LOCUS       NM_001320863            2144 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens isoamyl acetate hydrolyzing esterase 1 (putative)
            (IAH1), transcript variant 5, mRNA.
ACCESSION   NM_001320863
VERSION     NM_001320863.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2144)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2144)
  AUTHORS   Kobayashi,M., Suzuki,M., Ohno,T., Tsuzuki,K., Taguchi,C.,
            Tateishi,S., Kawada,T., Kim,Y.I., Murai,A. and Horio,F.
  TITLE     Detection of differentially expressed candidate genes for a fatty
            liver QTL on mouse chromosome 12
  JOURNAL   BMC Genet 17 (1), 73 (2016)
   PUBMED   27266874
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2144)
  AUTHORS   Seppala,I., Kleber,M.E., Lyytikainen,L.P., Hernesniemi,J.A.,
            Makela,K.M., Oksala,N., Laaksonen,R., Pilz,S., Tomaschitz,A.,
            Silbernagel,G., Boehm,B.O., Grammer,T.B., Koskinen,T., Juonala,M.,
            Hutri-Kahonen,N., Alfthan,G., Viikari,J.S., Kahonen,M.,
            Raitakari,O.T., Marz,W., Meinitzer,A. and Lehtimaki,T.
  CONSRTM   AtheroRemo Consortium
  TITLE     Genome-wide association study on dimethylarginines reveals novel
            AGXT2 variants associated with heart rate variability but not with
            overall mortality
  JOURNAL   Eur Heart J 35 (8), 524-531 (2014)
   PUBMED   24159190
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY094056.1, BM553525.1, AC080162.7, BC111025.1 and AA761915.1.
            
            On May 31, 2019 this sequence version replaced NM_001320863.1.
            
            Transcript Variant: This variant (5) uses an alternate splice
            junction in the 5' end compared to variant 1. The resulting isoform
            (c) is shorter at the N-terminus compared to isoform a. Variants 3,
            4, and 5 all encode the same isoform (c).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.237241.1, BM553525.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                HY094056.1         24-50
            28-511              BM553525.1         1-484
            512-512             AC080162.7         131575-131575
            513-778             BM553525.1         486-751
            779-864             BC111025.1         821-906
            865-1026            AA761915.1         32-193              c
            1027-2144           AC080162.7         135686-136803
FEATURES             Location/Qualifiers
     source          1..2144
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p25.1"
     gene            1..2144
                     /gene="IAH1"
                     /note="isoamyl acetate hydrolyzing esterase 1 (putative)"
                     /db_xref="GeneID:285148"
                     /db_xref="HGNC:HGNC:27696"
     exon            1..97
                     /gene="IAH1"
                     /inference="alignment:Splign:2.1.0"
     exon            98..150
                     /gene="IAH1"
                     /inference="alignment:Splign:2.1.0"
     exon            151..267
                     /gene="IAH1"
                     /inference="alignment:Splign:2.1.0"
     exon            268..429
                     /gene="IAH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             324..731
                     /gene="IAH1"
                     /note="isoform c is encoded by transcript variant 5;
                     testicular tissue protein Li 92; isoamyl
                     acetate-hydrolyzing esterase 1 homolog"
                     /codon_start=1
                     /product="isoamyl acetate-hydrolyzing esterase 1 homolog
                     isoform c"
                     /protein_id="NP_001307792.1"
                     /db_xref="CCDS:CCDS82418.1"
                     /db_xref="GeneID:285148"
                     /db_xref="HGNC:HGNC:27696"
                     /translation="MVQYLKSVDIPENRVILITPTPLCETAWEEQCIIQGCKLNRLNS
                     VVGEYANACLQVAQDCGTDVLDLWTLMQDSQDFSSYLSDGLHLSPKGNEFLFSHLWPL
                     IEKKVSSLPLLLPYWRDVAEAKPELSLLGDGDH"
     exon            430..548
                     /gene="IAH1"
                     /inference="alignment:Splign:2.1.0"
     exon            549..2144
                     /gene="IAH1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      840..845
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IAH1"
                     /note="hexamer: AATAAA"
     polyA_site      869
                     /gene="IAH1"
                     /note="major polyA site"
     regulatory      1005..1010
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IAH1"
                     /note="hexamer: TATAAA"
     polyA_site      1012
                     /gene="IAH1"
     polyA_site      1026
                     /gene="IAH1"
     regulatory      1409..1414
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IAH1"
                     /note="hexamer: AATAAA"
     polyA_site      1431
                     /gene="IAH1"
ORIGIN      
        1 cccgcccggc tgctccatgg cgctgtgcga ggccgcgggc tgcgggagtg ccctgctctg
       61 gcctcgcttg ttgctcttcg gggactccat cacccagttt tccttccagc agggtggatg
      121 gggagcatcg ctggctgaca ggctggtcag gttacaatac caggtgggcc aaaattatcc
      181 ttccaagatt aatcaggaaa ggaaacagtt tggacatccc agtagcagtt acaattttct
      241 ttggggccaa tgacagtgca ctaaaagatg agaatcccaa gcagcacatt cccctggagg
      301 agtacgctgc gaacctaaag agcatggtgc agtacctgaa gtccgtggac atccctgaga
      361 atcgagtcat tctcatcacg ccgaccccac tttgtgaaac agcctgggaa gaacagtgca
      421 tcatacaagg ttgcaaacta aatcgcctga actctgttgt tggtgaatat gccaatgcgt
      481 gtttacaagt ggcccaagac tgtgggactg acgtacttga cctgtggacc ctgatgcagg
      541 acagccagga cttctcatct tatttatcag atggactaca tttgtctcca aaggggaatg
      601 aatttttgtt ctcgcatctc tggcctttga tagagaaaaa ggtctcttct ctacctttgc
      661 tgcttcctta ctggcgggat gtagcagaag caaaacctga attaagtctg ctgggagatg
      721 gagaccatta gccaatcaca ggagacccaa atctgcttgt tatctacaga actcaaagtt
      781 gtcaatacgt agaggtacgc ttttttcctc aggcttaaac ctttgccact gatattaata
      841 ataaaagtat tagatgattt ttcagggaag ttttatactt aggtccattg tgtttcgaca
      901 gtatttatta atgcagatat cagtgctaca gctataaaat ataccctgag cagcttgtta
      961 attctataaa tgacaaagac tatgttttta aaaagtcaca attttataaa aatggttttt
     1021 cttacattct tttgagaact gtttcactca tacatacacc cacacacccc actcaacctt
     1081 gtatcaaatt ccaaaagtgt aactaaagta taagaatatc atgactagtt aaaagatagc
     1141 aaataccata aggtacaagt tcaagtatta gtataacaag tatctgagta acaaatgtcc
     1201 ttggaaatgg ggggtaggag gagatatgat tagtcacagg tttggttaac tgccctcaaa
     1261 atttacaagt taaaatgttt tggctggtga gcacatttca gttcttaggg gaaaaaaagc
     1321 ttttaatggc aatttataga aatcagaatc caggctaatg atttttatcc ttcacacagt
     1381 aaatgcagcc catccagaat cctggagcaa taaagtaaga agtaattcaa atatctgctt
     1441 gtgggtcaat aaaaagggtt tctgaagtat caagtcttgt ggggacagcc cccaacccta
     1501 agggcaggta gtattctatc tcctggctgg ctcatcacat tcaaaacaac ctgttttttt
     1561 tgttgttgtt gttgttaaga aatatctcac cctcttattc aatagtgttt gaaaacaggc
     1621 aatctttgta ttttaaatat tctaggtttg tagatagtga attttttttt tttttttttt
     1681 tttttgaggc agagtctcac tctgtcaccc aggctggagt gtagtggcgc aacctcagcc
     1741 tctccaagtg ctgggattac aggcatgagc caccactccc agccaatagt gaattttcta
     1801 agagcatgta tccctatcag taacagggat acatgaagat acttataaaa tacagaaaaa
     1861 ctgcccagca aatcagggcc ctaaacagtt ggtagattcc ataaattcaa ctggctacca
     1921 tgtatagccc tcactgtaag gtaggtggtt aggtttctag agagcattag tcttagaatt
     1981 atgaagagcc atattaaccc aaatgatttc taaatttaga tatatatttt ccctgctaca
     2041 taaaaactct gggtaataac tagaaataga cccacaattt agagacaatg tatactagat
     2101 ttatctcctt tgtttttagt tgaaggcaaa aaaaaaaaaa aaaa
//
