LOCUS       NM_002162               1735 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens intercellular adhesion molecule 3 (ICAM3), transcript
            variant 1, mRNA.
ACCESSION   NM_002162
VERSION     NM_002162.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1735)
  AUTHORS   Li,L., Yang,C., Aruna, Zhou,Q., Jiang,X., Du,W., Liu,C., Lv,P.,
            Wang,X., Fan,G., Zhao,S., Zhang,X., Jin,A. and Shen,W.
  TITLE     Functional evaluation of various ICAM3 transcript variants in
            diffuse large B-Cell lymphoma
  JOURNAL   Leuk Lymphoma 63 (12), 2869-2878 (2022)
   PUBMED   35849332
  REMARK    GeneRIF: Functional evaluation of various ICAM3 transcript variants
            in diffuse large B-Cell lymphoma.
REFERENCE   2  (bases 1 to 1735)
  AUTHORS   Zicheng,H., Xiao,Y., Rongzhong,H., Yongyong,L., Haitao,R. and
            Tingting,S.
  TITLE     Association of Circulating ICAM3 Concentrations with Severity and
            Short-term Outcomes of Acute Ischemic Stroke
  JOURNAL   Neurotox Res 39 (4), 1293-1299 (2021)
   PUBMED   33999358
  REMARK    GeneRIF: Association of Circulating ICAM3 Concentrations with
            Severity and Short-term Outcomes of Acute Ischemic Stroke.
REFERENCE   3  (bases 1 to 1735)
  AUTHORS   Pletsch-Borba,L., Grafetstatter,M., Husing,A., Johnson,T., Gonzalez
            Maldonado,S., Gross,M.L., Kloss,M., Hoffmeister,M., Bugert,P.,
            Kaaks,R. and Kuhn,T.
  TITLE     Vascular injury biomarkers and stroke risk: A population-based
            study
  JOURNAL   Neurology 94 (22), e2337-e2345 (2020)
   PUBMED   32371447
  REMARK    GeneRIF: Vascular injury biomarkers and stroke risk: A
            population-based study.
REFERENCE   4  (bases 1 to 1735)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1735)
  AUTHORS   Sokolovskaya,A., Korneeva,E., Zaichenko,D., Virus,E., Kolesov,D.,
            Moskovtsev,A. and Kubatiev,A.
  TITLE     Changes in the Surface Expression of Intercellular Adhesion
            Molecule 3, the Induction of Apoptosis, and the Inhibition of
            Cell-Cycle Progression of Human Multidrug-Resistant Jurkat/A4 Cells
            Exposed to a Random Positioning Machine
  JOURNAL   Int J Mol Sci 21 (3), 855 (2020)
   PUBMED   32013031
  REMARK    GeneRIF: Changes in the Surface Expression of Intercellular
            Adhesion Molecule 3, the Induction of Apoptosis, and the Inhibition
            of Cell-Cycle Progression of Human Multidrug-Resistant Jurkat/A4
            Cells Exposed to a Random Positioning Machine.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1735)
  AUTHORS   Pino-Otin,M.R., Juan,M., de la Fuente,M.A., Vinas,O.,
            Martinez-Caceres,E., Fernandez,M.D., Miralles,A., Vilella,R.,
            Yague,J., Vives,J. et al.
  TITLE     CD50 (intercellular adhesion molecule-3) is expressed at higher
            levels on memory than on naive human T cells but induces a similar
            calcium mobilization on both subsets
  JOURNAL   Tissue Antigens 46 (1), 32-44 (1995)
   PUBMED   7482494
REFERENCE   7  (bases 1 to 1735)
  AUTHORS   Simmons,D.L.
  TITLE     The role of ICAM expression in immunity and disease
  JOURNAL   Cancer Surv 24, 141-155 (1995)
   PUBMED   7553659
  REMARK    Review article
REFERENCE   8  (bases 1 to 1735)
  AUTHORS   Marazuela,M., Postigo,A.A., Acevedo,A., Diaz-Gonzalez,F.,
            Sanchez-Madrid,F. and de Landazuri,M.O.
  TITLE     Adhesion molecules from the LFA-1/ICAM-1,3 and VLA-4/VCAM-1
            pathways on T lymphocytes and vascular endothelium in Graves' and
            Hashimoto's thyroid glands
  JOURNAL   Eur J Immunol 24 (10), 2483-2490 (1994)
   PUBMED   7523142
REFERENCE   9  (bases 1 to 1735)
  AUTHORS   Vazeux,R., Hoffman,P.A., Tomita,J.K., Dickinson,E.S., Jasman,R.L.,
            St John,T. and Gallatin,W.M.
  TITLE     Cloning and characterization of a new intercellular adhesion
            molecule ICAM-R
  JOURNAL   Nature 360 (6403), 485-488 (1992)
   PUBMED   1448174
REFERENCE   10 (bases 1 to 1735)
  AUTHORS   Fawcett,J., Holness,C.L., Needham,L.A., Turley,H., Gatter,K.C.,
            Mason,D.Y. and Simmons,D.L.
  TITLE     Molecular cloning of ICAM-3, a third ligand for LFA-1,
            constitutively expressed on resting leukocytes
  JOURNAL   Nature 360 (6403), 481-484 (1992)
   PUBMED   1448173
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CR982084.1, AC114271.2,
            AK226023.1 and BC040123.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002162.4.
            
            Summary: The protein encoded by this gene is a member of the
            intercellular adhesion molecule (ICAM) family. All ICAM proteins
            are type I transmembrane glycoproteins, contain 2-9
            immunoglobulin-like C2-type domains, and bind to the leukocyte
            adhesion LFA-1 protein. This protein is constitutively and
            abundantly expressed by all leucocytes and may be the most
            important ligand for LFA-1 in the initiation of the immune
            response. It functions not only as an adhesion molecule, but also
            as a potent signalling molecule. Alternative splicing results in
            multiple transcript variants encoding different isoforms. [provided
            by RefSeq, Feb 2016].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.92873.1,
                                           SRR1163658.455224.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000160262.10/ ENSP00000160262.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-321               CR982084.1         211-531
            322-322             AC114271.2         7319-7319           c
            323-350             CR982084.1         533-560
            351-1732            AK226023.1         395-1776
            1733-1735           BC040123.1         1723-1725
FEATURES             Location/Qualifiers
     source          1..1735
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..1735
                     /gene="ICAM3"
                     /gene_synonym="CD50; CDW50; ICAM-R"
                     /note="intercellular adhesion molecule 3"
                     /db_xref="GeneID:3385"
                     /db_xref="HGNC:HGNC:5346"
                     /db_xref="MIM:146631"
     exon            1..86
                     /gene="ICAM3"
                     /gene_synonym="CD50; CDW50; ICAM-R"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..1654
                     /gene="ICAM3"
                     /gene_synonym="CD50; CDW50; ICAM-R"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; ICAM-3"
                     /codon_start=1
                     /product="intercellular adhesion molecule 3 isoform 1
                     precursor"
                     /protein_id="NP_002153.2"
                     /db_xref="CCDS:CCDS12235.1"
                     /db_xref="GeneID:3385"
                     /db_xref="HGNC:HGNC:5346"
                     /db_xref="MIM:146631"
                     /translation="MATMVPSVLWPRACWTLLVCCLLTPGVQGQEFLLRVEPQNPVLS
                     AGGSLFVNCSTDCPSSEKIALETSLSKELVASGMGWAAFNLSNVTGNSRILCSVYCNG
                     SQITGSSNITVYRLPERVELAPLPPWQPVGQNFTLRCQVEDGSPRTSLTVVLLRWEEE
                     LSRQPAVEEPAEVTATVLASRDDHGAPFSCRTELDMQPQGLGLFVNTSAPRQLRTFVL
                     PVTPPRLVAPRFLEVETSWPVDCTLDGLFPASEAQVYLALGDQMLNATVMNHGDTLTA
                     TATATARADQEGAREIVCNVTLGGERREARENLTVFSFLGPIVNLSEPTAHEGSTVTV
                     SCMAGARVQVTLDGVPAAAPGQPAQLQLNATESDDGRSFFCSATLEVDGEFLHRNSSV
                     QLRVLYGPKIDRATCPQHLKWKDKTRHVLQCQARGNPYPELRCLKEGSSREVPVGIPF
                     FVNVTHNGTYQCQASSSRGKYTLVVVMDIEAGSSHFVPVFVAVLLTLGVVTIVLALMY
                     VFREHQRSGSYHVREESTYLPLTSMQPTEAMGEEPSRAE"
     exon            87..353
                     /gene="ICAM3"
                     /gene_synonym="CD50; CDW50; ICAM-R"
                     /inference="alignment:Splign:2.1.0"
     exon            354..659
                     /gene="ICAM3"
                     /gene_synonym="CD50; CDW50; ICAM-R"
                     /inference="alignment:Splign:2.1.0"
     exon            660..947
                     /gene="ICAM3"
                     /gene_synonym="CD50; CDW50; ICAM-R"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1202
                     /gene="ICAM3"
                     /gene_synonym="CD50; CDW50; ICAM-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1451
                     /gene="ICAM3"
                     /gene_synonym="CD50; CDW50; ICAM-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1735
                     /gene="ICAM3"
                     /gene_synonym="CD50; CDW50; ICAM-R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1713..1718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ICAM3"
                     /gene_synonym="CD50; CDW50; ICAM-R"
                     /note="hexamer: AATAAA"
     polyA_site      1735
                     /gene="ICAM3"
                     /gene_synonym="CD50; CDW50; ICAM-R"
                     /note="major polyA site"
ORIGIN      
        1 ctctgtcaga atggccacca tggtaccatc cgtgttgtgg cccagggcct gctggactct
       61 gctggtctgc tgtctgctga ccccaggtgt ccaggggcag gagttccttt tgcgggtgga
      121 gccccagaac cctgtgctct ctgctggagg gtccctgttt gtgaactgca gtactgattg
      181 tcccagctct gagaaaatcg ccttggagac gtccctatca aaggagctgg tggccagtgg
      241 catgggctgg gcagccttca atctcagcaa cgtgactggc aacagtcgga tcctctgctc
      301 agtgtactgc aatggctctc agataacagg ctcctctaac atcaccgtgt acaggctccc
      361 ggagcgtgtg gagctggcac ccctgcctcc ttggcagccg gtgggccaga acttcaccct
      421 gcgctgccaa gtggaggatg ggtcgccccg gaccagcctc acggtggtgc tgcttcgctg
      481 ggaggaggag ctgagccggc agcccgcagt ggaggagcca gcggaggtca ctgccactgt
      541 gctggccagc agagacgacc acggagcccc tttctcatgc cgcacagaac tggacatgca
      601 gccccagggg ctgggactgt tcgtgaacac ctcagccccc cgccagctcc gaacctttgt
      661 cctgcccgtg acccccccgc gcctcgtggc cccccggttc ttggaggtgg aaacgtcgtg
      721 gccggtggac tgcaccctag acgggctttt tccagcctca gaggcccagg tctacctggc
      781 gctgggggac cagatgctga atgcgacagt catgaaccac ggggacacgc taacggccac
      841 agccacagcc acggcgcgcg cggatcagga gggtgcccgg gagatcgtct gcaacgtgac
      901 cctagggggc gagagacggg aggcccggga gaacttgacg gtctttagct tcctaggacc
      961 cattgtgaac ctcagcgagc ccaccgccca tgaggggtcc acagtgaccg tgagttgcat
     1021 ggctggggct cgagtccagg tcacgctgga cggagttccg gccgcggccc cggggcagcc
     1081 agctcaactt cagctaaatg ctaccgagag tgacgacgga cgcagcttct tctgcagtgc
     1141 cactctcgag gtggacggcg agttcttgca caggaacagt agcgtccagc tgcgagtcct
     1201 gtatggtccc aaaattgacc gagccacatg cccccagcac ttgaaatgga aagataaaac
     1261 gagacacgtc ctgcagtgcc aagccagggg caacccgtac cccgagctgc ggtgtttgaa
     1321 ggaaggctcc agccgggagg tgccggtggg gatcccgttc ttcgtcaacg taacacataa
     1381 tggtacttat cagtgccaag cgtccagctc acgaggcaaa tacaccctgg tcgtggtgat
     1441 ggacattgag gctgggagct cccactttgt ccccgtcttc gtggcggtgt tactgaccct
     1501 gggcgtggtg actatcgtac tggccttaat gtacgtcttc agggagcacc aacggagcgg
     1561 cagttaccat gttagggagg agagcaccta tctgcccctc acgtctatgc agccgacaga
     1621 agcaatgggg gaagaaccgt ccagagctga gtgacgctgg gatccgggat caaagttggc
     1681 gggggcttgg ctgtgccctc agattccgca ccaataaagc cttcaaactc cctaa
//
