LOCUS       NM_032369               1685 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens hydrogen voltage gated channel 1 (HVCN1), transcript
            variant 2, mRNA.
ACCESSION   NM_032369
VERSION     NM_032369.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1685)
  AUTHORS   Liu,Y., Li,C., Freites,J.A., Tobias,D.J. and Voth,G.A.
  TITLE     Quantitative insights into the mechanism of proton conduction and
            selectivity for the human voltage-gated proton channel Hv1
  JOURNAL   Proc Natl Acad Sci U S A 121 (38), e2407479121 (2024)
   PUBMED   39259593
  REMARK    GeneRIF: Quantitative insights into the mechanism of proton
            conduction and selectivity for the human voltage-gated proton
            channel Hv1.
REFERENCE   2  (bases 1 to 1685)
  AUTHORS   Zhang,L., Wu,X., Cao,X., Rao,K. and Hong,L.
  TITLE     Trp207 regulation of voltage-dependent activation of human Hv1
            proton channel
  JOURNAL   J Biol Chem 300 (3), 105674 (2024)
   PUBMED   38272234
  REMARK    GeneRIF: Trp207 regulation of voltage-dependent activation of human
            Hv1 proton channel.
REFERENCE   3  (bases 1 to 1685)
  AUTHORS   Han,S., Applewhite,S., DeCata,J., Jones,S., Cummings,J. and Wang,S.
  TITLE     Arachidonic acid reverses cholesterol and zinc inhibition of human
            voltage-gated proton channels
  JOURNAL   J Biol Chem 299 (7), 104918 (2023)
   PUBMED   37315791
  REMARK    GeneRIF: Arachidonic acid reverses cholesterol and zinc inhibition
            of human voltage-gated proton channels.
REFERENCE   4  (bases 1 to 1685)
  AUTHORS   Chaves,G., Jardin,C., Franzen,A., Mahorivska,I., Musset,B. and
            Derst,C.
  TITLE     Proton channels in molluscs: A new bivalvian-specific minimal HV 4
            channel
  JOURNAL   FEBS J 290 (13), 3436-3447 (2023)
   PUBMED   36788452
REFERENCE   5  (bases 1 to 1685)
  AUTHORS   Zhao,R., Dai,H., Arias,R.J., De Blas,G.A., Orta,G., Pavarotti,M.A.,
            Shen,R., Perozo,E., Mayorga,L.S., Darszon,A. and Goldstein,S.A.N.
  TITLE     Direct activation of the proton channel by albumin leads to human
            sperm capacitation and sustained release of inflammatory mediators
            by neutrophils
  JOURNAL   Nat Commun 12 (1), 3855 (2021)
   PUBMED   34158477
  REMARK    GeneRIF: Direct activation of the proton channel by albumin leads
            to human sperm capacitation and sustained release of inflammatory
            mediators by neutrophils.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1685)
  AUTHORS   Musset,B., Cherny,V.V., Morgan,D., Okamura,Y., Ramsey,I.S.,
            Clapham,D.E. and DeCoursey,T.E.
  TITLE     Detailed comparison of expressed and native voltage-gated proton
            channel currents
  JOURNAL   J Physiol 586 (10), 2477-2486 (2008)
   PUBMED   18356202
REFERENCE   7  (bases 1 to 1685)
  AUTHORS   Suenaga,T., Arase,H., Yamasaki,S., Kohno,M., Yokosuka,T.,
            Takeuchi,A., Hattori,T. and Saito,T.
  TITLE     Cloning of B cell-specific membrane tetraspanning molecule BTS
            possessing B cell proliferation-inhibitory function
  JOURNAL   Eur J Immunol 37 (11), 3197-3207 (2007)
   PUBMED   17948262
  REMARK    GeneRIF: We cloned a new B cell-specific tetraspanning (BTS)
            membrane molecule
REFERENCE   8  (bases 1 to 1685)
  AUTHORS   Sasaki,M., Takagi,M. and Okamura,Y.
  TITLE     A voltage sensor-domain protein is a voltage-gated proton channel
  JOURNAL   Science 312 (5773), 589-592 (2006)
   PUBMED   16556803
REFERENCE   9  (bases 1 to 1685)
  AUTHORS   Ramsey,I.S., Moran,M.M., Chong,J.A. and Clapham,D.E.
  TITLE     A voltage-gated proton-selective channel lacking the pore domain
  JOURNAL   Nature 440 (7088), 1213-1216 (2006)
   PUBMED   16554753
  REMARK    GeneRIF: data presented here identify H(v)1 as a long-sought
            voltage-gated H+ channel and establish H(v)1 as the founding member
            of a family of mammalian VSD proteins
REFERENCE   10 (bases 1 to 1685)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP369986.1, BC009731.1 and DB310328.1.
            
            On Jun 2, 2019 this sequence version replaced NM_032369.3.
            
            Summary: This gene encodes a voltage-gated protein channel protein
            expressed more highly in certain cells of the immune system.
            Phagocytic cells produce superoxide anions which require this
            channel protein, and in B cells this same process facilitates
            antibody production. This same channel protein, however, can also
            regulate functions in other cells including spermatozoa. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Jan 2012].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.619921.1,
                                           SRR3476690.695979.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000242607.13/ ENSP00000242607.8
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 BP369986.1         43-49
            8-1592              BC009731.1         1-1585
            1593-1685           DB310328.1         352-444
FEATURES             Location/Qualifiers
     source          1..1685
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.11"
     gene            1..1685
                     /gene="HVCN1"
                     /gene_synonym="HV1; VSOP"
                     /note="hydrogen voltage gated channel 1"
                     /db_xref="GeneID:84329"
                     /db_xref="HGNC:HGNC:28240"
                     /db_xref="MIM:611227"
     exon            1..36
                     /gene="HVCN1"
                     /gene_synonym="HV1; VSOP"
                     /inference="alignment:Splign:2.1.0"
     exon            37..120
                     /gene="HVCN1"
                     /gene_synonym="HV1; VSOP"
                     /inference="alignment:Splign:2.1.0"
     exon            121..160
                     /gene="HVCN1"
                     /gene_synonym="HV1; VSOP"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..961
                     /gene="HVCN1"
                     /gene_synonym="HV1; VSOP"
                     /note="isoform 1 is encoded by transcript variant 2;
                     voltage sensor domain-only protein; voltage-gated hydrogen
                     channel 1"
                     /codon_start=1
                     /product="voltage-gated hydrogen channel 1 isoform 1"
                     /protein_id="NP_115745.2"
                     /db_xref="CCDS:CCDS31900.1"
                     /db_xref="GeneID:84329"
                     /db_xref="HGNC:HGNC:28240"
                     /db_xref="MIM:611227"
                     /translation="MATWDEKAVTRRAKVAPAERMSKFLRHFTVVGDDYHAWNINYKK
                     WENEEEEEEEEQPPPTPVSGEEGRAAAPDVAPAPGPAPRAPLDFRGMLRKLFSSHRFQ
                     VIIICLVVLDALLVLAELILDLKIIQPDKNNYAAMVFHYMSITILVFFMMEIIFKLFV
                     FRLEFFHHKFEILDAVVVVVSFILDIVLLFQEHQFEALGLLILLRLWRVARIINGIII
                     SVKTRSERQLLRLKQMNVQLAAKIQHLEFSCSEKEQEIERLNKLLRQHGLLGEVN"
     exon            161..445
                     /gene="HVCN1"
                     /gene_synonym="HV1; VSOP"
                     /inference="alignment:Splign:2.1.0"
     exon            446..550
                     /gene="HVCN1"
                     /gene_synonym="HV1; VSOP"
                     /inference="alignment:Splign:2.1.0"
     exon            551..782
                     /gene="HVCN1"
                     /gene_synonym="HV1; VSOP"
                     /inference="alignment:Splign:2.1.0"
     exon            783..895
                     /gene="HVCN1"
                     /gene_synonym="HV1; VSOP"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1685
                     /gene="HVCN1"
                     /gene_synonym="HV1; VSOP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1569..1574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HVCN1"
                     /gene_synonym="HV1; VSOP"
                     /note="hexamer: AATAAA"
     polyA_site      1592
                     /gene="HVCN1"
                     /gene_synonym="HV1; VSOP"
                     /note="major polyA site"
ORIGIN      
        1 agtcgcagcg gtgaccgcgg gcgggtgggg cgccgggtga agaaaccaag acgcagagag
       61 gccaagcccc ttgccttggg tcacacagcc aaaggaggca gagccagaac tcacaaccag
      121 atccagaggc aacagggaca tggccacctg ggacgaaaag gcagtcaccc gcagggccaa
      181 ggtggctccc gctgagagga tgagcaagtt cttaaggcac ttcacggtcg tgggagacga
      241 ctaccatgcc tggaacatca actacaagaa atgggagaat gaagaggagg aggaggagga
      301 ggagcagcca ccacccacac cagtctcagg cgaggaaggc agagctgcag cccctgacgt
      361 tgcccctgcc cctggccccg cacccagggc cccccttgac ttcaggggca tgttgaggaa
      421 actgttcagc tcccacaggt ttcaggtcat catcatctgc ttggtggttc tggatgccct
      481 cctggtgctt gctgagctca tcctggacct gaagatcatc cagcccgaca agaataacta
      541 tgctgccatg gtattccact acatgagcat caccatcttg gtctttttta tgatggagat
      601 catctttaaa ttatttgtct tccgcctgga gttctttcac cacaagtttg agatcctgga
      661 tgccgtcgtg gtggtggtct cattcatcct cgacattgtc ctcctgttcc aggagcacca
      721 gtttgaggct ctgggcctgc tgattctgct ccggctgtgg cgggtggccc ggatcatcaa
      781 tgggattatc atctcagtta agacacgttc agaacggcaa ctcttaaggt taaaacagat
      841 gaatgtacaa ttggccgcca agattcaaca ccttgagttc agctgctctg agaaggaaca
      901 agaaattgaa agacttaaca aactattgcg acagcatgga cttcttggtg aagtgaacta
      961 gacccggacc agctcccctc aaaaagaaga cactgtctca tgggcctgtg ctgtcacgag
     1021 aggaacagct gcccctcctg ggccgcttgg tgagaggttt ggtttgatac ctctgcctcc
     1081 ctcctgccag catggattct gggtggacac agccttgtgg aaggtccagt accaccaaga
     1141 gctgcccatc cactcccacc ccacactgta tcaaatgtat cacattttct catgttgaac
     1201 actttagcct taattgaaaa tgagcaacaa agctggacaa ttgctagttg tatataaaat
     1261 ttaatctcac cgaatgtaca gttttcaaat ttcacgtgta tattaaggaa ctgatgcatc
     1321 tgagcattct gaaagaaaga aaaagaagct actttagctg ccaccccatt ctagaaaagt
     1381 ctcttatttt caagctgttc taaatagctt cgtctcagtt tccccaaaag gggtacccag
     1441 gcccctcctc tgtgtgcccc agctgcatca gccagcttct aggtggctcc attgttttct
     1501 gccacctgac aacatttttc ctcaattact gtacaactac tgtataaaat aaaacaacta
     1561 ctgtataaaa taaactctct cttttccctg gaccctccta ctgtattctt tcctctgtgg
     1621 cacccatacc agcctgccag tcggagagca agctagctac agtgcctggt gcagaaatgg
     1681 caatt
//
