LOCUS       XM_047441739           14707 bp    mRNA    linear   PRI 26-AUG-2024
DEFINITION  PREDICTED: Homo sapiens HECT, UBA and WWE domain containing E3
            ubiquitin protein ligase 1 (HUWE1), transcript variant X36, mRNA.
ACCESSION   XM_047441739
VERSION     XM_047441739.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000023.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..14707
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
     gene            1..14707
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /note="HECT, UBA and WWE domain containing E3 ubiquitin
                     protein ligase 1; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 11 mRNAs, 349 ESTs, 3240
                     long SRA reads, 2 Proteins, and 100% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     11 samples with support for all annotated introns"
                     /db_xref="GeneID:10075"
                     /db_xref="HGNC:HGNC:30892"
                     /db_xref="MIM:300697"
     CDS             394..13494
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase HUWE1 isoform X18"
                     /protein_id="XP_047297695.1"
                     /db_xref="GeneID:10075"
                     /db_xref="HGNC:HGNC:30892"
                     /db_xref="MIM:300697"
                     /translation="MKVDRTKLKKTPTEAPADCRALIDKLKVCNDEQLLLELQQIKTW
                     NIGKCELYHWVDLLDRFDGILADAGQTVENMSWMLVCDRPEREQLKMLLLAVLNFTAL
                     LIEYSFSRHLYSSIEHLTTLLASSDMQVVLAVLNLLYVFSKRSNYITRLGSDKRTPLL
                     TRLQHLAESWGGKENGFGLAECCRDLHMMKYPPSATTLHFEFYADPGAEVKIEKRTTS
                     NTLHYIHIEQLDKISESPSEIMESLTKMYSIPKDKQMLLFTHIRLAHGFSNHRKRLQA
                     VQARLHAISILVFVSPFAVYSNALQESANSILYNGLIEELVDVLQITDKQLMEIKAAS
                     LRTLTSIVHLERTPKLSSIIDCTGTASYHGFLPVLVRNCIQAMIDPSMDPYPHQFATA
                     LFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLGDEQDQITFVTRAVRVVDLITNLD
                     MAAFQSHSGLSIFIYRLEHEVDLCRKECPFVIKPKIQRPNTTQEGEEMETDMDGVQCI
                     PQRAALLKSMLNFLKKAIQDPAFSDGIRHVMDGSLPTSLKHIISNAEYYGPSLFLLAT
                     EVVTVFVFQEPSLLSSLQDNGLTDVMLHALLIKDVPATREVLGSLPNVFSALCLNARG
                     LQSFVQCQPFERLFKVLLSPDYLPAMRRRRSSDPLGDTASNLGSAVDELMRHQPTLKT
                     DATTAIIKLLEEICNLGRDPKYICQKPSIQKADGTATAPPPRSNHAAEEASSEDEEEE
                     EVQAMQSFNSTQQNETEPNQQVVGTEERIPIPLMDYILNVMKFVESILSNNTTDDHCQ
                     EFVNQKGLLPLVTILGLPNLPIDFPTSAACQAVAGVCKSILTLSHEPKVLQEGLLQLD
                     SILSSLEPLHRPIESPGGSVLLRELACAGNVADATLSAQATPLLHALTAAHAYIMMFV
                     HTCRVGQSEIRSISVNQWGSQLGLSVLSKLSQLYCSLVWESTVLLSLCTPNSLPSGCE
                     FGQADMQKLVPKDEKAGTTQGGKRSDGEQDGAAGSMDASTQGLLEGIGLDGDTLAPME
                     TDEPTASDSKGKSKITPAMAARIKQIKPLLSASSRLGRALAELFGLLVKLCVGSPVRQ
                     RRSHHAASTTTAPTPAARSTASALTKLLTKGLSWQPPPYTPTPRFRLTFFICSVGFTS
                     PMLFDERKYPYHLMLQKFLCSGGHNALFETFNWALSMGGKVPVSEGLEHSDLPDGTGE
                     FLDAWLMLVEKMVNPTTVLESPHSLPAKLPGGVQNFPQFSALRFLVVTQKAAFTCIKN
                     LWNRKPLKVYGGRMAESMLAILCHILRGEPVIRERLSKEKEGSRGEEDTGQEEGGSRR
                     EPQVNQQQLQQLMDMGFTREHAMEALLNTSTMEQATEYLLTHPPPIMGGVVRDLSMSE
                     EDQMMRAIAMSLGQDIPMDQRAESPEEVACRKEEEERKAREKQEEEEAKCLEKFQDAD
                     PLEQDELHTFTDTMLPGCFHLLDELPDTVYRVCDLIMTAIKRNGADYRDMILKQVVNQ
                     VWEAADVLIKAALPLTTSDTKTVSEWISQMATLPQASNLATRILLLTLLFEELKLPCA
                     WVVESSGILNVLIKLLEVVQPCLQAAKEQKEVQTPKWITPVLLLIDFYEKTAISSKRR
                     AQMTKYLQSNSNNWRWFDDRSGRWCSYSASNNSTIDSAWKSGETSVRFTAGRRRYTVQ
                     FTTMVQVNEETGNRRPVMLTLLRVPRLNKNSKNSNGQELEKTLEESKEMDIKRKENKG
                     NDTPLALESTNTEKETSLEETKIGEILIQGLTEDMVTVLIRACVSMLGVPVDPDTLHA
                     TLRLCLRLTRDHKYAMMFAELKSTRMILNLTQSSGFNGFTPLVTLLLRHIIEDPCTLR
                     HTMEKVVRSAATSGAGSTTSGVVSGSLGSREINYILRVLGPAACRNPDIFTEVANCCI
                     RIALPAPRGSGTASDDEFENLRIKGPNAVQLVKTTPLKPSPLPVIPDTIKEVIYDMLN
                     ALAAYHAPEEADKSDPKPGVMTQEVGQLLQDMGDDVYQQYRSLTRQSSDFDTQSGFSI
                     NSQVFAADGASTETSASGTSQGEASTPEESRDGKKDKEGDRASEEGKQKGKGSKPLMP
                     TSTILRLLAELVRSYVGIATLIANYSYTVGQSELIKEDCSVLAFVLDHLLPHTQNAED
                     KDTPALARLFLASLAAAGSGTDAQVALVNEVKAALGRALAMAESTEKHARLQAVMCII
                     STIMESCPSTSSFYSSATAKTQHNGMNNIIRLFLKKGLVNDLARVPHSLDLSSPNMAN
                     TVNAALKPLETLSRIVNQPSSLFGSKSASSKNKSEQDAQGASQDSSSNQQDPGEPGEA
                     EVQEEDHDVTQTEVADGDIMDGEAETDSVVIAGQPEVLSSQEMQVENELEDLIDELLE
                     RDGGSGNSTIIVSRSGEDESQEDVLMDEAPSNLSQASTLQANREDSMNILDPEDEEEH
                     TQEEDSSGSNEDEDDSQDEEEEEEEDEEDDQEDDEGEEGDEDDDDDGSEMELDEDYPD
                     MNASPLVRFERFDREDDLIIEFDNMFSSATDIPPSPGNIPTTHPLMVRHADHSSLTLG
                     SGSSTTRLTQGIGRSQRTLRQLTANTGHTIHVHYPGNRQPNPPLILQRLLGPSAAADI
                     LQLSSSLPLQSRGRARLLVGNDDVHIIARSDDELLDDFFHDQSTATSQAGTLSSIPTA
                     LTRWTEECKVLDAESMHDCVSVVKVSIVNHLEFLRDEELEERREKRRKQLAEEETKIT
                     DKGKEDKENRDQSAQCTASKSNDSTEQNLSDGTPMPDSYPTTPSSTDAATSESKETLG
                     TLQSSQQQPTLPTPPALGEVPQELQSPAGEGGSSTQLLMPVEPEELGPTRPSGEAETT
                     QMELSPAPTITSLSPERAEDSDALTAVSSQLEGSPMDTSSLASCTLEEAVGDTSAAGS
                     SEQPRAGSSTPGDAPPAVAEVQGRSDGSGESAQPPEDSSPPASSESSSTRDSAVAISG
                     ADSRGILEEPLPSTSSEEEDPLAGISLPEGVDPSFLAALPDDIRREVLQNQLGIRPPT
                     RTAPSTNSSAPAVVGNPGVTEVSPEFLAALPPAIQEEVLAQQRAEQQRRELAQNASSD
                     TPMDPVTFIQTLPSDLRRSVLEDMEDSVLAVMPPDIAAEAQALRREQEARQRQLMHER
                     LFGHSSTSALSAILRSPAFTSRLSGNRGVQYTRLAVQRGGTFQMGGSSSHNRPSGSNV
                     DTLLRLRGRLLLDHEALSCLLVLLFVDEPKLNTSRLHRVLRNLCYHAQTRHWVIRSLL
                     SILQRSSESELCIETPKLTTSEEKGKKSSKSCGSSSHENRPLDLLHKMESKSSNQLSW
                     LSVSMDAALGCRTNIFQIQRSGGRKHTEKHASGGSTVHIHPQAAPVVCRHVLDTLIQL
                     AKVFPSHFTQQRTKETNCESDRERGNKACSPCSSQSSSSGICTDFWDLLVKLDNMNVS
                     RKGKNSVKSVPVSAGGEGETSPYSLEASPLGQLMNMLSHPVIRRSSLLTEKLLRLLSL
                     ISIALPENKVSEAQANSGSGASSTTTATSTTSTTTTTAASTTPTPPTAPTPVTSAPAL
                     VAATAISTIVVAASTTVTTPTTATTTVSISPTTKGSKSPAKVSDGGSSSTDFKMVSSG
                     LTENQLQLSVEVLTSHSCSEEGLEDAANVLLQLSRGDSGTRDTVLKLLLNGARHLGYT
                     LCKQIGTLLAELREYNLEQQRRAQCETLSPDGLPEEQPQTTKLKGKMQSRFDMAENVV
                     IVASQKRPLGGRELQLPSMSMLTSKTSTQKFFLRVLQVIIQLRDDTRRANKKAKQTGR
                     LGSSGLGSASSIQAAVRQLEAEADAIIQMSESSQSEASVRREESPMDVDQPSPSAQDT
                     QSIASDGTPQGEKEKEERPPELPLLSEQLSLDELWDMLGECLKELEESHDQHAVLVLQ
                     PAVEAFFLVHATERESKPPVRDTRESQLAHIKDEPPPLSPAPLTPATPSSLDPFFSRE
                     PSSMHISSSLPPDTQKFLRFAETHRTVLNQILRQSTTHLADGPFAVLVDYIRVLDFDV
                     KRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEE
                     GQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGR
                     IVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGY
                     DLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLE
                     GFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYHKYQSNSIQIQWFWRALR
                     SFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQ
                     LDLPAYESFEKLRHMLLLAIQECSEGFGLA"
ORIGIN      
        1 gactgagggc tagcgagggg agcagggctg gagcagggct ggagcagggc tggagcaggg
       61 ctgaagcagg gctgaagcag ggccgcggac cccgcacgct cctgcgggcc ccgcggagcc
      121 attgcggccg aggcctcggc aggcgccagc ggagagctag ccgcatcttc gggggcagcc
      181 cggcagctgc cggcggcgcg gcgagagagc ggctgacaga ggggatgcga ggtcctccag
      241 cagcctgacc tgagtgggtt agtgatccag agaaaccagc aggccaactt ggtcaggaag
      301 gttcgggaag ctgttggagc agtgtgggga atttcccacc aggatgagta tgattggctg
      361 tgattttaga tcgtaaagct gaaaattgaa atcatgaaag tagacaggac taaactgaag
      421 aagacaccta ctgaggctcc tgcagactgc agagccttaa tagacaaact caaagtttgt
      481 aatgatgagc aacttctctt ggaactgcag cagatcaaaa catggaacat tggaaagtgc
      541 gagttatatc actgggtgga cctgttggac cgcttcgatg gaatactggc agatgctgga
      601 cagacagtgg agaatatgtc atggatgctc gtatgtgata ggccagaaag agagcaactg
      661 aaaatgcttc tcttggctgt gttgaacttc acagccttgc tcattgagta cagcttttcc
      721 cggcatctgt acagttccat agagcatttg acaactttat tggcttcctc tgatatgcaa
      781 gtggtgctgg cagtcctcaa tctcctatat gtatttagca aaagatcaaa ctacatcact
      841 cgtctgggat ctgacaagag gaccccgctg ctaactcggc tacaacattt ggcagagagc
      901 tggggtggaa aggagaatgg ctttggactt gcagaatgtt gcagagactt gcatatgatg
      961 aaatatccac ccagtgcaac tacactacac tttgaattct atgcagatcc tggggccgag
     1021 gtcaaaattg agaaaaggac aactagtaac acactacatt atattcacat agagcaactt
     1081 gacaagattt cagaaagccc ttctgaaatc atggaatctc ttaccaaaat gtacagcatt
     1141 cctaaggata agcagatgct gttatttaca cacatacgac tggcccatgg cttttctaat
     1201 cacaggaagc gattgcaggc agttcaggcc agactgcatg caatatctat attagtgttt
     1261 gtttctcctt ttgcagtgta ttccaatgcc ttgcaggaat cagcaaacag tatcttgtat
     1321 aatggcttga tagaggagtt ggtagatgtc cttcagataa cggataagca gcttatggag
     1381 attaaagcag cttctttacg aacattaaca tcaattgtcc acttggagag aactcccaaa
     1441 ctcagcagta ttattgactg tactggaact gcctcctacc atggattttt gccagtgctt
     1501 gtaaggaact gtatccaggc catgattgat ccttccatgg atccataccc tcaccagttt
     1561 gccactgctc tcttctcttt tttataccat ctggccagct acgatgctgg tggtgaagcc
     1621 ttggtctcct gtggaatgat ggaagcctta ttgaaggtca taaagtttct tggcgatgaa
     1681 caggaccaga taacatttgt caccagagcc gtcagagtgg ttgaccttat caccaacctg
     1741 gatatggcag cttttcaatc ccatagtgga ctttctatct tcatttatag acttgagcat
     1801 gaagtagatt tgtgccgaaa agaatgtccg tttgtgatca agccaaagat ccagagaccc
     1861 aatactacac aagaaggaga ggaaatggaa actgatatgg atggagtcca gtgtattcca
     1921 caacgagcag cacttctgaa atccatgttg aatttcctca agaaggccat ccaagaccct
     1981 gctttctcag atggcatacg acatgtgatg gatggttctc tgcctacctc cctgaaacac
     2041 atcatcagca atgcagaata ctatggccca tcactcttcc tcctagctac tgaagtggtg
     2101 actgtgtttg tatttcaaga accatcactg ctctcctcac tccaggacaa tggattgaca
     2161 gatgtcatgc tgcatgcact gcttatcaaa gatgttcctg ctacccgtga agtccttggc
     2221 tccctcccaa atgtattcag tgcactctgt ttgaatgccc gaggtcttca gtcttttgtt
     2281 cagtgtcagc cttttgaacg cctcttcaaa gttcttctgt ctccagatta cctcccagcc
     2341 atgcggagga ggagaagttc tgatcccctt ggggatactg catccaacct ggggagtgct
     2401 gtcgatgagc tcatgagaca tcagcccacc cttaaaacag atgcaacgac tgccatcatc
     2461 aagttacttg aagaaatctg taatcttgga agggacccca aatacatctg tcagaagcca
     2521 tcaatccaga aggcagatgg cactgccact gctcctcccc caaggtctaa tcatgccgca
     2581 gaagaagcct ctagtgagga tgaggaggaa gaggaagtac aggccatgca gagctttaat
     2641 tctacccagc aaaatgaaac tgagcctaat cagcaggttg ttggtacaga ggaacgtatt
     2701 cctattcccc tcatggatta catccttaat gtgatgaaat ttgtggaatc tattctgagc
     2761 aacaatacaa cagatgacca ctgccaggaa tttgtgaatc agaaaggact gttgcctttg
     2821 gttaccattt tgggtcttcc caatctgccc attgactttc ccacatctgc tgcctgtcag
     2881 gctgttgcag gtgtctgcaa atccatattg acactgtcac atgaacccaa agtccttcaa
     2941 gagggtctcc ttcagttgga ctccatcctc tcctccctgg agcccttaca ccgccccatt
     3001 gaatcccctg ggggctcagt gttgttgcga gaactggctt gcgcaggcaa tgttgctgat
     3061 gctaccctct cagcccaggc cacacctctg ctgcatgcac tcactgctgc ccatgcctac
     3121 atcatgatgt ttgttcatac ttgcagagtt ggacagagtg aaattcgttc catctccgta
     3181 aaccagtggg gctctcaatt gggtctgagt gttttgagca agctgagcca gttatactgt
     3241 tccctggtgt gggaaagcac tgtcctcctc tctctgtgta ccccaaacag cctaccatct
     3301 gggtgtgaat ttggccaggc agatatgcag aaactggttc caaaggatga gaaggcaggt
     3361 acgacccagg gcggaaaaag atcagatggg gaacaggatg gagcagctgg aagtatggat
     3421 gcttctaccc agggcttatt agaaggcatt gggctagatg gtgacacatt ggctcccatg
     3481 gagacagatg aacctactgc ttcagactct aagggcaaat ctaaaatcac accagcaatg
     3541 gctgccagaa ttaagcaaat caagcctttg ttatcagctt cctccagatt aggccgagca
     3601 cttgctgagc tatttggact tcttgttaaa ctttgtgtgg gatctcctgt ccgccagaga
     3661 aggagccatc atgctgccag caccactaca gcaccgacac ctgccgcgcg atcaacagcc
     3721 tcagctctca ctaagctctt gactaagggg ttatcttggc agcccccacc atatacacct
     3781 actccccgat tcaggctgac attcttcatc tgttcagttg gtttcacatc cccaatgctg
     3841 tttgatgaga ggaagtatcc ctaccacctc atgctgcaaa aatttctctg ctccggaggc
     3901 cacaatgctc tttttgaaac tttcaactgg gctctgtcca tgggaggtaa agttcctgtt
     3961 tctgagggat tggaacactc agacttgcct gatggcacag gagaattcct agatgcctgg
     4021 cttatgctgg tggagaagat ggtgaatccc accacggtgc ttgaatctcc acattcgctg
     4081 cctgccaaat tgcctggagg tgtccagaac tttccccagt tcagtgcact gcgcttcctt
     4141 gtggtaactc agaaagcagc ctttacttgc atcaaaaact tatggaaccg gaaacccctg
     4201 aaggtatatg gtggacgaat ggctgaatcg atgctggcca ttctatgcca catcctccga
     4261 ggagaacctg tgattcgaga gagactaagc aaggagaagg aggggtctcg aggagaagag
     4321 gatacagggc aagaggaagg tggctcccgc cgggaacctc aagtcaacca gcaacaactg
     4381 caacagctca tggacatggg cttcacaagg gaacatgcaa tggaggcact gttgaacacc
     4441 agcaccatgg agcaggccac agagtacctt ttaacccacc ctcctccaat catgggagga
     4501 gttgttcggg atctcagcat gtctgaagag gaccagatga tgagagcaat tgctatgtct
     4561 ctgggacagg atattccaat ggatcaaagg gcagagtcac ctgaggaagt tgcttgccgg
     4621 aaggaggaag aggaacggaa agctcgggaa aagcaggagg aggaagaggc taaatgtcta
     4681 gagaagttcc aggatgctga cccgttggaa caagatgagc tccacacttt cacagatact
     4741 atgttgccag gctgcttcca ccttcttgat gagctgccag acacagtata ccgtgtgtgt
     4801 gacctgatca tgacagcaat caaacgtaat ggagcagatt atcgtgacat gattctgaag
     4861 caagtagtca atcaggtgtg ggaagctgct gatgtattga tcaaagctgc tcttcccctg
     4921 acaacaagtg acacaaaaac cgtgtcagag tggataagtc agatggccac actgccccag
     4981 gcctccaatt tggctactag aatcttgctt ttaacgctac tttttgagga gttgaagcta
     5041 ccttgtgctt gggtggttga atcaagtggc atccttaatg tcctaatcaa actcttggaa
     5101 gtggttcagc cctgcctcca ggcagccaag gagcagaagg aagtccagac cccaaagtgg
     5161 atcacaccag tgttgctcct gattgatttc tatgaaaaga cagccatctc ctcaaaaagg
     5221 agagcccaga tgactaagta cctgcaatcc aacagcaaca actggcgctg gtttgatgat
     5281 cgctctgggc gttggtgtag ttacagtgca agcaacaata gcactattga ttctgcctgg
     5341 aaatctggag agacaagcgt gcgattcact gcaggccgaa gaagatacac ggtccaattc
     5401 actacaatgg tgcaggttaa tgaggaaaca gggaaccgac gccctgtgat gctgactctc
     5461 ctcagggtac ctcggctgaa taaaaattca aaaaacagca atggacagga actagagaag
     5521 acgctggaag aaagcaaaga aatggatatc aaacgtaaag aaaataaagg caatgatacc
     5581 cctttggccc tagagagtac aaacactgaa aaggagacaa gcctggagga aacaaaaatc
     5641 ggggagatcc tgatccaggg cttgacagaa gatatggtga ctgttttaat ccgggcctgc
     5701 gtgagcatgc tgggagtccc tgtggaccca gatactttgc atgccaccct tcgtctctgt
     5761 ctgaggctca cccgggacca caaatatgcc atgatgtttg cagaactgaa gagtacccgc
     5821 atgatcttga atttgaccca gagctcaggc ttcaatgggt ttactcccct ggtcaccctt
     5881 ctcttaagac acatcattga ggacccctgt acccttcgtc ataccatgga aaaggttgtt
     5941 cgctcagcag ctacaagtgg agctggtagc actacctctg gtgttgtgtc tggcagcctc
     6001 ggctctcggg agatcaacta catccttcgt gtccttgggc cagccgcatg ccgcaatcca
     6061 gacatattca cagaagtggc caactgctgt atccgcatcg cccttcctgc ccctcgaggc
     6121 tcaggaactg cttcagatga tgaatttgag aatcttagaa ttaaaggccc taatgctgta
     6181 cagctggtga agaccacccc tttgaagccc tcacctctgc ctgtcatccc tgatactatc
     6241 aaggaagtga tctatgatat gctgaatgct ctggctgcat accatgctcc agaggaagca
     6301 gataaatctg atcctaaacc tggggttatg acccaagagg ttggccagct cctgcaagac
     6361 atgggtgatg atgtatacca gcagtaccgg tcacttacgc gtcagagcag tgactttgat
     6421 acgcagtcag gtttttccat taatagtcag gtctttgctg cagatggtgc ctccactgag
     6481 acttccgcat ctgggacctc ccaaggagag gcttcaactc cagaggagtc tcgagatggg
     6541 aagaaagata aagaagggga ccgggcctct gaggaaggca aacagaaagg caagggcagc
     6601 aaacctttaa tgcctacctc cactatcctt cgtcttctgg cagagttggt gaggtcctat
     6661 gttggtattg ctaccctgat tgccaactac agctacactg tgggccagtc tgaactgatc
     6721 aaagaggact gcagtgtgct agcttttgtt ctggaccacc tgctcccaca tacccagaat
     6781 gcagaagaca aggacacccc tgccttggcc cgcctgttcc tcgcaagcct ggctgctgca
     6841 gggagtggca cagatgccca ggtggcccta gtgaatgaag taaaagcagc ccttggacgg
     6901 gcactggcta tggctgagag tacagagaaa catgccaggc ttcaggcagt gatgtgtatc
     6961 atcagtacta tcatggagtc ctgcccctcc acctccagct tctacagcag tgccacagcg
     7021 aagacccagc acaatggcat gaacaacatc attcggcttt tcctgaagaa gggactggtt
     7081 aatgacctgg ccagagtacc tcacagctta gacctgtcca gtcccaacat ggccaacaca
     7141 gtcaatgctg ctctgaagcc tttggaaaca ctttcccgga ttgtgaacca gcccagtagc
     7201 ctttttggca gcaagagtgc ttctagcaag aacaagtctg agcaggatgc ccaaggagcc
     7261 tctcaagatt ccagtagcaa ccagcaggac ccaggcgagc ctggggaagc agaagtgcag
     7321 gaggaggatc atgatgtcac tcagacagag gtggcagatg gggatatcat ggatggggag
     7381 gctgaaaccg actcagtggt gattgctggg cagcctgagg tgctcagttc acaagagatg
     7441 caggttgaga atgagctgga ggacctgata gatgagttgc ttgagaggga tggcggatct
     7501 gggaacagta caattatagt gagcagaagt ggagaggatg aatcacaaga ggacgtgctg
     7561 atggatgaag ctccttccaa cctcagccaa gcttccacct tgcaggccaa ccgagaagat
     7621 tccatgaata tcctggaccc tgaggatgag gaggagcaca ctcaggaaga ggacagcagt
     7681 ggcagtaacg aggatgagga tgatagtcag gatgaagagg aggaggagga ggaagatgag
     7741 gaagatgatc aggaggatga tgaaggtgaa gagggagatg aagacgatga cgacgatggc
     7801 tctgagatgg aattggatga ggattatcct gatatgaacg cttctccctt ggtccgattt
     7861 gagcgctttg accgggagga tgatctcatc attgagtttg acaacatgtt ctccagtgct
     7921 acagacatcc ccccatcccc aggaaatatc cctaccaccc atccactgat ggtgcgccat
     7981 gcagaccaca gttctctgac actgggcagt ggctcttcaa caactcgtct cacccagggc
     8041 atcgggcgca gtcagaggac cctaaggcag ctgacggcca atactggcca caccattcat
     8101 gttcactacc ctgggaatcg ccagcccaac cctcctctta tactgcagag gttgcttggt
     8161 ccctcagctg ctgctgacat ccttcagctg agcagcagcc ttcccctaca aagccggggt
     8221 cgggcccgcc tcctggtagg caacgatgac gtccacatca tcgcccgttc tgatgatgag
     8281 ctgctggatg actttttcca tgatcagagc acagctacca gccaagcagg aaccctgtcc
     8341 agcatcccca cagccctgac ccgctggaca gaagaatgca aagttctcga tgctgagagc
     8401 atgcatgact gtgtttcagt ggttaaagtg tccattgtca atcacctgga attcctgagg
     8461 gatgaggagc tggaagaaag gcgagagaag cgcaggaaac aactggctga ggaagaaaca
     8521 aagataactg ataaaggcaa agaagataag gagaacaggg atcagagtgc acagtgtact
     8581 gcatctaagt caaatgactc cactgaacag aatctctcag atgggacgcc tatgcctgac
     8641 agctacccaa caaccccatc ttcaactgat gcagctacat ctgagtccaa ggagaccctt
     8701 ggcactctgc aatcctcaca acagcaacca acactcccaa ccccaccagc tttgggagag
     8761 gttcctcagg agctgcagtc tccagctgga gaagggggca gctctacaca gctattgatg
     8821 cctgtagagc cagaggaatt gggtcccaca aggccaagtg gggaagcaga aacaactcag
     8881 atggagttat ccccagctcc cactataacc tcactttccc cagagagagc tgaggattct
     8941 gatgcactga cggctgtcag cagtcagcta gaaggctctc ctatggatac aagcagcctg
     9001 gcttcctgta ccttagagga ggctgtgggt gacacttcag cagctggcag ttctgagcag
     9061 cccagagcag gcagctccac tcctggggat gccccaccag ctgtggcgga agtgcaaggc
     9121 aggagtgatg ggtcagggga atctgcccag ccacctgagg acagctcccc acctgcatcc
     9181 tctgagagct cttccaccag agattctgcc gtggccattt ctggagcaga ttcccgagga
     9241 atcctagaag agccgttgcc ttcaacaagc agtgaagaag aagatcccct tgcgggtatc
     9301 agtctccctg aaggtgtgga cccctctttt ctggctgccc tgcctgatga catccgtcgg
     9361 gaagttctac agaaccagct aggcattcgt ccaccaaccc ggactgcccc ctccacaaat
     9421 agctcagcgc ctgcagtggt ggggaatcct ggtgtgactg aagtgagccc tgagtttctg
     9481 gctgccctgc ctccagccat tcaggaggaa gtactggcac agcagagagc tgagcagcag
     9541 cgacgagaac tagcacagaa tgccagctca gacaccccta tggaccctgt gaccttcatc
     9601 cagactctgc cctcagacct gcgccgtagt gtcctagagg atatggagga cagtgtgtta
     9661 gctgtgatgc cacctgacat tgcagctgag gctcaagccc tgagacgaga gcaagaagcc
     9721 cggcagcgac agctcatgca tgagcgtctg tttgggcaca gtagcacctc cgcactctct
     9781 gctattctcc gaagcccggc tttcaccagt cgcttaagtg gcaaccgtgg ggtccagtat
     9841 actcgccttg ctgtgcagag aggtggcacc ttccagatgg ggggtagcag cagccataac
     9901 aggccttctg gcagtaatgt agatactctc ctccgcctcc gaggacggct ccttctggac
     9961 cacgaagccc tttcttgtct cttggtccta ctttttgtgg atgagccaaa gctcaatact
    10021 agccgtctac accgagtact gagaaatctc tgctaccatg cccagacccg ccactgggtc
    10081 atccgcagtc tgctctccat cttgcagcgc agcagtgaga gtgagctatg cattgaaaca
    10141 cccaaactca ctacaagtga ggaaaagggc aaaaagtcga gcaagagctg tgggtcaagt
    10201 agccatgaga accgtcccct ggacctgcta cacaagatgg agtcaaagag ctccaaccag
    10261 ctttcctggc tctcagtatc catggatgca gccctaggct gcaggactaa tatatttcag
    10321 atccagcgtt caggggggcg taaacatacc gagaagcatg caagcggtgg ctccaccgtc
    10381 cacatccatc cccaagctgc tcctgttgtc tgcagacacg ttttggatac actcattcaa
    10441 ttggccaagg tatttcccag ccacttcaca cagcagcgga ccaaagaaac aaactgtgag
    10501 agtgatcggg aaaggggcaa taaggcctgt agcccatgct cctcacagtc ctccagcagt
    10561 ggcatttgca cagacttctg ggacttattg gtaaaactgg acaacatgaa tgtcagccgg
    10621 aaaggcaaga actccgtgaa gtcagtgcca gtgagcgctg gcggtgaggg ggaaacctct
    10681 ccatacagcc tcgaggcctc tccactgggg cagctcatga acatgttgtc acacccagtc
    10741 atccgccgga gctctctctt aactgagaaa ctcctcagac tcctttctct catctcaatt
    10801 gctctcccag aaaacaaggt gtcagaagca caggctaatt ctggcagcgg tgcttcctcc
    10861 accaccactg ccacctcaac cacatctacc accaccacca ctgccgcctc caccacgccc
    10921 acacccccta ctgcacccac ccctgtcact tctgctccag ccctggttgc tgccacggct
    10981 atttccacca ttgtcgtagc tgcttcgacc acagtgacta cccccacgac tgctaccact
    11041 actgtttcaa tttctcccac tactaagggc agcaaatctc cagcgaaggt gagtgatggg
    11101 ggcagcagca gtacagactt taagatggtg tcctctggcc tcactgaaaa ccagctacag
    11161 ctctctgtag aggtgttgac atcccactct tgttctgagg aaggcttaga ggatgcagcc
    11221 aacgtactac tgcagctctc ccggggggac tctgggaccc gggacactgt tctcaagctg
    11281 ctactgaatg gagcccgcca tctgggttat accctttgta aacaaatagg taccctgctg
    11341 gccgagctgc gggaatacaa cctcgagcag cagcggcgag cccaatgtga aaccctctct
    11401 cctgatggcc tgcctgagga gcagccacag accaccaagc tgaagggcaa aatgcagagc
    11461 aggtttgaca tggctgagaa tgtggtaatt gtggcatctc agaagcgacc tttgggtggc
    11521 cgggagctcc agctgccttc tatgtccatg ttgacatcca agacatctac ccagaagttc
    11581 ttcttgaggg tactacaggt catcatccag ctccgggacg acacgcgccg ggctaacaag
    11641 aaagccaagc agacaggcag gctaggttcc tccggtttag gctcagctag cagcatccag
    11701 gcagctgttc ggcagctgga ggctgaggct gatgccatta tacaaatgtc ggagtctagc
    11761 cagtcagagg cgtctgtccg gagggaggaa tcacccatgg atgtggacca gccatctccc
    11821 agtgctcaag atactcaatc cattgcctcc gatggaaccc cacaggggga gaaggaaaag
    11881 gaagaaagac cacctgagtt acccctgctc agcgagcagc tgagtttgga cgagctgtgg
    11941 gacatgcttg gggagtgtct aaaggaacta gaggaatccc atgaccagca tgcggtgcta
    12001 gtgctacagc ctgctgtcga ggccttcttt ctggtccatg ccacagagcg ggagagcaag
    12061 cctcctgtcc gagacacccg tgagagccag ctggcacaca tcaaggacga gcctcctcca
    12121 ctctcccctg cccccttaac cccagccacg ccttcctccc ttgacccatt cttctcccgg
    12181 gagccctcat ctatgcacat ctcctcaagc ctgccccctg acacacagaa gttccttcgc
    12241 tttgcagaga ctcaccgcac tgtgttaaac cagatcctac ggcagtccac gacccacctt
    12301 gctgatgggc cttttgctgt cctggtagac tacattcgtg tcctcgactt tgatgtcaag
    12361 cgcaaatatt tccgccaaga gctggagcgt ttagatgagg ggctccggaa agaagacatg
    12421 gctgtgcatg tccgtcgtga ccatgtgttt gaagactcct atcgtgagct gcatcgcaaa
    12481 tcccccgaag aaatgaagaa tcgattgtat atagtatttg aaggagaaga agggcaggat
    12541 gctggtgggc tcctgcggga gtggtatatg atcatctctc gagagatgtt taaccctatg
    12601 tatgccttgt tccgtacctc acctggtgat cgagtcacct acaccatcaa tccatcttcc
    12661 cactgcaacc ccaaccacct cagctacttc aagtttgtcg gacgcattgt ggccaaagct
    12721 gtatatgaca accgtcttct ggagtgctac tttactcgat ccttttacaa acacatcttg
    12781 ggcaagtcag tcagatatac agatatggag agtgaagatt accacttcta ccaaggtctg
    12841 gtttatctgc tggaaaatga tgtctccaca ctaggctatg acctcacctt cagcactgag
    12901 gtccaagagt ttggagtttg tgaagttcgt gacctcaaac ccaatggggc caacatcttg
    12961 gtaacagagg agaataagaa ggagtatgta cacctggtat gccagatgag aatgacagga
    13021 gccatccgca agcagttggc ggctttctta gaaggcttct atgagatcat tccaaagcgc
    13081 ctcatttcca tcttcactga gcaggagtta gagctgctta tatcaggact gcccaccatt
    13141 gacatcgatg atctgaaatc caacactgaa taccacaagt accagtccaa ctctattcag
    13201 atccagtggt tctggagagc attgcgttct ttcgatcaag ctgaccgtgc caagttcctc
    13261 cagtttgtca caggtacttc caaggtaccc ctgcaaggct ttgctgccct cgaaggcatg
    13321 aatggcattc agaagtttca gatccatcga gatgacaggt ccacagatcg cctgccttca
    13381 gctcacacat gttttaatca gctggatctg cctgcctatg agagctttga gaagctccgc
    13441 cacatgctac tgttggctat ccaggagtgc tctgaaggct ttgggctggc ctaataaggc
    13501 cctgcccaac tccgtggggt tttttttacc attgttggac ctggggaggg gggagttaaa
    13561 aaaagaacca gaaagaaatt gtcaaaaacc aataaatgaa atccaccaac tcaccgtgtg
    13621 tgtcccagct gccccatctt ccccagcgca tacctgttcc tcttctcatt ctctccccgc
    13681 cgcctgtttc ctcaccttct ctcccctttc catgccgtcc atgatcccca ccccatgtgt
    13741 tttaaaaagg cagtagcctt tgcagggacc tgtctgtccc aactgtttga acagtgtgct
    13801 cctcagattc tgtgttcaga aggatttgct gcattgagac ttgaaacctt tggatagggg
    13861 aaaaaattat atatatatat atttttttgt tctgtttgca tttcttaatt tgtgcttgga
    13921 atgtgttgat gtgcacagct aatgattcaa tgcgagacaa gattggcgtc tgtgttgtgg
    13981 aggtttcaaa taaagagcac tcttcataac tcacttttca caatggagtt tttttcaaac
    14041 ttaaaaaaaa aaacaaaaaa ctcttaagca catgctaggc atctggagaa aagatggatt
    14101 ctccaggaaa ccatccctgc cctacccgct tgcccacctg cctccaccac tggtgcaact
    14161 tcctccttca gagtcagttt ctgcagtcag gagagatgag cagttcacca ggaattgggg
    14221 gtgggggcat ctgttttttt tttttagaat gggagctgca cttggggatg gtgatggtgt
    14281 tagagattgc agcccaggac aaagcatcac cttgctcaag gggaacaaac tgcagcaggt
    14341 tgtacaaaac attcagagag ctcacttgac ccaaccgagg gttttacttg gtgagccttt
    14401 ctagtagtct tgagtctggg gctcagtttt agatttttat ttcattaatg tttgtttatt
    14461 tctaataaat tttaataagc gagtaattta actaggtcgc cagaagacca ttatttttgt
    14521 ttgtctattt ttgttgtcgt cactccctct ctcgtcatct gtctgccagt ctgttcacag
    14581 atcaccttgt agtcccttgt ggtttttact ccatccagtg cttaaagctg atctaaggac
    14641 ttcgatggtt ccagccttca aagaaaaaat aatttaataa aaatttagtt agaaaaaata
    14701 accccaa
//
