LOCUS       NM_001099789            1135 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens intercellular adhesion molecule 2 (ICAM2), transcript
            variant 4, mRNA.
ACCESSION   NM_001099789
VERSION     NM_001099789.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1135)
  AUTHORS   Tang,X., Huang,J., Jiang,Y., Qiu,J., Li,T., Li,W., Chen,Z.,
            Huang,Z., Yu,X., Yang,T., Ji,X., Tan,R., Lv,L., Yang,Z. and Chen,H.
  TITLE     Intercellular adhesion molecule 2 as a novel prospective tumor
            suppressor induced by ERG promotes ubiquitination-mediated radixin
            degradation to inhibit gastric cancer tumorigenicity and metastasis
  JOURNAL   J Transl Med 21 (1), 670 (2023)
   PUBMED   37759298
  REMARK    GeneRIF: Intercellular adhesion molecule 2 as a novel prospective
            tumor suppressor induced by ERG promotes ubiquitination-mediated
            radixin degradation to inhibit gastric cancer tumorigenicity and
            metastasis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1135)
  AUTHORS   Chong,D.L.W., Rebeyrol,C., Jose,R.J., Williams,A.E., Brown,J.S.,
            Scotton,C.J. and Porter,J.C.
  TITLE     ICAM-1 and ICAM-2 Are Differentially Expressed and Up-Regulated on
            Inflamed Pulmonary Epithelium, but Neither ICAM-2 nor LFA-1: ICAM-1
            Are Required for Neutrophil Migration Into the Airways In Vivo
  JOURNAL   Front Immunol 12, 691957 (2021)
   PUBMED   34484188
  REMARK    GeneRIF: ICAM-1 and ICAM-2 Are Differentially Expressed and
            Up-Regulated on Inflamed Pulmonary Epithelium, but Neither ICAM-2
            nor LFA-1: ICAM-1 Are Required for Neutrophil Migration Into the
            Airways In Vivo.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1135)
  AUTHORS   Jin,X., Bu,Q., Zou,Y., Feng,Y. and Wei,M.
  TITLE     Lewis-antigen-containing ICAM-2/3 on Jurkat leukemia cells interact
            with DC-SIGN to regulate DC functions
  JOURNAL   Glycoconj J 35 (3), 287-297 (2018)
   PUBMED   29671117
  REMARK    GeneRIF: Lewis-antigen-containing ICAM-2/3 on Jurkat leukemia cells
            interact with DC-SIGN to regulate DC functions.
REFERENCE   4  (bases 1 to 1135)
  AUTHORS   Zuo,Y., Cui,Y., Di Poto,C., Varghese,R.S., Yu,G., Li,R. and
            Ressom,H.W.
  TITLE     INDEED: Integrated differential expression and differential network
            analysis of omic data for biomarker discovery
  JOURNAL   Methods 111, 12-20 (2016)
   PUBMED   27592383
  REMARK    GeneRIF: INDEED also identified some candidates previously reported
            to be relevant to HCC, such as intercellular adhesion molecule 2
            (ICAM2) and c4b-binding protein alpha chain (C4BPA), which were
            missed by both Differential expression and differential network
            analyses
REFERENCE   5  (bases 1 to 1135)
  AUTHORS   Sasaki,Y., Tamura,M., Takeda,K., Ogi,K., Nakagaki,T., Koyama,R.,
            Idogawa,M., Hiratsuka,H. and Tokino,T.
  TITLE     Identification and characterization of the intercellular adhesion
            molecule-2 gene as a novel p53 target
  JOURNAL   Oncotarget 7 (38), 61426-61437 (2016)
   PUBMED   27556181
  REMARK    GeneRIF: ICAM2 induction by p53 has a key role in inhibiting cancer
            cell migration and invasion.ICAM2 acts at least in part through the
            suppression of the MEK-ERK signaling pathway.
REFERENCE   6  (bases 1 to 1135)
  AUTHORS   Bujia,J., Holly,A., Kim,C., Scanady,N. and Kastenbauer,E.
  TITLE     Expression of human intercellular adhesion molecules in middle ear
            cholesteatoma
  JOURNAL   Am J Otolaryngol 15 (4), 271-275 (1994)
   PUBMED   7526720
REFERENCE   7  (bases 1 to 1135)
  AUTHORS   Fawcett,J., Holness,C.L., Needham,L.A., Turley,H., Gatter,K.C.,
            Mason,D.Y. and Simmons,D.L.
  TITLE     Molecular cloning of ICAM-3, a third ligand for LFA-1,
            constitutively expressed on resting leukocytes
  JOURNAL   Nature 360 (6403), 481-484 (1992)
   PUBMED   1448173
REFERENCE   8  (bases 1 to 1135)
  AUTHORS   Sansom,D., Borrow,J., Solomon,E. and Trowsdale,J.
  TITLE     The human ICAM2 gene maps to 17q23-25
  JOURNAL   Genomics 11 (2), 462-464 (1991)
   PUBMED   1769660
REFERENCE   9  (bases 1 to 1135)
  AUTHORS   de Fougerolles,A.R., Stacker,S.A., Schwarting,R. and Springer,T.A.
  TITLE     Characterization of ICAM-2 and evidence for a third
            counter-receptor for LFA-1
  JOURNAL   J Exp Med 174 (1), 253-267 (1991)
   PUBMED   1676048
REFERENCE   10 (bases 1 to 1135)
  AUTHORS   Staunton,D.E., Dustin,M.L. and Springer,T.A.
  TITLE     Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1
            homologous to ICAM-1
  JOURNAL   Nature 339 (6219), 61-64 (1989)
   PUBMED   2497351
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CA841927.1 and AK223219.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001099789.1.
            
            Summary: The protein encoded by this gene is a member of the
            intercellular adhesion molecule (ICAM) family. All ICAM proteins
            are type I transmembrane glycoproteins, contain 2-9
            immunoglobulin-like C2-type domains, and bind to the leukocyte
            adhesion LFA-1 protein. This protein may play a role in lymphocyte
            recirculation by blocking LFA-1-dependent cell adhesion. It
            mediates adhesive interactions important for antigen-specific
            immune response, NK-cell mediated clearance, lymphocyte
            recirculation, and other cellular interactions important for immune
            response and surveillance. Several transcript variants encoding the
            same protein have been found for this gene. [provided by RefSeq,
            Jul 2008].
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 1. All 5 variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.259991.1,
                                           SRR5189655.154757.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680, SAMEA2150385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000579788.6/ ENSP00000464665.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               CA841927.1         12-122
            112-1135            AK223219.1         33-1056
FEATURES             Location/Qualifiers
     source          1..1135
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q23.3"
     gene            1..1135
                     /gene="ICAM2"
                     /gene_synonym="CD102"
                     /note="intercellular adhesion molecule 2"
                     /db_xref="GeneID:3384"
                     /db_xref="HGNC:HGNC:5345"
                     /db_xref="MIM:146630"
     exon            1..111
                     /gene="ICAM2"
                     /gene_synonym="CD102"
                     /inference="alignment:Splign:2.1.0"
     exon            112..216
                     /gene="ICAM2"
                     /gene_synonym="CD102"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..983
                     /gene="ICAM2"
                     /gene_synonym="CD102"
                     /note="ICAM-2"
                     /codon_start=1
                     /product="intercellular adhesion molecule 2 precursor"
                     /protein_id="NP_001093259.1"
                     /db_xref="CCDS:CCDS11657.1"
                     /db_xref="GeneID:3384"
                     /db_xref="HGNC:HGNC:5345"
                     /db_xref="MIM:146630"
                     /translation="MSSFGYRTLTVALFTLICCPGSDEKVFEVHVRPKKLAVEPKGSL
                     EVNCSTTCNQPEVGGLETSLDKILLDEQAQWKHYLVSNISHDTVLQCHFTCSGKQESM
                     NSNVSVYQPPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSLTLFLFRGNETLHYET
                     FGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYEP
                     VSDSQMVIIVTVVSVLLSLFVTSVLLCFIFGQHLRQQRMGTYGVRAAWRRLPQAFRP"
     exon            217..483
                     /gene="ICAM2"
                     /gene_synonym="CD102"
                     /inference="alignment:Splign:2.1.0"
     exon            484..804
                     /gene="ICAM2"
                     /gene_synonym="CD102"
                     /inference="alignment:Splign:2.1.0"
     exon            805..1135
                     /gene="ICAM2"
                     /gene_synonym="CD102"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1116..1121
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ICAM2"
                     /gene_synonym="CD102"
                     /note="hexamer: AATACA"
     polyA_site      1135
                     /gene="ICAM2"
                     /gene_synonym="CD102"
                     /note="major polyA site"
ORIGIN      
        1 gagaagactg aataagccgt gaactgggca gctgtgacac gcgcaccttg tcaccttgtc
       61 accaatttcc tgcccgggat cccagagcta cccttcttgg agcccacagg ggcagccctt
      121 ggctggtccc tgcgagcccg tggagactgc cagagatgtc ctctttcggt tacaggaccc
      181 tgactgtggc cctcttcacc ctgatctgct gtccaggatc ggatgagaag gtattcgagg
      241 tacacgtgag gccaaagaag ctggcggttg agcccaaagg gtccctcgag gtcaactgca
      301 gcaccacctg taaccagcct gaagtgggtg gtctggagac ctctctagat aagattctgc
      361 tggacgaaca ggctcagtgg aaacattact tggtctcaaa catctcccat gacacggtcc
      421 tccaatgcca cttcacctgc tccgggaagc aggagtcaat gaattccaac gtcagcgtgt
      481 accagcctcc aaggcaggtc atcctgacac tgcaacccac tttggtggct gtgggcaagt
      541 ccttcaccat tgagtgcagg gtgcccaccg tggagcccct ggacagcctc accctcttcc
      601 tgttccgtgg caatgagact ctgcactatg agaccttcgg gaaggcagcc cctgctccgc
      661 aggaggccac agccacattc aacagcacgg ctgacagaga ggatggccac cgcaacttct
      721 cctgcctggc tgtgctggac ttgatgtctc gcggtggcaa catctttcac aaacactcag
      781 ccccgaagat gttggagatc tatgagcctg tgtcggacag ccagatggtc atcatagtca
      841 cggtggtgtc ggtgttgctg tccctgttcg tgacatctgt cctgctctgc ttcatcttcg
      901 gccagcactt gcgccagcag cggatgggca cctacggggt gcgagcggct tggaggaggc
      961 tgccccaggc cttccggcca tagcaaccat gagtggcatg gccaccacca cggtggtcac
     1021 tggaactcag tgtgactcct cagggttgag gtccagccct ggctgaagga ctgtgacagg
     1081 cagcagagac ttgggacatt gccttttcta gcccgaatac aaacacctgg actta
//
