LOCUS       NM_001190880            1221 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens hydroxypyruvate isomerase (putative) (HYI), transcript
            variant 3, mRNA.
ACCESSION   NM_001190880
VERSION     NM_001190880.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1221)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1221)
  AUTHORS   Wang,J., Liu,Y., Zhang,K., Ma,B. and Zhao,Y.
  TITLE     [Analysis of the binding domain of hydroxypyruvate isomerase
            homologues in hypertrophic scar fibroblasts]
  JOURNAL   Zhonghua Shao Shang Za Zhi 28 (1), 60-64 (2012)
   PUBMED   22490543
  REMARK    GeneRIF: Protein HYI may closely bind with protein P311 by an alpha
            helix in hypertrophic scar fibroblasts.
REFERENCE   3  (bases 1 to 1221)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   4  (bases 1 to 1221)
  AUTHORS   Wistow,G., Bernstein,S.L., Ray,S., Wyatt,M.K., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of adult human iris for the NEIBank
            Project: steroid-response factors and similarities with retinal
            pigment epithelium
  JOURNAL   Mol Vis 8, 185-195 (2002)
   PUBMED   12107412
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1221)
  AUTHORS   Ashiuchi,M. and Misono,H.
  TITLE     Biochemical evidence that Escherichia coli hyi (orf b0508, gip)
            gene encodes hydroxypyruvate isomerase
  JOURNAL   Biochim Biophys Acta 1435 (1-2), 153-159 (1999)
   PUBMED   10561547
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM715679.1, BC006140.1,
            BC019041.2, AI023272.1 and AL583862.35.
            
            On Aug 14, 2020 this sequence version replaced NM_001190880.2.
            
            Summary: This gene encodes a putative hydroxypyruvate isomerase,
            which likely catalyzes the conversion of hydroxypyruvate to
            2-hydroxy-3-oxopropanoate, and may be involved in carbohydrate
            transport and metabolism. Alternatively spliced transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (3) contains two alternate splice
            junctions compared to variant 5. The resulting isoform (3) contains
            an alternate internal segment and lacks another alternate internal
            segment compared to isoform 5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006140.1, BX396306.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2144835
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372430.9/ ENSP00000361507.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-391               BM715679.1         59-449
            392-852             BC006140.1         136-596
            853-880             BC019041.2         713-740
            881-947             BC006140.1         625-691
            948-1052            BC019041.2         790-894
            1053-1207           AI023272.1         5-159               c
            1208-1221           AL583862.35        43486-43499         c
FEATURES             Location/Qualifiers
     source          1..1221
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.2"
     gene            1..1221
                     /gene="HYI"
                     /gene_synonym="HT036"
                     /note="hydroxypyruvate isomerase (putative)"
                     /db_xref="GeneID:81888"
                     /db_xref="HGNC:HGNC:26948"
                     /db_xref="MIM:619128"
     exon            1..337
                     /gene="HYI"
                     /gene_synonym="HT036"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..972
                     /gene="HYI"
                     /gene_synonym="HT036"
                     /EC_number="5.3.1.22"
                     /note="isoform 3 is encoded by transcript variant 3;
                     endothelial cell apoptosis protein E-CE1; hydroxypyruvate
                     isomerase homolog"
                     /codon_start=1
                     /product="putative hydroxypyruvate isomerase isoform 3"
                     /protein_id="NP_001177809.1"
                     /db_xref="CCDS:CCDS53309.1"
                     /db_xref="GeneID:81888"
                     /db_xref="HGNC:HGNC:26948"
                     /db_xref="MIM:619128"
                     /translation="MAPLRFSANLSWLFPELSGLPARVRAAGSSGFEAVEVAWPYAET
                     PEALARAAREAGLRLVLINTPPGDQEKGEMGLGAVPGRQAAFREGLEQAVRYAKALGC
                     PRIHLMAGRVPQGADRIAVKAEMEAVFLENLRHAAGVLAQEDLVGLLEPINTRITDPQ
                     YFLDTPQQAAAILQKVGRPNLQLQMDIFHWQIMDGNLTGNIREFLPIVGHVQVAQVPG
                     RGEPSSPGELNFPYLFQLLEDEGYKGFVGCEYQPRGDTVEGLSWLRSYWDRRGHPEAG
                     Q"
     exon            338..449
                     /gene="HYI"
                     /gene_synonym="HT036"
                     /inference="alignment:Splign:2.1.0"
     exon            450..564
                     /gene="HYI"
                     /gene_synonym="HT036"
                     /inference="alignment:Splign:2.1.0"
     exon            565..643
                     /gene="HYI"
                     /gene_synonym="HT036"
                     /inference="alignment:Splign:2.1.0"
     exon            644..693
                     /gene="HYI"
                     /gene_synonym="HT036"
                     /inference="alignment:Splign:2.1.0"
     exon            694..763
                     /gene="HYI"
                     /gene_synonym="HT036"
                     /inference="alignment:Splign:2.1.0"
     exon            764..898
                     /gene="HYI"
                     /gene_synonym="HT036"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1221
                     /gene="HYI"
                     /gene_synonym="HT036"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1033..1038
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HYI"
                     /gene_synonym="HT036"
                     /note="hexamer: ATTAAA"
     polyA_site      1052
                     /gene="HYI"
                     /gene_synonym="HT036"
                     /note="major polyA site"
     regulatory      1187..1192
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HYI"
                     /gene_synonym="HT036"
                     /note="hexamer: ATTAAA"
     polyA_site      1221
                     /gene="HYI"
                     /gene_synonym="HT036"
ORIGIN      
        1 cttcgctttt ctaaccacga acagtgctcg ttcgttcgca gggccagcaa ggagagcccc
       61 gcccccgccc gccgcccgcc gcccgccgcc cgccgccttt ggatcccgcg gactccgccc
      121 ggcccggcct ccccaggcat ggcgccgctg cgcttctccg ccaatctgtc ctggctattc
      181 cccgagctct ccggcctccc cgcgcgggtg cgggccgcgg gcagctcggg cttcgaggcc
      241 gtcgaggtgg cctggccgta cgcggagacg cctgaggcgc tggcgcgcgc cgcgcgagaa
      301 gcggggctgc ggcttgtact gatcaacacg cccccgggag accaagagaa gggggaaatg
      361 gggctggggg ccgtccccgg gagacaggcg gccttccgag agggactgga gcaggccgtg
      421 cggtatgcca aagccctggg ctgtcccagg atccacctga tggctggccg agtaccccag
      481 ggagctgatc gaatagcagt caaggctgag atggaggccg tttttctgga gaacctgagg
      541 catgcagctg gggttttggc tcaggaggac ctcgtgggac tgctggagcc catcaacacc
      601 cgcatcactg acccccagta cttcctggac acgccccagc aggcggcagc catcttacag
      661 aaggtaggaa gacccaacct ccaattacaa atggacatat tccactggca gatcatggat
      721 gggaacctga caggaaacat ccgggagttc ctgcccattg ttgggcatgt gcaggtggca
      781 caggtcccag gccgagggga gcccagcagc cccggagagc tgaatttccc ctatctgttt
      841 caactgctgg aagatgaagg ctacaaaggc ttcgtgggct gtgagtatca gcctcgagga
      901 gacacagtag agggcttgag ttggctacgt tcatactggg ataggcgggg ccacccagag
      961 gctggccagt gagggcccgc acaccaccca cgtgcctcca gacagcgagt gacatcccat
     1021 ctcctcctct gcattaaaga tgacctgctg aacattgtca tatgtctctg taatggggtg
     1081 gtgggacaca tagtgtctaa cacttcagtt tctctgctgc ttccctccca ttgagaagcc
     1141 agtgccaggg ttgctgtgaa gatgggagag cttctgaacc cacctcatta aaggatgaga
     1201 aacccagggt ccgagagcaa a
//
