LOCUS       NM_001288622            7961 bp    mRNA    linear   PRI 30-JAN-2025
DEFINITION  Homo sapiens islet cell autoantigen 1 like (ICA1L), transcript
            variant 3, mRNA.
ACCESSION   NM_001288622 XM_005246290
VERSION     NM_001288622.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7961)
  AUTHORS   Cullell,N., Gallego-Fabrega,C., Carcel-Marquez,J., Muino,E.,
            Llucia-Carol,L., Lledos,M., Martin-Campos,J.M., Molina,J.,
            Casas,L., Almeria,M., Fernandez-Cadenas,I. and Krupinski,J.
  TITLE     ICA1L Is Associated with Small Vessel Disease: A Proteome-Wide
            Association Study in Small Vessel Stroke and Intracerebral
            Haemorrhage
  JOURNAL   Int J Mol Sci 23 (6), 3161 (2022)
   PUBMED   35328582
  REMARK    GeneRIF: ICA1L Is Associated with Small Vessel Disease: A
            Proteome-Wide Association Study in Small Vessel Stroke and
            Intracerebral Haemorrhage.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7961)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 7961)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 7961)
  AUTHORS   He,J., Xia,M., Tsang,W.H., Chow,K.L. and Xia,J.
  TITLE     ICA1L forms BAR-domain complexes with PICK1 and is crucial for
            acrosome formation in spermiogenesis
  JOURNAL   J Cell Sci 128 (20), 3822-3836 (2015)
   PUBMED   26306493
REFERENCE   5  (bases 1 to 7961)
  AUTHORS   Hadano,S., Hand,C.K., Osuga,H., Yanagisawa,Y., Otomo,A.,
            Devon,R.S., Miyamoto,N., Showguchi-Miyata,J., Okada,Y.,
            Singaraja,R., Figlewicz,D.A., Kwiatkowski,T., Hosler,B.A.,
            Sagie,T., Skaug,J., Nasir,J., Brown,R.H. Jr., Scherer,S.W.,
            Rouleau,G.A., Hayden,M.R. and Ikeda,J.E.
  TITLE     A gene encoding a putative GTPase regulator is mutated in familial
            amyotrophic lateral sclerosis 2
  JOURNAL   Nat Genet 29 (2), 166-173 (2001)
   PUBMED   11586298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK092310.1, AL833904.1, BC063876.1, AK124756.1 and AC098831.2.
            
            On Aug 13, 2020 this sequence version replaced NM_001288622.2.
            
            Transcript Variant: This variant (3) lacks a 5' non-coding exon,
            therefore, has a shorter 5' UTR compared to variant 1. Variants 1,
            3 and 4 encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK092310.1, SRR11853566.16411.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358299.7/ ENSP00000351047.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2528              AK092310.1         220-2747
            2529-3260           AL833904.1         2532-3263
            3261-4092           AL833904.1         3266-4097
            4093-5165           BC063876.1         2856-3928
            5166-6020           AK124756.1         387-1241
            6021-6021           AC098831.2         40254-40254         c
            6022-7129           AK124756.1         1243-2350
            7130-7604           AK124756.1         2352-2826
            7605-7961           AK124756.1         2828-3184
FEATURES             Location/Qualifiers
     source          1..7961
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.2"
     gene            1..7961
                     /gene="ICA1L"
                     /gene_synonym="ALS2CR14; ALS2CR15"
                     /note="islet cell autoantigen 1 like"
                     /db_xref="GeneID:130026"
                     /db_xref="HGNC:HGNC:14442"
                     /db_xref="MIM:621083"
     exon            1..148
                     /gene="ICA1L"
                     /gene_synonym="ALS2CR14; ALS2CR15"
                     /inference="alignment:Splign:2.1.0"
     exon            149..317
                     /gene="ICA1L"
                     /gene_synonym="ALS2CR14; ALS2CR15"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1604
                     /gene="ICA1L"
                     /gene_synonym="ALS2CR14; ALS2CR15"
                     /note="isoform 1 is encoded by transcript variant 3; islet
                     cell autoantigen 1-like protein; amyotrophic lateral
                     sclerosis 2 (juvenile) chromosome region, candidate 15;
                     amyotrophic lateral sclerosis 2 (juvenile) chromosome
                     region, candidate 14; Ica69-related protein; amyotrophic
                     lateral sclerosis 2 chromosomal region candidate gene 14
                     protein; amyotrophic lateral sclerosis 2 chromosomal
                     region candidate gene 15 protein; islet cell autoantigen
                     1,69kDa-like"
                     /codon_start=1
                     /product="islet cell autoantigen 1-like protein isoform 1"
                     /protein_id="NP_001275551.1"
                     /db_xref="CCDS:CCDS2354.1"
                     /db_xref="GeneID:130026"
                     /db_xref="HGNC:HGNC:14442"
                     /db_xref="MIM:621083"
                     /translation="MDSFGQPRPEDNQSVVRRMQKKYWKTKQVFIKATGKKEDEHLVA
                     SDAELDAKLEVFHSVQETCTELLKIIEKYQLRLNVISEEENELGLFLKFQAERDATQA
                     GKMMDATGKALCSSAKQRLALCTPLSRLKQEVATFSQRAVSDTLMTINRMEQARTEYR
                     GALLWMKDVSQELDPDTLKQMEKFRKVQMQVRNSKASFDKLKMDVCQKVDLLGASRCN
                     MLSHSLTTYQRTLLGFWKKTARMMSQIHEACIGFHPYDFVALKQLQDTPSKISEDNKD
                     EQIGGFLTEQLNKLVLSDEEASFESEQANKDHNEKHSQMREFGAPQFSNSENVAKDLP
                     VDSLEGEDFEKEFSFLNNLLSSGSSSTSEFTQECQTAFGSPSASLTSQEPSMGSEPLA
                     HSSRFLPSQLFDLGFHVAGAFNNWVSQEESELCLSHTDNQPVPSQSPKKLTRSPNNGN
                     QDMSAWFNLFADLDPLSNPDAIGHSDDELLNA"
     exon            318..390
                     /gene="ICA1L"
                     /gene_synonym="ALS2CR14; ALS2CR15"
                     /inference="alignment:Splign:2.1.0"
     exon            391..514
                     /gene="ICA1L"
                     /gene_synonym="ALS2CR14; ALS2CR15"
                     /inference="alignment:Splign:2.1.0"
     exon            515..713
                     /gene="ICA1L"
                     /gene_synonym="ALS2CR14; ALS2CR15"
                     /inference="alignment:Splign:2.1.0"
     exon            714..839
                     /gene="ICA1L"
                     /gene_synonym="ALS2CR14; ALS2CR15"
                     /inference="alignment:Splign:2.1.0"
     exon            840..938
                     /gene="ICA1L"
                     /gene_synonym="ALS2CR14; ALS2CR15"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1021
                     /gene="ICA1L"
                     /gene_synonym="ALS2CR14; ALS2CR15"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1065
                     /gene="ICA1L"
                     /gene_synonym="ALS2CR14; ALS2CR15"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1140
                     /gene="ICA1L"
                     /gene_synonym="ALS2CR14; ALS2CR15"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1398
                     /gene="ICA1L"
                     /gene_synonym="ALS2CR14; ALS2CR15"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1488
                     /gene="ICA1L"
                     /gene_synonym="ALS2CR14; ALS2CR15"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..7961
                     /gene="ICA1L"
                     /gene_synonym="ALS2CR14; ALS2CR15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5140..5145
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ICA1L"
                     /gene_synonym="ALS2CR14; ALS2CR15"
                     /note="hexamer: AATAAA"
     polyA_site      5170
                     /gene="ICA1L"
                     /gene_synonym="ALS2CR14; ALS2CR15"
                     /note="major polyA site"
     regulatory      6207..6212
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ICA1L"
                     /gene_synonym="ALS2CR14; ALS2CR15"
                     /note="hexamer: AATACA"
     polyA_site      6225
                     /gene="ICA1L"
                     /gene_synonym="ALS2CR14; ALS2CR15"
     regulatory      7935..7940
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ICA1L"
                     /gene_synonym="ALS2CR14; ALS2CR15"
                     /note="hexamer: ATTAAA"
     polyA_site      7961
                     /gene="ICA1L"
                     /gene_synonym="ALS2CR14; ALS2CR15"
ORIGIN      
        1 ctgacacctc cacgcactgg tgcggagggg cactggctgc cggagggccg ggagtcggcg
       61 cggggctcgc gggcggtggc cggaacgggt gccgggacgg atcaccgtac ggccgaacgc
      121 gacccgagga ggcggaagag cggcgccgtc actccatgga ttcctttggg caacccagac
      181 cagaagataa tcagtcagta gtcagaagaa tgcaaaagaa atactggaaa actaaacagg
      241 tctttatcaa agcaacagga aaaaaagagg atgagcactt ggtggcgtct gatgctgaac
      301 tggatgctaa acttgaggtt tttcactctg ttcaagagac atgcactgaa cttctgaaga
      361 taatcgagaa ataccagcta agactcaatg ttatatcaga ggaagaaaat gagctagggc
      421 tctttttaaa atttcaagca gaacgggatg caactcaagc tggcaaaatg atggatgcca
      481 ctggcaaggc actttgttct tcagccaagc aaagattggc cctgtgtact cctctgtctc
      541 gtctgaagca agaagtagca acattcagtc aaagggcagt atctgatacc ttgatgacaa
      601 ttaatcggat ggagcaggca cgcacagaat acagaggagc tctactgtgg atgaaagatg
      661 tatcccaaga gctggaccca gacaccttaa agcaaatgga aaagtttaga aaagtacaga
      721 tgcaagtgag aaatagcaaa gcttcttttg acaagttaaa gatggatgtt tgtcagaaag
      781 tggatttact tggagctagt cgctgcaata tgctatctca ttcgctcact acctaccaga
      841 gaacactgct tggattctgg aagaaaacag ctcgaatgat gtcccaaatt catgaagcct
      901 gtattggctt tcatccgtat gattttgtag ctctcaagca actacaagac acgccaagca
      961 agattagtga agacaataaa gatgaacaaa taggcggttt tcttactgaa cagctcaata
     1021 agctagtttt gtctgatgag gaagcaagct ttgagagtga acaagcaaac aaagatcaca
     1081 atgaaaaaca ttctcaaatg agagaatttg gagcacctca gttttctaac tctgaaaatg
     1141 ttgcaaaaga tctacctgta gattcattgg aaggagaaga ttttgagaag gaattctcat
     1201 ttctgaacaa cctcctaagt tctggttctt caagtactag tgaatttacc caagaatgcc
     1261 agactgcctt tgggagcccc agtgccagtc tcacatccca ggagccttcc atggggtctg
     1321 agcccctcgc tcattcttct cgattccttc cttcacaact ctttgacctt ggctttcatg
     1381 tggctggagc gttcaacaac tgggtctccc aagaggaatc agaactttgt ctttcacaca
     1441 ctgataacca gccagtgcct tcacagagtc caaagaaatt aacaagatcc cccaacaatg
     1501 gcaaccaaga catgtcagcc tggttcaatc tgtttgcaga cttggatcca ctttcaaacc
     1561 cagatgctat tggacactca gatgatgaac ttcttaatgc ttgactgaag ttataatgtc
     1621 acttcagtgg ccttgagaca tcaattttgc aacgtatttc cttcgtggaa aggatttaga
     1681 ttgtaacccg cacacaaaag cacggtgttt gtgaatataa cacctgtcag ccaactttag
     1741 acagatggta aagaccacat ttgaataagt acacatcttt catatcttgg atttgcagct
     1801 gttggtacta tgtggaaaat attagaaact tctatgtgga aaatattaga aactacagag
     1861 tttgcgatat ttagatactg aaatttatgt caaaataacg gctaggaata attctgtcaa
     1921 tatggagttg agcttatttc tttggaaacc cttttaagtt gccttgctgg ctgtgagaat
     1981 tttatatgtg gataacaaag atagatagat agcatgtaaa ttgggttgtg gtttggggtc
     2041 agtttttaaa tgaaatagta gcgaggagga ttttctgttt tggaaaacac cattagaacc
     2101 agaccagctt tgttttgggt tagagagagt aagatttgag aactcagttt gctttaatga
     2161 aatcacagag aaacttggta cttgtttttc ttcatttgga ggctaaaatg taatgttttt
     2221 tcattcatac aaaataatgg acactcccta attccattat taaatcttga aggggaagta
     2281 gcaggataat taatttgcta agcccatcct ctgcagaaac agaaaaatct atcttcccat
     2341 ctcctaaaac tcagaatgca cagtaatact taaggcttgt acaagtgtct tcagacccac
     2401 tttttcatac acttgctata tagtagtatg cagtatttat attattcctg aaaataaaat
     2461 gaggggagaa tattccctaa gcaactggca atagtattcc tgaaatacct agaaatttct
     2521 atctgaatga gggagacact tatgaacacc ttatccttac atatatttgc atacttatct
     2581 catattttgt gacataatta tttaacccag aatactttct ggcagacata cagaaagctc
     2641 tgtgtgatca ataagggagt gtctcatttt tctacttccc tctttctgtg ggtgacatga
     2701 tctgaggttc tatttgatta ctaagcaaaa tctgttaccc ctacagggtt tagaacctaa
     2761 gtattagaga ggaaggctat ttaatggaag ttagtgtaag ctgataaaaa cgtagctacc
     2821 gtacacacac atcaatcact caatttcctg tccttttaaa ttgcccaccc tttaattttg
     2881 aagcaatttc ccaagtgtgt gtttgtttta tatttgtcat ccagtccatt gcatttccat
     2941 aagaagacat tttgactggc tgggtgcggt ggctcacgct tgtaatccca gcactttggg
     3001 aggctgaggc aggcggatca cgaggtcagg agatggagac catcctggct aacatggtga
     3061 aaccccgtct ctactaaaaa tacaaaaaat tagccaggcg tggtggcacg tgcctgtagt
     3121 cccagctact ccggaggctg aggcaggaga atggcgtgaa cccgggaggc ggagcttgca
     3181 gtgagctgag atggcgccac tgcactccag cctaggcaac agagcaagac tccgtctcaa
     3241 aaaaaaaaaa aaaaaaaaaa gacattttaa ctaagttatt cacagtagct tccatgtgct
     3301 cttagttcta ttctaaacag gcttatttag aaaaggattg cttgtaatgt ttgtcatggt
     3361 acatagaaaa cattggacca gagtaggtaa aatgcagtcc atgtcccatc catagccatc
     3421 tacaatagta actgcccaca ggctctccag aaaactacta caatggccaa gtacagtata
     3481 ggctggaaag accttatctg aaggtcagaa acattgactc agaaaaaagg tatgaagtct
     3541 ttccataaaa tcttttcaca atattactcc tatttctttt agattttaat gagccattac
     3601 ttatctcttc agaagactta agtcttcctt tatactcagt gaaatttccc agaatgtaat
     3661 actgtcactg ttctgccaag ttccaatcac caagatcatg attacgaatc ccaatctgaa
     3721 ttctataccc atggtgactc tgatgctctc aacttttgag tgcctcaaaa aatgctaaaa
     3781 ctttggctgg gcatggtggc tcacgcctgt aatcccagca ctttgggagg ccatggcggg
     3841 tggaacattt gagggcatga gttcgagacc agcctggcca acatggtgaa accctgtctc
     3901 tactaaaaat acaaaaatta gccaggtgtg gaggtacatg cctgtaatcc cagctactca
     3961 ggaggctgag gcagaagaat tgcttgaacc caggcggcag aggttgcagt gagtcgagat
     4021 tgcaccacta cactccagcc tgggcaacag agagcgactc tctcaaaaaa aaaaaaaaaa
     4081 aaaaaaaaaa aagctaactt tatgtcttga gagtttgtac catttttctt tgtagtggtc
     4141 accttgctaa tgcattagtt ctgagatatt tatctccctc acatgtgtgc aaggaagtcc
     4201 ctgttatcga atacagatac tttaacaagc agacaaagca gaaacccaaa gtccatacta
     4261 ggaacaccct aaattttcca aaagcaaaag ttctcccgaa atggagacat acaagggact
     4321 tttattattc tgttactagt ttctataaca tttcttcttt caacagagta tatgtttccc
     4381 atttaaccca gagcaacatt aacttcctta gcaagtccag ttctaacttc caacaagtcc
     4441 aaccactgtt tttgaagagc atatcagtaa ctatattaag atgaaggtaa ccacattcgt
     4501 attttctcaa gattagttat ttgaagctca gcagtttttg tggtcagaaa gaaattttgc
     4561 tctattaaac caatactgct aatataaaaa accaccacac tgaagaaacg agggaaagga
     4621 cgggataagc acagaacaga gaatgactgg ttgctttttg tctcaatcta gataatccat
     4681 tcaataagaa gtaaattaat tatccttaac caatggtagg ctgagaacaa ccctcaaaat
     4741 agatattttt tatgttaaat ggggagaaat atctatactt tatgttatac tggataaaaa
     4801 tgtgttttaa gtctaaaaaa aaccagacga gctaaacttt gcctagtgtg tctacaacca
     4861 ttttttagga gacgcaggaa taccagggca taataagatc agattggtgt aattttgtat
     4921 gtttttgaaa tccttcatta attgtagaac cttgatatga ttagaaacaa actgtatttc
     4981 aacaaacagg tttcagtatt tgcacactga aaaagtgttt tgtattttaa ctataaatat
     5041 ttcacgtatc tgtatagacc atctagaaat gtagaggtct tacagcatta gaacgaagga
     5101 agtttacatg tgctctatct atttttctga gcctctttta ataaagattg caagaaggca
     5161 taaaacaaga gtttgtttcc tgaagttttt agtacaatta ttgttttcct attcaaaaac
     5221 ttgggtttta cctcaagatc atagtattag gaaagtacat tgagttgata cggacatggg
     5281 agaacgaaaa taaaaccagg gcaattaata tccttgtaag gccaggcgcg gtagctcacg
     5341 cctatataac agcactttgg gaggccaagg caggcagatc acttgaagtt gggagtttga
     5401 gaccaccctg gccaacatgg tgaaacccca tctctatgaa aaatataaaa attagctggg
     5461 catggtggca gatgcctgta atcccagcta cttgggaggc tgaggcagga gaatcgcttg
     5521 aacccgggag gtggaggttg cagtgagctg agatcaggcc atgcactcca gcctgggtga
     5581 cagagtgaga ctccgtctca aaagaaaatc cttgtgagat gaattcgttc ttatttcata
     5641 tacaagggga ctatgtaaga tatgggaaat aatataatgt acgttattta tgtaaatact
     5701 ttcagtaaca aaaactaaca aatatcaaaa atctgagcct agacacaaac aattaaatat
     5761 aagccatagt atgtaacctg acttattgaa ggcaggaata aaaagaagag agccagaatt
     5821 gattcagtta tttttgtctt ccatagtgtt ggcagggccc tgcatttctc taccttgagc
     5881 aatgaagcag tcccagaatt ttggaatata gaaattagga aggaaaaacg aactttaaaa
     5941 tattaattta gtagaactga aagtaatgca tttcatgcaa cagtaaagtg cttaaacatg
     6001 gcaaagaaaa ctaagggaca agataagaaa aatggttggt aaagatgggt cacatccaga
     6061 agcccaacat aagctatttt tccatctttt tctgtaccat ttaaaagact actaaagagt
     6121 tcaaaacaaa ctgtccttgg catttaaagt caaaacatgg ttcttcactc agtggtgtaa
     6181 attaactact cattggccaa agagtaaata caaaaaggag atgaagttct gactggtgtt
     6241 gtgggtgaga ttttgcagtg tatgttttta catttgtagt gtacgtttta aacttccggt
     6301 tttcttgctg cctcaacatc tccacaaaca ggctgtgagc acctggccca gtgtgatatg
     6361 ggtggcccct gccacaagtt tcccttgcta ccttgcccat gacctagtaa catttaaatg
     6421 caccagtgaa attctctttt tcttgtgtgc ttctccctga cccaaaggct cctgcccatg
     6481 tcttaggcct ctccgctccc cacctgcttg gctgagcccc ctcccatgtg accccctctc
     6541 agcatgcagt gactggtctc tctaggacct gtgagtatat tacaactttt tttcctgtgt
     6601 ctctcctgtg atatctcttg tggctaaacc tcactgacca taacctaaaa aaacacatac
     6661 aaaaaacatg aaagaaaaag ttgtttcttg agctggcctg gacgaacggg gagccagggg
     6721 ctcgaccctg gctgttggag gcgcagtgag gcctggtctc cggctgccag accacgctga
     6781 gcggagcgcg cggcaggctc gcctcagcgc tgcggggaac gcgcgcgccg ccgtccgcgg
     6841 tcgcccgtag gtgcctgcac gcgtcggggt cacggccttt ggccgacagg agcgagaaga
     6901 ctcaggagcc gccccgcgcc ttcgatccgg cgctgctgga gttcctggtg tgcccgctct
     6961 ccaagaagcc gctcagatat gaagcatcaa caaatgaatt gattaatgaa gagttgagaa
     7021 tagcttatcc aatcattgat gggattccta atattatcat attaggcagc taggatgaca
     7081 catcaaagaa gcaagaagtg gagcagcgct agttcataat ttaaaaaaat aaaacagcca
     7141 actcttctta gtaccatata ccttttaaaa cacagtggca agtaataagc ggaagagaag
     7201 aatctttctg tctctttcta cgttgactgt tcttattcca ctggtttatt tagcaggact
     7261 gttccactca gcctctgtag aagaaaactt cccacagggc tgcacttgca cagctagcct
     7321 ttgcttttac agcctgctct tgcctattac cataccggtg tatgtattct tccacctttg
     7381 gacctggatg gttattaaac tcttcatgca taactgatgc aactagagtc aatatgctgt
     7441 atatattaat gatagctctt gggcatctat ctctgaaagc tcaaatggat ggaatttagt
     7501 ttgtgggaaa gaggctttgc tttgagcata tcaggcttag gactgtggac ggcttaagtt
     7561 gcagacgctt cttttattgt actcttgttc tgcccgtgtt ttttgaaggc tctgacataa
     7621 ctgctttatc agaagaaaca ttttgacagt gtcttgttgg agataaacat ccctaattga
     7681 catgtgatga ctacttctta ttccattcat ctaagagtca ttgaaatttt gttttctttg
     7741 tttgtttagc ttcaaggtct ttggtagtca catgttaggg atgactgaaa taattccaaa
     7801 ggagtgatgt tggaatagtc cctctaaggg aaagaaatgc atttgaacga atgtgatata
     7861 aaaccacata atcaaataga aatttcatgt acttacaaaa atttagtttg taaaattacc
     7921 ttcatttctt tgacattaaa tgcttatatt agcaataaag a
//
