa gccgtgctgg acaggcatgg ccatttacac ccaggatcct gctgagaaca
     6721 gcaaccaact caccaccctc gcatcatgat ccttgccaca caggggctct ggtggctttg
     6781 gtggcctggg ctgtggctct gctgccagcc accttgagtg aagatccggg ttctctgggt
     6841 gctactcagc tgctatgtgg ggagctggcc cctggggtga tgagggccct tcccaacccg
     6901 ccctcagccc ttggacagcc aggatcaccc ggggctgtct gcatacagac ttctcagggg
     6961 agttctcagc ttggaccctt atctccccag aatcctggaa cctgctcctt ctgctctcgt
     7021 gactgactgt gttctctatg caacttccaa taaaacctct tcatttgaaa ggaaaaaa
//
