LOCUS       NM_001544               1290 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens intercellular adhesion molecule 4 (Landsteiner-Wiener
            blood group) (ICAM4), transcript variant 1, mRNA.
ACCESSION   NM_001544
VERSION     NM_001544.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1290)
  AUTHORS   Zhu,Y., Shi,W., Han,W., Wang,M., Chen,J. and Zhou,J.
  TITLE     DNA methylation of ICAM4 and NOXO1 participate in the formation of
            uterine fibroids via regulating immune cell infiltration
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (11), 173-179 (2023)
   PUBMED   38015525
  REMARK    GeneRIF: DNA methylation of ICAM4 and NOXO1 participate in the
            formation of uterine fibroids via regulating immune cell
            infiltration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1290)
  AUTHORS   Al-Shimmery,A.H.S., Mahdi,Z.A., Al-Hindy,H.A.M., Al-Mammori,R.T.O.,
            Mokif,T.A., Al-Dahmoshi,H.O.M. and Al-Khafaji,N.S.K.
  TITLE     Immunological Study of IFN-gamma, ICAM-4, and Vitamin D3 Markers
            among Gastrointestinal Tumor Patients in Babylon Province, Iraq
  JOURNAL   Asian Pac J Cancer Prev 24 (1), 301-305 (2023)
   PUBMED   36708580
  REMARK    GeneRIF: Immunological Study of IFN-gamma, ICAM-4, and Vitamin D3
            Markers among Gastrointestinal Tumor Patients in Babylon Province,
            Iraq.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1290)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1290)
  AUTHORS   Zhang,J., Abiraman,K., Jones,S.M., Lykotrafitis,G. and
            Andemariam,B.
  TITLE     Regulation of Active ICAM-4 on Normal and Sickle Cell Disease RBCs
            via AKAPs Is Revealed by AFM
  JOURNAL   Biophys J 112 (1), 143-152 (2017)
   PUBMED   28076805
  REMARK    GeneRIF: the effect of modulation of the cAMP-PKA-dependent pathway
            on ICAM-4 receptor activation
REFERENCE   5  (bases 1 to 1290)
  AUTHORS   Brousse,V., Colin,Y., Pereira,C., Arnaud,C., Odievre,M.H.,
            Boutemy,A., Guitton,C., de Montalembert,M., Lapoumeroulie,C.,
            Picot,J., Le Van Kim,C. and El Nemer,W.
  TITLE     Erythroid Adhesion Molecules in Sickle Cell Anaemia Infants:
            Insights Into Early Pathophysiology
  JOURNAL   EBioMedicine 2 (2), 154-157 (2014)
   PUBMED   26137540
  REMARK    GeneRIF: Cytometry analysis evidenced a specific expression profile
            on reticulocytes of SCA infants, with notably an increased
            expression of the adhesion molecules Lu/BCAM, ICAM-4 and LFA-3,
            both in percentage of positive cells and in surface density.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1290)
  AUTHORS   Cherif-Zahar,B., Raynal,V., Gane,P., Mattei,M.G., Bailly,P.,
            Gibbs,B., Colin,Y. and Cartron,J.P.
  TITLE     Candidate gene acting as a suppressor of the RH locus in most cases
            of Rh-deficiency
  JOURNAL   Nat Genet 12 (2), 168-173 (1996)
   PUBMED   8563755
REFERENCE   7  (bases 1 to 1290)
  AUTHORS   Bailly,P., Tontti,E., Hermand,P., Cartron,J.P. and Gahmberg,C.G.
  TITLE     The red cell LW blood group protein is an intercellular adhesion
            molecule which binds to CD11/CD18 leukocyte integrins
  JOURNAL   Eur J Immunol 25 (12), 3316-3320 (1995)
   PUBMED   8566017
REFERENCE   8  (bases 1 to 1290)
  AUTHORS   Hermand,P., Gane,P., Mattei,M.G., Sistonen,P., Cartron,J.P. and
            Bailly,P.
  TITLE     Molecular basis and expression of the LWa/LWb blood group
            polymorphism
  JOURNAL   Blood 86 (4), 1590-1594 (1995)
   PUBMED   7632968
REFERENCE   9  (bases 1 to 1290)
  AUTHORS   Bailly,P., Hermand,P., Callebaut,I., Sonneborn,H.H., Khamlichi,S.,
            Mornon,J.P. and Cartron,J.P.
  TITLE     The LW blood group glycoprotein is homologous to intercellular
            adhesion molecules
  JOURNAL   Proc Natl Acad Sci U S A 91 (12), 5306-5310 (1994)
   PUBMED   8202485
REFERENCE   10 (bases 1 to 1290)
  AUTHORS   Sistonen,P.
  TITLE     Linkage of the LW blood group locus with the complement C3 and
            Lutheran blood group loci
  JOURNAL   Ann Hum Genet 48 (3), 239-242 (1984)
   PUBMED   6431896
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011511.12, BC029364.1 and
            BX114065.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 18, 2018 this sequence version replaced NM_001544.4.
            
            Summary: This gene encodes the Landsteiner-Wiener (LW) blood group
            antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and
            that shares similarity with the intercellular adhesion molecule
            (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type
            domains and binds to the leukocyte adhesion LFA-1 protein. The
            molecular basis of the LW(A)/LW(B) blood group antigens is a single
            aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B).
            Alternative splicing results in multiple transcript variants
            encoding distinct isoforms. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.183774.1,
                                           DRR138524.358474.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380770.5/ ENSP00000370147.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC011511.12        101598-101609
            13-1223             BC029364.1         1-1211
            1224-1290           BX114065.1         77-143              c
FEATURES             Location/Qualifiers
     source          1..1290
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..1290
                     /gene="ICAM4"
                     /gene_synonym="CD242; LW"
                     /note="intercellular adhesion molecule 4
                     (Landsteiner-Wiener blood group)"
                     /db_xref="GeneID:3386"
                     /db_xref="HGNC:HGNC:5347"
                     /db_xref="MIM:614088"
     exon            1..452
                     /gene="ICAM4"
                     /gene_synonym="CD242; LW"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..874
                     /gene="ICAM4"
                     /gene_synonym="CD242; LW"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; intercellular adhesion molecule 4 (LW blood
                     group); Landsteiner-Wiener blood group glycoprotein;
                     Landsteiner-Wiener blood group antigen a; CD242 antigen;
                     LW antigen a; bloodgroup LW protein"
                     /codon_start=1
                     /product="intercellular adhesion molecule 4 isoform 1
                     precursor"
                     /protein_id="NP_001535.1"
                     /db_xref="CCDS:CCDS12232.1"
                     /db_xref="GeneID:3386"
                     /db_xref="HGNC:HGNC:5347"
                     /db_xref="MIM:614088"
                     /translation="MGSLFPLSLLFFLAAAYPGVGSALGRRTKRAQSPKGSPLAPSGT
                     SVPFWVRMSPEFVAVQPGKSVQLNCSNSCPQPQNSSLRTPLRQGKTLRGPGWVSYQLL
                     DVRAWSSLAHCLVTCAGKTRWATSRITAYKPPHSVILEPPVLKGRKYTLRCHVTQVFP
                     VGYLVVTLRHGSRVIYSESLERFTGLDLANVTLTYEFAAGPRDFWQPVICHARLNLDG
                     LVVRNSSAPITLMLAWSPAPTALASGSIAALVGILLTVGAAYLCKCLAMKSQA"
     exon            453..755
                     /gene="ICAM4"
                     /gene_synonym="CD242; LW"
                     /inference="alignment:Splign:2.1.0"
     exon            756..1290
                     /gene="ICAM4"
                     /gene_synonym="CD242; LW"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1239..1244
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ICAM4"
                     /gene_synonym="CD242; LW"
                     /note="hexamer: AATAAA"
     polyA_site      1272
                     /gene="ICAM4"
                     /gene_synonym="CD242; LW"
ORIGIN      
        1 atctctagag ccggccctgg ctctctggcg cggggcccct tagtccgggc tttttgccat
       61 ggggtctctg ttccctctgt cgctgctgtt ttttttggcg gccgcctacc cgggagttgg
      121 gagcgcgctg ggacgccgga ctaagcgggc gcaaagcccc aagggtagcc ctctcgcgcc
      181 ctccgggacc tcagtgccct tctgggtgcg catgagcccg gagttcgtgg ctgtgcagcc
      241 ggggaagtca gtgcagctca attgcagcaa cagctgtccc cagccgcaga attccagcct
      301 ccgcaccccg ctgcggcaag gcaagacgct cagagggccg ggttgggtgt cttaccagct
      361 gctcgacgtg agggcctgga gctccctcgc gcactgcctc gtgacctgcg caggaaaaac
      421 acgctgggcc acctccagga tcaccgccta caaaccgccc cacagcgtga ttttggagcc
      481 tccggtctta aagggcagga aatacacttt gcgctgccac gtgacgcagg tgttcccggt
      541 gggctacttg gtggtgaccc tgaggcatgg aagccgggtc atctattccg aaagcctgga
      601 gcgcttcacc ggcctggatc tggccaacgt gaccttgacc tacgagtttg ctgctggacc
      661 ccgcgacttc tggcagcccg tgatctgcca cgcgcgcctc aatctcgacg gcctggtggt
      721 ccgcaacagc tcggcaccca ttacactgat gctcgcttgg agccccgcgc ccacagcttt
      781 ggcctccggt tccatcgctg cccttgtagg gatcctcctc actgtgggcg ctgcgtacct
      841 atgcaagtgc ctagctatga agtcccaggc gtaaaggggg atgttctatg ccggctgagc
      901 gagaaaaaga ggaatatgaa acaatctggg gaaatggcca tacatggtgg ctgacgcctg
      961 taatcccagc actttgggag gccgaggcag gagaatcgct tgagcccagg agttcgagac
     1021 cagcctggac aacatagtga gaccccgtct atgcaaaaaa tacacaaatt agcctggtgt
     1081 ggtggcccgc acctgtggtc ccagctaccc gggaggctga gttgggagga tcctttgagc
     1141 cctgaaagtc gaggttgcag tgagccttga tcgtgccact gcactccagc ctgggggaca
     1201 gagcacgacc ctgtctccaa aaataaaata aaaataaaaa taaatattgg cgggggaacc
     1261 ctctggaatc aataaaggct tccttaacca
//
