LOCUS       NM_001039613            2176 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens isoamyl acetate hydrolyzing esterase 1 (putative)
            (IAH1), transcript variant 1, mRNA.
ACCESSION   NM_001039613
VERSION     NM_001039613.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2176)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2176)
  AUTHORS   Kobayashi,M., Suzuki,M., Ohno,T., Tsuzuki,K., Taguchi,C.,
            Tateishi,S., Kawada,T., Kim,Y.I., Murai,A. and Horio,F.
  TITLE     Detection of differentially expressed candidate genes for a fatty
            liver QTL on mouse chromosome 12
  JOURNAL   BMC Genet 17 (1), 73 (2016)
   PUBMED   27266874
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2176)
  AUTHORS   Seppala,I., Kleber,M.E., Lyytikainen,L.P., Hernesniemi,J.A.,
            Makela,K.M., Oksala,N., Laaksonen,R., Pilz,S., Tomaschitz,A.,
            Silbernagel,G., Boehm,B.O., Grammer,T.B., Koskinen,T., Juonala,M.,
            Hutri-Kahonen,N., Alfthan,G., Viikari,J.S., Kahonen,M.,
            Raitakari,O.T., Marz,W., Meinitzer,A. and Lehtimaki,T.
  CONSRTM   AtheroRemo Consortium
  TITLE     Genome-wide association study on dimethylarginines reveals novel
            AGXT2 variants associated with heart rate variability but not with
            overall mortality
  JOURNAL   Eur Heart J 35 (8), 524-531 (2014)
   PUBMED   24159190
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC111025.1, AA761915.1 and AC080162.7.
            
            On May 17, 2019 this sequence version replaced NM_001039613.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.323360.1,
                                           SRR1660803.239358.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000497473.6/ ENSP00000417580.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-896               BC111025.1         11-906
            897-1058            AA761915.1         32-193              c
            1059-2176           AC080162.7         135686-136803
FEATURES             Location/Qualifiers
     source          1..2176
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p25.1"
     gene            1..2176
                     /gene="IAH1"
                     /note="isoamyl acetate hydrolyzing esterase 1 (putative)"
                     /db_xref="GeneID:285148"
                     /db_xref="HGNC:HGNC:27696"
     exon            1..97
                     /gene="IAH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..763
                     /gene="IAH1"
                     /note="isoform a is encoded by transcript variant 1;
                     testicular tissue protein Li 92; isoamyl
                     acetate-hydrolyzing esterase 1 homolog"
                     /codon_start=1
                     /product="isoamyl acetate-hydrolyzing esterase 1 homolog
                     isoform a"
                     /protein_id="NP_001034702.1"
                     /db_xref="CCDS:CCDS42651.1"
                     /db_xref="GeneID:285148"
                     /db_xref="HGNC:HGNC:27696"
                     /translation="MALCEAAGCGSALLWPRLLLFGDSITQFSFQQGGWGASLADRLV
                     RKCDVLNRGFSGYNTRWAKIILPRLIRKGNSLDIPVAVTIFFGANDSALKDENPKQHI
                     PLEEYAANLKSMVQYLKSVDIPENRVILITPTPLCETAWEEQCIIQGCKLNRLNSVVG
                     EYANACLQVAQDCGTDVLDLWTLMQDSQDFSSYLSDGLHLSPKGNEFLFSHLWPLIEK
                     KVSSLPLLLPYWRDVAEAKPELSLLGDGDH"
     exon            98..150
                     /gene="IAH1"
                     /inference="alignment:Splign:2.1.0"
     exon            151..299
                     /gene="IAH1"
                     /inference="alignment:Splign:2.1.0"
     exon            300..461
                     /gene="IAH1"
                     /inference="alignment:Splign:2.1.0"
     exon            462..580
                     /gene="IAH1"
                     /inference="alignment:Splign:2.1.0"
     exon            581..2176
                     /gene="IAH1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      872..877
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IAH1"
                     /note="hexamer: AATAAA"
     polyA_site      901
                     /gene="IAH1"
                     /note="major polyA site"
     regulatory      1037..1042
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IAH1"
                     /note="hexamer: TATAAA"
     polyA_site      1044
                     /gene="IAH1"
     polyA_site      1058
                     /gene="IAH1"
     regulatory      1441..1446
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IAH1"
                     /note="hexamer: AATAAA"
     polyA_site      1463
                     /gene="IAH1"
ORIGIN      
        1 cccgcccggc tgctccatgg cgctgtgcga ggccgcgggc tgcgggagtg ccctgctctg
       61 gcctcgcttg ttgctcttcg gggactccat cacccagttt tccttccagc agggtggatg
      121 gggagcatcg ctggctgaca ggctggtcag aaaatgtgat gttctgaatc gtggattttc
      181 aggttacaat accaggtggg ccaaaattat ccttccaaga ttaatcagga aaggaaacag
      241 tttggacatc ccagtagcag ttacaatttt ctttggggcc aatgacagtg cactaaaaga
      301 tgagaatccc aagcagcaca ttcccctgga ggagtacgct gcgaacctaa agagcatggt
      361 gcagtacctg aagtccgtgg acatccctga gaatcgagtc attctcatca cgccgacccc
      421 actttgtgaa acagcctggg aagaacagtg catcatacaa ggttgcaaac taaatcgcct
      481 gaactctgtt gttggtgaat atgccaatgc gtgtttacaa gtggcccaag actgtgggac
      541 tgacgtactt gacctgtgga ccctgatgca ggacagccag gacttctcat cttatttatc
      601 agatggacta catttgtctc caaaggggaa tgaatttttg ttctcgcatc tctggccttt
      661 gatagagaaa aaggtctctt ctctaccttt gctgcttcct tactggcggg atgtagcaga
      721 agcaaaacct gaattaagtc tgctgggaga tggagaccat tagccaatca caggagaccc
      781 aaatctgctt gttatctaca gaactcaaag ttgtcaatac gtagaggtac gcttttttcc
      841 tcaggcttaa acctttgcca ctgatattaa taataaaagt attagatgat ttttcaggga
      901 agttttatac ttaggtccat tgtgtttcga cagtatttat taatgcagat atcagtgcta
      961 cagctataaa atataccctg agcagcttgt taattctata aatgacaaag actatgtttt
     1021 taaaaagtca caattttata aaaatggttt ttcttacatt cttttgagaa ctgtttcact
     1081 catacataca cccacacacc ccactcaacc ttgtatcaaa ttccaaaagt gtaactaaag
     1141 tataagaata tcatgactag ttaaaagata gcaaatacca taaggtacaa gttcaagtat
     1201 tagtataaca agtatctgag taacaaatgt ccttggaaat ggggggtagg aggagatatg
     1261 attagtcaca ggtttggtta actgccctca aaatttacaa gttaaaatgt tttggctggt
     1321 gagcacattt cagttcttag gggaaaaaaa gcttttaatg gcaatttata gaaatcagaa
     1381 tccaggctaa tgatttttat ccttcacaca gtaaatgcag cccatccaga atcctggagc
     1441 aataaagtaa gaagtaattc aaatatctgc ttgtgggtca ataaaaaggg tttctgaagt
     1501 atcaagtctt gtggggacag cccccaaccc taagggcagg tagtattcta tctcctggct
     1561 ggctcatcac attcaaaaca acctgttttt tttgttgttg ttgttgttaa gaaatatctc
     1621 accctcttat tcaatagtgt ttgaaaacag gcaatctttg tattttaaat attctaggtt
     1681 tgtagatagt gaattttttt tttttttttt tttttttgag gcagagtctc actctgtcac
     1741 ccaggctgga gtgtagtggc gcaacctcag cctctccaag tgctgggatt acaggcatga
     1801 gccaccactc ccagccaata gtgaattttc taagagcatg tatccctatc agtaacaggg
     1861 atacatgaag atacttataa aatacagaaa aactgcccag caaatcaggg ccctaaacag
     1921 ttggtagatt ccataaattc aactggctac catgtatagc cctcactgta aggtaggtgg
     1981 ttaggtttct agagagcatt agtcttagaa ttatgaagag ccatattaac ccaaatgatt
     2041 tctaaattta gatatatatt ttccctgcta cataaaaact ctgggtaata actagaaata
     2101 gacccacaat ttagagacaa tgtatactag atttatctcc tttgttttta gttgaaggca
     2161 aaaaaaaaaa aaaaaa
//
