LOCUS       NM_000415               1942 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens islet amyloid polypeptide (IAPP), transcript variant
            1, mRNA.
ACCESSION   NM_000415
VERSION     NM_000415.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1942)
  AUTHORS   Dai,Z., Ben-Younis,A., Vlachaki,A., Raleigh,D. and Thalassinos,K.
  TITLE     Understanding the structural dynamics of human islet amyloid
            polypeptide: Advancements in and applications of ion-mobility mass
            spectrometry
  JOURNAL   Biophys Chem 312, 107285 (2024)
   PUBMED   38941872
  REMARK    GeneRIF: Understanding the structural dynamics of human islet
            amyloid polypeptide: Advancements in and applications of
            ion-mobility mass spectrometry.
            Review article
REFERENCE   2  (bases 1 to 1942)
  AUTHORS   Deng,J., Liu,B., Tao,Q., Luo,Y., Zhu,Y., Huang,X. and Yue,F.
  TITLE     The Co-oligomers of Abeta42 and Human Islet Amyloid Polypeptide
            Exacerbate Neurotoxicity and Alzheimer-like Pathology at Cellular
            Level
  JOURNAL   Neuroscience 547, 37-55 (2024)
   PUBMED   38604526
  REMARK    GeneRIF: The Co-oligomers of Abeta42 and Human Islet Amyloid
            Polypeptide Exacerbate Neurotoxicity and Alzheimer-like Pathology
            at Cellular Level.
REFERENCE   3  (bases 1 to 1942)
  AUTHORS   Erzen,S., Tonin,G., Jurisic Erzen,D. and Klen,J.
  TITLE     Amylin, Another Important Neuroendocrine Hormone for the Treatment
            of Diabesity
  JOURNAL   Int J Mol Sci 25 (3), 1517 (2024)
   PUBMED   38338796
  REMARK    GeneRIF: Amylin, Another Important Neuroendocrine Hormone for the
            Treatment of Diabesity.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1942)
  AUTHORS   Kachkin,D.V., Lashkul,V.V., Gorsheneva,N.A., Fedotov,S.A.,
            Rubel,M.S., Chernoff,Y.O. and Rubel,A.A.
  TITLE     The Abeta42 Peptide and IAPP Physically Interact in a Yeast-Based
            Assay
  JOURNAL   Int J Mol Sci 24 (18), 14122 (2023)
   PUBMED   37762425
  REMARK    GeneRIF: The Abeta42 Peptide and IAPP Physically Interact in a
            Yeast-Based Assay.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1942)
  AUTHORS   Mietlicki-Baase,E.G.
  TITLE     Amylin-mediated control of glycemia, energy balance, and cognition
  JOURNAL   Physiol Behav 162, 130-140 (2016)
   PUBMED   26922873
  REMARK    Review article
REFERENCE   6  (bases 1 to 1942)
  AUTHORS   Wang,L., Liu,Q., Chen,J.C., Cui,Y.X., Zhou,B., Chen,Y.X., Zhao,Y.F.
            and Li,Y.M.
  TITLE     Antimicrobial activity of human islet amyloid polypeptides: an
            insight into amyloid peptides' connection with antimicrobial
            peptides
  JOURNAL   Biol Chem 393 (7), 641-646 (2012)
   PUBMED   22944668
  REMARK    GeneRIF: antimicrobial activity of human islet amyloid polypeptide
            against clinically relevant bacteria
REFERENCE   7  (bases 1 to 1942)
  AUTHORS   Hoppener,J.W., Oosterwijk,C., Visser-Vernooy,H.J., Lips,C.J. and
            Jansz,H.S.
  TITLE     Characterization of the human islet amyloid polypeptide/amylin gene
            transcripts: identification of a new polyadenylation site
  JOURNAL   Biochem Biophys Res Commun 189 (3), 1569-1577 (1992)
   PUBMED   1282806
REFERENCE   8  (bases 1 to 1942)
  AUTHORS   Hubbard,J.A., Martin,S.R., Chaplin,L.C., Bose,C., Kelly,S.M. and
            Price,N.C.
  TITLE     Solution structures of calcitonin-gene-related-peptide analogues of
            calcitonin-gene-related peptide and amylin
  JOURNAL   Biochem J 275 (Pt 3) (Pt 3), 785-788 (1991)
   PUBMED   2039456
REFERENCE   9  (bases 1 to 1942)
  AUTHORS   van Mansfeld,A.D., Mosselman,S., Hoppener,J.W., Zandberg,J., van
            Teeffelen,H.A., Baas,P.D., Lips,C.J. and Jansz,H.S.
  TITLE     Islet amyloid polypeptide: structure and upstream sequences of the
            IAPP gene in rat and man
  JOURNAL   Biochim Biophys Acta 1087 (2), 235-240 (1990)
   PUBMED   2223885
REFERENCE   10 (bases 1 to 1942)
  AUTHORS   Butler,P.C., Chou,J., Carter,W.B., Wang,Y.N., Bu,B.H., Chang,D.,
            Chang,J.K. and Rizza,R.A.
  TITLE     Effects of meal ingestion on plasma amylin concentration in NIDDM
            and nondiabetic humans
  JOURNAL   Diabetes 39 (6), 752-756 (1990)
   PUBMED   2189768
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from J04422.1, X14905.1 and
            BQ548699.1.
            
            On May 17, 2019 this sequence version replaced NM_000415.2.
            
            Summary: This gene encodes a member of the calcitonin family of
            peptide hormones. This hormone is released from pancreatic beta
            cells following food intake to regulate blood glucose levels and
            act as a satiation signal. Human patients with type 1 and advanced
            type 2 diabetes exhibit reduced levels of the encoded hormone in
            blood and pancreas. This protein also exhibits a bactericidal,
            antimicrobial activity. [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J04422.1, BP323132.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2144335
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000240652.8/
                                                  ENSP00000240652.3
            Protein has antimicrobial activity :: PMID: 22944668
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-783               J04422.1           19-801
            784-1035            X14905.1           454-705
            1036-1444           J04422.1           1054-1462
            1445-1942           BQ548699.1         17-514              c
FEATURES             Location/Qualifiers
     source          1..1942
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p12.1"
     gene            1..1942
                     /gene="IAPP"
                     /gene_synonym="DAP; IAP"
                     /note="islet amyloid polypeptide"
                     /db_xref="GeneID:3375"
                     /db_xref="HGNC:HGNC:5329"
                     /db_xref="MIM:147940"
     exon            1..103
                     /gene="IAPP"
                     /gene_synonym="DAP; IAP"
                     /inference="alignment:Splign:2.1.0"
     exon            104..198
                     /gene="IAPP"
                     /gene_synonym="DAP; IAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..388
                     /gene="IAPP"
                     /gene_synonym="DAP; IAP"
                     /note="Islet amyloid polypeptide (diabetes-associated
                     peptide; amylin); insulinoma amyloid peptide"
                     /codon_start=1
                     /product="islet amyloid polypeptide preproprotein"
                     /protein_id="NP_000406.1"
                     /db_xref="CCDS:CCDS8688.1"
                     /db_xref="GeneID:3375"
                     /db_xref="HGNC:HGNC:5329"
                     /db_xref="MIM:147940"
                     /translation="MGILKLQVFLIVLSVALNHLKATPIESHQVEKRKCNTATCATQR
                     LANFLVHSSNNFGAILSSTNVGSNTYGKRNAVEVLKREPLNYLPL"
     exon            199..1942
                     /gene="IAPP"
                     /gene_synonym="DAP; IAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      562..567
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IAPP"
                     /gene_synonym="DAP; IAP"
                     /note="hexamer: AATAAA"
     polyA_site      591
                     /gene="IAPP"
                     /gene_synonym="DAP; IAP"
                     /note="major polyA site"
     regulatory      1422..1427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IAPP"
                     /gene_synonym="DAP; IAP"
                     /note="hexamer: ATTAAA"
     polyA_site      1447
                     /gene="IAPP"
                     /gene_synonym="DAP; IAP"
                     /note="major polyA site"
ORIGIN      
        1 gagggggtaa atattccagt ggatacaagc ttggactctt ttcttgaagc tttctttcta
       61 tcagaagcat ttgctgatat tgctgacatt gaaacattaa aagaaaattt gagaagcaat
      121 gggcatcctg aagctgcaag tatttctcat tgtgctctct gttgcattga accatctgaa
      181 agctacaccc attgaaagtc atcaggtgga aaagcggaaa tgcaacactg ccacatgtgc
      241 aacgcagcgc ctggcaaatt ttttagttca ttccagcaac aactttggtg ccattctctc
      301 atctaccaac gtgggatcca atacatatgg caagaggaat gcagtagagg ttttaaagag
      361 agagccactg aattacttgc ccctttagag gacaatgtaa ctctatagtt attgttttat
      421 gttctagtga tttcctgtat aatttaacag tgcccttttc atctccagtg tgaatatatg
      481 gtctgtgtgt ctgatgtttg ttgctaggac atataccttc tcaaaagatt gttttatatg
      541 tagtactaac taaggtccca taataaaaag atagtatctt ttaaaatgaa atgtttttgc
      601 tatagatttg tattttaaaa cataagaacg tcattttggg acctatatct cagtggcaca
      661 ggtttaagaa cgaaggagaa aaaggtagtt tgaaccttgg taaattgtaa acagctaata
      721 atgaagttat tcttgacatg agaaaatcag taattggacc aggcgcggtg gctcttgcct
      781 gtaatcccag cactttggga ggccgaggca ggcagatcac aaggtcagga gttcgagacc
      841 agcctgacca acatggtgaa accctgtctc tactaaaaat acaaaaatta gccgggggtg
      901 gtgacatgtg cctgtaatcc cagctactca ggaggctaag gcaggagaat cgcttaaacc
      961 caggaggcgg aggttgcagt gagccgagat tgcaccactg cactccagcc tgggtggcag
     1021 agtgagactc gtctcaaaaa aaagaaagaa aattagtaat tgtaagtacc cctgataagc
     1081 aaattagtaa ttgtcaatac ccctgttaag caattccttt ttgcagtata tttctgaaat
     1141 gacagaatgc tgttttaaaa acaaagaaat aaaatcctgc tcctgactcg gtcaaaatat
     1201 tttttaaagt ctattgtttg ttgtgcttgc tggtactaag aggctattta aaagtataaa
     1261 actgctttgt atccatgagg gtttcattgt gtgttagcag cagtgagctt ctattaaatg
     1321 tatatgtcat ttattttgtt taagtggctt tcagcaaacc tcagtcatat tcttatgcag
     1381 ggtattgcga aacaacttgt gttctattaa tcgtgtcttc aattaaaaga ccacagactt
     1441 ctggaaactc tttgctgtat aagaattatt tcttttgttt aacaaattag acatttctgg
     1501 cagaggttat gtatatgata cacttttttt gatagcagct gcaatgttgg acagaagatg
     1561 aaatgctttg ctttgagtca gattcttatg aatatctgct tttccctgac tttgagttag
     1621 gtagctttgg aagtagcatt aattcagata aactgccatc atgctgcgtt atgccatttc
     1681 taaagacact caacttgtac ttttaaaaaa atagaaaaaa taagcatttc aatctaagtg
     1741 gaaatttgac tcattgactt acatttctaa gttaaaattt ccctttatga agtgtgcctt
     1801 aggttaccaa attgtagagg ctttcgttgg tggtggtaag tggtagcggt agtgagtgta
     1861 tagaggcagg gaaatatatt tataataaat tctatgtcat gaattacata ttgaaataaa
     1921 taggtgaata tacaaattta ta
//
