LOCUS       NM_001283050            1112 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens inducible T cell costimulator ligand (ICOSLG),
            transcript variant 2, mRNA.
ACCESSION   NM_001283050 XM_005261101
VERSION     NM_001283050.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1112)
  AUTHORS   Zong,L., Zheng,Y., Yu,X., Dai,X., Huang,R., Yan,G., Xu,Y. and
            Zheng,M.
  TITLE     ICOS-ICOSL pathway enhances NKT-like cell antiviral function in
            pregnant women with COVID-19
  JOURNAL   Int J Med Sci 21 (10), 1890-1902 (2024)
   PUBMED   39113896
  REMARK    GeneRIF: ICOS-ICOSL pathway enhances NKT-like cell antiviral
            function in pregnant women with COVID-19.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1112)
  AUTHORS   Leopizzi,M., Mundo,L., Messina,E., Campolo,F., Lazzi,S.,
            Angeloni,A., Marchese,C., Leoncini,L., Giordano,C., Slack,F.,
            Trivedi,P. and Anastasiadou,E.
  TITLE     Epstein-Barr virus-encoded EBNA2 downregulates ICOSL by inducing
            miR-24 in B-cell lymphoma
  JOURNAL   Blood 143 (5), 429-443 (2024)
   PUBMED   37847858
  REMARK    GeneRIF: Epstein-Barr virus-encoded EBNA2 downregulates ICOSL by
            inducing miR-24 in B-cell lymphoma.
REFERENCE   3  (bases 1 to 1112)
  AUTHORS   Zhang,L. and Gao,Y.
  TITLE     ICOSLG acts as an oncogene to promote glycolysis, proliferation,
            migration, and invasion in gastric cancer cells
  JOURNAL   Arch Biochem Biophys 752, 109841 (2024)
   PUBMED   38081339
  REMARK    GeneRIF: ICOSLG acts as an oncogene to promote glycolysis,
            proliferation, migration, and invasion in gastric cancer cells.
REFERENCE   4  (bases 1 to 1112)
  AUTHORS   Provera,A., Ramavath,N.N., Gadipudi,L.L., Gigliotti,C.L.,
            Boggio,E., Vecchio,C., Stoppa,I., Rolla,R., Boldorini,R.,
            Pirisi,M., Smirne,C., Albano,E., Dianzani,U. and Sutti,S.
  TITLE     Role of the co-stimulatory molecule inducible T-cell co-stimulator
            ligand (ICOSL) in the progression of experimental metabolic
            dysfunction-associated steatohepatitis
  JOURNAL   Front Immunol 14, 1290391 (2023)
   PUBMED   38077334
  REMARK    GeneRIF: Role of the co-stimulatory molecule inducible T-cell
            co-stimulator ligand (ICOSL) in the progression of experimental
            metabolic dysfunction-associated steatohepatitis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1112)
  AUTHORS   Zhan,X.K., Liu,X.K., Zhang,S. and Chen,H.
  TITLE     Expression and prognosis of inducible T-cell co-stimulator and its
            ligand in Chinese stage I-III lung adenocarcinoma patients
  JOURNAL   Animal Model Exp Med 6 (5), 464-473 (2023)
   PUBMED   37850501
  REMARK    GeneRIF: Expression and prognosis of inducible T-cell co-stimulator
            and its ligand in Chinese stage I-III lung adenocarcinoma patients.
REFERENCE   6  (bases 1 to 1112)
  AUTHORS   Ling,V., Wu,P.W., Miyashiro,J.S., Marusic,S., Finnerty,H.F. and
            Collins,M.
  TITLE     Differential expression of inducible costimulator-ligand splice
            variants: lymphoid regulation of mouse GL50-B and human GL50
            molecules
  JOURNAL   J Immunol 166 (12), 7300-7308 (2001)
   PUBMED   11390480
REFERENCE   7  (bases 1 to 1112)
  AUTHORS   Wang,S., Zhu,G., Chapoval,A.I., Dong,H., Tamada,K., Ni,J. and
            Chen,L.
  TITLE     Costimulation of T cells by B7-H2, a B7-like molecule that binds
            ICOS
  JOURNAL   Blood 96 (8), 2808-2813 (2000)
   PUBMED   11023515
REFERENCE   8  (bases 1 to 1112)
  AUTHORS   Yoshinaga,S.K., Zhang,M., Pistillo,J., Horan,T., Khare,S.D.,
            Miner,K., Sonnenberg,M., Boone,T., Brankow,D., Dai,T., Delaney,J.,
            Han,H., Hui,A., Kohno,T., Manoukian,R., Whoriskey,J.S. and
            Coccia,M.A.
  TITLE     Characterization of a new human B7-related protein: B7RP-1 is the
            ligand to the co-stimulatory protein ICOS
  JOURNAL   Int Immunol 12 (10), 1439-1447 (2000)
   PUBMED   11007762
REFERENCE   9  (bases 1 to 1112)
  AUTHORS   Aicher,A., Hayden-Ledbetter,M., Brady,W.A., Pezzutto,A.,
            Richter,G., Magaletti,D., Buckwalter,S., Ledbetter,J.A. and
            Clark,E.A.
  TITLE     Characterization of human inducible costimulator ligand expression
            and function
  JOURNAL   J Immunol 164 (9), 4689-4696 (2000)
   PUBMED   10779774
REFERENCE   10 (bases 1 to 1112)
  AUTHORS   Ling,V., Wu,P.W., Finnerty,H.F., Bean,K.M., Spaulding,V.,
            Fouser,L.A., Leonard,J.P., Hunter,S.E., Zollner,R., Thomas,J.L.,
            Miyashiro,J.S., Jacobs,K.A. and Collins,M.
  TITLE     Cutting edge: identification of GL50, a novel B7-like protein that
            functionally binds to ICOS receptor
  JOURNAL   J Immunol 164 (4), 1653-1657 (2000)
   PUBMED   10657606
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC365972.1, AF199028.1 and AA781960.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001283050.1.
            
            Transcript Variant: This variant (2) uses an alternate 3' terminal
            exon and it thus differs in the 3' coding region and 3' UTR,
            compared to variant 1. The encoded isoform (b) has a distinct and
            longer C-terminus, compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3456259.457275.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               DC365972.1         62-164
            104-1104            AF199028.1         1-1001
            1105-1112           AA781960.1         16-23               c
FEATURES             Location/Qualifiers
     source          1..1112
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..1112
                     /gene="ICOSLG"
                     /gene_synonym="B7-H2; B7h; B7H2; B7RP-1; B7RP1; CD275;
                     GL50; ICOS-L; ICOSL; IMD119; LICOS"
                     /note="inducible T cell costimulator ligand"
                     /db_xref="GeneID:23308"
                     /db_xref="HGNC:HGNC:17087"
                     /db_xref="MIM:605717"
     exon            1..140
                     /gene="ICOSLG"
                     /gene_synonym="B7-H2; B7h; B7H2; B7RP-1; B7RP1; CD275;
                     GL50; ICOS-L; ICOSL; IMD119; LICOS"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..1056
                     /gene="ICOSLG"
                     /gene_synonym="B7-H2; B7h; B7H2; B7RP-1; B7RP1; CD275;
                     GL50; ICOS-L; ICOSL; IMD119; LICOS"
                     /note="isoform b precursor is encoded by transcript
                     variant 2; B7 homologue 2; transmembrane protein B7-H2
                     ICOS ligand; B7 homolog 2; B7-like protein Gl50;
                     B7-related protein 1"
                     /codon_start=1
                     /product="ICOS ligand isoform b precursor"
                     /protein_id="NP_001269979.1"
                     /db_xref="CCDS:CCDS63379.1"
                     /db_xref="GeneID:23308"
                     /db_xref="HGNC:HGNC:17087"
                     /db_xref="MIM:605717"
                     /translation="MRLGSPGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSR
                     FDLNDVYVYWQTSESKTVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFN
                     VTPQDEQKFHCLVLSQSLGFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTS
                     INGYPRPNVYWINKTDNSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIE
                     NVLLQQNLTVGSQTGNDIGERDKITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWV
                     CRDRCLQHSYAGAWAVSPETELTESWNLLLLLS"
     exon            141..181
                     /gene="ICOSLG"
                     /gene_synonym="B7-H2; B7h; B7H2; B7RP-1; B7RP1; CD275;
                     GL50; ICOS-L; ICOSL; IMD119; LICOS"
                     /inference="alignment:Splign:2.1.0"
     exon            182..532
                     /gene="ICOSLG"
                     /gene_synonym="B7-H2; B7h; B7H2; B7RP-1; B7RP1; CD275;
                     GL50; ICOS-L; ICOSL; IMD119; LICOS"
                     /inference="alignment:Splign:2.1.0"
     exon            533..823
                     /gene="ICOSLG"
                     /gene_synonym="B7-H2; B7h; B7H2; B7RP-1; B7RP1; CD275;
                     GL50; ICOS-L; ICOSL; IMD119; LICOS"
                     /inference="alignment:Splign:2.1.0"
     exon            824..988
                     /gene="ICOSLG"
                     /gene_synonym="B7-H2; B7h; B7H2; B7RP-1; B7RP1; CD275;
                     GL50; ICOS-L; ICOSL; IMD119; LICOS"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1024
                     /gene="ICOSLG"
                     /gene_synonym="B7-H2; B7h; B7H2; B7RP-1; B7RP1; CD275;
                     GL50; ICOS-L; ICOSL; IMD119; LICOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1112
                     /gene="ICOSLG"
                     /gene_synonym="B7-H2; B7h; B7H2; B7RP-1; B7RP1; CD275;
                     GL50; ICOS-L; ICOSL; IMD119; LICOS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1083..1088
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ICOSLG"
                     /gene_synonym="B7-H2; B7h; B7H2; B7RP-1; B7RP1; CD275;
                     GL50; ICOS-L; ICOSL; IMD119; LICOS"
                     /note="hexamer: AATAAA"
     polyA_site      1112
                     /gene="ICOSLG"
                     /gene_synonym="B7-H2; B7h; B7H2; B7RP-1; B7RP1; CD275;
                     GL50; ICOS-L; ICOSL; IMD119; LICOS"
                     /note="major polyA site"
ORIGIN      
        1 gcagttagag ccgatctccc gcgccccgag gttgctcctc tccgaggtct cccgcggccc
       61 aagttctccg cgccccgagg tctccgcgcc ccgaggtctc cgcggcccga ggtctccgcc
      121 cgcaccatgc ggctgggcag tcctggactg ctcttcctgc tcttcagcag ccttcgagct
      181 gatactcagg agaaggaagt cagagcgatg gtaggcagcg acgtggagct cagctgcgct
      241 tgccctgaag gaagccgttt tgatttaaat gatgtttacg tatattggca aaccagtgag
      301 tcgaaaaccg tggtgaccta ccacatccca cagaacagct ccttggaaaa cgtggacagc
      361 cgctaccgga accgagccct gatgtcaccg gccggcatgc tgcggggcga cttctccctg
      421 cgcttgttca acgtcacccc ccaggacgag cagaagtttc actgcctggt gttgagccaa
      481 tccctgggat tccaggaggt tttgagcgtt gaggttacac tgcatgtggc agcaaacttc
      541 agcgtgcccg tcgtcagcgc cccccacagc ccctcccagg atgagctcac cttcacgtgt
      601 acatccataa acggctaccc caggcccaac gtgtactgga tcaataagac ggacaacagc
      661 ctgctggacc aggctctgca gaatgacacc gtcttcttga acatgcgggg cttgtatgac
      721 gtggtcagcg tgctgaggat cgcacggacc cccagcgtga acattggctg ctgcatagag
      781 aacgtgcttc tgcagcagaa cctgactgtc ggcagccaga caggaaatga catcggagag
      841 agagacaaga tcacagagaa tccagtcagt accggcgaga aaaacgcggc cacgtggagc
      901 atcctggctg tcctgtgcct gcttgtggtc gtggcggtgg ccataggctg ggtgtgcagg
      961 gaccgatgcc tccaacacag ctatgcaggt gcctgggctg tgagtccgga gacagagctc
     1021 actgaatcct ggaacctgct ccttctgctc tcgtgactga ctgtgttctc tatgcaactt
     1081 ccaataaaac ctcttcattt gaaaggaaaa aa
//
