LOCUS       NM_004967               1573 bp    mRNA    linear   PRI 14-APR-2024
DEFINITION  Homo sapiens integrin binding sialoprotein (IBSP), mRNA.
ACCESSION   NM_004967
VERSION     NM_004967.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1573)
  AUTHORS   Ma,Y., Chen,B., Zhang,B., Zhang,C., Zhu,Q., Wang,X., Liu,Z. and
            Liu,H.
  TITLE     High expression of integrin-binding sialoprotein (IBSP) is
            associated with poor prognosis of osteosarcoma
  JOURNAL   Aging (Albany NY) 16 (1), 28-42 (2023)
   PUBMED   38006395
  REMARK    GeneRIF: High expression of integrin-binding sialoprotein (IBSP) is
            associated with poor prognosis of osteosarcoma.
REFERENCE   2  (bases 1 to 1573)
  AUTHORS   Fonseca,J.M., Martins,M.D., Vargas,P.A., Silva,W.G.,
            Normando,A.G.C., Palmier,N.R., Ribeiro,A.C.P., Brandao,T.B.,
            Lopes,M.A., Goes,M.F. and Santos-Silva,A.R.
  TITLE     Preservation of immunoexpression of type I collagen, BSP and BMP4
            in the dentin-pulp complex of head and neck cancer patients after
            radiotherapy
  JOURNAL   Braz Oral Res 36, e012 (2022)
   PUBMED   35081229
  REMARK    GeneRIF: Preservation of immunoexpression of type I collagen, BSP
            and BMP4 in the dentin-pulp complex of head and neck cancer
            patients after radiotherapy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1573)
  AUTHORS   Chen,Y., Qin,Y., Dai,M., Liu,L., Ni,Y., Sun,Q., Li,L., Zhou,Y.,
            Qiu,C. and Jiang,Y.
  TITLE     IBSP, a potential recurrence biomarker, promotes the progression of
            colorectal cancer via Fyn/beta-catenin signaling pathway
  JOURNAL   Cancer Med 10 (12), 4030-4045 (2021)
   PUBMED   33987980
  REMARK    GeneRIF: IBSP, a potential recurrence biomarker, promotes the
            progression of colorectal cancer via Fyn/beta-catenin signaling
            pathway.
REFERENCE   4  (bases 1 to 1573)
  AUTHORS   Benz,F., Bogen,A., Praktiknjo,M., Jansen,C., Meyer,C., Wree,A.,
            Demir,M., Loosen,S., Vucur,M., Schierwagen,R., Tacke,F.,
            Trebicka,J. and Roderburg,C.
  TITLE     Serum levels of bone sialoprotein correlate with portal pressure in
            patients with liver cirrhosis
  JOURNAL   PLoS One 15 (4), e0231701 (2020)
   PUBMED   32302330
  REMARK    GeneRIF: Study analyzed circulating bone sialoprotein (BSP) in a
            large cohort of patients with liver cirrhosis. Serum levels of BSP
            were similar in patients with different disease stages and were not
            indicative for prognosis. BSP serum levels did correlate inversely
            with portal pressure. BSP might represent a previously unrecognized
            marker for portal hypertension in patients with liver cirrhosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1573)
  AUTHORS   Maaroufi,A., Khadem-Ansari,M.H., Khalkhali,H.R. and Rasmi,Y.
  TITLE     Serum levels of bone sialoprotein, osteopontin, and
            beta2-microglobulin in stage I of multiple myeloma
  JOURNAL   J Cancer Res Ther 16 (1), 98-101 (2020)
   PUBMED   32362616
  REMARK    GeneRIF: Serum levels of bone sialoprotein, osteopontin, and
            beta2-microglobulin in stage I of multiple myeloma.
REFERENCE   6  (bases 1 to 1573)
  AUTHORS   Kim,R.H., Shapiro,H.S., Li,J.J., Wrana,J.L. and Sodek,J.
  TITLE     Characterization of the human bone sialoprotein (BSP) gene and its
            promoter sequence
  JOURNAL   Matrix Biol 14 (1), 31-40 (1994)
   PUBMED   8061918
REFERENCE   7  (bases 1 to 1573)
  AUTHORS   Goold,R.D., diSibio,G.L., Xu,H., Lang,D.B., Dadgar,J.,
            Magrane,G.G., Dugaiczyk,A., Smith,K.A., Cox,D.R., Masters,S.B. et
            al.
  TITLE     The development of sequence-tagged sites for human chromosome 4
  JOURNAL   Hum Mol Genet 2 (8), 1271-1288 (1993)
   PUBMED   8401509
REFERENCE   8  (bases 1 to 1573)
  AUTHORS   Fisher,L.W., McBride,O.W., Termine,J.D. and Young,M.F.
  TITLE     Human bone sialoprotein. Deduced protein sequence and chromosomal
            localization
  JOURNAL   J Biol Chem 265 (4), 2347-2351 (1990)
   PUBMED   2404984
REFERENCE   9  (bases 1 to 1573)
  AUTHORS   Oldberg,A., Franzen,A., Heinegard,D., Pierschbacher,M. and
            Ruoslahti,E.
  TITLE     Identification of a bone sialoprotein receptor in osteosarcoma
            cells
  JOURNAL   J Biol Chem 263 (36), 19433-19436 (1988)
   PUBMED   2461939
REFERENCE   10 (bases 1 to 1573)
  AUTHORS   Fisher,L.W., Hawkins,G.R., Tuross,N. and Termine,J.D.
  TITLE     Purification and partial characterization of small proteoglycans I
            and II, bone sialoproteins I and II, and osteonectin from the
            mineral compartment of developing human bone
  JOURNAL   J Biol Chem 262 (20), 9702-9708 (1987)
   PUBMED   3597437
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093768.3, AI751848.1,
            J05213.1, DV462680.1, BQ573754.1 and AA452255.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004967.3.
            
            Summary: The protein encoded by this gene is a major structural
            protein of the bone matrix. It constitutes approximately 12% of the
            noncollagenous proteins in human bone and is synthesized by
            skeletal-associated cell types, including hypertrophic
            chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only
            extraskeletal site of its synthesis is the trophoblast. This
            protein binds to calcium and hydroxyapatite via its acidic amino
            acid clusters, and mediates cell attachment through an RGD sequence
            that recognizes the vitronectin receptor. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.193979.1,
                                           SRR1660807.136311.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2153307
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000226284.7/ ENSP00000226284.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AC093768.3         30253-30274
            23-379              AI751848.1         9-365
            380-516             J05213.1           357-493
            517-517             AC093768.3         42078-42078
            518-731             J05213.1           495-708
            732-732             AC093768.3         42293-42293
            733-748             J05213.1           710-725
            749-881             DV462680.1         6-138
            882-1461            BQ573754.1         18-597              c
            1462-1573           AA452255.1         19-130              c
FEATURES             Location/Qualifiers
     source          1..1573
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q22.1"
     gene            1..1573
                     /gene="IBSP"
                     /gene_synonym="BNSP; BSP; BSP-II; SP-II"
                     /note="integrin binding sialoprotein"
                     /db_xref="GeneID:3381"
                     /db_xref="HGNC:HGNC:5341"
                     /db_xref="MIM:147563"
     exon            1..80
                     /gene="IBSP"
                     /gene_synonym="BNSP; BSP; BSP-II; SP-II"
                     /inference="alignment:Splign:2.1.0"
     exon            81..148
                     /gene="IBSP"
                     /gene_synonym="BNSP; BSP; BSP-II; SP-II"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1048
                     /gene="IBSP"
                     /gene_synonym="BNSP; BSP; BSP-II; SP-II"
                     /note="bone sialoprotein II; bone sialoprotein 2; BSP II;
                     cell-binding sialoprotein"
                     /codon_start=1
                     /product="integrin-binding sialoprotein precursor"
                     /protein_id="NP_004958.2"
                     /db_xref="CCDS:CCDS3624.1"
                     /db_xref="GeneID:3381"
                     /db_xref="HGNC:HGNC:5341"
                     /db_xref="MIM:147563"
                     /translation="MKTALILLSILGMACAFSMKNLHRRVKIEDSEENGVFKYRPRYY
                     LYKHAYFYPHLKRFPVQGSSDSSEENGDDSSEEEEEEEETSNEGENNEESNEDEDSEA
                     ENTTLSATTLGYGEDATPGTGYTGLAAIQLPKKAGDITNKATKEKESDEEEEEEEEGN
                     ENEESEAEVDENEQGINGTSTNSTEAENGNGSSGGDNGEEGEEESVTGANAEDTTETG
                     RQGKGTSKTTTSPNGGFEPTTPPQVYRTTSPPFGKTTTVEYEGEYEYTGANEYDNGYE
                     IYESENGEPRGDNYRAYEDEYSYFKGQGYDGYDGQNYYHHQ"
     exon            149..199
                     /gene="IBSP"
                     /gene_synonym="BNSP; BSP; BSP-II; SP-II"
                     /inference="alignment:Splign:2.1.0"
     exon            200..277
                     /gene="IBSP"
                     /gene_synonym="BNSP; BSP; BSP-II; SP-II"
                     /inference="alignment:Splign:2.1.0"
     exon            278..340
                     /gene="IBSP"
                     /gene_synonym="BNSP; BSP; BSP-II; SP-II"
                     /inference="alignment:Splign:2.1.0"
     exon            341..499
                     /gene="IBSP"
                     /gene_synonym="BNSP; BSP; BSP-II; SP-II"
                     /inference="alignment:Splign:2.1.0"
     exon            500..1573
                     /gene="IBSP"
                     /gene_synonym="BNSP; BSP; BSP-II; SP-II"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1552..1557
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IBSP"
                     /gene_synonym="BNSP; BSP; BSP-II; SP-II"
                     /note="hexamer: AATAAA"
     polyA_site      1573
                     /gene="IBSP"
                     /gene_synonym="BNSP; BSP; BSP-II; SP-II"
                     /note="major polyA site"
ORIGIN      
        1 gagtgagagg gcagaggaaa tactcaatct gtgccactca ctgccttgag cctgcttcct
       61 cactccagga ctgccagagg aagcaatcac caaaatgaag actgctttaa ttttgctcag
      121 cattttggga atggcctgtg ctttctcaat gaaaaatttg catcgaagag tcaaaataga
      181 ggattctgaa gaaaatgggg tctttaagta caggccacga tattatcttt acaagcatgc
      241 ctacttttat cctcatttaa aacgatttcc agttcagggc agtagtgact catccgaaga
      301 aaatggagat gacagttcag aagaggagga ggaagaagag gagacttcaa atgaaggaga
      361 aaacaatgaa gaatcgaatg aagatgaaga ctctgaggct gagaatacca cactttctgc
      421 tacaacactg ggctatggag aggacgccac gcctggcaca gggtatacag ggttagctgc
      481 aatccagctt cccaagaagg ctggggatat aacaaataaa gctacaaaag agaaggaaag
      541 tgatgaagaa gaagaggagg aagaggaagg aaatgaaaac gaagaaagcg aagcagaagt
      601 ggatgaaaac gaacaaggca taaacggcac cagtaccaac agcacagagg cagaaaacgg
      661 caacggcagc agcggaggag acaatggaga agaaggggaa gaagaaagtg tcactggagc
      721 caatgcagaa gacaccacag agaccggaag gcagggcaag ggcacctcga agacaacaac
      781 ctctccaaat ggtgggtttg aacctacaac cccaccacaa gtctatagaa ccacttcccc
      841 accttttggg aaaaccacca ccgttgaata cgagggggag tacgaataca cgggcgccaa
      901 tgaatacgac aatggatatg aaatctatga aagtgagaac ggggaacctc gtggggacaa
      961 ttaccgagcc tatgaagatg agtacagcta ctttaaagga caaggctacg atggctatga
     1021 tggtcagaat tactaccacc accagtgaag ctccagcctg ggatgaattc atccattctg
     1081 gctttgcatc cggctaccat tttcgaagtt caactcagga aggtgcaata taacaaatgt
     1141 gcatattata atgaggaatg gtactaccgt tccagatttt ctgtaattgc ttctgcaaag
     1201 taataggctt cttgtccctt ttttttctgg catgttatgg aatgatcatt gtaaatcagg
     1261 accatttatc aagcagtaca ccaactcata agatcaaatt tcattgaatg gtttgaggtt
     1321 gtagctctat aaatagtagt ttttaacatg cctgtagtat tgctaactgc aaaaacatac
     1381 tctttgtaca agaagtgctt ctaagaattt cattgacatt aatgacactg tatacaataa
     1441 atgtgtagtt tcttaatcgc actacctatg caacactgtg tattaggttt atcatcctca
     1501 tgtattttta tgtgacctgt atgtatattc taatctacga gttttatcac aaataaaaat
     1561 gcaatccttc aaa
//
