LOCUS       NM_024611               7206 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens interactor of little elongation complex ELL subunit 2
            (ICE2), transcript variant 1, mRNA.
ACCESSION   NM_024611 XM_352908
VERSION     NM_024611.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7206)
  AUTHORS   Egloff,S., Vitali,P., Tellier,M., Raffel,R., Murphy,S. and Kiss,T.
  TITLE     The 7SK snRNP associates with the little elongation complex to
            promote snRNA gene expression
  JOURNAL   EMBO J 36 (7), 934-948 (2017)
   PUBMED   28254838
REFERENCE   2  (bases 1 to 7206)
  AUTHORS   Tanabe,S., Kawabata,T., Aoyagi,K., Yokozaki,H. and Sasaki,H.
  TITLE     Gene expression and pathway analysis of CTNNB1 in cancer and stem
            cells
  JOURNAL   World J Stem Cells 8 (11), 384-395 (2016)
   PUBMED   27928465
REFERENCE   3  (bases 1 to 7206)
  AUTHORS   Anwar,D., Takahashi,H., Watanabe,M., Suzuki,M., Fukuda,S. and
            Hatakeyama,S.
  TITLE     p53 represses the transcription of snRNA genes by preventing the
            formation of little elongation complex
  JOURNAL   Biochim Biophys Acta 1859 (8), 975-982 (2016)
   PUBMED   27268141
REFERENCE   4  (bases 1 to 7206)
  AUTHORS   Takahashi,H., Takigawa,I., Watanabe,M., Anwar,D., Shibata,M.,
            Tomomori-Sato,C., Sato,S., Ranjan,A., Seidel,C.W., Tsukiyama,T.,
            Mizushima,W., Hayashi,M., Ohkawa,Y., Conaway,J.W., Conaway,R.C. and
            Hatakeyama,S.
  TITLE     MED26 regulates the transcription of snRNA genes through the
            recruitment of little elongation complex
  JOURNAL   Nat Commun 6, 5941 (2015)
   PUBMED   25575120
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7206)
  AUTHORS   Hu,D., Smith,E.R., Garruss,A.S., Mohaghegh,N., Varberg,J.M.,
            Lin,C., Jackson,J., Gao,X., Saraf,A., Florens,L., Washburn,M.P.,
            Eissenberg,J.C. and Shilatifard,A.
  TITLE     The little elongation complex functions at initiation and
            elongation phases of snRNA gene transcription
  JOURNAL   Mol Cell 51 (4), 493-505 (2013)
   PUBMED   23932780
REFERENCE   6  (bases 1 to 7206)
  AUTHORS   Smith,E.R., Lin,C., Garrett,A.S., Thornton,J., Mohaghegh,N., Hu,D.,
            Jackson,J., Saraf,A., Swanson,S.K., Seidel,C., Florens,L.,
            Washburn,M.P., Eissenberg,J.C. and Shilatifard,A.
  TITLE     The little elongation complex regulates small nuclear RNA
            transcription
  JOURNAL   Mol Cell 44 (6), 954-965 (2011)
   PUBMED   22195968
REFERENCE   7  (bases 1 to 7206)
  AUTHORS   Takahashi,H., Parmely,T.J., Sato,S., Tomomori-Sato,C., Banks,C.A.,
            Kong,S.E., Szutorisz,H., Swanson,S.K., Martin-Brown,S.,
            Washburn,M.P., Florens,L., Seidel,C.W., Lin,C., Smith,E.R.,
            Shilatifard,A., Conaway,R.C. and Conaway,J.W.
  TITLE     Human mediator subunit MED26 functions as a docking site for
            transcription elongation factors
  JOURNAL   Cell 146 (1), 92-104 (2011)
   PUBMED   21729782
REFERENCE   8  (bases 1 to 7206)
  AUTHORS   Sugiura,N., Dadashev,V. and Corriveau,R.A.
  TITLE     NARG2 encodes a novel nuclear protein with (S/T)PXX motifs that is
            expressed during development
  JOURNAL   Eur J Biochem 271 (23-24), 4629-4637 (2004)
   PUBMED   15606750
REFERENCE   9  (bases 1 to 7206)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   10 (bases 1 to 7206)
  AUTHORS   Sugiura,N., Patel,R.G. and Corriveau,R.A.
  TITLE     N-methyl-D-aspartate receptors regulate a group of transiently
            expressed genes in the developing brain
  JOURNAL   J Biol Chem 276 (17), 14257-14263 (2001)
   PUBMED   11297529
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN342776.1, BC140894.1,
            AC087385.5 and BU738348.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_024611.5.
            
            Summary: This gene encodes a protein component of the little
            elongation complex (LEC), which plays a role in small nuclear RNA
            (snRNA) transcription. The LEC regulates snRNA transcription by
            enhancing both RNA Polymerase II occupancy and transcriptional
            elongation. The encoded protein and other LEC components have been
            shown to localize to Cajal bodies, which are sites of
            ribonucleoprotein (RNP) complex assembly. Pseudogenes of this gene
            have been identified on chromosomes 3 and 4. [provided by RefSeq,
            May 2017].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC140894.1, SRR1803617.272564.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261520.9/ ENSP00000261520.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                CN342776.1         21-83
            64-4087             BC140894.1         1-4024
            4088-6851           AC087385.5         96793-99556
            6852-7206           BU738348.1         18-372              c
FEATURES             Location/Qualifiers
     source          1..7206
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.2"
     gene            1..7206
                     /gene="ICE2"
                     /gene_synonym="BRCC1; NARG2"
                     /note="interactor of little elongation complex ELL subunit
                     2"
                     /db_xref="GeneID:79664"
                     /db_xref="HGNC:HGNC:29885"
                     /db_xref="MIM:610835"
     exon            1..140
                     /gene="ICE2"
                     /gene_synonym="BRCC1; NARG2"
                     /inference="alignment:Splign:2.1.0"
     exon            141..273
                     /gene="ICE2"
                     /gene_synonym="BRCC1; NARG2"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..3181
                     /gene="ICE2"
                     /gene_synonym="BRCC1; NARG2"
                     /note="isoform a is encoded by transcript variant 1;
                     breast cancer cell 1; NMDA receptor-regulated gene 2; NMDA
                     receptor-regulated protein 2; NMDA receptor regulated 2;
                     little elongation complex subunit 2; interactor of little
                     elongator complex ELL subunit 2"
                     /codon_start=1
                     /product="little elongation complex subunit 2 isoform a"
                     /protein_id="NP_078887.2"
                     /db_xref="CCDS:CCDS10176.1"
                     /db_xref="GeneID:79664"
                     /db_xref="HGNC:HGNC:29885"
                     /db_xref="MIM:610835"
                     /translation="MSSKMVISEPGLNWDISPKNGLKTFFSRENYKDHSMAPSLKELR
                     VLSNRRIGENLNASASSVENEPAVSSATQAKEKVKTTIGMVLLPKPRVPYPRFSRFSQ
                     REQRSYVDLLVKYAKIPANSKAVGINKNDYLQYLDMKKHVNEEVTEFLKFLQNSAKKC
                     AQDYNMLSDDARLFTEKILRACIEQVKKYSEFYTLHEVTSLMGFFPFRVEMGLKLEKT
                     LLALGSVKYVKTVFPSMPIKLQLSKDDIATIETSEQTAEAMHYDISKDPNAEKLVSRY
                     HPQIALTSQSLFTLLNNHGPTYKEQWEIPVCIQVIPVAGSKPVKVIYINSPLPQKKMT
                     MRERNQIFHEVPLKFMMSKNTSVPVSAVFMDKPEEFISEMDMSCEVNECRKIESLENL
                     YLDFDDDVTELETFGVTTTKVSKSPSPASTSTVPNMTDAPTAPKAGTTTVAPSAPDIS
                     ANSRSLSQILMEQLQKEKQLVTGMDGGPEECKNKDDQGFESCEKVSNSDKPLIQDSDL
                     KTSDALQLENSQEIETSNKNDMTIDILHADGERPNVLENLDNSKEKTVGSEAAKTEDT
                     VLCSSDTDEECLIIDTECKNNSDGKTAVVGSNLSSRPASPNSSSGQASVGNQTNTACS
                     PEESCVLKKPIKRVYKKFDPVGEILKMQDELLKPISRKVPELPLMNLENSKQPSVSEQ
                     LSGPSDSSSWPKSGWPSAFQKPKGRLPYELQDYVEDTSEYLAPQEGNFVYKLFSLQDL
                     LLLVRCSVQRIETRPRSKKRKKIRRQFPVYVLPKVEYQACYGVEALTESELCRLWTES
                     LLHSNSSFYVGHIDAFTSKLFLLEEITSEELKEKLSALKISNLFNILQHILKKLSSLQ
                     EGSYLLSHAAEDSSLLIYKASDGKVTRTAYNLYKTHCGLPGVPSSLSVPWVPLDPSLL
                     LPYHIHHGRIPCTFPPKSLDTTTQQKIGGTRMPTRSHRNPVSMETKSSCLPAQQVETE
                     GVAPHKRKIT"
     exon            274..378
                     /gene="ICE2"
                     /gene_synonym="BRCC1; NARG2"
                     /inference="alignment:Splign:2.1.0"
     exon            379..640
                     /gene="ICE2"
                     /gene_synonym="BRCC1; NARG2"
                     /inference="alignment:Splign:2.1.0"
     exon            641..760
                     /gene="ICE2"
                     /gene_synonym="BRCC1; NARG2"
                     /inference="alignment:Splign:2.1.0"
     exon            761..898
                     /gene="ICE2"
                     /gene_synonym="BRCC1; NARG2"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1015
                     /gene="ICE2"
                     /gene_synonym="BRCC1; NARG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1175
                     /gene="ICE2"
                     /gene_synonym="BRCC1; NARG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1357
                     /gene="ICE2"
                     /gene_synonym="BRCC1; NARG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..2351
                     /gene="ICE2"
                     /gene_synonym="BRCC1; NARG2"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..2527
                     /gene="ICE2"
                     /gene_synonym="BRCC1; NARG2"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..2657
                     /gene="ICE2"
                     /gene_synonym="BRCC1; NARG2"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2742
                     /gene="ICE2"
                     /gene_synonym="BRCC1; NARG2"
                     /inference="alignment:Splign:2.1.0"
     exon            2743..2793
                     /gene="ICE2"
                     /gene_synonym="BRCC1; NARG2"
                     /inference="alignment:Splign:2.1.0"
     exon            2794..3052
                     /gene="ICE2"
                     /gene_synonym="BRCC1; NARG2"
                     /inference="alignment:Splign:2.1.0"
     exon            3053..7206
                     /gene="ICE2"
                     /gene_synonym="BRCC1; NARG2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3672..3677
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ICE2"
                     /gene_synonym="BRCC1; NARG2"
                     /note="hexamer: AATAAA"
     polyA_site      3694
                     /gene="ICE2"
                     /gene_synonym="BRCC1; NARG2"
                     /note="major polyA site"
     regulatory      3791..3796
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ICE2"
                     /gene_synonym="BRCC1; NARG2"
                     /note="hexamer: AATAAA"
     regulatory      3796..3801
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ICE2"
                     /gene_synonym="BRCC1; NARG2"
                     /note="hexamer: AAGAAA"
     polyA_site      3814
                     /gene="ICE2"
                     /gene_synonym="BRCC1; NARG2"
                     /note="major polyA site"
     polyA_site      3817
                     /gene="ICE2"
                     /gene_synonym="BRCC1; NARG2"
     regulatory      5320..5325
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ICE2"
                     /gene_synonym="BRCC1; NARG2"
                     /note="hexamer: TATAAA"
     polyA_site      5347
                     /gene="ICE2"
                     /gene_synonym="BRCC1; NARG2"
     regulatory      7179..7184
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ICE2"
                     /gene_synonym="BRCC1; NARG2"
                     /note="hexamer: AATAAA"
     polyA_site      7206
                     /gene="ICE2"
                     /gene_synonym="BRCC1; NARG2"
ORIGIN      
        1 gtcatcacgc agggccgagt cggcgcggcc acatccttta aatatggtct tttttgggcg
       61 cgcgcgacaa tgtgaggagt ggggtggagc gtgtgtggtg tgtggctgcg gcctgggcaa
      121 gagccgccgc ggaccatgag ctgagtaagt tctggaggga tcctgcctct tggagccttc
      181 gcagccaggc agctgtgaac tgtgagctag agtgaagcag aaatctagga agatgagctc
      241 caagatggtc ataagtgaac caggactgaa ttgggatatt tcccccaaaa atggccttaa
      301 gacatttttc tctcgagaaa attataaaga tcattccatg gctccaagtt taaaagaact
      361 acgtgtttta tccaacagac gtataggaga aaatttgaat gcctcagcaa gttctgtaga
      421 aaatgagccg gcagttagtt cagcaactca agcaaaggaa aaagttaaaa ccacaattgg
      481 aatggttctt cttccaaaac caagagttcc ttatcctcgt ttctctcgtt tctcacagag
      541 agagcagagg agttatgtgg acttgttggt taaatacgca aagattcctg caaattccaa
      601 agctgttgga ataaataaaa atgactactt gcagtacttg gatatgaaaa aacatgtgaa
      661 cgaagaagtt actgagttcc taaagttttt gcagaattct gcaaagaaat gtgcgcagga
      721 ttataatatg ctttctgatg atgcccgtct cttcacagag aaaattttaa gagcttgcat
      781 tgaacaagtg aaaaagtatt cagaattcta tactctccac gaggtcacca gcttaatggg
      841 attcttccca ttcagagtag agatgggatt aaagttagaa aaaactcttc tcgcattggg
      901 cagtgtaaaa tatgtgaaaa cagtatttcc ctcaatgcct ataaagttgc agctgtcaaa
      961 ggacgatata gctaccattg aaacgtcaga acaaacagct gaagctatgc attatgatat
     1021 tagtaaagat ccaaatgcag agaagcttgt ttccagatat caccctcaga tagctctaac
     1081 tagtcagtca ttatttacct tattaaataa tcatggacca acgtacaagg aacagtggga
     1141 aattccagtg tgtattcaag taatacctgt tgcaggttca aaaccagtta aagtaatata
     1201 tattaattca ccacttcccc aaaagaaaat gactatgaga gagagaaatc aaatctttca
     1261 tgaagttcca ttaaaattta tgatgtccaa aaacacatct gttccagtct ctgcagtctt
     1321 tatggacaaa cctgaagagt ttatatctga aatggacatg tcctgtgaag tcaacgagtg
     1381 ccgaaaaatt gagagtcttg aaaacttgta tttggatttt gatgatgatg tcacagaact
     1441 tgaaactttt ggagtaacca ccaccaaagt atcaaaatca ccaagtccag caagtacttc
     1501 cacagtacct aacatgacag atgctcctac agcccccaaa gcaggaacta caactgtggc
     1561 accaagtgca ccagacattt ctgctaattc tagaagttta tctcagattc tgatggaaca
     1621 attgcaaaag gagaaacagc tggtcactgg tatggatggt ggccctgagg aatgcaaaaa
     1681 taaagatgat cagggatttg aatcatgtga aaaggtatca aattctgaca agcctttgat
     1741 acaagatagt gacttgaaaa catctgatgc cttacagtta gaaaattctc aggaaattga
     1801 aacttctaat aaaaatgata tgactataga tatattacat gctgatggtg aaagacctaa
     1861 tgttctagaa aacctagaca actcaaagga aaagactgtt ggatcagaag cagcaaaaac
     1921 tgaagataca gttctctgca gcagtgatac agatgaggag tgtttaatca ttgatacaga
     1981 atgtaaaaat aatagtgatg gaaagacagc tgttgtgggt tctaacttaa gttccagacc
     2041 agctagtcca aattcttcct caggacaggc ttctgtagga aaccagacta atactgcttg
     2101 tagtcctgaa gagtcatgtg ttttaaaaaa acctatcaaa cgagtatata aaaaatttga
     2161 tccagttgga gagattttaa aaatgcagga tgagctctta aagccaattt ccagaaaagt
     2221 accagaattg cccttaatga atttagaaaa ttctaaacag ccttctgttt ctgagcaatt
     2281 gtctggtcct tcagactcct ctagttggcc gaaatctgga tggccttctg catttcagaa
     2341 gccaaaagga cgattgccat atgaacttca ggactatgtt gaagatacat cggaatacct
     2401 agctcctcag gaaggaaatt ttgtttataa gttatttagc ctgcaagacc tgttgttact
     2461 cgtacgctgc agtgtccaga ggatagagac aagaccacgt tctaaaaaac ggaagaaaat
     2521 cagaagacaa tttccagttt atgtactacc aaaagtagag tatcaagctt gttatggagt
     2581 tgaagctctg actgaaagtg aactttgtcg cttatggact gaaagtttat tgcattccaa
     2641 cagctcattt tatgttgggc atatcgatgc atttacttca aaactttttc tactggaaga
     2701 aattacctca gaagaattaa aagaaaagct ttcagcactc aagatttcca atttatttaa
     2761 catcctccaa cacattctaa agaaactaag tagcttgcag gagggttcct acttgttatc
     2821 tcatgcagca gaagattctt cactcctgat ttataaggcc tctgatggaa aagttactag
     2881 gacagcatac aatttgtata aaacacattg cggccttcct ggtgtacctt ccagtctctc
     2941 agttccctgg gtcccattag atcccagcct gttattacca tatcatatcc atcatggaag
     3001 aataccttgt acttttccac cgaaatcact ggataccaca acacaacaaa agattggtgg
     3061 aacgagaatg cctacacgca gccacaggaa tccagtttcc atggaaacca aaagcagttg
     3121 cttgcctgct cagcaagttg aaactgaagg agtggctcca cataaaagaa aaataacttg
     3181 aggactgtac catggaaaac taaatttaaa aaaacagtta taacagtgtt taatttagat
     3241 aagtttgagg gaaaataatc agtaggcaag aggaacattt ttcctgtagt agctagagtg
     3301 ccttgaaaaa atgtgttggc tatgtgaagg aatatttcaa ctaaaatgga atggtatgct
     3361 tttcaccctt gaagtttgag gaggatcttg atatgtttta acattatcat ggcagggaaa
     3421 tatataaaga agaaaaatat ttttacatta aaccttttct aaaaattgta aatagaaaaa
     3481 taatttggtt ttttatcaag aacaacactt atcgttatgt attgtgttag ttatattgcc
     3541 agtctgttgc gactgactca aaaagttaaa tgttgccact gctgaagatg attatgagca
     3601 tcgcaaactt tgtttctgac ccattttgac agtttttata tactccttta aaatgatgaa
     3661 tgttacaggt taataaagtt aataccttta aaaacttggt gaaattccat tacagaagcc
     3721 aaaaataaaa actccctgcc tctgaaaagt cagattactg acttcttgtt tggcaaccat
     3781 cagtttgttt aataaaagaa aaaatttggt ggtataacat gtttgatgac agatgcctct
     3841 atctctagat tcaagctgag tgttgaaata cactgctgaa agcaaagaga taggtatgtt
     3901 ttccagaaaa aaagtcagtg tcattgctcc agatgacaag gttaatgtgg taaagcataa
     3961 gctttttttt ttttttgaga tggagtctcg ctctgttgcc caggctggag tgcagtggca
     4021 tgatctcagc tcaccacaac atccacctcc tggattaaag cgattctcct gcctcatcct
     4081 cccgagtagc tgggactaca ggcacctacc accaggcttg gctaattttt ttttgtattt
     4141 ttagtagaga cagggtgtta ccatgttggc cgggctggtc tcaaactcct gaccttgtga
     4201 tccgcctgcc ttggcctccc aaagtgctgg gattacaggg gtaagccacc gtgcctggcc
     4261 agcataagct atttttatcc tcatctatac tgattgattt aaattttccg ggcctgcaga
     4321 tgaatttgga aaagggcata atcaactgat gttgctgtag caaatttgga cttaagaaac
     4381 tacagacagg gccgggcgtg gtggctcaca cctgtaattc cagcacttcg caaggccgag
     4441 gcgggagaat cacttgagtc caggggttgg agaccagtct gggcaacaca gacctcatct
     4501 ctacaaataa aaaagttagc cgggtgtggt ggggtgtgcc tgtagtccca gctactcaaa
     4561 aggctgaggc agaagaattg cttgagccca agaagtcaag gctacagtga gttgtgatcg
     4621 caccacagaa ctcagcttga gtatcagagt gtgaccctgt ctcaaagaaa aaaaaaaaca
     4681 ggacaggctt gtttaatctt tagaaccctt acactaaaat tttcagaaat tatgtatgtc
     4741 atttgtaaaa tataagtttt gtaatcctag ataattgctt cacattgaaa ttttttagct
     4801 attctgtgta aagaatagct attcttttgg cctaatttct gagaaattag accgaaaaat
     4861 ctcctcaagt attgtaacag ttgaaaatac ttatattcaa ctaccaagtt ttgtttcatt
     4921 ttgatttttt gttataaaac atttttaagt tatttgagaa gtaattatta gtaaaattgt
     4981 atcttgataa atcatttcct catcctgcca ttccctttta taaaacactg agttttttta
     5041 ttccttaagt cacatatccc agaaatgttt tggttgtgaa tcatttgcca gcgagccaag
     5101 ggagaggcag ggattccctt gaaatgtact cttacacttt tttattttat ttttaatgta
     5161 catttgtgtg caccagaatg gaatgtgctc tttttaaaga gctggacagt ggttgcttca
     5221 gacttctgaa taccagaaag acttgccttt taatttttaa atattacttt ttacatcata
     5281 aaatgtgtta tcttatccat gtatttgaat aacatcatat ataaaggtag ttttttgctt
     5341 gtgcttagtg aagcctcctt ttttaacata catttgatat gctttatgtt ctttttcttg
     5401 atttttagta ctgagaattt ataagccaag aagtaactga caatatgttt agcaggatgt
     5461 aatcccagct acttgggaag ctgaggtggg aggatcgctt gagtctagga gtttgaggct
     5521 gcagtgagct atgatggtgc cactgcactc catcctgggt gagagatcaa gaccctatct
     5581 caaaaaatga gcaagttttt tttttttttt taaatcagac ttagggctag caaggatgtg
     5641 atcaccctgg cccatttata cctcagcagt gaaggtgtaa tttatacaca cctctttgaa
     5701 aacagtttaa ttcagtaagt gagtgcaact atgtgccatg cactccaaag taggtcccca
     5761 cagttattct ctcatagcct tgttttttca gatctcacca tatttatttg tttctttgat
     5821 tttcttttct tatagattac aagctctgca aggacagggg catatttgtt ttgttcacca
     5881 ttaagtaata aacacctaat acagtgcctg tcatgtagtt gcttagcaga tattagttag
     5941 atgcatgaat gtgtaggtat caaagatttt ttttttcagg agatcacatt ctagtggaag
     6001 acactatact gctttatgtg ataagtgctt tgataaagta agcaagtcat ctaaccagat
     6061 cttggtagtt aaggttttct gagatagaac ttgagctgag tcttttaaaa atagtaggat
     6121 ttataaggga aaattaaagg tcttccacaa agaaactaag tgaaactaag cagcctatga
     6181 aaaggtgaaa gttggagaga ttataggcta tgaacatggg agatgagaga gaaaactgca
     6241 ggatagggac agaaacactg tgctaagaca tttgaacttt gtcctgtgca atgtgggaac
     6301 cagtagtgaa ggttaattaa ctgacatgat cagatatgta tttgaaaagg gctcttgttg
     6361 gcattagtct agagaatgcg atggagctgg gaagcgaaag aagaaatgtt gggagcctgt
     6421 gttgtagtaa ctgaaaaatg gcaatggccc agaattaaag cagcaagaat aggagtgggc
     6481 tcaagtgatg tataaggaaa aaaaaaaaaa tgacaactca gttttgttgt tggtaaggag
     6541 agtaaagtat ggcttctggg tttctcattt gagatactga gtaaatgatg gtgttaaccc
     6601 attgagaaaa tagtgtggtt agagtgggaa gaaagttaat ttaaaatgtt catttttttt
     6661 tttagtcatt tctacttttg gattctaggt ttgtgtgcta tattggttat aaccaatttg
     6721 ctgaataata aattatccca aaacttagct acttaaaaca acaaacatta tctcacagtt
     6781 tctgtaagtc aaaagtccag gtctctcatg aagttgcagt caggctcttg gctagggctg
     6841 cagtcatctg aaggattagt aagtcgctaa gcccacactt aagctccacc cttgaaggga
     6901 gaagtttgga aagaatttgt gaacatattt ttaaatcaca tatgctatga acaggtttag
     6961 gggagggaga ggaaagaaaa ctttaacttt tcattagcat actgcatctg tagttcctaa
     7021 tgggcatgtt gtaaagatgt taagacgttt tctatgcatt ataggtatat agtagtattt
     7081 tgttttgttc tgtttttttg tttggtatgt agtagttttt aatcaaacct taacgtattt
     7141 gatattaaga tttattgagt ttcttgttga gatgtagaaa taaaggggat ccatttcatt
     7201 tatcca
//
