LOCUS       NM_003549               1878 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens hyaluronidase 3 (HYAL3), transcript variant 1, mRNA.
ACCESSION   NM_003549
VERSION     NM_003549.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1878)
  AUTHORS   Liu,J.P., Fang,Y.T., Jiang,Y.F. and Lin,H.
  TITLE     HYAL3 as a potential novel marker of BLCA patient prognosis
  JOURNAL   BMC Genom Data 23 (1), 63 (2022)
   PUBMED   35945500
  REMARK    GeneRIF: HYAL3 as a potential novel marker of BLCA patient
            prognosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1878)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1878)
  AUTHORS   Krupkova,O., Greutert,H., Boos,N., Lemcke,J., Liebscher,T. and
            Wuertz-Kozak,K.
  TITLE     Expression and activity of hyaluronidases HYAL-1, HYAL-2 and HYAL-3
            in the human intervertebral disc
  JOURNAL   Eur Spine J 29 (3), 605-615 (2020)
   PUBMED   31758257
  REMARK    GeneRIF: Expression and activity of hyaluronidases HYAL-1, HYAL-2
            and HYAL-3 in the human intervertebral disc.
REFERENCE   4  (bases 1 to 1878)
  AUTHORS   Nikolic,D.S., Ziori,C., Kostaki,M., Fontao,L., Saurat,J.H. and
            Kaya,G.
  TITLE     Hyalurosome gene regulation and dose-dependent restoration of skin
            atrophy by retinaldehyde and defined-size hyaluronate fragments in
            dermatoporosis
  JOURNAL   Dermatology 229 (2), 110-115 (2014)
   PUBMED   25138066
  REMARK    GeneRIF: the relative expression of hyalurosome (CD44, HAS3,
            HB-EGF) genes was found to be reduced in patients prior to topical
            treatment and to be notably increased following treatment.
REFERENCE   5  (bases 1 to 1878)
  AUTHORS   Lokeshwar,V.B., Schroeder,G.L., Carey,R.I., Soloway,M.S. and
            Iida,N.
  TITLE     Regulation of hyaluronidase activity by alternative mRNA splicing
  JOURNAL   J Biol Chem 277 (37), 33654-33663 (2002)
   PUBMED   12084718
  REMARK    GeneRIF: Alternative mRNA splicing controls cellular expression of
            enzymatically active hyaluronidase.
REFERENCE   6  (bases 1 to 1878)
  AUTHORS   Csoka,A.B., Frost,G.I. and Stern,R.
  TITLE     The six hyaluronidase-like genes in the human and mouse genomes
  JOURNAL   Matrix Biol 20 (8), 499-508 (2001)
   PUBMED   11731267
  REMARK    Review article
REFERENCE   7  (bases 1 to 1878)
  AUTHORS   Rai,S.K., Duh,F.M., Vigdorovich,V., Danilkovitch-Miagkova,A.,
            Lerman,M.I. and Miller,A.D.
  TITLE     Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol
            (GPI)-anchored cell-surface receptor for jaagsiekte sheep
            retrovirus, the envelope protein of which mediates oncogenic
            transformation
  JOURNAL   Proc Natl Acad Sci U S A 98 (8), 4443-4448 (2001)
   PUBMED   11296287
REFERENCE   8  (bases 1 to 1878)
  AUTHORS   Fiszer-Szafarz,B., Litynska,A. and Zou,L.
  TITLE     Human hyaluronidases: electrophoretic multiple forms in somatic
            tissues and body fluids. Evidence for conserved hyaluronidase
            potential N-glycosylation sites in different mammalian species
  JOURNAL   J Biochem Biophys Methods 45 (2), 103-116 (2000)
   PUBMED   10989127
REFERENCE   9  (bases 1 to 1878)
  AUTHORS   Csoka,A.B., Scherer,S.W. and Stern,R.
  TITLE     Expression analysis of six paralogous human hyaluronidase genes
            clustered on chromosomes 3p21 and 7q31
  JOURNAL   Genomics 60 (3), 356-361 (1999)
   PUBMED   10493834
REFERENCE   10 (bases 1 to 1878)
  AUTHORS   Triggs-Raine,B., Salo,T.J., Zhang,H., Wicklow,B.A. and
            Natowicz,M.R.
  TITLE     Mutations in HYAL1, a member of a tandemly distributed multigene
            family encoding disparate hyaluronidase activities, cause a newly
            described lysosomal disorder, mucopolysaccharidosis IX
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6296-6300 (1999)
   PUBMED   10339581
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF036035.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003549.3.
            
            Summary: This gene encodes a member of the hyaluronidase family.
            Hyaluronidases are endoglycosidase enzymes that degrade hyaluronan,
            one of the major glycosaminoglycans of the extracellular matrix.
            The regulated turnover of hyaluronan plays a critical role in many
            biological processes including cell proliferation, migration and
            differentiation. The encoded protein may also play an important
            role in sperm function. This gene is one of several related genes
            in a region of chromosome 3p21.3 associated with tumor suppression,
            and the expression of specific transcript variants may be
            indicative of tumor status. Alternatively spliced transcript
            variants encoding multiple isoforms have been observed for this
            gene, and some isoforms may lack hyaluronidase activity. This gene
            overlaps and is on the same strand as N-acetyltransferase 6
            (GCN5-related), and some transcripts of each gene share a portion
            of the first exon. [provided by RefSeq, Jan 2011].
            
            Transcript Variant: This variant (1), also known as HYAL3-wt,
            represents the longest transcript and encodes the longest isoform
            (1). Both variants 1 and 5 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.932406.1, AF036035.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336307.6/ ENSP00000337425.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1878              AF036035.1         64-1941
FEATURES             Location/Qualifiers
     source          1..1878
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..1878
                     /gene="HYAL3"
                     /gene_synonym="HYAL-3; LUCA-3; LUCA3"
                     /note="hyaluronidase 3"
                     /db_xref="GeneID:8372"
                     /db_xref="HGNC:HGNC:5322"
                     /db_xref="MIM:604038"
     exon            1..193
                     /gene="HYAL3"
                     /gene_synonym="HYAL-3; LUCA-3; LUCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            194..1104
                     /gene="HYAL3"
                     /gene_synonym="HYAL-3; LUCA-3; LUCA3"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..1464
                     /gene="HYAL3"
                     /gene_synonym="HYAL-3; LUCA-3; LUCA3"
                     /EC_number="3.2.1.35"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; lung carcinoma protein 3;
                     hyaluronoglucosaminidase 3"
                     /codon_start=1
                     /product="hyaluronidase-3 isoform 1 precursor"
                     /protein_id="NP_003540.2"
                     /db_xref="CCDS:CCDS2815.1"
                     /db_xref="GeneID:8372"
                     /db_xref="HGNC:HGNC:5322"
                     /db_xref="MIM:604038"
                     /translation="MTTQLGPALVLGVALCLGCGQPLPQVPERPFSVLWNVPSAHCEA
                     RFGVHLPLNALGIIANRGQHFHGQNMTIFYKNQLGLYPYFGPRGTAHNGGIPQALPLD
                     RHLALAAYQIHHSLRPGFAGPAVLDWEEWCPLWAGNWGRRRAYQAASWAWAQQVFPDL
                     DPQEQLYKAYTGFEQAARALMEDTLRVAQALRPHGLWGFYHYPACGNGWHSMASNYTG
                     RCHAATLARNTQLHWLWAASSALFPSIYLPPRLPPAHHQAFVRHRLEEAFRVALVGHR
                     HPLPVLAYVRLTHRRSGRFLSQDDLVQSIGVSAALGAAGVVLWGDLSLSSSEEECWHL
                     HDYLVDTLGPYVINVTRAAMACSHQRCHGHGRCARRDPGQMEAFLHLWPDGSLGDWKS
                     FSCHCYWGWAGPTCQEPRPGPKEAV"
     exon            1105..1194
                     /gene="HYAL3"
                     /gene_synonym="HYAL-3; LUCA-3; LUCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1878
                     /gene="HYAL3"
                     /gene_synonym="HYAL-3; LUCA-3; LUCA3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1856..1861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HYAL3"
                     /gene_synonym="HYAL-3; LUCA-3; LUCA3"
                     /note="hexamer: CATAAA"
     polyA_site      1878
                     /gene="HYAL3"
                     /gene_synonym="HYAL-3; LUCA-3; LUCA3"
                     /note="major polyA site"
ORIGIN      
        1 ctaagcggcg acgcgcgggt gctgggaggc cttagaacgc cgtggcgtgc cgcaggacgc
       61 gacggctgca gaacatccgc cgcaccgctg ggggccaacg ttgtcggacc gaggagtccg
      121 aggtggcgac tgagtgagat acccagctgt gcggagctag gacgcggaac atcccagagg
      181 ccagcatcaa catgtttcca tccttgggga atgaccacgc aactgggccc agccctggtg
      241 ctgggggtgg ccctgtgcct gggttgtggc cagcccctac cacaggtccc tgaacgcccc
      301 ttctctgtgc tgtggaatgt accctcagca cactgtgagg cccgctttgg tgtgcacctg
      361 ccactcaatg ctctgggcat catagccaac cgtggccagc attttcacgg tcagaacatg
      421 accattttct acaagaacca actcggcctc tatccctact ttggacccag gggcacagct
      481 cacaatgggg gcatccccca ggctttgccc cttgaccgcc acctggcact ggctgcctac
      541 cagatccacc acagcctgag acctggcttt gctggcccag cagtgctgga ttgggaggag
      601 tggtgtccac tctgggctgg gaactggggc cgccgccgag cttatcaggc agcctcttgg
      661 gcttgggcac agcaggtatt ccctgacctg gaccctcagg agcagctcta caaggcctat
      721 actggctttg agcaggcggc ccgtgcactg atggaggata cgctgcgggt ggcccaggca
      781 ctacggcccc atggactctg gggcttctat cactacccag cctgtggcaa tggctggcat
      841 agtatggctt ccaactatac cggccgctgc catgcagcca cccttgcccg caacactcaa
      901 ctgcattggc tctgggccgc ctccagtgcc ctcttcccca gcatctacct cccacccagg
      961 ctgccacctg cccaccacca ggcctttgtc cgacatcgcc tggaggaggc cttccgtgtg
     1021 gcccttgttg ggcaccgaca tcccctgcct gtcctggcct atgtccgcct cacacaccgg
     1081 agatctggga ggttcctgtc ccaggatgac cttgtgcagt ccattggtgt gagtgcagca
     1141 ctaggggcag ccggcgtggt gctctggggg gacctgagcc tctccagctc tgaggaggag
     1201 tgctggcatc tccatgacta cctggtggac accttgggcc cctatgtgat caatgtgacc
     1261 agggcagcga tggcctgcag tcaccagcgg tgccatggcc acgggcgctg tgcccggcga
     1321 gatccaggac agatggaagc ctttctacac ctgtggccag acggcagcct tggagattgg
     1381 aagtccttca gctgccactg ttactggggc tgggctggcc ccacctgcca ggagcccagg
     1441 cctgggccta aagaagcagt ataaagccag ggcccctgcc actgcctctt cttttccctg
     1501 ctgccacttt tccagtcctg gaactactct gtcccactct tgctctattc agtttacagt
     1561 caaccctccc aagcacacac cccgcttccc ttggaatccc tgaggggtag aaggggccag
     1621 aaaaaacgct tataaaacca gaggccctct gagatcatgt gagtcctcca tggcaaggaa
     1681 gcagttccag ggagagtcag gttccagcta gttagggctg ccagcctagg gctttgtgcc
     1741 tacacctcac taagcccatg gagaggtcac agatgggccg tgcacgggca gatgggcccc
     1801 aaaaaatctt ggcgaaggtc ggtaaagtgc taagctgttg tctgcactct ttcatcataa
     1861 agtcactttt ttccactg
//
