LOCUS       NM_012092               2630 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens inducible T cell costimulator (ICOS), mRNA.
ACCESSION   NM_012092
VERSION     NM_012092.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2630)
  AUTHORS   Zong,L., Zheng,Y., Yu,X., Dai,X., Huang,R., Yan,G., Xu,Y. and
            Zheng,M.
  TITLE     ICOS-ICOSL pathway enhances NKT-like cell antiviral function in
            pregnant women with COVID-19
  JOURNAL   Int J Med Sci 21 (10), 1890-1902 (2024)
   PUBMED   39113896
  REMARK    GeneRIF: ICOS-ICOSL pathway enhances NKT-like cell antiviral
            function in pregnant women with COVID-19.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2630)
  AUTHORS   Meng,L.B., Li,Y., Lv,T., Lv,C., Liu,L. and Zhang,P.
  TITLE     Joint effects of CD8A and ICOS in Long QT Syndrome (LQTS) and
            Beckwith-Wiedemann Syndrome (BWS)
  JOURNAL   J Cardiothorac Surg 19 (1), 321 (2024)
   PUBMED   38845009
  REMARK    GeneRIF: Joint effects of CD8A and ICOS in Long QT Syndrome (LQTS)
            and Beckwith-Wiedemann Syndrome (BWS).
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2630)
  AUTHORS   Kim,T., Martinez-Bonet,M., Wang,Q., Hackert,N., Sparks,J.A.,
            Baglaenko,Y., Koh,B., Darbousset,R., Laza-Briviesca,R., Chen,X.,
            Aguiar,V.R.C., Chiu,D.J., Westra,H.J., Gutierrez-Arcelus,M.,
            Weirauch,M.T., Raychaudhuri,S., Rao,D.A. and Nigrovic,P.A.
  TITLE     Non-coding autoimmune risk variant defines role for ICOS in T
            peripheral helper cell development
  JOURNAL   Nat Commun 15 (1), 2150 (2024)
   PUBMED   38459032
  REMARK    GeneRIF: Non-coding autoimmune risk variant defines role for ICOS
            in T peripheral helper cell development.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2630)
  AUTHORS   Chen,M., Yan,X., Hong,B., Xiao,Y. and Qian,Y.
  TITLE     The Expression and Prognostic Significance of ICOS in NSCLC
            Integrated Pan-Cancer and Multi-Omics Analyses
  JOURNAL   Int J Med Sci 21 (5), 795-808 (2024)
   PUBMED   38616999
  REMARK    GeneRIF: The Expression and Prognostic Significance of ICOS in
            NSCLC Integrated Pan-Cancer and Multi-Omics Analyses.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2630)
  AUTHORS   Chu,J., Wu,Y., Qu,Z., Zhuang,J., Liu,J., Han,S., Wu,W. and Han,S.
  TITLE     Transcriptional profile and immune infiltration in colorectal
            cancer reveal the significance of inducible T-cell costimulator as
            a crucial immune checkpoint molecule
  JOURNAL   Cancer Med 13 (6), e7097 (2024)
   PUBMED   38506253
  REMARK    GeneRIF: Transcriptional profile and immune infiltration in
            colorectal cancer reveal the significance of inducible T-cell
            costimulator as a crucial immune checkpoint molecule.
REFERENCE   6  (bases 1 to 2630)
  AUTHORS   Machado,R.D., Pauciulo,M.W., Fretwell,N., Veal,C., Thomson,J.R.,
            Vilarino Guell,C., Aldred,M., Brannon,C.A., Trembath,R.C. and
            Nichols,W.C.
  TITLE     A physical and transcript map based upon refinement of the critical
            interval for PPH1, a gene for familial primary pulmonary
            hypertension. The International PPH Consortium
  JOURNAL   Genomics 68 (2), 220-228 (2000)
   PUBMED   10964520
REFERENCE   7  (bases 1 to 2630)
  AUTHORS   Aicher,A., Hayden-Ledbetter,M., Brady,W.A., Pezzutto,A.,
            Richter,G., Magaletti,D., Buckwalter,S., Ledbetter,J.A. and
            Clark,E.A.
  TITLE     Characterization of human inducible costimulator ligand expression
            and function
  JOURNAL   J Immunol 164 (9), 4689-4696 (2000)
   PUBMED   10779774
REFERENCE   8  (bases 1 to 2630)
  AUTHORS   Ling,V., Wu,P.W., Finnerty,H.F., Bean,K.M., Spaulding,V.,
            Fouser,L.A., Leonard,J.P., Hunter,S.E., Zollner,R., Thomas,J.L.,
            Miyashiro,J.S., Jacobs,K.A. and Collins,M.
  TITLE     Cutting edge: identification of GL50, a novel B7-like protein that
            functionally binds to ICOS receptor
  JOURNAL   J Immunol 164 (4), 1653-1657 (2000)
   PUBMED   10657606
REFERENCE   9  (bases 1 to 2630)
  AUTHORS   Yoshinaga,S.K., Whoriskey,J.S., Khare,S.D., Sarmiento,U., Guo,J.,
            Horan,T., Shih,G., Zhang,M., Coccia,M.A., Kohno,T.,
            Tafuri-Bladt,A., Brankow,D., Campbell,P., Chang,D., Chiu,L.,
            Dai,T., Duncan,G., Elliott,G.S., Hui,A., McCabe,S.M., Scully,S.,
            Shahinian,A., Shaklee,C.L., Van,G., Mak,T.W. and Senaldi,G.
  TITLE     T-cell co-stimulation through B7RP-1 and ICOS
  JOURNAL   Nature 402 (6763), 827-832 (1999)
   PUBMED   10617205
REFERENCE   10 (bases 1 to 2630)
  AUTHORS   Hutloff,A., Dittrich,A.M., Beier,K.C., Eljaschewitsch,B., Kraft,R.,
            Anagnostopoulos,I. and Kroczek,R.A.
  TITLE     ICOS is an inducible T-cell co-stimulator structurally and
            functionally related to CD28
  JOURNAL   Nature 397 (6716), 263-266 (1999)
   PUBMED   9930702
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Jouni Valiaho, Mauno Vihinen. The reference
            sequence was derived from AJ277832.1 and CB528580.1.
            
            On Aug 31, 2019 this sequence version replaced NM_012092.3.
            
            Summary: The protein encoded by this gene belongs to the CD28 and
            CTLA-4 cell-surface receptor family. It forms homodimers and plays
            an important role in cell-cell signaling, immune responses, and
            regulation of cell proliferation. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028210.1, AB023135.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316386.11/ ENSP00000319476.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2626              AJ277832.1         16-2641
            2627-2630           CB528580.1         15-18               c
FEATURES             Location/Qualifiers
     source          1..2630
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.2"
     gene            1..2630
                     /gene="ICOS"
                     /gene_synonym="AILIM; CD278; CVID1"
                     /note="inducible T cell costimulator"
                     /db_xref="GeneID:29851"
                     /db_xref="HGNC:HGNC:5351"
                     /db_xref="MIM:604558"
     exon            1..110
                     /gene="ICOS"
                     /gene_synonym="AILIM; CD278; CVID1"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..652
                     /gene="ICOS"
                     /gene_synonym="AILIM; CD278; CVID1"
                     /note="activation-inducible lymphocyte immunomediatory
                     molecule; inducible costimulator; inducible T-cell
                     co-stimulator"
                     /codon_start=1
                     /product="inducible T-cell costimulator precursor"
                     /protein_id="NP_036224.1"
                     /db_xref="CCDS:CCDS2363.1"
                     /db_xref="GeneID:29851"
                     /db_xref="HGNC:HGNC:5351"
                     /db_xref="MIM:604558"
                     /translation="MKSGLWYFFLFCLRIKVLTGEINGSANYEMFIFHNGGVQILCKY
                     PDIVQQFKMQLLKGGQILCDLTKTKGSGNTVSIKSLKFCHSQLSNNSVSFFLYNLDHS
                     HANYYFCNLSIFDPPPFKVTLTGGYLHIYESQLCCQLKFWLPIGCAAFVVVCILGCIL
                     ICWLTKKKYSSSVHDPNGEYMFMRAVNTAKKSRLTDVTL"
     exon            111..446
                     /gene="ICOS"
                     /gene_synonym="AILIM; CD278; CVID1"
                     /inference="alignment:Splign:2.1.0"
     exon            447..553
                     /gene="ICOS"
                     /gene_synonym="AILIM; CD278; CVID1"
                     /inference="alignment:Splign:2.1.0"
     exon            554..638
                     /gene="ICOS"
                     /gene_synonym="AILIM; CD278; CVID1"
                     /inference="alignment:Splign:2.1.0"
     exon            639..2630
                     /gene="ICOS"
                     /gene_synonym="AILIM; CD278; CVID1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2601..2606
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ICOS"
                     /gene_synonym="AILIM; CD278; CVID1"
                     /note="hexamer: AATAAA"
     polyA_site      2630
                     /gene="ICOS"
                     /gene_synonym="AILIM; CD278; CVID1"
                     /note="major polyA site"
ORIGIN      
        1 actgtcagct ttgaacactg aacgcgagga ctgttaactg tttctggcaa acatgaagtc
       61 aggcctctgg tatttctttc tcttctgctt gcgcattaaa gttttaacag gagaaatcaa
      121 tggttctgcc aattatgaga tgtttatatt tcacaacgga ggtgtacaaa ttttatgcaa
      181 atatcctgac attgtccagc aatttaaaat gcagttgctg aaaggggggc aaatactctg
      241 cgatctcact aagacaaaag gaagtggaaa cacagtgtcc attaagagtc tgaaattctg
      301 ccattctcag ttatccaaca acagtgtctc tttttttcta tacaacttgg accattctca
      361 tgccaactat tacttctgca acctatcaat ttttgatcct cctcctttta aagtaactct
      421 tacaggagga tatttgcata tttatgaatc acaactttgt tgccagctga agttctggtt
      481 acccatagga tgtgcagcct ttgttgtagt ctgcattttg ggatgcatac ttatttgttg
      541 gcttacaaaa aagaagtatt catccagtgt gcacgaccct aacggtgaat acatgttcat
      601 gagagcagtg aacacagcca aaaaatctag actcacagat gtgaccctat aatatggaac
      661 tctggcaccc aggcatgaag cacgttggcc agttttcctc aacttgaagt gcaagattct
      721 cttatttccg ggaccacgga gagtctgact taactacata catcttctgc tggtgttttg
      781 ttcaatctgg aagaatgact gtatcagtca atggggattt taacagactg ccttggtact
      841 gccgagtcct ctcaaaacaa acaccctctt gcaaccagct ttggagaaag cccagctcct
      901 gtgtgctcac tgggagtgga atccctgtct ccacatctgc tcctagcagt gcatcagcca
      961 gtaaaacaaa cacatttaca agaaaaatgt tttaaagatg ccaggggtac tgaatctgca
     1021 aagcaaatga gcagccaagg accagcatct gtccgcattt cactatcata ctacctcttc
     1081 tttctgtagg gatgagaatt cctcttttaa tcagtcaagg gagatgcttc aaagctggag
     1141 ctattttatt tctgagatgt tgatgtgaac tgtacattag tacatactca gtactctcct
     1201 tcaattgctg aaccccagtt gaccatttta ccaagacttt agatgctttc ttgtgccctc
     1261 aattttcttt ttaaaaatac ttctacatga ctgcttgaca gcccaacagc cactctcaat
     1321 agagagctat gtcttacatt ctttcctctg ctgctcaata gttttatata tctatgcata
     1381 catatataca cacatatgta tataaaattc ataatgaata tatttgccta tattctccct
     1441 acaagaatat ttttgctcca gaaagacatg ttcttttctc aaattcagtt aaaatggttt
     1501 actttgttca agttagtggt aggaaacatt gcccggaatt gaaagcaaat ttattttatt
     1561 atcctatttt ctaccattat ctatgttttc atggtgctat taattacaag tttagttctt
     1621 tttgtagatc atattaaaat tgcaaacaaa atcatcttta atgggccagc attctcatgg
     1681 ggtagagcag aatattcatt tagcctgaaa gctgcagtta ctataggttg ctgtcagact
     1741 atacccatgg tgcctctggg cttgacaggt caaaatggtc cccatcagcc tggagcagcc
     1801 ctccagacct gggtggaatt ccagggttga gagactcccc tgagccagag gccactaggt
     1861 attcttgctc ccagaggctg aagtcaccct gggaatcaca gtggtctacc tgcattcata
     1921 attccaggat ctgtgaagag cacatatgtg tcagggcaca attccctctc ataaaaacca
     1981 cacagcctgg aaattggccc tggcccttca agatagcctt ctttagaata tgatttggct
     2041 agaaagattc ttaaatatgt ggaatatgat tattcttagc tggaatattt tctctacttc
     2101 ctgtctgcat gcccaaggct tctgaagcag ccaatgtcga tgcaacaaca tttgtaactt
     2161 taggtaaact gggattatgt tgtagtttaa cattttgtaa ctgtgtgctt atagtttaca
     2221 agtgagaccc gatatgtcat tatgcatact tatattatct taagcatgtg taatgctgga
     2281 tgtgtacagt acagtactga acttgtaatt tgaatctagt atggtgttct gttttcagct
     2341 gacttggaca acctgactgg ctttgcacag gtgttccctg agttgtttgc aggtttctgt
     2401 gtgtggggtg gggtatgggg aggagaacct tcatggtggc ccacctggcc tggttgtcca
     2461 agctgtgcct cgacacatcc tcatccccag catgggacac ctcaagatga ataataattc
     2521 acaaaatttc tgtgaaatca aatccagttt taagaggagc cacttatcaa agagatttta
     2581 acagtagtaa gaaggcaaag aataaacatt tgatattcag caactgaaaa
//
