LOCUS       NM_016400               3011 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens huntingtin interacting protein K (HYPK), transcript
            variant 1, mRNA.
ACCESSION   NM_016400
VERSION     NM_016400.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3011)
  AUTHORS   Firouzbakht,A., Haider,A., Gaalswyk,K., Alaeen,S., Ghosh,K. and
            Gruebele,M.
  TITLE     HYPK: A marginally disordered protein sensitive to charge
            decoration
  JOURNAL   Proc Natl Acad Sci U S A 121 (18), e2316408121 (2024)
   PUBMED   38657047
  REMARK    GeneRIF: HYPK: A marginally disordered protein sensitive to charge
            decoration.
REFERENCE   2  (bases 1 to 3011)
  AUTHORS   Ghosh,D.K. and Ranjan,A.
  TITLE     HYPK coordinates degradation of polyneddylated proteins by
            autophagy
  JOURNAL   Autophagy 18 (8), 1763-1784 (2022)
   PUBMED   34836490
  REMARK    GeneRIF: HYPK coordinates degradation of polyneddylated proteins by
            autophagy.
REFERENCE   3  (bases 1 to 3011)
  AUTHORS   Lin,M.C., Yu,C.J. and Lee,F.S.
  TITLE     Phosphorylation of Arl4A/D promotes their binding by the HYPK
            chaperone for their stable recruitment to the plasma membrane
  JOURNAL   Proc Natl Acad Sci U S A 119 (30), e2207414119 (2022)
   PUBMED   35857868
  REMARK    GeneRIF: Phosphorylation of Arl4A/D promotes their binding by the
            HYPK chaperone for their stable recruitment to the plasma membrane.
REFERENCE   4  (bases 1 to 3011)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3011)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 3011)
  AUTHORS   Raychaudhuri,S., Majumder,P., Sarkar,S., Giri,K., Mukhopadhyay,D.
            and Bhattacharyya,N.P.
  TITLE     Huntingtin interacting protein HYPK is intrinsically unstructured
  JOURNAL   Proteins 71 (4), 1686-1698 (2008)
   PUBMED   18076027
REFERENCE   7  (bases 1 to 3011)
  AUTHORS   Raychaudhuri,S., Sinha,M., Mukhopadhyay,D. and Bhattacharyya,N.P.
  TITLE     HYPK, a Huntingtin interacting protein, reduces aggregates and
            apoptosis induced by N-terminal Huntingtin with 40 glutamines in
            Neuro2a cells and exhibits chaperone-like activity
  JOURNAL   Hum Mol Genet 17 (2), 240-255 (2008)
   PUBMED   17947297
  REMARK    GeneRIF: The present study, has confirmed, by confocal microscopy
            and immunoprecipitation, that HYPK interacts with the N-terminal of
            Htt.
REFERENCE   8  (bases 1 to 3011)
  AUTHORS   Kaltenbach,L.S., Romero,E., Becklin,R.R., Chettier,R., Bell,R.,
            Phansalkar,A., Strand,A., Torcassi,C., Savage,J., Hurlburt,A.,
            Cha,G.H., Ukani,L., Chepanoske,C.L., Zhen,Y., Sahasrabudhe,S.,
            Olson,J., Kurschner,C., Ellerby,L.M., Peltier,J.M., Botas,J. and
            Hughes,R.E.
  TITLE     Huntingtin interacting proteins are genetic modifiers of
            neurodegeneration
  JOURNAL   PLoS Genet 3 (5), e82 (2007)
   PUBMED   17500595
REFERENCE   9  (bases 1 to 3011)
  AUTHORS   Perez-Gonzalez,A., Rodriguez,A., Huarte,M., Salanueva,I.J. and
            Nieto,A.
  TITLE     hCLE/CGI-99, a human protein that interacts with the influenza
            virus polymerase, is a mRNA transcription modulator
  JOURNAL   J Mol Biol 362 (5), 887-900 (2006)
   PUBMED   16950395
REFERENCE   10 (bases 1 to 3011)
  AUTHORS   Faber,P.W., Barnes,G.T., Srinidhi,J., Chen,J., Gusella,J.F. and
            MacDonald,M.E.
  TITLE     Huntingtin interacts with a family of WW domain proteins
  JOURNAL   Hum Mol Genet 7 (9), 1463-1474 (1998)
   PUBMED   9700202
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC018512.6.
            
            On Aug 21, 2019 this sequence version replaced NM_016400.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019262.1, DA488635.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000442995.4/
                                                ENSP00000401155.3
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression,
                                                longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-186               AC018512.6         115797-115982
            187-242             AC018512.6         116330-116385
            243-294             AC018512.6         116716-116767
            295-3011            AC018512.6         116909-119625
FEATURES             Location/Qualifiers
     source          1..3011
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.3"
     gene            1..3011
                     /gene="HYPK"
                     /gene_synonym="C15orf63; HSPC136"
                     /note="huntingtin interacting protein K"
                     /db_xref="GeneID:25764"
                     /db_xref="HGNC:HGNC:18418"
                     /db_xref="MIM:612784"
     exon            1..186
                     /gene="HYPK"
                     /gene_synonym="C15orf63; HSPC136"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..390
                     /gene="HYPK"
                     /gene_synonym="C15orf63; HSPC136"
                     /note="isoform 1 is encoded by transcript variant 1;
                     huntingtin yeast partner K"
                     /codon_start=1
                     /product="huntingtin-interacting protein K isoform 1"
                     /protein_id="NP_057484.4"
                     /db_xref="CCDS:CCDS10104.2"
                     /db_xref="GeneID:25764"
                     /db_xref="HGNC:HGNC:18418"
                     /db_xref="MIM:612784"
                     /translation="MATEGDVELELETETSGPERPPEKPRKHDSGAADLERVTDYAEE
                     KEIQSSNLETAMSVIGDRRSREQKAKQEREKELAKVTIKKEDLELIMTEMEISRAAAE
                     RSLREHMGNVVEALIALTN"
     exon            187..242
                     /gene="HYPK"
                     /gene_synonym="C15orf63; HSPC136"
                     /inference="alignment:Splign:2.1.0"
     exon            243..294
                     /gene="HYPK"
                     /gene_synonym="C15orf63; HSPC136"
                     /inference="alignment:Splign:2.1.0"
     exon            295..3011
                     /gene="HYPK"
                     /gene_synonym="C15orf63; HSPC136"
                     /inference="alignment:Splign:2.1.0"
     regulatory      432..437
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HYPK"
                     /gene_synonym="C15orf63; HSPC136"
                     /note="hexamer: AATAAA"
     polyA_site      463
                     /gene="HYPK"
                     /gene_synonym="C15orf63; HSPC136"
                     /note="major polyA site"
     regulatory      548..553
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HYPK"
                     /gene_synonym="C15orf63; HSPC136"
                     /note="hexamer: ATTAAA"
     polyA_site      576
                     /gene="HYPK"
                     /gene_synonym="C15orf63; HSPC136"
     regulatory      2989..2994
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HYPK"
                     /gene_synonym="C15orf63; HSPC136"
                     /note="hexamer: AATAAA"
     polyA_site      3011
                     /gene="HYPK"
                     /gene_synonym="C15orf63; HSPC136"
ORIGIN      
        1 atgcggcggc gtggtgaaat agatatggcg accgaggggg atgtggagct ggagttggag
       61 actgagacca gtggaccaga gcggcctccg gagaagccac ggaaacatga cagcggtgcg
      121 gcggacttgg agcgggtcac cgactatgca gaggagaagg agatccagag ttccaatctg
      181 gagacggcca tgtctgtgat tggagacaga aggtcccggg agcagaaagc caaacaggag
      241 cgggagaaag aactggcaaa agtcactatc aagaaggaag atctggagct aataatgact
      301 gagatggaga tatctcgagc agcagcagaa cgcagtttgc gggaacacat gggcaacgtg
      361 gtagaggcgc ttattgccct aaccaactga tgcgtgcttt ctcaaatata cctactggat
      421 taatttatgg caataaaatt tttttttgtc tttttcagtt ttatcatctt gggtcaagta
      481 gagtgtatac tatatcctat gttgtggaga atttatatgt tggagactaa ctgaatttaa
      541 gtgacccatt aaaatctagc acacctgtat gaaaaatcag tgtagaagaa tacctcatgt
      601 gcagatgcta ggtggcaggc cagtctcatt catctgacta gctctcaaca gtattcaagg
      661 tacatctgga gtctcagcag agttactgta ctcaaatggc atgtgtctcc aagacagctt
      721 atgaatatct aaaaggccag ctacctgcct aggagccact atatatatag atagatgtag
      781 gttatgaacc cagttcatag gccaccttga gttagaattt tggtacctac aacatgcttg
      841 attttgagtg attaaaaaaa aataatttgg ctgggtgctg tggctcacac ctctaatccc
      901 agcactttgg gaggtcgagg caggtagatc acgaggtcag gaattcaaga ccagcctggc
      961 caacatgtga aaccccgtct ccactgaaaa tagaaaaatt agctgggcat ggtggtgggc
     1021 gcctataatc ccagctattc tggaggctga ggcaggaatc gcttgaaatt ggaaagcaga
     1081 ggttgcagtg agctgagatc acactactgt actactgtac tccagcctgg gggaaagagt
     1141 gaaactccat ctcaaaaaaa aaaaaaaaaa aaaaagcccg ggcacagtgg ctcacacctg
     1201 taatcccagc actttgggag gctgaggcag tcggatcatg aggtcaggag ttgaagacaa
     1261 gcctggccaa catggtgaaa ccctgtctct actaaaaata caaaaaaaat aaaattagcc
     1321 aggcgtggtg gtgcatgcct gtagtcccag ctactcagga ggctgaagca gaagaattgc
     1381 ttgaaccagg gaggcggaag ttgcagtgag ctgagattgt gccactgtac tccagcctgg
     1441 gtgacagagc gagactgtct caaaaacaaa acaacaaaaa agaatttagg ggccaggcat
     1501 ggtggctcat gcctgtaatc ccaacacctt gggaagctga ggcaagacga tcacttgagc
     1561 ccagcagttt gagaccagct tgggcaacac agtgagattt cgtctctacc gcgctccccc
     1621 caccaccaaa aaaagaattt aggtacctga gggttagaac atggtaagac tagaagatat
     1681 caaaggttgg gccaggtgtg gtgactcatg cctgtaaccc cagcactttg gggaggctgg
     1741 gctgggagga ctgtgtcagg tcaggatttc cagaccagcc tgggcaacat agcatgacct
     1801 tgtctctact aaaattaaaa aaaaaaaaag ccaggcatgg tggcatgtgc ctgtctgtgg
     1861 tcccagatac tctggaggct gagatggatt tgcttgagcc tgggaggttg aggctgcagt
     1921 gagctgagat tgtgctactg cactccagcc tgggcgacag agcaagactg tctcaaaacg
     1981 aaaaaaacct atgaaaggtt ttgattggta ttcaaattct aagccataat acattctaca
     2041 tgccatttcc tatcctagag agaaggtaat tttactttaa aggttaatca gggccgggcg
     2101 tggtggcgca tgcctataat cccagcactc tgggaggccg aggcaggtgg atcacctggg
     2161 atcaggagtt tgagacgagc ctggccaaaa tggtgaaacc ccatctctac taaaagtaca
     2221 aaaaaaaatt agctgggtgt ggtggtggac gcctgtaatt ccagctacta gggaggctga
     2281 ggcaggagaa tctcttgaac ccaggaggtt gcagtgagca gagatcgcgc cactgcactc
     2341 cagactgggc aacaagagtg aaactccatc tcaaaaaaaa aaaaaaaaaa aatcagcttg
     2401 gaccaactca cacatgttga actagtttcc tcaactataa aactgtgacg gccccagcta
     2461 ggcacagtgg ctcaacgcct gtaatctcag cactttggga ggctgaggcg ggcggatcgc
     2521 gaagtgaaga tcaagaccat cctggctaac atggtgaaac cccgtctcta ctaaaaatac
     2581 aaaaattagc caggcatggt ggcaggcgcc tgtagtccca gctactcggg aggctgaggc
     2641 actctagcct gggcaacaga gccgtctctt taaaacaaac aaacaaacaa aaaaaaaacc
     2701 ctgcaacggc ccctgagtct gctgtaagga cactcaaatg gcaattacag acatttctcc
     2761 aagagtttca aggccttacc ctcattctga ctctaggata attcttagat tgtatcccac
     2821 acaacagtga cttgtacctg tgttcatctt tatgtattta ccacctcata gtaattattt
     2881 gcattcattt ttatcgtacg acactaaact atttgattct tccagtggga catttaaagg
     2941 atgtgagaag accttggtct tctcaaaaac atctgtattt ggtcatggaa taaatccaga
     3001 tgctacctaa a
//
