LOCUS       NM_015325               7930 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens interactor of little elongation complex ELL subunit 1
            (ICE1), mRNA.
ACCESSION   NM_015325 XM_029101 XM_940469
VERSION     NM_015325.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7930)
  AUTHORS   Baird,T.D., Cheng,K.C., Chen,Y.C., Buehler,E., Martin,S.E.,
            Inglese,J. and Hogg,J.R.
  TITLE     ICE1 promotes the link between splicing and nonsense-mediated mRNA
            decay
  JOURNAL   Elife 7, e33178 (2018)
   PUBMED   29528287
  REMARK    GeneRIF: RNAseq studies reveal that depletion of ICE1 globally
            enhances accumulation and stability of NMD-target mRNAs. Further,
            our data suggest that ICE1 uses a putative MIF4G domain to interact
            with exon junction complex (EJC) proteins and promotes the
            association of the NMD protein UPF3B with the EJC.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7930)
  AUTHORS   Anwar,D., Takahashi,H., Watanabe,M., Suzuki,M., Fukuda,S. and
            Hatakeyama,S.
  TITLE     p53 represses the transcription of snRNA genes by preventing the
            formation of little elongation complex
  JOURNAL   Biochim Biophys Acta 1859 (8), 975-982 (2016)
   PUBMED   27268141
  REMARK    GeneRIF: The results indicate that p53 interferes with the
            interaction between ELL/EAF and ICE1 and represses transcription of
            small nuclear RNA genes by Pol II.
REFERENCE   3  (bases 1 to 7930)
  AUTHORS   Zhang,B., Willing,M., Grange,D.K., Shinawi,M., Manwaring,L.,
            Vineyard,M., Kulkarni,S. and Cottrell,C.E.
  TITLE     Multigenerational autosomal dominant inheritance of 5p chromosomal
            deletions
  JOURNAL   Am J Med Genet A 170 (3), 583-593 (2016)
   PUBMED   26601658
  REMARK    GeneRIF: Multigenerational autosomal dominant inheritance of 5p
            chromosomal deletions resulting in Cri-du-Chat Syndrome with
            SEMA5A, CTNND2, and ICE1 deficiencies has been described.
REFERENCE   4  (bases 1 to 7930)
  AUTHORS   Hu,D., Smith,E.R., Garruss,A.S., Mohaghegh,N., Varberg,J.M.,
            Lin,C., Jackson,J., Gao,X., Saraf,A., Florens,L., Washburn,M.P.,
            Eissenberg,J.C. and Shilatifard,A.
  TITLE     The little elongation complex functions at initiation and
            elongation phases of snRNA gene transcription
  JOURNAL   Mol Cell 51 (4), 493-505 (2013)
   PUBMED   23932780
REFERENCE   5  (bases 1 to 7930)
  AUTHORS   Smith,E.R., Lin,C., Garrett,A.S., Thornton,J., Mohaghegh,N., Hu,D.,
            Jackson,J., Saraf,A., Swanson,S.K., Seidel,C., Florens,L.,
            Washburn,M.P., Eissenberg,J.C. and Shilatifard,A.
  TITLE     The little elongation complex regulates small nuclear RNA
            transcription
  JOURNAL   Mol Cell 44 (6), 954-965 (2011)
   PUBMED   22195968
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA217623.1, AB023164.3, CR749441.1 and AL832204.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015325.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.174928.1, AB023164.3
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296564.9/ ENSP00000296564.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                DA217623.1         5-21
            18-1360             AB023164.3         1-1343
            1361-2700           CR749441.1         636-1975
            2701-3797           AL832204.1         1176-2272
            3798-7920           AB023164.3         3781-7903
            7921-7930           AL832204.1         6396-6405
FEATURES             Location/Qualifiers
     source          1..7930
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p15.32"
     gene            1..7930
                     /gene="ICE1"
                     /gene_synonym="KIAA0947"
                     /note="interactor of little elongation complex ELL subunit
                     1"
                     /db_xref="GeneID:23379"
                     /db_xref="HGNC:HGNC:29154"
                     /db_xref="MIM:617958"
     exon            1..323
                     /gene="ICE1"
                     /gene_synonym="KIAA0947"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..7040
                     /gene="ICE1"
                     /gene_synonym="KIAA0947"
                     /note="interactor of little elongator complex ELL subunit
                     1"
                     /codon_start=1
                     /product="little elongation complex subunit 1"
                     /protein_id="NP_056140.1"
                     /db_xref="CCDS:CCDS47187.1"
                     /db_xref="GeneID:23379"
                     /db_xref="HGNC:HGNC:29154"
                     /db_xref="MIM:617958"
                     /translation="MMPGETHSAAPGTAADLSRCQGCASLQQNLNEYVEALITLKQKI
                     INTDNLLTEYQKKCDELQFARRENSNLHHQVEEMLQKISPLQKCQEELGSLKAELEEK
                     KSSLKLYQDTHQEYARVKEECLKSDAQKKKLEAKVKKLQEAAVKQTQDFKQLRNEKKI
                     LEKEFKKTQERLDEFSKQKNEKELRHIGTQISSDSYGSIDKRKVKLLLKELWLCVNTT
                     HRLPGEGSRCVPEKPAKAITSSRVPGEDGTLPPTQGSPLRTSNVQTCLTKLSMEIKED
                     FLCQNVEKQSSSGTNCSSDHVFNENGNLEVLVQSHRDGGSTEFVDHDHFFDEDLQAAI
                     DFFKLPPPLLSPVPSPPPMSSPHPGSLPSSFAPETYFGEYTDSSDNDSVQLRNSAECV
                     SEDDTTESQNYFGSLRKNKGSGTWEEKPKSHEAIQALNTWEVNKVTTSGLETFTATLR
                     ESSATHSLVGEKHWTTASRSMSDRKRDILHETKTQMEVREMDKSVQTEKTIHKLTRGL
                     CIERLSASPAQEKEAAPGKSELCSSPLGKRPLNELMESEGKTVLSKMMGSPKSEFTKW
                     TRINEITSEPDRITVSGHFHRLSRELEKEKEDTQGFTLGESPESEDDDSGDGMDVAGL
                     DIETSFSSSSTLVALSVGSNPQSSSGLDCGNDTDITTKVFSTEPHHSEHKLQTKTLNT
                     LHLQSEPPECSIGGNNLENSLCALSPELGASNFNDQKSSGIEYTKVVKGLTKIHSLPR
                     SVFMKATKDGQCESQDPRIELTLNKPDFTSLIGSQAALIKSGLGFVKSTSWHHSDLLR
                     KGGEESLRAKSEHEQKTSHQLQKAMPFLQNRGPTPKPDLLRENNNPVEFKTTASVLPN
                     QVSVITKQTRPEKVQSAKLEHLRPHRVEPTLVTENSGNKTGMSTVAKCDGERDDTTQN
                     ITEVAAVKSISPEVSASRRKLDFNSPGGSSPVENSDCSTNSRLSFSPENILIQNQDIV
                     REAAVQGDGQKQRQPQATDLDSSGTHGSEMLPATEVTVSGGFSVEETSCGDTGRSGGE
                     ALAVANDSTSTPQNANGLWKLKSTTPGGALPECFGTTDTTFSSAFCRKHGETQDTSQS
                     SLPGTLHCYTGIREGGDDTEVESEAFSCSEGSEQQDAPDDSQKNLGDTDAAVAEVRPS
                     LEVGYLTSALQDFNISTFSELDRLSTSEVVMFLESCQLGDYSSGDSVSECSSKGTLSK
                     EMNKELKASEIGEKYRKQPCEEETLGTCEEWIESEEDDYSLKNTSQLTQCSLETLSEV
                     LTKIRQELQTNSEDCNGKDTGSLLLLNVNNNMTTENLKEKSPFRETTGSSSHASEPTP
                     QAAALDTEGSSPISGMPQNENPQSRPEARSDAGRQTDGGEEDLPEPVEPSALCSDSVM
                     EPSIEQSSNCEAETTFQCQIATVTSEVINVLINKDQNLVIEKGDNWTIISGVAVLPHV
                     DQVTLCDIPGDIPISQDQGELEAGCIPVTSAEKSPEASHTGPAFQEAPCGNNLSCPQE
                     DVSSSGQSTNFDKSRLRNRPVKPSIWISSQIYDQNFETQIVASDHTYYNSKLEPSGKN
                     KNRSKISNKDQSNKPVKTSASSRVETHQSEVAQSFSGEKANTKTQRSQTQTILANADT
                     STPTDCSPDTLSKIRQEVGPPLPPLLAPLIATPPRTSQPLSPLISSSSPSSPASPVGQ
                     VSPFRETPVPPAMSPWPEDPRRASPPDPSPSPSAASASERVVPSPLQFCAATPKHALP
                     VPGRLPPCASGHAAVGGPQENSVKILDTMYPELSARARTLNILKGNIQLTRGPPADCK
                     NLPGPASAMIGFKTITSAATAFVKTGSSSGGDCNQDKSRDLGTQQDSSGKRTLSTSTL
                     RSAKRLRLDTGSPEPETRGVTAEGIHKNLPGNLPPAEVATTNEERSCSSPAVSAVSQL
                     PLSPKETVESHDKAIANALKKIAEFSFDLLPVIRSHVYVGNISKKPVMRDQEKEVVYE
                     FSTTKKHLAECLLHSILSELKIQKISMDHNYIHALCRVYVGICRQLGDLERARLFCYS
                     LLKEDFPESEKLTLFIANMWHDIFLSQSVINKAMQLVARQRAKGEVLNCLRAFLNWEK
                     NAPVDVGFMVSKLLLTIQLCPKTEFQPSEKFGEDLSDNTWEYIFAIDLLCCHQKWIWT
                     HDNIISKELWPVMDKWIKYRKGHANIAYTPDIIIASILRLIGRLGQLGLKEGFPSAVK
                     NISSVIGMFIQHAHDEDIPWGIQLAAVYALCDLSPSNPAEISKILEAWRREASKSVPS
                     AIVSCLEEVSALSTEELG"
     exon            324..382
                     /gene="ICE1"
                     /gene_synonym="KIAA0947"
                     /inference="alignment:Splign:2.1.0"
     exon            383..417
                     /gene="ICE1"
                     /gene_synonym="KIAA0947"
                     /inference="alignment:Splign:2.1.0"
     exon            418..436
                     /gene="ICE1"
                     /gene_synonym="KIAA0947"
                     /inference="alignment:Splign:2.1.0"
     exon            437..548
                     /gene="ICE1"
                     /gene_synonym="KIAA0947"
                     /inference="alignment:Splign:2.1.0"
     exon            549..625
                     /gene="ICE1"
                     /gene_synonym="KIAA0947"
                     /inference="alignment:Splign:2.1.0"
     exon            626..663
                     /gene="ICE1"
                     /gene_synonym="KIAA0947"
                     /inference="alignment:Splign:2.1.0"
     exon            664..746
                     /gene="ICE1"
                     /gene_synonym="KIAA0947"
                     /inference="alignment:Splign:2.1.0"
     exon            747..786
                     /gene="ICE1"
                     /gene_synonym="KIAA0947"
                     /inference="alignment:Splign:2.1.0"
     exon            787..843
                     /gene="ICE1"
                     /gene_synonym="KIAA0947"
                     /inference="alignment:Splign:2.1.0"
     exon            844..930
                     /gene="ICE1"
                     /gene_synonym="KIAA0947"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1340
                     /gene="ICE1"
                     /gene_synonym="KIAA0947"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..6131
                     /gene="ICE1"
                     /gene_synonym="KIAA0947"
                     /inference="alignment:Splign:2.1.0"
     exon            6132..6300
                     /gene="ICE1"
                     /gene_synonym="KIAA0947"
                     /inference="alignment:Splign:2.1.0"
     exon            6301..6461
                     /gene="ICE1"
                     /gene_synonym="KIAA0947"
                     /inference="alignment:Splign:2.1.0"
     exon            6462..6652
                     /gene="ICE1"
                     /gene_synonym="KIAA0947"
                     /inference="alignment:Splign:2.1.0"
     exon            6653..6759
                     /gene="ICE1"
                     /gene_synonym="KIAA0947"
                     /inference="alignment:Splign:2.1.0"
     exon            6760..6858
                     /gene="ICE1"
                     /gene_synonym="KIAA0947"
                     /inference="alignment:Splign:2.1.0"
     exon            6859..7930
                     /gene="ICE1"
                     /gene_synonym="KIAA0947"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7905..7910
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ICE1"
                     /gene_synonym="KIAA0947"
                     /note="hexamer: AATAAA"
     polyA_site      7930
                     /gene="ICE1"
                     /gene_synonym="KIAA0947"
                     /note="major polyA site"
ORIGIN      
        1 ggactgcgtc gcgctcgggg gccgcgccgg gtagcgtttc tttttagtgc ctgaggcagc
       61 tctggctcgg agagcctttt gctagcccca cggggacctc tgtgcacgga tggacccgcc
      121 cggacctggc gggaagcggc ctggcaggcg gcggccccgg cggcatcagc agagacagga
      181 cggggccgac gccgcgggcc cctgaggcgt gcgtgcccac cgggcccggc ggcggcacca
      241 tgatgccggg cgagacccat tcggcggcgc ccgggacggc ggcggacctg tcgcgatgtc
      301 agggctgcgc ctctctgcag cagaatttga atgaatatgt tgaagcatta attaccttga
      361 aacaaaaaat tatcaataca gataatttgt taacagaata tcagaagaaa tgtgatgagc
      421 tgcagtttgc aagaagagag aatagtaatc tgcatcacca agtggaagag atgcttcaaa
      481 aaatttctcc tctacagaaa tgtcaggaag aactgggatc tttaaaagca gagctagaag
      541 agaaaaagag ttctttaaag ttgtatcagg atactcatca ggaatatgct cgtgtaaagg
      601 aagaatgctt gaagagtgat gctcagaaga agaaactaga agctaaggtg aagaagctgc
      661 aagaggctgc tgtcaagcaa actcaggact tcaagcaact gagaaatgaa aagaaaatac
      721 ttgaaaagga atttaagaag acacaggaaa ggcttgacga attttctaaa cagaaaaatg
      781 aaaaggagtt gagacatatt ggaacacaaa tttcaagtga ttcatatgga agcatagata
      841 aaagaaaagt gaaactgctt ctgaaggaac tctggctctg tgtaaacaca acacacagac
      901 tacctggtga aggcagcagg tgtgtcccag aaaaacctgc caaagcaatc accagctcca
      961 gagtgcctgg ggaagatggt acgctacctc caacacaggg cagccctctc aggacctcaa
     1021 atgtgcagac atgcctcaca aaactgtcca tggagataaa ggaggacttt ttatgtcaaa
     1081 atgtggaaaa acagagctcc agtggaacaa attgtagttc tgaccatgtt tttaatgaga
     1141 atggaaatct tgaggtttta gtacaaagtc atcgtgacgg tggtagtact gaatttgttg
     1201 atcatgatca tttttttgat gaagatcttc aagctgcaat tgacttcttc aaacttcccc
     1261 ctcctcttct gtcaccagtg ccctcgcccc ctccgatgtc atcacctcac ccgggttcct
     1321 taccgtcttc atttgcacct gaaacctact ttggagaata cacagattcc agcgataatg
     1381 actcagtcca gcttagaaat tctgctgagt gtgtttcaga agatgataca actgaatcac
     1441 agaattattt tggctcattg agaaaaaata aaggaagtgg cacatgggag gaaaagccca
     1501 aatcacatga agctatccaa gctctgaata catgggaagt aaataaagtg acaacttctg
     1561 gactcgagac tttcacagca acactgagag aatcttctgc cacacactcc ttagttggtg
     1621 aaaaacactg gaccacagca tctcgatcca tgagtgatag aaaaagagac attttacatg
     1681 agacaaaaac acaaatggag gttagggaga tggataagtc agtacaaact gagaagacca
     1741 ttcataaact cactcgaggt ctatgcattg agagattgtc tgccagccct gcacaagaga
     1801 aggaagctgc ccctgggaag tctgagttgt gttcttctcc ccttggcaaa aggccattaa
     1861 atgaactcat ggaatctgaa ggaaaaaccg tattgtctaa aatgatggga tcgcccaaat
     1921 cagagtttac taagtggaca cgaattaatg aaatcacttc tgaaccagac cgtatcacag
     1981 tttctggcca ttttcacaga ctatctagag aattggaaaa ggaaaaagaa gatactcaag
     2041 ggttcacttt aggagaatca cctgaatcag aagatgatga ctcaggtgat ggaatggatg
     2101 tagcagggct tgacattgaa accagttttt cttcctcttc taccttggta gcattgtctg
     2161 ttggcagtaa tccccagtct tcttctgggt tagactgtgg taatgataca gatattacta
     2221 ctaaagtatt ctctactgaa ccgcatcatt cagaacataa attgcaaact aaaactttaa
     2281 acacattaca tctgcagtct gagccaccgg agtgttctat aggaggaaac aacttggaga
     2341 atagcttgtg tgccttgagc cctgaattgg gagcatctaa ttttaatgat cagaagagca
     2401 gtgggataga atatacaaaa gtagtaaaag gcttgaccaa aatacattca cttcctcggt
     2461 cagtatttat gaaagctaca aaagatgggc aatgtgaaag tcaagatcca agaattgagc
     2521 tcacactaaa taagccagat ttcacatcat taataggttc tcaggctgcc ttgatcaaga
     2581 gtggtttggg ttttgttaaa agtacttcat ggcaccatag tgatttatta aggaaaggtg
     2641 gcgaagaaag tctgagagcc aaatcagaac atgaacagaa gactagccat cagttacaaa
     2701 aggcaatgcc attcctacaa aatagaggac caacacccaa gcctgatctt cttagagaaa
     2761 ataacaatcc tgtagaattc aagaccactg catcggtgtt gcctaatcaa gtatcagtta
     2821 tcacaaaaca gacaagacct gaaaaggttc agagtgccaa attggaacac ttgaggccac
     2881 atagggttga gcctacctta gtaacagaaa atagtggcaa caaaaccggt atgtcaactg
     2941 tagcaaaatg tgatggggaa agagatgata caacacaaaa catcacggag gtggctgctg
     3001 tgaaaagcat ttcaccagaa gtttctgcct ctaggagaaa attagatttt aattctccag
     3061 gtggttcttc accagtagaa aattctgatt gttccacaaa tagcagatta tctttctctc
     3121 ctgaaaatat cctcatccaa aaccaagaca ttgtgagaga agctgcagtg cagggagatg
     3181 ggcagaagca aaggcagcct caggccacag atctggactc cagtgggaca catggcagtg
     3241 agatgcttcc agccacagaa gtgactgtgt caggagggtt ttctgttgaa gaaaccagct
     3301 gtggagacac agggagatct ggtggtgagg ccctggctgt tgcaaatgat tctaccagca
     3361 caccacaaaa tgctaatgga ctttggaaat tgaaatctac aactcccggt ggtgctttgc
     3421 ctgagtgttt tggcaccaca gacactactt tttcttcagc attttgcaga aaacatggag
     3481 agacacagga tacctcccaa agtagcctgc ctggtacctt acattgttac acaggcattc
     3541 gagagggggg agacgacact gaggtagaga gtgaggcatt tagctgcagt gaggggagcg
     3601 aacagcaaga tgctcctgat gactcacaga aaaatttagg agacacagat gctgctgtag
     3661 ccgaggtgag accttcctta gaggtaggtt atttgacgtc agctctgcaa gattttaaca
     3721 taagtacttt ttctgagctg gatagacttt ccacatcaga ggttgtgatg tttcttgaga
     3781 gctgtcagtt aggggattat agttcagggg actctgtttc tgaatgttct agtaaaggaa
     3841 ccctaagtaa agaaatgaac aaagaattaa aggcaagtga aataggagaa aaatacagaa
     3901 agcaaccctg tgaggaagaa acacttggaa cctgtgaaga gtggattgaa tcagaggaag
     3961 atgattattc gttaaaaaat acaagtcagc tcactcagtg ttctttggaa actctgtctg
     4021 aggttctgac caagattagg caagaacttc aaacaaattc tgaagattgc aatggtaaag
     4081 atactggcag tttattgctc ttaaatgtaa ataacaacat gaccactgag aatttaaaag
     4141 agaaaagtcc atttcgggaa acgactggct cctcatcaca tgcttcagaa ccaaccccac
     4201 aagcagctgc cttggacact gagggcagct ctcccatcag cggtatgcct cagaatgaaa
     4261 accctcagag cagaccagag gcccgttcag atgcaggcag gcaaaccgat ggtggggaag
     4321 aagacctgcc agaacctgtg gagccatcag ccttgtgctc tgactctgtg atggagccat
     4381 ccatagagca aagttctaac tgcgaggccg aaacaacatt tcagtgtcag atagcaacag
     4441 tgacctcaga agttataaac gtacttataa ataaggatca gaatctagtc attgaaaagg
     4501 gggacaactg gacaatcatc agtggtgtag ctgtcttgcc acatgtggac caggtcacac
     4561 tgtgtgacat tcctggagac atccctattt ctcaggatca aggagagctg gaagctggtt
     4621 gcatcccagt gacttctgct gagaagtccc cagaggccag tcacactggc cctgcatttc
     4681 aggaggctcc atgtggcaat aatctttcat gtccccaaga ggatgtttca agcagtggtc
     4741 agagcaccaa ctttgataag agtcgtttgc gaaatagacc cgttaagcct agtatatgga
     4801 ttagttctca aatctatgat caaaacttcg agactcagat tgttgcgtct gatcacacat
     4861 attataactc aaaactagag ccatctggca aaaataagaa tcgatcaaag atttcaaaca
     4921 aagatcagtc aaacaaacca gtaaaaactt cagcgtcgag cagagttgaa actcatcaga
     4981 gtgaagttgc tcagtcattt tcaggggaaa aagctaatac aaaaactcaa agaagccaaa
     5041 ctcagaccat tttagcaaat gctgatacat ccactcctac agattgttct cctgacacac
     5101 tgagtaaaat acggcaagag gtggggcctc ctttgccgcc tctgcttgct cctctgatag
     5161 ctacacctcc aaggacttca cagccactgt ctccactgat atcgagttct agtccttcct
     5221 caccagcctc tcctgttggc caggtttctc ccttccgtga aaccccagtg cctcctgcca
     5281 tgtctccatg gccagaggac cccagacgtg cctctcctcc agatccttct ccatctccat
     5341 ctgcagcttc agccagtgag agggtagtgc cgtctcctct gcagttctgt gcggccacgc
     5401 cgaagcacgc acttcctgtg cctggccgac tcccaccctg tgcatctggc cacgctgctg
     5461 tgggagggcc tcaggagaat tctgtgaaaa tccttgacac catgtatcca gagttatctg
     5521 ccagggcccg gaccctcaac atcctcaaag ggaatattca actcacacga ggtccgcctg
     5581 ctgactgtaa gaatttaccg ggacctgcca gtgctatgat aggattcaaa acgatcactt
     5641 cagcagcaac tgcttttgtc aaaactggga gcagctctgg tggtgactgt aaccaagaca
     5701 agtcaagaga tttggggact cagcaggatt caagcgggaa aagaacactg tcaacgtcta
     5761 cactgagaag tgctaaaaga ctgcgcctgg acactgggtc cccagaacca gaaaccaggg
     5821 gagtcactgc agaaggaatc cacaaaaacc tcccagggaa cctccctcca gctgaagttg
     5881 caacaacaaa tgaggaaaga agttgttcta gtccagccgt cagtgcagtt tcacagttgc
     5941 ctttaagccc aaaagaaact gtggagtccc atgataaagc catagctaat gccctgaaga
     6001 aaattgcaga gttttctttt gatctgttac ctgtcattcg tagtcatgtg tatgtgggaa
     6061 atatctccaa aaagcccgta atgagagatc aagagaagga agttgtttat gaatttagca
     6121 caacaaaaaa gcatttagca gagtgcttgc ttcactctat tctctcagaa ctaaaaattc
     6181 agaagatatc tatggaccac aattacattc acgccctctg cagggtgtat gtgggtattt
     6241 gtcggcaact cggagacttg gaaagagctc gtttgttttg ctacagccta cttaaagaag
     6301 attttccgga gtctgaaaaa ttaactttgt ttattgcaaa catgtggcat gatatatttc
     6361 tctctcaatc ggtgattaat aaagcaatgc agttagttgc caggcaacgt gctaaaggag
     6421 aggttctgaa ctgcttgaga gcttttctta attgggaaaa gaatgccccg gtagatgttg
     6481 gcttcatggt ttctaagctg cttttgacca tacagttatg tccaaaaaca gaatttcaac
     6541 ctagtgaaaa atttggtgaa gacctaagtg ataacacttg ggaatacata tttgccattg
     6601 atctgctctg ctgccatcag aaatggatct ggacgcatga taacatcata agtaaggagc
     6661 tgtggcctgt gatggataaa tggataaaat acagaaaagg acatgcaaac attgcgtata
     6721 ctcctgatat tattatagcc tcaatactga ggctgattgg tcgtttaggc caattgggtt
     6781 tgaaagaagg atttccatct gctgtgaaaa atattagttc ggttattggt atgtttatac
     6841 agcatgctca cgatgaagat ataccatggg gtatacagtt agcagccgtg tatgctcttt
     6901 gtgacttgag tcccagcaat ccagcagaaa tttccaagat cctggaagct tggcggagag
     6961 aggcctccaa aagcgttccg tctgcgattg tcagctgcct agaggaagtc agtgccctga
     7021 gcacagagga gcttggctga cctgggatgc cactgaggct tgagaagtgc cttgacacat
     7081 tttgaacaca aatagtttga tcagctttca gaatacaaag ggaggtttca aaacaaaaag
     7141 acataaaata gataaaacag accagaggct ctccttattg tttggcaagg agacaggaga
     7201 aacaagcagt cgcatagtcg tttttcccta aatctaatac gtttcactta aggctgttgt
     7261 gatctgtgac atatgggtta tattattgtg tctttgtcaa acaacaaaaa cttgaactta
     7321 gccctttttt tgctgcagaa agtgtccttt tagtggcttc ttaaaattga gtggcatttt
     7381 ataatgaact taccaatata aaaacatgat ttggttcctg agctgttgtt gttggacttg
     7441 tgttccaatg agtgactagg aaaaaataaa ttggcaaaaa cctagagttt tctgctatct
     7501 ttgctggaaa tgagttgcaa aagtttttct caagatgtag tgcgtaattg atcagagcaa
     7561 aacatgcaga gcccttagca gaaacccact ttaatgcatt ttcttcatat ccctaaagtt
     7621 ccttaaaaat atgtgacaat gcatcaggaa gaggagaact gaagagtaga agttcccttg
     7681 cagatttttt tatcagtgac atgtaatgag caattcacag atgagcgcag gcagagctct
     7741 gtgtgccgtg tacatatgga ccgtgctatg atgtgtctca cattggatga tattccactt
     7801 tgggaatttt agtatttgta tatagaaaat gggtttaata actcaccatg gttttgattt
     7861 gtcttatatt cgttatttct taaaactctt gtatgtgttt ttataataaa aaataaaagt
     7921 aagccatgga
//
