LOCUS       NM_001320606            2032 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens intercellular adhesion molecule 3 (ICAM3), transcript
            variant 3, mRNA.
ACCESSION   NM_001320606 XM_011527959
VERSION     NM_001320606.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2032)
  AUTHORS   Li,L., Yang,C., Aruna, Zhou,Q., Jiang,X., Du,W., Liu,C., Lv,P.,
            Wang,X., Fan,G., Zhao,S., Zhang,X., Jin,A. and Shen,W.
  TITLE     Functional evaluation of various ICAM3 transcript variants in
            diffuse large B-Cell lymphoma
  JOURNAL   Leuk Lymphoma 63 (12), 2869-2878 (2022)
   PUBMED   35849332
  REMARK    GeneRIF: Functional evaluation of various ICAM3 transcript variants
            in diffuse large B-Cell lymphoma.
REFERENCE   2  (bases 1 to 2032)
  AUTHORS   Zicheng,H., Xiao,Y., Rongzhong,H., Yongyong,L., Haitao,R. and
            Tingting,S.
  TITLE     Association of Circulating ICAM3 Concentrations with Severity and
            Short-term Outcomes of Acute Ischemic Stroke
  JOURNAL   Neurotox Res 39 (4), 1293-1299 (2021)
   PUBMED   33999358
  REMARK    GeneRIF: Association of Circulating ICAM3 Concentrations with
            Severity and Short-term Outcomes of Acute Ischemic Stroke.
REFERENCE   3  (bases 1 to 2032)
  AUTHORS   Pletsch-Borba,L., Grafetstatter,M., Husing,A., Johnson,T., Gonzalez
            Maldonado,S., Gross,M.L., Kloss,M., Hoffmeister,M., Bugert,P.,
            Kaaks,R. and Kuhn,T.
  TITLE     Vascular injury biomarkers and stroke risk: A population-based
            study
  JOURNAL   Neurology 94 (22), e2337-e2345 (2020)
   PUBMED   32371447
  REMARK    GeneRIF: Vascular injury biomarkers and stroke risk: A
            population-based study.
REFERENCE   4  (bases 1 to 2032)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2032)
  AUTHORS   Sokolovskaya,A., Korneeva,E., Zaichenko,D., Virus,E., Kolesov,D.,
            Moskovtsev,A. and Kubatiev,A.
  TITLE     Changes in the Surface Expression of Intercellular Adhesion
            Molecule 3, the Induction of Apoptosis, and the Inhibition of
            Cell-Cycle Progression of Human Multidrug-Resistant Jurkat/A4 Cells
            Exposed to a Random Positioning Machine
  JOURNAL   Int J Mol Sci 21 (3), 855 (2020)
   PUBMED   32013031
  REMARK    GeneRIF: Changes in the Surface Expression of Intercellular
            Adhesion Molecule 3, the Induction of Apoptosis, and the Inhibition
            of Cell-Cycle Progression of Human Multidrug-Resistant Jurkat/A4
            Cells Exposed to a Random Positioning Machine.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2032)
  AUTHORS   Pino-Otin,M.R., Juan,M., de la Fuente,M.A., Vinas,O.,
            Martinez-Caceres,E., Fernandez,M.D., Miralles,A., Vilella,R.,
            Yague,J., Vives,J. et al.
  TITLE     CD50 (intercellular adhesion molecule-3) is expressed at higher
            levels on memory than on naive human T cells but induces a similar
            calcium mobilization on both subsets
  JOURNAL   Tissue Antigens 46 (1), 32-44 (1995)
   PUBMED   7482494
REFERENCE   7  (bases 1 to 2032)
  AUTHORS   Simmons,D.L.
  TITLE     The role of ICAM expression in immunity and disease
  JOURNAL   Cancer Surv 24, 141-155 (1995)
   PUBMED   7553659
  REMARK    Review article
REFERENCE   8  (bases 1 to 2032)
  AUTHORS   Marazuela,M., Postigo,A.A., Acevedo,A., Diaz-Gonzalez,F.,
            Sanchez-Madrid,F. and de Landazuri,M.O.
  TITLE     Adhesion molecules from the LFA-1/ICAM-1,3 and VLA-4/VCAM-1
            pathways on T lymphocytes and vascular endothelium in Graves' and
            Hashimoto's thyroid glands
  JOURNAL   Eur J Immunol 24 (10), 2483-2490 (1994)
   PUBMED   7523142
REFERENCE   9  (bases 1 to 2032)
  AUTHORS   Vazeux,R., Hoffman,P.A., Tomita,J.K., Dickinson,E.S., Jasman,R.L.,
            St John,T. and Gallatin,W.M.
  TITLE     Cloning and characterization of a new intercellular adhesion
            molecule ICAM-R
  JOURNAL   Nature 360 (6403), 485-488 (1992)
   PUBMED   1448174
REFERENCE   10 (bases 1 to 2032)
  AUTHORS   Fawcett,J., Holness,C.L., Needham,L.A., Turley,H., Gatter,K.C.,
            Mason,D.Y. and Simmons,D.L.
  TITLE     Molecular cloning of ICAM-3, a third ligand for LFA-1,
            constitutively expressed on resting leukocytes
  JOURNAL   Nature 360 (6403), 481-484 (1992)
   PUBMED   1448173
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CR982084.1, AK309643.1 and
            BC040123.1.
            
            On Jun 1, 2019 this sequence version replaced NM_001320606.1.
            
            Summary: The protein encoded by this gene is a member of the
            intercellular adhesion molecule (ICAM) family. All ICAM proteins
            are type I transmembrane glycoproteins, contain 2-9
            immunoglobulin-like C2-type domains, and bind to the leukocyte
            adhesion LFA-1 protein. This protein is constitutively and
            abundantly expressed by all leucocytes and may be the most
            important ligand for LFA-1 in the initiation of the immune
            response. It functions not only as an adhesion molecule, but also
            as a potent signalling molecule. Alternative splicing results in
            multiple transcript variants encoding different isoforms. [provided
            by RefSeq, Feb 2016].
            
            Transcript Variant: This variant (3) differs in the 5' UTR, lacks a
            portion of the 5' coding region and initiates translation at a
            downstream start codon, compared to variant 1. It encodes isoform 3
            which is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK309643.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 CR982084.1         211-215
            6-2029              AK309643.1         1-2024
            2030-2032           BC040123.1         1723-1725
FEATURES             Location/Qualifiers
     source          1..2032
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..2032
                     /gene="ICAM3"
                     /gene_synonym="CD50; CDW50; ICAM-R"
                     /note="intercellular adhesion molecule 3"
                     /db_xref="GeneID:3385"
                     /db_xref="HGNC:HGNC:5346"
                     /db_xref="MIM:146631"
     exon            1..86
                     /gene="ICAM3"
                     /gene_synonym="CD50; CDW50; ICAM-R"
                     /inference="alignment:Splign:2.1.0"
     exon            87..650
                     /gene="ICAM3"
                     /gene_synonym="CD50; CDW50; ICAM-R"
                     /inference="alignment:Splign:2.1.0"
     CDS             539..1951
                     /gene="ICAM3"
                     /gene_synonym="CD50; CDW50; ICAM-R"
                     /note="isoform 3 is encoded by transcript variant 3;
                     ICAM-3"
                     /codon_start=1
                     /product="intercellular adhesion molecule 3 isoform 3"
                     /protein_id="NP_001307535.1"
                     /db_xref="CCDS:CCDS82290.1"
                     /db_xref="GeneID:3385"
                     /db_xref="HGNC:HGNC:5346"
                     /db_xref="MIM:146631"
                     /translation="MGWAAFNLSNVTGNSRILCSVYCNGSQITGSSNITVYRLPERVE
                     LAPLPPWQPVGQNFTLRCQVEDGSPRTSLTVVLLRWEEELSRQPAVEEPAEVTATVLA
                     SRDDHGAPFSCRTELDMQPQGLGLFVNTSAPRQLRTFVLPVTPPRLVAPRFLEVETSW
                     PVDCTLDGLFPASEAQVYLALGDQMLNATVMNHGDTLTATATATARADQEGAREIVCN
                     VTLGGERREARENLTVFSFLGPIVNLSEPTAHEGSTVTVSCMAGARVQVTLDGVPAAA
                     PGQPAQLQLNATESDDGRSFFCSATLEVDGEFLHRNSSVQLRVLYGPKIDRATCPQHL
                     KWKDKTRHVLQCQARGNPYPELRCLKEGSSREVPVGIPFFVNVTHNGTYQCQASSSRG
                     KYTLVVVMDIEAGSSHFVPVFVAVLLTLGVVTIVLALMYVFREHQRSGSYHVREESTY
                     LPLTSMQPTEAMGEEPSRAE"
     exon            651..956
                     /gene="ICAM3"
                     /gene_synonym="CD50; CDW50; ICAM-R"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1244
                     /gene="ICAM3"
                     /gene_synonym="CD50; CDW50; ICAM-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1499
                     /gene="ICAM3"
                     /gene_synonym="CD50; CDW50; ICAM-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1748
                     /gene="ICAM3"
                     /gene_synonym="CD50; CDW50; ICAM-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..2032
                     /gene="ICAM3"
                     /gene_synonym="CD50; CDW50; ICAM-R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2010..2015
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ICAM3"
                     /gene_synonym="CD50; CDW50; ICAM-R"
                     /note="hexamer: AATAAA"
     polyA_site      2032
                     /gene="ICAM3"
                     /gene_synonym="CD50; CDW50; ICAM-R"
                     /note="major polyA site"
ORIGIN      
        1 ctctgtcaga atggccacca tggtaccatc cgtgttgtgg cccagggcct gctggactct
       61 gctggtctgc tgtctgctga ccccaggatc acctgtccct ttcacttgct aactcctact
      121 tagccttcag tttcgggctg caatggtccc cgcttccagg aagccttccc tgactcacct
      181 cctcctatgc tggatcagag cctcttctgg cctccttctg agttctcccc ggtctctgat
      241 ggattctacc tttcccactg gaccatgaag gcaggaaccc ttctgtctcg gcacaaggag
      301 agaggtgtta aatggtgggg cctgttgatg cgtgggttgg gggacaagga aacaaacacc
      361 aggacttctt catgttcctg aaggtgtcca ggggcaggag ttccttttgc gggtggagcc
      421 ccagaaccct gtgctctctg ctggagggtc cctgtttgtg aactgcagta ctgattgtcc
      481 cagctctgag aaaatcgcct tggagacgtc cctatcaaag gagctggtgg ccagtggcat
      541 gggctgggca gccttcaatc tcagcaacgt gactggcaac agtcggatcc tctgctcagt
      601 gtactgcaat ggctctcaga taacaggctc ctctaacatc accgtgtaca ggctcccgga
      661 gcgtgtggag ctggcacccc tgcctccttg gcagccggtg ggccagaact tcaccctgcg
      721 ctgccaagtg gaggatgggt cgccccggac cagcctcacg gtggtgctgc ttcgctggga
      781 ggaggagctg agccggcagc ccgcagtgga ggagccagcg gaggtcactg ccactgtgct
      841 ggccagcaga gacgaccacg gagccccttt ctcatgccgc acagaactgg acatgcagcc
      901 ccaggggctg ggactgttcg tgaacacctc agccccccgc cagctccgaa cctttgtcct
      961 gcccgtgacc cccccgcgcc tcgtggcccc ccggttcttg gaggtggaaa cgtcgtggcc
     1021 ggtggactgc accctagacg ggctttttcc agcctcagag gcccaggtct acctggcgct
     1081 gggggaccag atgctgaatg cgacagtcat gaaccacggg gacacgctaa cggccacagc
     1141 cacagccacg gcgcgcgcgg atcaggaggg tgcccgggag atcgtctgca acgtgaccct
     1201 agggggcgag agacgggagg cccgggagaa cttgacggtc tttagcttcc taggacccat
     1261 tgtgaacctc agcgagccca ccgcccatga ggggtccaca gtgaccgtga gttgcatggc
     1321 tggggctcga gtccaggtca cgctggacgg agttccggcc gcggccccgg ggcagccagc
     1381 tcaacttcag ctaaatgcta ccgagagtga cgacggacgc agcttcttct gcagtgccac
     1441 tctcgaggtg gacggcgagt tcttgcacag gaacagtagc gtccagctgc gagtcctgta
     1501 tggtcccaaa attgaccgag ccacatgccc ccagcacttg aaatggaaag ataaaacgag
     1561 acacgtcctg cagtgccaag ccaggggcaa cccgtacccc gagctgcggt gtttgaagga
     1621 aggctccagc cgggaggtgc cggtggggat cccgttcttc gtcaacgtaa cacataatgg
     1681 tacttatcag tgccaagcgt ccagctcacg aggcaaatac accctggtcg tggtgatgga
     1741 cattgaggct gggagctccc actttgtccc cgtcttcgtg gcggtgttac tgaccctggg
     1801 cgtggtgact atcgtactgg ccttaatgta cgtcttcagg gagcaccaac ggagcggcag
     1861 ttaccatgtt agggaggaga gcacctatct gcccctcacg tctatgcagc cgacagaagc
     1921 aatgggggaa gaaccgtcca gagctgagtg acgctgggat ccgggatcaa agttggcggg
     1981 ggcttggctg tgccctcaga ttccgcacca ataaagcctt caaactccct aa
//
