LOCUS       NM_000201               2967 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens intercellular adhesion molecule 1 (ICAM1), mRNA.
ACCESSION   NM_000201
VERSION     NM_000201.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2967)
  AUTHORS   Jabeen,A., Riaz,S., Usman,M., Parveen,A., Mukhtar,M., Wajid,A.,
            Hanif,A. and Batool,A.
  TITLE     Association of polymorphism of NLRP3, ICAM-1, PTPN22, INS genes in
            childhood onset type 1 diabetes in a Pakistani population
  JOURNAL   Mol Biol Rep 51 (1), 1070 (2024)
   PUBMED   39425874
  REMARK    GeneRIF: Association of polymorphism of NLRP3, ICAM-1, PTPN22, INS
            genes in childhood onset type 1 diabetes in a Pakistani population.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2967)
  AUTHORS   Sibiya,S., Mlambo,Z.P., Mthembu,M.H., Mkhwanazi,N.P. and Naicker,T.
  TITLE     Analysis of ICAM-1 rs3093030, VCAM-1 rs3783605, and E-Selectin
            rs1805193 Polymorphisms in African Women Living with HIV and
            Preeclampsia
  JOURNAL   Int J Mol Sci 25 (19), 10860 (2024)
   PUBMED   39409189
  REMARK    GeneRIF: Analysis of ICAM-1 rs3093030, VCAM-1 rs3783605, and
            E-Selectin rs1805193 Polymorphisms in African Women Living with HIV
            and Preeclampsia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2967)
  AUTHORS   Wang,S., Wang,J., Liu,C., Yang,L., Tan,X., Chen,S., Xue,Y., Ji,H.,
            Ge,G. and Chen,J.
  TITLE     Neoplastic ICAM-1 protects lung carcinoma from apoptosis through
            ligation of fibrinogen
  JOURNAL   Cell Death Dis 15 (8), 605 (2024)
   PUBMED   39168965
  REMARK    GeneRIF: Neoplastic ICAM-1 protects lung carcinoma from apoptosis
            through ligation of fibrinogen.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2967)
  AUTHORS   Tinajero-Rodriguez,J.M., Ramirez-Vidal,L., Becerril-Rico,J.,
            Alvarado-Ortiz,E., Romero-Rodriguez,D.P., Lopez-Casillas,F.,
            Hernandez-Sotelo,D., Fernandez-Ramirez,F., Contreras-Paredes,A. and
            Ortiz-Sanchez,E.
  TITLE     ICAM1 (CD54) Contributes to the Metastatic Capacity of Gastric
            Cancer Stem Cells
  JOURNAL   Int J Mol Sci 25 (16), 8865 (2024)
   PUBMED   39201551
  REMARK    GeneRIF: ICAM1 (CD54) Contributes to the Metastatic Capacity of
            Gastric Cancer Stem Cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2967)
  AUTHORS   Pantovic-Stefanovic,M., Petronijevic,N., Dunjic-Kostic,B.,
            Velimirovic,M., Jurisic,V., Nikolic,T., Dodic,S. and Ivkovic,M.
  TITLE     Differentiating Stages of Bipolar and Unipolar Depression-The
            Possible Role of sICAM-1 and sVCAM-1
  JOURNAL   Cells 13 (14), 1213 (2024)
   PUBMED   39056795
  REMARK    GeneRIF: Differentiating Stages of Bipolar and Unipolar
            Depression-The Possible Role of sICAM-1 and sVCAM-1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2967)
  AUTHORS   Fawcett,J., Holness,C.L., Needham,L.A., Turley,H., Gatter,K.C.,
            Mason,D.Y. and Simmons,D.L.
  TITLE     Molecular cloning of ICAM-3, a third ligand for LFA-1,
            constitutively expressed on resting leukocytes
  JOURNAL   Nature 360 (6403), 481-484 (1992)
   PUBMED   1448173
REFERENCE   7  (bases 1 to 2967)
  AUTHORS   Viac,J., Chardonnet,Y., Euvrard,S. and Schmitt,D.
  TITLE     Epidermotropism of T cells correlates with intercellular adhesion
            molecule (ICAM1) expression in human papillomavirus (HPV)-induced
            lesions
  JOURNAL   J Pathol 168 (3), 301-306 (1992)
   PUBMED   1361527
REFERENCE   8  (bases 1 to 2967)
  AUTHORS   Rossler,K., Neuchrist,C., Kitz,K., Scheiner,O., Kraft,D. and
            Lassmann,H.
  TITLE     Expression of leucocyte adhesion molecules at the human blood-brain
            barrier (BBB)
  JOURNAL   J Neurosci Res 31 (2), 365-374 (1992)
   PUBMED   1374132
REFERENCE   9  (bases 1 to 2967)
  AUTHORS   Denkers,I.A., de Jong-de Boer,T.J., Beelen,R.H., Ossenkoppele,G.J.
            and Langenhuijsen,M.M.
  TITLE     VLA molecule expression may be involved in the release of acute
            myeloid leukaemic cells from the bone marrow
  JOURNAL   Leuk Res 16 (5), 469-474 (1992)
   PUBMED   1625472
REFERENCE   10 (bases 1 to 2967)
  AUTHORS   Degitz,K., Li,L.J. and Caughman,S.W.
  TITLE     Cloning and characterization of the 5'-transcriptional regulatory
            region of the human intercellular adhesion molecule 1 gene
  JOURNAL   J Biol Chem 266 (21), 14024-14030 (1991)
   PUBMED   1677359
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC015969.2 and BG149901.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_000201.2.
            
            Summary: This gene encodes a cell surface glycoprotein which is
            typically expressed on endothelial cells and cells of the immune
            system. It binds to integrins of type CD11a / CD18, or CD11b / CD18
            and is also exploited by Rhinovirus as a receptor. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC015969.2, GQ901042.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264832.8/ ENSP00000264832.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2806              BC015969.2         32-2837
            2807-2967           BG149901.1         4-164               c
FEATURES             Location/Qualifiers
     source          1..2967
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..2967
                     /gene="ICAM1"
                     /gene_synonym="BB2; CD54; P3.58"
                     /note="intercellular adhesion molecule 1"
                     /db_xref="GeneID:3383"
                     /db_xref="HGNC:HGNC:5344"
                     /db_xref="MIM:147840"
     exon            1..107
                     /gene="ICAM1"
                     /gene_synonym="BB2; CD54; P3.58"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1639
                     /gene="ICAM1"
                     /gene_synonym="BB2; CD54; P3.58"
                     /note="intercellular adhesion molecule 1 (CD54), human
                     rhinovirus receptor; cell surface glycoprotein P3.58;
                     ICAM-1; major group rhinovirus receptor; epididymis
                     secretory sperm binding protein"
                     /codon_start=1
                     /product="intercellular adhesion molecule 1 precursor"
                     /protein_id="NP_000192.2"
                     /db_xref="CCDS:CCDS12231.1"
                     /db_xref="GeneID:3383"
                     /db_xref="HGNC:HGNC:5344"
                     /db_xref="MIM:147840"
                     /translation="MAPSSPRPALPALLVLLGALFPGPGNAQTSVSPSKVILPRGGSV
                     LVTCSTSCDQPKLLGIETPLPKKELLLPGNNRKVYELSNVQEDSQPMCYSNCPDGQST
                     AKTFLTVYWTPERVELAPLPSWQPVGKNLTLRCQVEGGAPRANLTVVLLRGEKELKRE
                     PAVGEPAEVTTTVLVRRDHHGANFSCRTELDLRPQGLELFENTSAPYQLQTFVLPATP
                     PQLVSPRVLEVDTQGTVVCSLDGLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASV
                     SVTAEDEGTQRLTCAVILGNQSQETLQTVTIYSFPAPNVILTKPEVSEGTEVTVKCEA
                     HPRAKVTLNGVPAQPLGPRAQLLLKATPEDNGRSFSCSATLEVAGQLIHKNQTRELRV
                     LYGPRLDERDCPGNWTWPENSQQTPMCQAWGNPLPELKCLKDGTFPLPIGESVTVTRD
                     LEGTYLCRARSTQGEVTRKVTVNVLSPRYEIVIITVVAAAVIMGTAGLSTYLYNRQRK
                     IKKYRLQQAQKGTPMKPNTQATPP"
     exon            108..371
                     /gene="ICAM1"
                     /gene_synonym="BB2; CD54; P3.58"
                     /inference="alignment:Splign:2.1.0"
     exon            372..677
                     /gene="ICAM1"
                     /gene_synonym="BB2; CD54; P3.58"
                     /inference="alignment:Splign:2.1.0"
     exon            678..965
                     /gene="ICAM1"
                     /gene_synonym="BB2; CD54; P3.58"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1220
                     /gene="ICAM1"
                     /gene_synonym="BB2; CD54; P3.58"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1466
                     /gene="ICAM1"
                     /gene_synonym="BB2; CD54; P3.58"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..2967
                     /gene="ICAM1"
                     /gene_synonym="BB2; CD54; P3.58"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2167
                     /gene="ICAM1"
                     /gene_synonym="BB2; CD54; P3.58"
     regulatory      2947..2952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ICAM1"
                     /gene_synonym="BB2; CD54; P3.58"
                     /note="hexamer: AATAAA"
     polyA_site      2967
                     /gene="ICAM1"
                     /gene_synonym="BB2; CD54; P3.58"
                     /note="major polyA site"
ORIGIN      
        1 gagctcctct gctactcaga gttgcaacct cagcctcgct atggctccca gcagcccccg
       61 gcccgcgctg cccgcactcc tggtcctgct cggggctctg ttcccaggac ctggcaatgc
      121 ccagacatct gtgtccccct caaaagtcat cctgccccgg ggaggctccg tgctggtgac
      181 atgcagcacc tcctgtgacc agcccaagtt gttgggcata gagaccccgt tgcctaaaaa
      241 ggagttgctc ctgcctggga acaaccggaa ggtgtatgaa ctgagcaatg tgcaagaaga
      301 tagccaacca atgtgctatt caaactgccc tgatgggcag tcaacagcta aaaccttcct
      361 caccgtgtac tggactccag aacgggtgga actggcaccc ctcccctctt ggcagccagt
      421 gggcaagaac cttaccctac gctgccaggt ggagggtggg gcaccccggg ccaacctcac
      481 cgtggtgctg ctccgtgggg agaaggagct gaaacgggag ccagctgtgg gggagcccgc
      541 tgaggtcacg accacggtgc tggtgaggag agatcaccat ggagccaatt tctcgtgccg
      601 cactgaactg gacctgcggc cccaagggct ggagctgttt gagaacacct cggcccccta
      661 ccagctccag acctttgtcc tgccagcgac tcccccacaa cttgtcagcc cccgggtcct
      721 agaggtggac acgcagggga ccgtggtctg ttccctggac gggctgttcc cagtctcgga
      781 ggcccaggtc cacctggcac tgggggacca gaggttgaac cccacagtca cctatggcaa
      841 cgactccttc tcggccaagg cctcagtcag tgtgaccgca gaggacgagg gcacccagcg
      901 gctgacgtgt gcagtaatac tggggaacca gagccaggag acactgcaga cagtgaccat
      961 ctacagcttt ccggcgccca acgtgattct gacgaagcca gaggtctcag aagggaccga
     1021 ggtgacagtg aagtgtgagg cccaccctag agccaaggtg acgctgaatg gggttccagc
     1081 ccagccactg ggcccgaggg cccagctcct gctgaaggcc accccagagg acaacgggcg
     1141 cagcttctcc tgctctgcaa ccctggaggt ggccggccag cttatacaca agaaccagac
     1201 ccgggagctt cgtgtcctgt atggcccccg actggacgag agggattgtc cgggaaactg
     1261 gacgtggcca gaaaattccc agcagactcc aatgtgccag gcttggggga acccattgcc
     1321 cgagctcaag tgtctaaagg atggcacttt cccactgccc atcggggaat cagtgactgt
     1381 cactcgagat cttgagggca cctacctctg tcgggccagg agcactcaag gggaggtcac
     1441 ccgcaaggtg accgtgaatg tgctctcccc ccggtatgag attgtcatca tcactgtggt
     1501 agcagccgca gtcataatgg gcactgcagg cctcagcacg tacctctata accgccagcg
     1561 gaagatcaag aaatacagac tacaacaggc ccaaaaaggg acccccatga aaccgaacac
     1621 acaagccacg cctccctgaa cctatcccgg gacagggcct cttcctcggc cttcccatat
     1681 tggtggcagt ggtgccacac tgaacagagt ggaagacata tgccatgcag ctacacctac
     1741 cggccctggg acgccggagg acagggcatt gtcctcagtc agatacaaca gcatttgggg
     1801 ccatggtacc tgcacaccta aaacactagg ccacgcatct gatctgtagt cacatgacta
     1861 agccaagagg aaggagcaag actcaagaca tgattgatgg atgttaaagt ctagcctgat
     1921 gagaggggaa gtggtggggg agacatagcc ccaccatgag gacatacaac tgggaaatac
     1981 tgaaacttgc tgcctattgg gtatgctgag gccccacaga cttacagaag aagtggccct
     2041 ccatagacat gtgtagcatc aaaacacaaa ggcccacact tcctgacgga tgccagcttg
     2101 ggcactgctg tctactgacc ccaacccttg atgatatgta tttattcatt tgttatttta
     2161 ccagctattt attgagtgtc ttttatgtag gctaaatgaa cataggtctc tggcctcacg
     2221 gagctcccag tcctaatcac attcaaggtc accaggtaca gttgtacagg ttgtacactg
     2281 caggagagtg cctggcaaaa agatcaaatg gggctgggac ttctcattgg ccaacctgcc
     2341 tttccccaga aggagtgatt tttctatcgg cacaaaagca ctatatggac tggtaatggt
     2401 tacaggttca gagattaccc agtgaggcct tattcctccc ttccccccaa aactgacacc
     2461 tttgttagcc acctccccac ccacatacat ttctgccagt gttcacaatg acactcagcg
     2521 gtcatgtctg gacatgagtg cccagggaat atgcccaagc tatgccttgt cctcttgtcc
     2581 tgtttgcatt tcactgggag cttgcactat gcagctccag tttcctgcag tgatcagggt
     2641 cctgcaagca gtggggaagg gggccaaggt attggaggac tccctcccag ctttggaagc
     2701 ctcatccgcg tgtgtgtgtg tgtgtatgtg tagacaagct ctcgctctgt cacccaggct
     2761 ggagtgcagt ggtgcaatca tggttcactg cagtcttgac cttttgggct caagtgatcc
     2821 tcccacctca gcctcctgag tagctgggac cataggctca caacaccaca cctggcaaat
     2881 ttgatttttt ttttttttcc agagacgggg tctcgcaaca ttgcccagac ttcctttgtg
     2941 ttagttaata aagctttctc aactgcc
//
