LOCUS       XM_047441720           14982 bp    mRNA    linear   PRI 26-AUG-2024
DEFINITION  PREDICTED: Homo sapiens HECT, UBA and WWE domain containing E3
            ubiquitin protein ligase 1 (HUWE1), transcript variant X16, mRNA.
ACCESSION   XM_047441720
VERSION     XM_047441720.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000023.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..14982
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
     gene            1..14982
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /note="HECT, UBA and WWE domain containing E3 ubiquitin
                     protein ligase 1; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 9 mRNAs, 349 ESTs, 3057
                     long SRA reads, 1 Protein, and 100% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     69 samples with support for all annotated introns"
                     /db_xref="GeneID:10075"
                     /db_xref="HGNC:HGNC:30892"
                     /db_xref="MIM:300697"
     CDS             426..13769
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase HUWE1 isoform X7"
                     /protein_id="XP_047297676.1"
                     /db_xref="GeneID:10075"
                     /db_xref="HGNC:HGNC:30892"
                     /db_xref="MIM:300697"
                     /translation="MKVDRTKLKKTPTEAPADCRALIDKLKVCNDEQLLLELQQIKTW
                     NIGKCELYHWVDLLDRFDGILADAGQTVENMSWMLVCDRPEREQLKMLLLAVLNFTAL
                     LIEYSFSRHLYSSIEHLTTLLASSDMQVVLAVLNLLYVFSKRSNYITRLGSDKRTPLL
                     TRLQHLAESWGGKENGFGLAECCRDLHMMKYPPSATTLHFEFYADPGAEVKIEKRTTS
                     NTLHYIHIEQLDKISESPSEIMESLTKMYSIPKDKQMLLFTHIRLAHGFSNHRKRLQA
                     VQARLHAISILVFVSPFAVYSNALQESANSILYNGLIEELVDVLQITDKQLMEIKAAS
                     LRTLTSIVHLERTPKLSSIIDCTGTASYHGFLPVLVRNCIQAMIDPSMDPYPHQFATA
                     LFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLGDEQDQITFVTRAVRVVDLITNLD
                     MAAFQSHSGLSIFIYRLEHEVDLCRKECPFVIKPKIQRPNTTQEGEEMETDMDVADVA
                     MESSPGSSISMEHRLDVELRASGSSSSTNISSGPSPGPSPGPGTGPGPGPGPGPGPGP
                     GPGPGPGPGPGPGPGPGPRPGVQCIPQRAALLKSMLNFLKKAIQDPAFSDGIRHVMDG
                     SLPTSLKHIISNAEYYGPSLFLLATEVVTVFVFQEPSLLSSLQDNGLTDVMLHALLIK
                     DVPATREVLGSLPNVFSALCLNARGLQSFVQCQPFERLFKVLLSPDYLPAMRRRRSSD
                     PLGDTASNLGSAVDELMRHQPTLKTDATTAIIKLLEEICNLGRDPKYICQKPSIQKAD
                     GTATAPPPRSNHAAEEASSEDEEEEEVQAMQSFNSTQQNETEPNQQVVGTEERIPIPL
                     MDYILNVMKFVESILSNNTTDDHCQEFVNQKGLLPLVTILGLPNLPIDFPTSAACQAV
                     AGVCKSILTLSHEPKVLQEGLLQLDSILSSLEPLHRPIESPGGSVLLRELACAGNVAD
                     ATLSAQATPLLHALTAAHAYIMMFVHTCRVGQSEIRSISVNQWGSQLGLSVLSKLSQL
                     YCSLVWESTVLLSLCTPNSLPSGCEFGQADMQKLVPKDEKAGTTQGGKRSDGEQDGAA
                     GSMDASTQGLLEGIGLDGDTLAPMETDEPTASDSKGKSKITPAMAARIKQIKPLLSAS
                     SRLGRALAELFGLLVKLCVGSPVRQRRSHHAASTTTAPTPAARSTASALTKLLTKGLS
                     WQPPPYTPTPRFRLTFFICSVGFTSPMLFDERKYPYHLMLQKFLCSGGHNALFETFNW
                     ALSMGGKVPVSEGLEHSDLPDGTGEFLDAWLMLVEKMVNPTTVLESPHSLPAKLPGGV
                     QNFPQFSALRFLVVTQKAAFTCIKNLWNRKPLKVYGGRMAESMLAILCHILRGEPVIR
                     ERLSKEKEGSRGEEDTGQEEGGSRREPQVNQQQLQQLMDMGFTREHAMEALLNTSTME
                     QATEYLLTHPPPIMGGVVRDLSMSEEDQMMRAIAMSLGQDIPMDQRAESPEEVACRKE
                     EEERKAREKQEEEEAKCLEKFQDADPLEQDELHTFTDTMLPGCFHLLDELPDTVYRVC
                     DLIMTAIKRNGADYRDMILKQVVNQVWEAADVLIKAALPLTTSDTKTVSEWISQMATL
                     PQASNLATRILLLTLLFEELKLPCAWVVESSGILNVLIKLLEVVQPCLQAAKEQKEVQ
                     TPKWITPVLLLIDFYEKTAISSKRRAQMTKYLQSNSNNWRWFDDRSGRWCSYSASNNS
                     TIDSAWKSGETSVRFTAGRRRYTVQFTTMVQVNEETGNRRPVMLTLLRVPRLNKNSKN
                     SNGQELEKTLEESKEMDIKRKENKGNDTPLALESTNTEKETSLEETKIGEILIQGLTE
                     DMVTVLIRACVSMLGVPVDPDTLHATLRLCLRLTRDHKYAMMFAELKSTRMILNLTQS
                     SGFNGFTPLVTLLLRHIIEDPCTLRHTMEKVVRSAATSGAGSTTSGVVSGSLGSREIN
                     YILRVLGPAACRNPDIFTEVANCCIRIALPAPRGSGTASDDEFENLRIKGPNAVQLVK
                     TTPLKPSPLPVIPDTIKEVIYDMLNALAAYHAPEEDKSDPKPGVMTQEVGQLLQDMGD
                     DVYQQYRSLTRQSSDFDTQSGFSINSQVFAADGASTETSASGTSQGEASTPEESRDGK
                     KDKEGDRASEEGKQKGKGSKPLMPTSTILRLLAELVRSYVGIATLIANYSYTVGQSEL
                     IKEDCSVLAFVLDHLLPHTQNAEDKDTPALARLFLASLAAAGSGTDAQVALVNEVKAA
                     LGRALAMAESTEKHARLQAVMCIISTIMESCPSTSSFYSSATAKTQHNGMNNIIRLFL
                     KKGLVNDLARVPHSLDLSSPNMANTVNAALKPLETLSRIVNQPSSLFGSKSASSKNKS
                     EQDAQGASQDSSSNQQDPGEPGEAEVQEEDHDVTQTEVADGDIMDGEAETDSVVIAGQ
                     PEVLSSQEMQVENELEDLIDELLERDGGSGNSTIIVSRSGEDESQEDVLMDEAPSNLS
                     QASTLQANREDSMNILDPEDEEEHTQEEDSSGSNEDEDDSQDEEEEEEEDEEDDQEDD
                     EGEEGDEDDDDDGSEMELDEDYPDMNASPLVRFERFDREDDLIIEFDNMFSSATDIPP
                     SPGNIPTTHPLMVRHADHSSLTLGSGSSTTRLTQGIGRSQRTLRQLTANTGHTIHVHY
                     PGNRQPNPPLILQRLLGPSAAADILQLSSSLPLQSRGRARLLVGNDDVHIIARSDDEL
                     LDDFFHDQSTATSQAGTLSSIPTALTRWTEECKVLDAESMHDCVSVVKVSIVNHLEFL
                     RDEELEERREKRRKQLAEEETKITDKGKEDKENRDQSAQCTASKSNDSTEQNLSDGTP
                     MPDSYPTTPSSTDAATSESKETLGTLQSSQQQPTLPTPPALGEVPQELQSPAGEGGSS
                     TQLLMPVEPEELGPTRPSGEAETTQMELSPAPTITSLSPERAEDSDALTAVSSQLEGS
                     PMDTSSLASCTLEEAVGDTSAAGSSEQPRAGSSTPGDAPPAVAEVQGRSDGSGESAQP
                     PEDSSPPASSESSSTRDSAVAISGADSRGILEEPLPSTSSEEEDPLAGISLPEGVDPS
                     FLAALPDDIRREVLQNQLGIRPPTRTAPSTNSSAPAVVGNPGVTEVLAQQRAEQQRRE
                     LAQNASSDTPMDPVTFIQTLPSDLRRSVLEDMEDSVLAVMPPDIAAEAQALRREQEAR
                     QRQLMHERLFGHSSTSALSAILRSPAFTSRLSGNRGVQYTRLAVQRGGTFQMGGSSSH
                     NRPSGSNVDTLLRLRGRLLLDHEALSCLLVLLFVDEPKLNTSRLHRVLRNLCYHAQTR
                     HWVIRSLLSILQRSSESELCIETPKLTTSEEKGKKSSKSCGSSSHENRPLDLLHKMES
                     KSSNQLSWLSVSMDAALGCRTNIFQIQRSGGRKHTEKHASGGSTVHIHPQAAPVVCRH
                     VLDTLIQLAKVFPSHFTQQRTKETNCESDRERGNKACSPCSSQSSSSGICTDFWDLLV
                     KLDNMNVSRKGKNSVKSVPVSAGGEGETSPYSLEASPLGQLMNMLSHPVIRRSSLLTE
                     KLLRLLSLISIALPENKVSEAQANSGSGASSTTTATSTTSTTTTTAASTTPTPPTAPT
                     PVTSAPALVAATAISTIVVAASTTVTTPTTATTTVSISPTTKGSKSPAKVSDGGSSST
                     DFKMVSSGLTENQLQLSVEVLTSHSCSEEGLEDAANVLLQLSRGDSGTRDTVLKLLLN
                     GARHLGYTLCKQIGTLLAELREYNLEQQRRAQCETLSPDGLPEEQPQTTKLKGKMQSR
                     FDMAENVVIVASQKRPLGGRELQLPSMSMLTSKTSTQKFFLRVLQVIIQLRDDTRRAN
                     KKAKQTGRLGSSGLGSASSIQAAVRQLEAEADAIIQMVREGQRARRQQQAATSESSQS
                     EASVRREESPMDVDQPSPSAQDTQSIASDGTPQGEKEKEERPPELPLLSEQLSLDELW
                     DMLGECLKELEESHDQHAVLVLQPAVEAFFLVHATERESKPPVRDTRESQLAHIKDEP
                     PPLSPAPLTPATPSSLDPFFSREPSSMHISSSLPPDTQKFLRFAETHRTVLNQILRQS
                     TTHLADGPFAVLVDYIRVLDFDVKRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDSY
                     RELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRV
                     TYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDME
                     SEDYHFYQGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKE
                     YVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLK
                     SNTEYHKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQ
                     KFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGFGLA"
ORIGIN      
        1 atttgctttt cgcttcgcgt agggtgaagc tgtagctact tcggctttgg tgggagggag
       61 gaggggtctg gaaagggctg ggctcaggct tttcccgtcc ggtagaggtt ctcgcgggat
      121 cgcgcggagg cggcggtggc tcggttactg actgcagtag ccgcggaggc ggcggcaagg
      181 tcttcggctc gtgccgttct aagccggaga attctcgcgg gagcagggtt acgtcctcgt
      241 gggattcgtt ggcggtggct gaggtcctcc agcagcctga cctgagtggg ttagtgatcc
      301 agagaaacca gcaggccaac ttggtcagga aggttcggga agctgttgga gcagtgtggg
      361 gaatttccca ccaggatgag tatgattggc tgtgatttta gatcgtaaag ctgaaaattg
      421 aaatcatgaa agtagacagg actaaactga agaagacacc tactgaggct cctgcagact
      481 gcagagcctt aatagacaaa ctcaaagttt gtaatgatga gcaacttctc ttggaactgc
      541 agcagatcaa aacatggaac attggaaagt gcgagttata tcactgggtg gacctgttgg
      601 accgcttcga tggaatactg gcagatgctg gacagacagt ggagaatatg tcatggatgc
      661 tcgtatgtga taggccagaa agagagcaac tgaaaatgct tctcttggct gtgttgaact
      721 tcacagcctt gctcattgag tacagctttt cccggcatct gtacagttcc atagagcatt
      781 tgacaacttt attggcttcc tctgatatgc aagtggtgct ggcagtcctc aatctcctat
      841 atgtatttag caaaagatca aactacatca ctcgtctggg atctgacaag aggaccccgc
      901 tgctaactcg gctacaacat ttggcagaga gctggggtgg aaaggagaat ggctttggac
      961 ttgcagaatg ttgcagagac ttgcatatga tgaaatatcc acccagtgca actacactac
     1021 actttgaatt ctatgcagat cctggggccg aggtcaaaat tgagaaaagg acaactagta
     1081 acacactaca ttatattcac atagagcaac ttgacaagat ttcagaaagc ccttctgaaa
     1141 tcatggaatc tcttaccaaa atgtacagca ttcctaagga taagcagatg ctgttattta
     1201 cacacatacg actggcccat ggcttttcta atcacaggaa gcgattgcag gcagttcagg
     1261 ccagactgca tgcaatatct atattagtgt ttgtttctcc ttttgcagtg tattccaatg
     1321 ccttgcagga atcagcaaac agtatcttgt ataatggctt gatagaggag ttggtagatg
     1381 tccttcagat aacggataag cagcttatgg agattaaagc agcttcttta cgaacattaa
     1441 catcaattgt ccacttggag agaactccca aactcagcag tattattgac tgtactggaa
     1501 ctgcctccta ccatggattt ttgccagtgc ttgtaaggaa ctgtatccag gccatgattg
     1561 atccttccat ggatccatac cctcaccagt ttgccactgc tctcttctct tttttatacc
     1621 atctggccag ctacgatgct ggtggtgaag ccttggtctc ctgtggaatg atggaagcct
     1681 tattgaaggt cataaagttt cttggcgatg aacaggacca gataacattt gtcaccagag
     1741 ccgtcagagt ggttgacctt atcaccaacc tggatatggc agcttttcaa tcccatagtg
     1801 gactttctat cttcatttat agacttgagc atgaagtaga tttgtgccga aaagaatgtc
     1861 cgtttgtgat caagccaaag atccagagac ccaatactac acaagaagga gaggaaatgg
     1921 aaactgatat ggatgttgca gatgtggcta tggaaagcag tccaggctca tccatctcta
     1981 tggagcacag gctggatgtt gaattaaggg catcaggttc cagcagcagc actaacatct
     2041 cttctggccc cagccctggt cccagtcccg gccccggcac cggccctggc cccggccccg
     2101 gccccggccc cggccctggc cccggccccg gccccggtcc tggtcccggc cctggccccg
     2161 gccctggccc tggcccccgt cctggagtcc agtgtattcc acaacgagca gcacttctga
     2221 aatccatgtt gaatttcctc aagaaggcca tccaagaccc tgctttctca gatggcatac
     2281 gacatgtgat ggatggttct ctgcctacct ccctgaaaca catcatcagc aatgcagaat
     2341 actatggccc atcactcttc ctcctagcta ctgaagtggt gactgtgttt gtatttcaag
     2401 aaccatcact gctctcctca ctccaggaca atggattgac agatgtcatg ctgcatgcac
     2461 tgcttatcaa agatgttcct gctacccgtg aagtccttgg ctccctccca aatgtattca
     2521 gtgcactctg tttgaatgcc cgaggtcttc agtcttttgt tcagtgtcag ccttttgaac
     2581 gcctcttcaa agttcttctg tctccagatt acctcccagc catgcggagg aggagaagtt
     2641 ctgatcccct tggggatact gcatccaacc tggggagtgc tgtcgatgag ctcatgagac
     2701 atcagcccac ccttaaaaca gatgcaacga ctgccatcat caagttactt gaagaaatct
     2761 gtaatcttgg aagggacccc aaatacatct gtcagaagcc atcaatccag aaggcagatg
     2821 gcactgccac tgctcctccc ccaaggtcta atcatgccgc agaagaagcc tctagtgagg
     2881 atgaggagga agaggaagta caggccatgc agagctttaa ttctacccag caaaatgaaa
     2941 ctgagcctaa tcagcaggtt gttggtacag aggaacgtat tcctattccc ctcatggatt
     3001 acatccttaa tgtgatgaaa tttgtggaat ctattctgag caacaataca acagatgacc
     3061 actgccagga atttgtgaat cagaaaggac tgttgccttt ggttaccatt ttgggtcttc
     3121 ccaatctgcc cattgacttt cccacatctg ctgcctgtca ggctgttgca ggtgtctgca
     3181 aatccatatt gacactgtca catgaaccca aagtccttca agagggtctc cttcagttgg
     3241 actccatcct ctcctccctg gagcccttac accgccccat tgaatcccct gggggctcag
     3301 tgttgttgcg agaactggct tgcgcaggca atgttgctga tgctaccctc tcagcccagg
     3361 ccacacctct gctgcatgca ctcactgctg cccatgccta catcatgatg tttgttcata
     3421 cttgcagagt tggacagagt gaaattcgtt ccatctccgt aaaccagtgg ggctctcaat
     3481 tgggtctgag tgttttgagc aagctgagcc agttatactg ttccctggtg tgggaaagca
     3541 ctgtcctcct ctctctgtgt accccaaaca gcctaccatc tgggtgtgaa tttggccagg
     3601 cagatatgca gaaactggtt ccaaaggatg agaaggcagg tacgacccag ggcggaaaaa
     3661 gatcagatgg ggaacaggat ggagcagctg gaagtatgga tgcttctacc cagggcttat
     3721 tagaaggcat tgggctagat ggtgacacat tggctcccat ggagacagat gaacctactg
     3781 cttcagactc taagggcaaa tctaaaatca caccagcaat ggctgccaga attaagcaaa
     3841 tcaagccttt gttatcagct tcctccagat taggccgagc acttgctgag ctatttggac
     3901 ttcttgttaa actttgtgtg ggatctcctg tccgccagag aaggagccat catgctgcca
     3961 gcaccactac agcaccgaca cctgccgcgc gatcaacagc ctcagctctc actaagctct
     4021 tgactaaggg gttatcttgg cagcccccac catatacacc tactccccga ttcaggctga
     4081 cattcttcat ctgttcagtt ggtttcacat ccccaatgct gtttgatgag aggaagtatc
     4141 cctaccacct catgctgcaa aaatttctct gctccggagg ccacaatgct ctttttgaaa
     4201 ctttcaactg ggctctgtcc atgggaggta aagttcctgt ttctgaggga ttggaacact
     4261 cagacttgcc tgatggcaca ggagaattcc tagatgcctg gcttatgctg gtggagaaga
     4321 tggtgaatcc caccacggtg cttgaatctc cacattcgct gcctgccaaa ttgcctggag
     4381 gtgtccagaa ctttccccag ttcagtgcac tgcgcttcct tgtggtaact cagaaagcag
     4441 cctttacttg catcaaaaac ttatggaacc ggaaacccct gaaggtatat ggtggacgaa
     4501 tggctgaatc gatgctggcc attctatgcc acatcctccg aggagaacct gtgattcgag
     4561 agagactaag caaggagaag gaggggtctc gaggagaaga ggatacaggg caagaggaag
     4621 gtggctcccg ccgggaacct caagtcaacc agcaacaact gcaacagctc atggacatgg
     4681 gcttcacaag ggaacatgca atggaggcac tgttgaacac cagcaccatg gagcaggcca
     4741 cagagtacct tttaacccac cctcctccaa tcatgggagg agttgttcgg gatctcagca
     4801 tgtctgaaga ggaccagatg atgagagcaa ttgctatgtc tctgggacag gatattccaa
     4861 tggatcaaag ggcagagtca cctgaggaag ttgcttgccg gaaggaggaa gaggaacgga
     4921 aagctcggga aaagcaggag gaggaagagg ctaaatgtct agagaagttc caggatgctg
     4981 acccgttgga acaagatgag ctccacactt tcacagatac tatgttgcca ggctgcttcc
     5041 accttcttga tgagctgcca gacacagtat accgtgtgtg tgacctgatc atgacagcaa
     5101 tcaaacgtaa tggagcagat tatcgtgaca tgattctgaa gcaagtagtc aatcaggtgt
     5161 gggaagctgc tgatgtattg atcaaagctg ctcttcccct gacaacaagt gacacaaaaa
     5221 ccgtgtcaga gtggataagt cagatggcca cactgcccca ggcctccaat ttggctacta
     5281 gaatcttgct tttaacgcta ctttttgagg agttgaagct accttgtgct tgggtggttg
     5341 aatcaagtgg catccttaat gtcctaatca aactcttgga agtggttcag ccctgcctcc
     5401 aggcagccaa ggagcagaag gaagtccaga ccccaaagtg gatcacacca gtgttgctcc
     5461 tgattgattt ctatgaaaag acagccatct cctcaaaaag gagagcccag atgactaagt
     5521 acctgcaatc caacagcaac aactggcgct ggtttgatga tcgctctggg cgttggtgta
     5581 gttacagtgc aagcaacaat agcactattg attctgcctg gaaatctgga gagacaagcg
     5641 tgcgattcac tgcaggccga agaagataca cggtccaatt cactacaatg gtgcaggtta
     5701 atgaggaaac agggaaccga cgccctgtga tgctgactct cctcagggta cctcggctga
     5761 ataaaaattc aaaaaacagc aatggacagg aactagagaa gacgctggaa gaaagcaaag
     5821 aaatggatat caaacgtaaa gaaaataaag gcaatgatac ccctttggcc ctagagagta
     5881 caaacactga aaaggagaca agcctggagg aaacaaaaat cggggagatc ctgatccagg
     5941 gcttgacaga agatatggtg actgttttaa tccgggcctg cgtgagcatg ctgggagtcc
     6001 ctgtggaccc agatactttg catgccaccc ttcgtctctg tctgaggctc acccgggacc
     6061 acaaatatgc catgatgttt gcagaactga agagtacccg catgatcttg aatttgaccc
     6121 agagctcagg cttcaatggg tttactcccc tggtcaccct tctcttaaga cacatcattg
     6181 aggacccctg tacccttcgt cataccatgg aaaaggttgt tcgctcagca gctacaagtg
     6241 gagctggtag cactacctct ggtgttgtgt ctggcagcct cggctctcgg gagatcaact
     6301 acatccttcg tgtccttggg ccagccgcat gccgcaatcc agacatattc acagaagtgg
     6361 ccaactgctg tatccgcatc gcccttcctg cccctcgagg ctcaggaact gcttcagatg
     6421 atgaatttga gaatcttaga attaaaggcc ctaatgctgt acagctggtg aagaccaccc
     6481 ctttgaagcc ctcacctctg cctgtcatcc ctgatactat caaggaagtg atctatgata
     6541 tgctgaatgc tctggctgca taccatgctc cagaggaaga taaatctgat cctaaacctg
     6601 gggttatgac ccaagaggtt ggccagctcc tgcaagacat gggtgatgat gtataccagc
     6661 agtaccggtc acttacgcgt cagagcagtg actttgatac gcagtcaggt ttttccatta
     6721 atagtcaggt ctttgctgca gatggtgcct ccactgagac ttccgcatct gggacctccc
     6781 aaggagaggc ttcaactcca gaggagtctc gagatgggaa gaaagataaa gaaggggacc
     6841 gggcctctga ggaaggcaaa cagaaaggca agggcagcaa acctttaatg cctacctcca
     6901 ctatccttcg tcttctggca gagttggtga ggtcctatgt tggtattgct accctgattg
     6961 ccaactacag ctacactgtg ggccagtctg aactgatcaa agaggactgc agtgtgctag
     7021 cttttgttct ggaccacctg ctcccacata cccagaatgc agaagacaag gacacccctg
     7081 ccttggcccg cctgttcctc gcaagcctgg ctgctgcagg gagtggcaca gatgcccagg
     7141 tggccctagt gaatgaagta aaagcagccc ttggacgggc actggctatg gctgagagta
     7201 cagagaaaca tgccaggctt caggcagtga tgtgtatcat cagtactatc atggagtcct
     7261 gcccctccac ctccagcttc tacagcagtg ccacagcgaa gacccagcac aatggcatga
     7321 acaacatcat tcggcttttc ctgaagaagg gactggttaa tgacctggcc agagtacctc
     7381 acagcttaga cctgtccagt cccaacatgg ccaacacagt caatgctgct ctgaagcctt
     7441 tggaaacact ttcccggatt gtgaaccagc ccagtagcct ttttggcagc aagagtgctt
     7501 ctagcaagaa caagtctgag caggatgccc aaggagcctc tcaagattcc agtagcaacc
     7561 agcaggaccc aggcgagcct ggggaagcag aagtgcagga ggaggatcat gatgtcactc
     7621 agacagaggt ggcagatggg gatatcatgg atggggaggc tgaaaccgac tcagtggtga
     7681 ttgctgggca gcctgaggtg ctcagttcac aagagatgca ggttgagaat gagctggagg
     7741 acctgataga tgagttgctt gagagggatg gcggatctgg gaacagtaca attatagtga
     7801 gcagaagtgg agaggatgaa tcacaagagg acgtgctgat ggatgaagct ccttccaacc
     7861 tcagccaagc ttccaccttg caggccaacc gagaagattc catgaatatc ctggaccctg
     7921 aggatgagga ggagcacact caggaagagg acagcagtgg cagtaacgag gatgaggatg
     7981 atagtcagga tgaagaggag gaggaggagg aagatgagga agatgatcag gaggatgatg
     8041 aaggtgaaga gggagatgaa gacgatgacg acgatggctc tgagatggaa ttggatgagg
     8101 attatcctga tatgaacgct tctcccttgg tccgatttga gcgctttgac cgggaggatg
     8161 atctcatcat tgagtttgac aacatgttct ccagtgctac agacatcccc ccatccccag
     8221 gaaatatccc taccacccat ccactgatgg tgcgccatgc agaccacagt tctctgacac
     8281 tgggcagtgg ctcttcaaca actcgtctca cccagggcat cgggcgcagt cagaggaccc
     8341 taaggcagct gacggccaat actggccaca ccattcatgt tcactaccct gggaatcgcc
     8401 agcccaaccc tcctcttata ctgcagaggt tgcttggtcc ctcagctgct gctgacatcc
     8461 ttcagctgag cagcagcctt cccctacaaa gccggggtcg ggcccgcctc ctggtaggca
     8521 acgatgacgt ccacatcatc gcccgttctg atgatgagct gctggatgac tttttccatg
     8581 atcagagcac agctaccagc caagcaggaa ccctgtccag catccccaca gccctgaccc
     8641 gctggacaga agaatgcaaa gttctcgatg ctgagagcat gcatgactgt gtttcagtgg
     8701 ttaaagtgtc cattgtcaat cacctggaat tcctgaggga tgaggagctg gaagaaaggc
     8761 gagagaagcg caggaaacaa ctggctgagg aagaaacaaa gataactgat aaaggcaaag
     8821 aagataagga gaacagggat cagagtgcac agtgtactgc atctaagtca aatgactcca
     8881 ctgaacagaa tctctcagat gggacgccta tgcctgacag ctacccaaca accccatctt
     8941 caactgatgc agctacatct gagtccaagg agacccttgg cactctgcaa tcctcacaac
     9001 agcaaccaac actcccaacc ccaccagctt tgggagaggt tcctcaggag ctgcagtctc
     9061 cagctggaga agggggcagc tctacacagc tattgatgcc tgtagagcca gaggaattgg
     9121 gtcccacaag gccaagtggg gaagcagaaa caactcagat ggagttatcc ccagctccca
     9181 ctataacctc actttcccca gagagagctg aggattctga tgcactgacg gctgtcagca
     9241 gtcagctaga aggctctcct atggatacaa gcagcctggc ttcctgtacc ttagaggagg
     9301 ctgtgggtga cacttcagca gctggcagtt ctgagcagcc cagagcaggc agctccactc
     9361 ctggggatgc cccaccagct gtggcggaag tgcaaggcag gagtgatggg tcaggggaat
     9421 ctgcccagcc acctgaggac agctccccac ctgcatcctc tgagagctct tccaccagag
     9481 attctgccgt ggccatttct ggagcagatt cccgaggaat cctagaagag ccgttgcctt
     9541 caacaagcag tgaagaagaa gatccccttg cgggtatcag tctccctgaa ggtgtggacc
     9601 cctcttttct ggctgccctg cctgatgaca tccgtcggga agttctacag aaccagctag
     9661 gcattcgtcc accaacccgg actgccccct ccacaaatag ctcagcgcct gcagtggtgg
     9721 ggaatcctgg tgtgactgaa gtactggcac agcagagagc tgagcagcag cgacgagaac
     9781 tagcacagaa tgccagctca gacaccccta tggaccctgt gaccttcatc cagactctgc
     9841 cctcagacct gcgccgtagt gtcctagagg atatggagga cagtgtgtta gctgtgatgc
     9901 cacctgacat tgcagctgag gctcaagccc tgagacgaga gcaagaagcc cggcagcgac
     9961 agctcatgca tgagcgtctg tttgggcaca gtagcacctc cgcactctct gctattctcc
    10021 gaagcccggc tttcaccagt cgcttaagtg gcaaccgtgg ggtccagtat actcgccttg
    10081 ctgtgcagag aggtggcacc ttccagatgg ggggtagcag cagccataac aggccttctg
    10141 gcagtaatgt agatactctc ctccgcctcc gaggacggct ccttctggac cacgaagccc
    10201 tttcttgtct cttggtccta ctttttgtgg atgagccaaa gctcaatact agccgtctac
    10261 accgagtact gagaaatctc tgctaccatg cccagacccg ccactgggtc atccgcagtc
    10321 tgctctccat cttgcagcgc agcagtgaga gtgagctatg cattgaaaca cccaaactca
    10381 ctacaagtga ggaaaagggc aaaaagtcga gcaagagctg tgggtcaagt agccatgaga
    10441 accgtcccct ggacctgcta cacaagatgg agtcaaagag ctccaaccag ctttcctggc
    10501 tctcagtatc catggatgca gccctaggct gcaggactaa tatatttcag atccagcgtt
    10561 caggggggcg taaacatacc gagaagcatg caagcggtgg ctccaccgtc cacatccatc
    10621 cccaagctgc tcctgttgtc tgcagacacg ttttggatac actcattcaa ttggccaagg
    10681 tatttcccag ccacttcaca cagcagcgga ccaaagaaac aaactgtgag agtgatcggg
    10741 aaaggggcaa taaggcctgt agcccatgct cctcacagtc ctccagcagt ggcatttgca
    10801 cagacttctg ggacttattg gtaaaactgg acaacatgaa tgtcagccgg aaaggcaaga
    10861 actccgtgaa gtcagtgcca gtgagcgctg gcggtgaggg ggaaacctct ccatacagcc
    10921 tcgaggcctc tccactgggg cagctcatga acatgttgtc acacccagtc atccgccgga
    10981 gctctctctt aactgagaaa ctcctcagac tcctttctct catctcaatt gctctcccag
    11041 aaaacaaggt gtcagaagca caggctaatt ctggcagcgg tgcttcctcc accaccactg
    11101 ccacctcaac cacatctacc accaccacca ctgccgcctc caccacgccc acacccccta
    11161 ctgcacccac ccctgtcact tctgctccag ccctggttgc tgccacggct atttccacca
    11221 ttgtcgtagc tgcttcgacc acagtgacta cccccacgac tgctaccact actgtttcaa
    11281 tttctcccac tactaagggc agcaaatctc cagcgaaggt gagtgatggg ggcagcagca
    11341 gtacagactt taagatggtg tcctctggcc tcactgaaaa ccagctacag ctctctgtag
    11401 aggtgttgac atcccactct tgttctgagg aaggcttaga ggatgcagcc aacgtactac
    11461 tgcagctctc ccggggggac tctgggaccc gggacactgt tctcaagctg ctactgaatg
    11521 gagcccgcca tctgggttat accctttgta aacaaatagg taccctgctg gccgagctgc
    11581 gggaatacaa cctcgagcag cagcggcgag cccaatgtga aaccctctct cctgatggcc
    11641 tgcctgagga gcagccacag accaccaagc tgaagggcaa aatgcagagc aggtttgaca
    11701 tggctgagaa tgtggtaatt gtggcatctc agaagcgacc tttgggtggc cgggagctcc
    11761 agctgccttc tatgtccatg ttgacatcca agacatctac ccagaagttc ttcttgaggg
    11821 tactacaggt catcatccag ctccgggacg acacgcgccg ggctaacaag aaagccaagc
    11881 agacaggcag gctaggttcc tccggtttag gctcagctag cagcatccag gcagctgttc
    11941 ggcagctgga ggctgaggct gatgccatta tacaaatggt acgtgagggt caaagggcgc
    12001 ggagacagca acaagcagca acgtcggagt ctagccagtc agaggcgtct gtccggaggg
    12061 aggaatcacc catggatgtg gaccagccat ctcccagtgc tcaagatact caatccattg
    12121 cctccgatgg aaccccacag ggggagaagg aaaaggaaga aagaccacct gagttacccc
    12181 tgctcagcga gcagctgagt ttggacgagc tgtgggacat gcttggggag tgtctaaagg
    12241 aactagagga atcccatgac cagcatgcgg tgctagtgct acagcctgct gtcgaggcct
    12301 tctttctggt ccatgccaca gagcgggaga gcaagcctcc tgtccgagac acccgtgaga
    12361 gccagctggc acacatcaag gacgagcctc ctccactctc ccctgccccc ttaaccccag
    12421 ccacgccttc ctcccttgac ccattcttct cccgggagcc ctcatctatg cacatctcct
    12481 caagcctgcc ccctgacaca cagaagttcc ttcgctttgc agagactcac cgcactgtgt
    12541 taaaccagat cctacggcag tccacgaccc accttgctga tgggcctttt gctgtcctgg
    12601 tagactacat tcgtgtcctc gactttgatg tcaagcgcaa atatttccgc caagagctgg
    12661 agcgtttaga tgaggggctc cggaaagaag acatggctgt gcatgtccgt cgtgaccatg
    12721 tgtttgaaga ctcctatcgt gagctgcatc gcaaatcccc cgaagaaatg aagaatcgat
    12781 tgtatatagt atttgaagga gaagaagggc aggatgctgg tgggctcctg cgggagtggt
    12841 atatgatcat ctctcgagag atgtttaacc ctatgtatgc cttgttccgt acctcacctg
    12901 gtgatcgagt cacctacacc atcaatccat cttcccactg caaccccaac cacctcagct
    12961 acttcaagtt tgtcggacgc attgtggcca aagctgtata tgacaaccgt cttctggagt
    13021 gctactttac tcgatccttt tacaaacaca tcttgggcaa gtcagtcaga tatacagata
    13081 tggagagtga agattaccac ttctaccaag gtctggttta tctgctggaa aatgatgtct
    13141 ccacactagg ctatgacctc accttcagca ctgaggtcca agagtttgga gtttgtgaag
    13201 ttcgtgacct caaacccaat ggggccaaca tcttggtaac agaggagaat aagaaggagt
    13261 atgtacacct ggtatgccag atgagaatga caggagccat ccgcaagcag ttggcggctt
    13321 tcttagaagg cttctatgag atcattccaa agcgcctcat ttccatcttc actgagcagg
    13381 agttagagct gcttatatca ggactgccca ccattgacat cgatgatctg aaatccaaca
    13441 ctgaatacca caagtaccag tccaactcta ttcagatcca gtggttctgg agagcattgc
    13501 gttctttcga tcaagctgac cgtgccaagt tcctccagtt tgtcacaggt acttccaagg
    13561 tacccctgca aggctttgct gccctcgaag gcatgaatgg cattcagaag tttcagatcc
    13621 atcgagatga caggtccaca gatcgcctgc cttcagctca cacatgtttt aatcagctgg
    13681 atctgcctgc ctatgagagc tttgagaagc tccgccacat gctactgttg gctatccagg
    13741 agtgctctga aggctttggg ctggcctaat aaggccctgc ccaactccgt ggggtttttt
    13801 ttaccattgt tggacctggg gaggggggag ttaaaaaaag aaccagaaag aaattgtcaa
    13861 aaaccaataa atgaaatcca ccaactcacc gtgtgtgtcc cagctgcccc atcttcccca
    13921 gcgcatacct gttcctcttc tcattctctc cccgccgcct gtttcctcac cttctctccc
    13981 ctttccatgc cgtccatgat ccccacccca tgtgttttaa aaaggcagta gcctttgcag
    14041 ggacctgtct gtcccaactg tttgaacagt gtgctcctca gattctgtgt tcagaaggat
    14101 ttgctgcatt gagacttgaa acctttggat aggggaaaaa attatatata tatatatttt
    14161 tttgttctgt ttgcatttct taatttgtgc ttggaatgtg ttgatgtgca cagctaatga
    14221 ttcaatgcga gacaagattg gcgtctgtgt tgtggaggtt tcaaataaag agcactcttc
    14281 ataactcact tttcacaatg gagttttttt caaacttaaa aaaaaaaaca aaaaactctt
    14341 aagcacatgc taggcatctg gagaaaagat ggattctcca ggaaaccatc cctgccctac
    14401 ccgcttgccc acctgcctcc accactggtg caacttcctc cttcagagtc agtttctgca
    14461 gtcaggagag atgagcagtt caccaggaat tgggggtggg ggcatctgtt tttttttttt
    14521 agaatgggag ctgcacttgg ggatggtgat ggtgttagag attgcagccc aggacaaagc
    14581 atcaccttgc tcaaggggaa caaactgcag caggttgtac aaaacattca gagagctcac
    14641 ttgacccaac cgagggtttt acttggtgag cctttctagt agtcttgagt ctggggctca
    14701 gttttagatt tttatttcat taatgtttgt ttatttctaa taaattttaa taagcgagta
    14761 atttaactag gtcgccagaa gaccattatt tttgtttgtc tatttttgtt gtcgtcactc
    14821 cctctctcgt catctgtctg ccagtctgtt cacagatcac cttgtagtcc cttgtggttt
    14881 ttactccatc cagtgcttaa agctgatcta aggacttcga tggttccagc cttcaaagaa
    14941 aaaataattt aataaaaatt tagttagaaa aaataacccc aa
//
