LOCUS       NM_003259               3029 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens intercellular adhesion molecule 5 (ICAM5), mRNA.
ACCESSION   NM_003259
VERSION     NM_003259.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3029)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 3029)
  AUTHORS   Wei,W., Guo,H., Chang,J., Yu,Y., Liu,G., Zhang,N., Willard,S.H.,
            Zheng,S. and Yu,X.F.
  TITLE     ICAM-5/Telencephalin Is a Functional Entry Receptor for Enterovirus
            D68
  JOURNAL   Cell Host Microbe 20 (5), 631-641 (2016)
   PUBMED   27923705
  REMARK    GeneRIF: Here the authors identify neuron-specific intercellular
            adhesion molecule 5 (ICAM-5/telencephalin) as a cellular receptor
            for sialic acid-dependent and -independent entry of enterovirus
            D68.
REFERENCE   3  (bases 1 to 3029)
  AUTHORS   Liu,L., Sun,M., Song,D. and Wang,Z.
  TITLE     The genetic polymorphisms of intercellular cell adhesion molecules
            and breast cancer susceptibility: a meta-analysis
  JOURNAL   Mol Biol Rep 40 (2), 1855-1860 (2013)
   PUBMED   23079714
  REMARK    GeneRIF: ICAM5 V301I and rs281439 variants may contribute to the
            susceptibility of breast cancer. [Meta-analysis]
REFERENCE   4  (bases 1 to 3029)
  AUTHORS   Raemaekers,T., Peric,A., Baatsen,P., Sannerud,R., Declerck,I.,
            Baert,V., Michiels,C. and Annaert,W.
  TITLE     ARF6-mediated endosomal transport of Telencephalin affects
            dendritic filopodia-to-spine maturation
  JOURNAL   EMBO J 31 (15), 3252-3269 (2012)
   PUBMED   22781129
  REMARK    GeneRIF: A specific microenvironment facilitating ARF6-mediated
            mobilization of TLN that contributes to promotion of dendritic
            spine development.
REFERENCE   5  (bases 1 to 3029)
  AUTHORS   Ho-Pun-Cheung,A., Assenat,E., Bascoul-Mollevi,C., Bibeau,F.,
            Boissiere-Michot,F., Thezenas,S., Cellier,D., Azria,D., Rouanet,P.,
            Senesse,P., Ychou,M. and Lopez-Crapez,E.
  TITLE     A large-scale candidate gene approach identifies SNPs in SOD2 and
            IL13 as predictive markers of response to preoperative
            chemoradiation in rectal cancer
  JOURNAL   Pharmacogenomics J 11 (6), 437-443 (2011)
   PUBMED   20644561
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   6  (bases 1 to 3029)
  AUTHORS   Rieckmann,P., Turner,T., Kligannon,P. and Steinhoff,B.J.
  TITLE     Telencephalin as an indicator for temporal-lobe dysfunction
  JOURNAL   Lancet 352 (9125), 370-371 (1998)
   PUBMED   9717930
REFERENCE   7  (bases 1 to 3029)
  AUTHORS   Benson,D.L., Yoshihara,Y. and Mori,K.
  TITLE     Polarized distribution and cell type-specific localization of
            telencephalin, an intercellular adhesion molecule
  JOURNAL   J Neurosci Res 52 (1), 43-53 (1998)
   PUBMED   9556028
REFERENCE   8  (bases 1 to 3029)
  AUTHORS   Hayflick,J.S., Kilgannon,P. and Gallatin,W.M.
  TITLE     The intercellular adhesion molecule (ICAM) family of proteins. New
            members and novel functions
  JOURNAL   Immunol Res 17 (3), 313-327 (1998)
   PUBMED   9638475
  REMARK    Review article
REFERENCE   9  (bases 1 to 3029)
  AUTHORS   Mizuno,T., Yoshihara,Y., Inazawa,J., Kagamiyama,H. and Mori,K.
  TITLE     cDNA cloning and chromosomal localization of the human
            telencephalin and its distinctive interaction with lymphocyte
            function-associated antigen-1
  JOURNAL   J Biol Chem 272 (2), 1156-1163 (1997)
   PUBMED   8995416
REFERENCE   10 (bases 1 to 3029)
  AUTHORS   Yoshihara,Y. and Mori,K.
  TITLE     Telencephalin: a neuronal area code molecule?
  JOURNAL   Neurosci Res 21 (2), 119-124 (1994)
   PUBMED   7724062
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011511.12, U72671.1,
            AI199660.1, BC030132.2 and AI568610.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003259.3.
            
            Summary: The protein encoded by this gene is a member of the
            intercellular adhesion molecule (ICAM) family. All ICAM proteins
            are type I transmembrane glycoproteins, contain 2-9
            immunoglobulin-like C2-type domains, and bind to the leukocyte
            adhesion LFA-1 protein. This protein is expressed on the surface of
            telencephalic neurons and displays two types of adhesion activity,
            homophilic binding between neurons and heterophilic binding between
            neurons and leukocytes. It may be a critical component in
            neuron-microglial cell interactions in the course of normal
            development or as part of neurodegenerative diseases. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026338.1, U72671.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154665, SAMN02400288
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000221980.5/ ENSP00000221980.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AC011511.12        104595-104621
            28-992              U72671.1           1-965
            993-1118            AI199660.1         290-415
            1119-1134           AC011511.12        107320-107335
            1135-2743           BC030132.2         707-2315
            2744-3029           AI568610.1         4-289               c
FEATURES             Location/Qualifiers
     source          1..3029
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..3029
                     /gene="ICAM5"
                     /gene_synonym="TLCN; TLN"
                     /note="intercellular adhesion molecule 5"
                     /db_xref="GeneID:7087"
                     /db_xref="HGNC:HGNC:5348"
                     /db_xref="MIM:601852"
     exon            1..174
                     /gene="ICAM5"
                     /gene_synonym="TLCN; TLN"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..2867
                     /gene="ICAM5"
                     /gene_synonym="TLCN; TLN"
                     /note="telencephalin; ICAM-5; intercellular adhesion
                     molecule 5, telencephalin"
                     /codon_start=1
                     /product="intercellular adhesion molecule 5 precursor"
                     /protein_id="NP_003250.3"
                     /db_xref="CCDS:CCDS12233.1"
                     /db_xref="GeneID:7087"
                     /db_xref="HGNC:HGNC:5348"
                     /db_xref="MIM:601852"
                     /translation="MPGPSPGLRRALLGLWAALGLGLFGLSAVSQEPFWADLQPRVAF
                     VERGGSLWLNCSTNCPRPERGGLETSLRRNGTQRGLRWLARQLVDIREPETQPVCFFR
                     CARRTLQARGLIRTFQRPDRVELMPLPPWQPVGENFTLSCRVPGAGPRASLTLTLLRG
                     AQELIRRSFAGEPPRARGAVLTATVLARREDHGANFSCRAELDLRPHGLGLFENSSAP
                     RELRTFSLSPDAPRLAAPRLLEVGSERPVSCTLDGLFPASEARVYLALGDQNLSPDVT
                     LEGDAFVATATATASAEQEGARQLVCNVTLGGENRETRENVTIYSFPAPLLTLSEPSV
                     SEGQMVTVTCAAGAQALVTLEGVPAAVPGQPAQLQLNATENDDRRSFFCDATLDVDGE
                     TLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHCARSDGGA
                     VLALGLLGPVTRALSGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCPERITWLEGT
                     EASLSCVAHGVPPPDVICVRSGELGAVIEGLLRVAREHAGTYRCEATNPRGSAAKNVA
                     VTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLPLAP
                     PDPSPRAPRIPRVLAPGIYVCNATNRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEG
                     AEASALACAARGRPSPGVRCSREGIPWPEQQRVSREDAGTYHCVATNAHGTDSRTVTV
                     GVEYRPVVAELAASPPGGVRPGGNFTLTCRAEAWPPAQISWRAPPGALNIGLSSNNST
                     LSVAGAMGSHGGEYECAATNAHGRHARRITVRVAGPWLWVAVGGAAGGAALLAAGAGL
                     AFYVQSTACKKGEYNVQEAESSGEAVCLNGAGGGAGGAAGAEGGPEAAGGAAESPAEG
                     EVFAIQLTSA"
     exon            175..444
                     /gene="ICAM5"
                     /gene_synonym="TLCN; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            445..765
                     /gene="ICAM5"
                     /gene_synonym="TLCN; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            766..1053
                     /gene="ICAM5"
                     /gene_synonym="TLCN; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1308
                     /gene="ICAM5"
                     /gene_synonym="TLCN; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1557
                     /gene="ICAM5"
                     /gene_synonym="TLCN; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1803
                     /gene="ICAM5"
                     /gene_synonym="TLCN; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..2082
                     /gene="ICAM5"
                     /gene_synonym="TLCN; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2322
                     /gene="ICAM5"
                     /gene_synonym="TLCN; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2589
                     /gene="ICAM5"
                     /gene_synonym="TLCN; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            2590..3029
                     /gene="ICAM5"
                     /gene_synonym="TLCN; TLN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3009..3014
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ICAM5"
                     /gene_synonym="TLCN; TLN"
                     /note="hexamer: AATAAA"
     polyA_site      3029
                     /gene="ICAM5"
                     /gene_synonym="TLCN; TLN"
                     /note="major polyA site"
ORIGIN      
        1 acaccccacc cgccgcgccg cgcggagccg tcctctagcc cagctcctcg gctcgcgctc
       61 tcctcgcctc ctgtgctttc cccgccgcgg cgatgccagg gccttcgcca gggctgcgcc
      121 gggcgctact cggcctctgg gctgctctgg gcctggggct cttcggcctc tcagcggtct
      181 cgcaggagcc cttctgggcg gacctgcagc ctcgcgtggc gttcgtggag cgcgggggct
      241 cgctgtggct gaattgcagc accaactgcc ctcggccgga gcgcggtggc ctggagacct
      301 cgctgcgccg aaacgggacc cagaggggtt tgcgttggtt ggcgcggcag ctggtggaca
      361 ttcgcgagcc ggagactcag cccgtctgct tcttccgctg cgcgcggcgc acactacagg
      421 cgcgtgggct cattcgcact ttccagcgac cagatcgcgt agagctgatg ccgctgcctc
      481 cctggcagcc ggtgggcgag aacttcaccc tgagctgtag ggtccccggc gccgggcccc
      541 gtgcgagcct cacgctgacc ctgctgcggg gcgcccagga gctgatccgc cgcagcttcg
      601 ccggtgaacc accccgagcg cggggcgcgg tgctcacagc cacggtactg gctcggaggg
      661 aggaccatgg agccaatttc tcgtgtcgcg ccgagctgga cctgcggccg cacggactgg
      721 gactgtttga aaacagctcg gcccccagag agctccgaac cttctccctg tctccggatg
      781 ccccgcgcct cgctgctccc cggctcttgg aagttggctc ggaaaggccc gtgagctgca
      841 ctctggacgg actgtttcca gcctcagagg ccagggtcta cctcgcactg ggggaccaga
      901 atctgagtcc tgatgtcacc ctcgaagggg acgcattcgt ggccactgcc acagccacag
      961 ctagcgcaga gcaggagggt gccaggcagc tggtctgcaa cgtcaccctg gggggcgaaa
     1021 accgggagac ccgggagaac gtgaccatct acagcttccc ggcaccactc ctgaccctga
     1081 gcgaacccag cgtctccgag gggcagatgg tgacagtaac ctgcgcagct ggggcccaag
     1141 ctctggtcac actggaggga gttccagccg cggtcccggg gcagcccgcc cagcttcagc
     1201 taaatgccac cgagaacgac gacagacgca gcttcttctg cgacgccacc ctcgatgtgg
     1261 acggggagac cctgatcaag aacaggagcg cagagcttcg tgtcctatac gctccccggc
     1321 tagacgattc ggactgcccc aggagttgga cgtggcccga gggcccagag cagacgctgc
     1381 gctgcgaggc ccgcgggaac ccagaaccct cagtgcactg tgcgcgctcc gacggcgggg
     1441 ccgtgctggc tctgggcctg ctgggtccag tcactcgggc gctctcaggc acttaccgct
     1501 gcaaggcggc caatgatcaa ggcgaggcgg tcaaggacgt aacgctaacg gtggagtacg
     1561 caccagcgct ggacagcgtg ggctgcccag aacgcattac ttggctggag ggaacagaag
     1621 cctcgctgag ctgtgtggcg cacggggtac cgccgcctga tgtgatctgc gtgcgctctg
     1681 gagaactcgg ggccgtcatc gaggggctgt tgcgtgtggc ccgggagcat gcgggcactt
     1741 accgctgcga agccaccaac cctcggggct ctgcggccaa aaatgtggcc gtcacggtgg
     1801 aatatggccc caggtttgag gagccgagct gccccagcaa ttggacatgg gtggaaggat
     1861 ctgggcgcct gttttcctgt gaggtcgatg ggaagccaca gccaagcgtg aagtgcgtgg
     1921 gctccggggg cgccactgag ggggtgctgc tgccgctggc acccccagac cctagtccca
     1981 gagctcccag aatccctaga gtcctggcac ccggtatcta cgtctgcaac gccaccaacc
     2041 gccacggctc cgtggccaaa acagtcgtcg tgagcgcgga gtcgccaccg gagatggatg
     2101 aatctacctg cccaagtcac cagacgtggc tggaaggggc tgaggcttcc gcgctggcct
     2161 gcgccgcccg gggtcgccct tccccaggag tgcgctgctc tcgggaaggc atcccatggc
     2221 ctgagcagca gcgcgtgtcc cgagaggacg cgggcactta ccactgtgtg gccaccaatg
     2281 cgcatggcac ggactcccgg accgtcactg tgggcgtgga ataccggcca gtggtggccg
     2341 aacttgctgc ctcgccccct ggaggcgtgc gcccaggagg aaacttcacg ttgacctgcc
     2401 gcgcggaggc ctggcctcca gcccagatca gctggcgcgc gcccccgggg gccctcaaca
     2461 tcggcctgtc gagcaacaac agcacactga gcgtggcagg cgccatggga agccacggcg
     2521 gcgagtacga gtgcgcagcc accaacgcgc acgggcgcca cgcgcggcgc atcacggtgc
     2581 gcgtggccgg tccgtggcta tgggtcgccg tgggcggcgc ggcggggggc gcggcgctgc
     2641 tggccgcggg ggccggcctg gccttctacg tgcagtccac cgcctgcaag aagggcgagt
     2701 acaacgtgca ggaggccgag agctcaggcg aggccgtgtg tctgaacgga gcgggcggcg
     2761 gcgctggcgg ggcggcaggc gcggagggcg gacccgaggc ggcggggggc gcggccgagt
     2821 cgccggcgga gggcgaggtc ttcgccatac agctgacatc ggcgtgagcc cgctcccctc
     2881 tccccgcggg ccgggggacg ccccccagac tcacacgggg gcttatttat tgctttattt
     2941 atttacttat tcatttattt atgtattcaa ctccaagggc gtcaccccca ttttctaccc
     3001 atcccctcaa taaagttttt ataaaggaa
//
