LOCUS       NM_031407              14731 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens HECT, UBA and WWE domain containing E3 ubiquitin
            protein ligase 1 (HUWE1), mRNA.
ACCESSION   NM_031407 NM_005703 NM_017627 XM_497119
VERSION     NM_031407.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 14731)
  AUTHORS   Lee,C., Park,S.H. and Yoon,S.K.
  TITLE     The E3 ligase HUWE1 increases the sensitivity of CRC to oxaliplatin
            through TOMM20 degradation
  JOURNAL   Oncogene 43 (9), 636-649 (2024)
   PUBMED   38184713
  REMARK    GeneRIF: The E3 ligase HUWE1 increases the sensitivity of CRC to
            oxaliplatin through TOMM20 degradation.
REFERENCE   2  (bases 1 to 14731)
  AUTHORS   Li,X.X., Xu,J.K., Su,W.J., Wu,H.L., Zhao,K., Zhang,C.M., Chen,X.K.
            and Yang,L.X.
  TITLE     The role of KDM4A-mediated histone methylation on temozolomide
            resistance in glioma cells through the HUWE1/ROCK2 axis
  JOURNAL   Kaohsiung J Med Sci 40 (2), 161-174 (2024)
   PUBMED   37873881
  REMARK    GeneRIF: The role of KDM4A-mediated histone methylation on
            temozolomide resistance in glioma cells through the HUWE1/ROCK2
            axis.
REFERENCE   3  (bases 1 to 14731)
  AUTHORS   Pettitt,S.J., Shao,N., Zatreanu,D., Frankum,J., Bajrami,I.,
            Brough,R., Krastev,D.B., Roumeliotis,T.I., Choudhary,J.S.,
            Lorenz,S., Rust,A., de Bono,J.S., Yap,T.A., Tutt,A.N.J. and
            Lord,C.J.
  TITLE     A HUWE1 defect causes PARP inhibitor resistance by modulating the
            BRCA1-11q splice variant
  JOURNAL   Oncogene 42 (36), 2701-2709 (2023)
   PUBMED   37491606
  REMARK    GeneRIF: A HUWE1 defect causes PARP inhibitor resistance by
            modulating the BRCA1-11q splice variant.
REFERENCE   4  (bases 1 to 14731)
  AUTHORS   Bernassola,F., Karin,M., Ciechanover,A. and Melino,G.
  TITLE     The HECT family of E3 ubiquitin ligases: multiple players in cancer
            development
  JOURNAL   Cancer Cell 14 (1), 10-21 (2008)
   PUBMED   18598940
  REMARK    Review article
REFERENCE   5  (bases 1 to 14731)
  AUTHORS   Zhong,Q., Gao,W., Du,F. and Wang,X.
  TITLE     Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the
            polyubiquitination of Mcl-1 and regulates apoptosis
  JOURNAL   Cell 121 (7), 1085-1095 (2005)
   PUBMED   15989957
  REMARK    GeneRIF: Mule is both required and sufficient for the
            polyubiquitination of Mcl-1; Mule is a unique BH3-containing E3
            ubiquitin ligase apical to Bcl-2 family proteins during DNA
            damage-induced apoptosis
            GeneRIF: Mule (HUWE1) poly-ubiquitinates anti-apoptotic gene Mcl-1.
REFERENCE   6  (bases 1 to 14731)
  AUTHORS   Chen,D., Kon,N., Li,M., Zhang,W., Qin,J. and Gu,W.
  TITLE     ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor
  JOURNAL   Cell 121 (7), 1071-1083 (2005)
   PUBMED   15989956
  REMARK    GeneRIF: study modifies the current view of ARF-mediated p53
            activation and reveals that ARF-BP1 is a critical mediator of both
            the p53-independent and p53-dependent tumor suppressor functions of
            ARF
            GeneRIF: Ubiquitin ligase activity of ARF-BP1 (HUWE1) is inhibited
            by Arf.
REFERENCE   7  (bases 1 to 14731)
  AUTHORS   Liu,Z., Oughtred,R. and Wing,S.S.
  TITLE     Characterization of E3Histone, a novel testis ubiquitin protein
            ligase which ubiquitinates histones
  JOURNAL   Mol Cell Biol 25 (7), 2819-2831 (2005)
   PUBMED   15767685
REFERENCE   8  (bases 1 to 14731)
  AUTHORS   Gu,J., Dubner,R., Fornace,A.J. Jr. and Iadarola,M.J.
  TITLE     UREB1, a tyrosine phosphorylated nuclear protein, inhibits p53
            transactivation
  JOURNAL   Oncogene 11 (10), 2175-2178 (1995)
   PUBMED   7478539
REFERENCE   9  (bases 1 to 14731)
  AUTHORS   Turner,G., Gedeon,A. and Mulley,J.
  TITLE     X-linked mental retardation with heterozygous expression and
            macrocephaly: pericentromeric gene localization
  JOURNAL   Am J Med Genet 51 (4), 575-580 (1994)
   PUBMED   7943042
REFERENCE   10 (bases 1 to 14731)
  AUTHORS   Gu,J., Ren,K., Dubner,R. and Iadarola,M.J.
  TITLE     Cloning of a DNA binding protein that is a tyrosine kinase
            substrate and recognizes an upstream initiator-like sequence in the
            promoter of the preprodynorphin gene
  JOURNAL   Brain Res Mol Brain Res 24 (1-4), 77-88 (1994)
   PUBMED   7968380
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DQ097177.1, BX323845.7,
            AY772009.1, AC231658.3, AB002310.3 and R60532.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_031407.6.
            
            Summary: This gene encodes a protein containing a C-terminal HECT
            (E6AP type E3 ubiquitin protein ligase) domain that functions as an
            E3 ubiquitin ligase. The encoded protein is required for the
            ubiquitination and subsequent degradation of the anti-apoptotic
            protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)).
            This protein also ubiquitinates the p53 tumor suppressor, core
            histones, and DNA polymerase beta. Mutations in this gene are
            associated with Turner type X-linked syndromic cognitive
            disability. [provided by RefSeq, Aug 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ097177.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262854.11/ ENSP00000262854.6
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                DQ097177.1         10-72
            64-64               BX323845.7         53285-53285         c
            65-12569            DQ097177.1         74-12578
            12570-13295         AY772009.1         12225-12950
            13296-13296         AC231658.3         136442-136442
            13297-14037         DQ097177.1         13306-14046
            14038-14729         AB002310.3         10099-10790
            14730-14731         R60532.1           7-8                 c
FEATURES             Location/Qualifiers
     source          1..14731
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.22"
     gene            1..14731
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /note="HECT, UBA and WWE domain containing E3 ubiquitin
                     protein ligase 1"
                     /db_xref="GeneID:10075"
                     /db_xref="HGNC:HGNC:30892"
                     /db_xref="MIM:300697"
     exon            1..132
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            133..231
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            232..369
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            370..438
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             394..13518
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /EC_number="2.3.2.26"
                     /note="Mcl-1 ubiquitin ligase E3; BJ-HCC-24 tumor antigen;
                     HECT domain protein LASU1; ARF-binding protein 1;
                     URE-binding protein 1; large structure of UREB1; upstream
                     regulatory element-binding protein 1; homologous to E6AP
                     carboxyl terminus homologous protein 9; HECT-type E3
                     ubiquitin transferase HUWE1; HECT, UBA and WWE domain
                     containing 1, E3 ubiquitin protein ligase"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase HUWE1"
                     /protein_id="NP_113584.3"
                     /db_xref="CCDS:CCDS35301.1"
                     /db_xref="GeneID:10075"
                     /db_xref="HGNC:HGNC:30892"
                     /db_xref="MIM:300697"
                     /translation="MKVDRTKLKKTPTEAPADCRALIDKLKVCNDEQLLLELQQIKTW
                     NIGKCELYHWVDLLDRFDGILADAGQTVENMSWMLVCDRPEREQLKMLLLAVLNFTAL
                     LIEYSFSRHLYSSIEHLTTLLASSDMQVVLAVLNLLYVFSKRSNYITRLGSDKRTPLL
                     TRLQHLAESWGGKENGFGLAECCRDLHMMKYPPSATTLHFEFYADPGAEVKIEKRTTS
                     NTLHYIHIEQLDKISESPSEIMESLTKMYSIPKDKQMLLFTHIRLAHGFSNHRKRLQA
                     VQARLHAISILVYSNALQESANSILYNGLIEELVDVLQITDKQLMEIKAASLRTLTSI
                     VHLERTPKLSSIIDCTGTASYHGFLPVLVRNCIQAMIDPSMDPYPHQFATALFSFLYH
                     LASYDAGGEALVSCGMMEALLKVIKFLGDEQDQITFVTRAVRVVDLITNLDMAAFQSH
                     SGLSIFIYRLEHEVDLCRKECPFVIKPKIQRPNTTQEGEEMETDMDGVQCIPQRAALL
                     KSMLNFLKKAIQDPAFSDGIRHVMDGSLPTSLKHIISNAEYYGPSLFLLATEVVTVFV
                     FQEPSLLSSLQDNGLTDVMLHALLIKDVPATREVLGSLPNVFSALCLNARGLQSFVQC
                     QPFERLFKVLLSPDYLPAMRRRRSSDPLGDTASNLGSAVDELMRHQPTLKTDATTAII
                     KLLEEICNLGRDPKYICQKPSIQKADGTATAPPPRSNHAAEEASSEDEEEEEVQAMQS
                     FNSTQQNETEPNQQVVGTEERIPIPLMDYILNVMKFVESILSNNTTDDHCQEFVNQKG
                     LLPLVTILGLPNLPIDFPTSAACQAVAGVCKSILTLSHEPKVLQEGLLQLDSILSSLE
                     PLHRPIESPGGSVLLRELACAGNVADATLSAQATPLLHALTAAHAYIMMFVHTCRVGQ
                     SEIRSISVNQWGSQLGLSVLSKLSQLYCSLVWESTVLLSLCTPNSLPSGCEFGQADMQ
                     KLVPKDEKAGTTQGGKRSDGEQDGAAGSMDASTQGLLEGIGLDGDTLAPMETDEPTAS
                     DSKGKSKITPAMAARIKQIKPLLSASSRLGRALAELFGLLVKLCVGSPVRQRRSHHAA
                     STTTAPTPAARSTASALTKLLTKGLSWQPPPYTPTPRFRLTFFICSVGFTSPMLFDER
                     KYPYHLMLQKFLCSGGHNALFETFNWALSMGGKVPVSEGLEHSDLPDGTGEFLDAWLM
                     LVEKMVNPTTVLESPHSLPAKLPGGVQNFPQFSALRFLVVTQKAAFTCIKNLWNRKPL
                     KVYGGRMAESMLAILCHILRGEPVIRERLSKEKEGSRGEEDTGQEEGGSRREPQVNQQ
                     QLQQLMDMGFTREHAMEALLNTSTMEQATEYLLTHPPPIMGGVVRDLSMSEEDQMMRA
                     IAMSLGQDIPMDQRAESPEEVACRKEEEERKAREKQEEEEAKCLEKFQDADPLEQDEL
                     HTFTDTMLPGCFHLLDELPDTVYRVCDLIMTAIKRNGADYRDMILKQVVNQVWEAADV
                     LIKAALPLTTSDTKTVSEWISQMATLPQASNLATRILLLTLLFEELKLPCAWVVESSG
                     ILNVLIKLLEVVQPCLQAAKEQKEVQTPKWITPVLLLIDFYEKTAISSKRRAQMTKYL
                     QSNSNNWRWFDDRSGRWCSYSASNNSTIDSAWKSGETSVRFTAGRRRYTVQFTTMVQV
                     NEETGNRRPVMLTLLRVPRLNKNSKNSNGQELEKTLEESKEMDIKRKENKGNDTPLAL
                     ESTNTEKETSLEETKIGEILIQGLTEDMVTVLIRACVSMLGVPVDPDTLHATLRLCLR
                     LTRDHKYAMMFAELKSTRMILNLTQSSGFNGFTPLVTLLLRHIIEDPCTLRHTMEKVV
                     RSAATSGAGSTTSGVVSGSLGSREINYILRVLGPAACRNPDIFTEVANCCIRIALPAP
                     RGSGTASDDEFENLRIKGPNAVQLVKTTPLKPSPLPVIPDTIKEVIYDMLNALAAYHA
                     PEEADKSDPKPGVMTQEVGQLLQDMGDDVYQQYRSLTRQSSDFDTQSGFSINSQVFAA
                     DGASTETSASGTSQGEASTPEESRDGKKDKEGDRASEEGKQKGKGSKPLMPTSTILRL
                     LAELVRSYVGIATLIANYSYTVGQSELIKEDCSVLAFVLDHLLPHTQNAEDKDTPALA
                     RLFLASLAAAGSGTDAQVALVNEVKAALGRALAMAESTEKHARLQAVMCIISTIMESC
                     PSTSSFYSSATAKTQHNGMNNIIRLFLKKGLVNDLARVPHSLDLSSPNMANTVNAALK
                     PLETLSRIVNQPSSLFGSKSASSKNKSEQDAQGASQDSSSNQQDPGEPGEAEVQEEDH
                     DVTQTEVADGDIMDGEAETDSVVIAGQPEVLSSQEMQVENELEDLIDELLERDGGSGN
                     STIIVSRSGEDESQEDVLMDEAPSNLSQASTLQANREDSMNILDPEDEEEHTQEEDSS
                     GSNEDEDDSQDEEEEEEEDEEDDQEDDEGEEGDEDDDDDGSEMELDEDYPDMNASPLV
                     RFERFDREDDLIIEFDNMFSSATDIPPSPGNIPTTHPLMVRHADHSSLTLGSGSSTTR
                     LTQGIGRSQRTLRQLTANTGHTIHVHYPGNRQPNPPLILQRLLGPSAAADILQLSSSL
                     PLQSRGRARLLVGNDDVHIIARSDDELLDDFFHDQSTATSQAGTLSSIPTALTRWTEE
                     CKVLDAESMHDCVSVVKVSIVNHLEFLRDEELEERREKRRKQLAEEETKITDKGKEDK
                     ENRDQSAQCTASKSNDSTEQNLSDGTPMPDSYPTTPSSTDAATSESKETLGTLQSSQQ
                     QPTLPTPPALGEVPQELQSPAGEGGSSTQLLMPVEPEELGPTRPSGEAETTQMELSPA
                     PTITSLSPERAEDSDALTAVSSQLEGSPMDTSSLASCTLEEAVGDTSAAGSSEQPRAG
                     SSTPGDAPPAVAEVQGRSDGSGESAQPPEDSSPPASSESSSTRDSAVAISGADSRGIL
                     EEPLPSTSSEEEDPLAGISLPEGVDPSFLAALPDDIRREVLQNQLGIRPPTRTAPSTN
                     SSAPAVVGNPGVTEVSPEFLAALPPAIQEEVLAQQRAEQQRRELAQNASSDTPMDPVT
                     FIQTLPSDLRRSVLEDMEDSVLAVMPPDIAAEAQALRREQEARQRQLMHERLFGHSST
                     SALSAILRSPAFTSRLSGNRGVQYTRLAVQRGGTFQMGGSSSHNRPSGSNVDTLLRLR
                     GRLLLDHEALSCLLVLLFVDEPKLNTSRLHRVLRNLCYHAQTRHWVIRSLLSILQRSS
                     ESELCIETPKLTTSEEKGKKSSKSCGSSSHENRPLDLLHKMESKSSNQLSWLSVSMDA
                     ALGCRTNIFQIQRSGGRKHTEKHASGGSTVHIHPQAAPVVCRHVLDTLIQLAKVFPSH
                     FTQQRTKETNCESDRERGNKACSPCSSQSSSSGICTDFWDLLVKLDNMNVSRKGKNSV
                     KSVPVSAGGEGETSPYSLEASPLGQLMNMLSHPVIRRSSLLTEKLLRLLSLISIALPE
                     NKVSEAQANSGSGASSTTTATSTTSTTTTTAASTTPTPPTAPTPVTSAPALVAATAIS
                     TIVVAASTTVTTPTTATTTVSISPTTKGSKSPAKVSDGGSSSTDFKMVSSGLTENQLQ
                     LSVEVLTSHSCSEEGLEDAANVLLQLSRGDSGTRDTVLKLLLNGARHLGYTLCKQIGT
                     LLAELREYNLEQQRRAQCETLSPDGLPEEQPQTTKLKGKMQSRFDMAENVVIVASQKR
                     PLGGRELQLPSMSMLTSKTSTQKFFLRVLQVIIQLRDDTRRANKKAKQTGRLGSSGLG
                     SASSIQAAVRQLEAEADAIIQMVREGQRARRQQQAATSESSQSEASVRREESPMDVDQ
                     PSPSAQDTQSIASDGTPQGEKEKEERPPELPLLSEQLSLDELWDMLGECLKELEESHD
                     QHAVLVLQPAVEAFFLVHATERESKPPVRDTRESQLAHIKDEPPPLSPAPLTPATPSS
                     LDPFFSREPSSMHISSSLPPDTQKFLRFAETHRTVLNQILRQSTTHLADGPFAVLVDY
                     IRVLDFDVKRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHRKSPEEMKNRL
                     YIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNHL
                     SYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLE
                     NDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIR
                     KQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYHKYQSNSIQI
                     QWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLP
                     SAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGFGLA"
     exon            439..537
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            538..744
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            745..897
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            898..960
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1038
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1086
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1155
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1255
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1356
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1507
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1635
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1776
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1882
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..1984
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2065
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2172
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2350
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..2442
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2443..2654
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..2712
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2713..2889
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2890..3135
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3136..3269
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3270..3364
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3365..3556
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3557..3773
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3774..3896
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3897..4134
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            4135..4365
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            4366..4488
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            4489..4584
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            4585..4854
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            4855..5007
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            5008..5135
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            5136..5217
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            5218..5394
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            5395..5554
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            5555..5913
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            5914..6109
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            6110..6277
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            6278..6423
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            6424..6490
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            6491..6705
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            6706..6917
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            6918..7100
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            7101..7273
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            7274..7422
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            7423..7498
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            7499..7597
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            7598..7731
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            7732..7900
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            7901..8129
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            8130..8308
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            8309..8398
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            8399..8553
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            8554..8599
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            8600..8887
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            8888..9143
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            9144..9274
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            9275..9489
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            9490..9778
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            9779..9881
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            9882..10428
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            10429..11029
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            11030..11151
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            11152..11308
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            11309..11441
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            11442..11644
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            11645..11772
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            11773..11869
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            11870..12025
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            12026..12271
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            12272..12389
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            12390..12530
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            12531..12818
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            12819..12924
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            12925..13042
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            13043..13224
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            13225..13415
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     exon            13416..14731
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      13615..13620
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /note="hexamer: AATAAA"
     polyA_site      13633
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
     regulatory      14013..14018
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /note="hexamer: AATAAA"
     polyA_site      14033
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /note="major polyA site"
     regulatory      14700..14705
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
                     /note="hexamer: AATAAA"
     polyA_site      14731
                     /gene="HUWE1"
                     /gene_synonym="ARF-BP1; HECTH9; HSPC272; Ib772; LASU1;
                     MRXST; MULE; URE-B1; UREB1"
ORIGIN      
        1 gactgagggc tagcgagggg agcagggctg gagcagggct ggagcagggc tggagcaggg
       61 ctgaagcagg gctgaagcag ggccgcggac cccgcacgct cctgcgggcc ccgcggagcc
      121 attgcggccg aggcctcggc aggcgccagc ggagagctag ccgcatcttc gggggcagcc
      181 cggcagctgc cggcggcgcg gcgagagagc ggctgacaga ggggatgcga ggtcctccag
      241 cagcctgacc tgagtgggtt agtgatccag agaaaccagc aggccaactt ggtcaggaag
      301 gttcgggaag ctgttggagc agtgtgggga atttcccacc aggatgagta tgattggctg
      361 tgattttaga tcgtaaagct gaaaattgaa atcatgaaag tagacaggac taaactgaag
      421 aagacaccta ctgaggctcc tgcagactgc agagccttaa tagacaaact caaagtttgt
      481 aatgatgagc aacttctctt ggaactgcag cagatcaaaa catggaacat tggaaagtgc
      541 gagttatatc actgggtgga cctgttggac cgcttcgatg gaatactggc agatgctgga
      601 cagacagtgg agaatatgtc atggatgctc gtatgtgata ggccagaaag agagcaactg
      661 aaaatgcttc tcttggctgt gttgaacttc acagccttgc tcattgagta cagcttttcc
      721 cggcatctgt acagttccat agagcatttg acaactttat tggcttcctc tgatatgcaa
      781 gtggtgctgg cagtcctcaa tctcctatat gtatttagca aaagatcaaa ctacatcact
      841 cgtctgggat ctgacaagag gaccccgctg ctaactcggc tacaacattt ggcagagagc
      901 tggggtggaa aggagaatgg ctttggactt gcagaatgtt gcagagactt gcatatgatg
      961 aaatatccac ccagtgcaac tacactacac tttgaattct atgcagatcc tggggccgag
     1021 gtcaaaattg agaaaaggac aactagtaac acactacatt atattcacat agagcaactt
     1081 gacaagattt cagaaagccc ttctgaaatc atggaatctc ttaccaaaat gtacagcatt
     1141 cctaaggata agcagatgct gttatttaca cacatacgac tggcccatgg cttttctaat
     1201 cacaggaagc gattgcaggc agttcaggcc agactgcatg caatatctat attagtgtat
     1261 tccaatgcct tgcaggaatc agcaaacagt atcttgtata atggcttgat agaggagttg
     1321 gtagatgtcc ttcagataac ggataagcag cttatggaga ttaaagcagc ttctttacga
     1381 acattaacat caattgtcca cttggagaga actcccaaac tcagcagtat tattgactgt
     1441 actggaactg cctcctacca tggatttttg ccagtgcttg taaggaactg tatccaggcc
     1501 atgattgatc cttccatgga tccataccct caccagtttg ccactgctct cttctctttt
     1561 ttataccatc tggccagcta cgatgctggt ggtgaagcct tggtctcctg tggaatgatg
     1621 gaagccttat tgaaggtcat aaagtttctt ggcgatgaac aggaccagat aacatttgtc
     1681 accagagccg tcagagtggt tgaccttatc accaacctgg atatggcagc ttttcaatcc
     1741 catagtggac tttctatctt catttataga cttgagcatg aagtagattt gtgccgaaaa
     1801 gaatgtccgt ttgtgatcaa gccaaagatc cagagaccca atactacaca agaaggagag
     1861 gaaatggaaa ctgatatgga tggagtccag tgtattccac aacgagcagc acttctgaaa
     1921 tccatgttga atttcctcaa gaaggccatc caagaccctg ctttctcaga tggcatacga
     1981 catgtgatgg atggttctct gcctacctcc ctgaaacaca tcatcagcaa tgcagaatac
     2041 tatggcccat cactcttcct cctagctact gaagtggtga ctgtgtttgt atttcaagaa
     2101 ccatcactgc tctcctcact ccaggacaat ggattgacag atgtcatgct gcatgcactg
     2161 cttatcaaag atgttcctgc tacccgtgaa gtccttggct ccctcccaaa tgtattcagt
     2221 gcactctgtt tgaatgcccg aggtcttcag tcttttgttc agtgtcagcc ttttgaacgc
     2281 ctcttcaaag ttcttctgtc tccagattac ctcccagcca tgcggaggag gagaagttct
     2341 gatccccttg gggatactgc atccaacctg gggagtgctg tcgatgagct catgagacat
     2401 cagcccaccc ttaaaacaga tgcaacgact gccatcatca agttacttga agaaatctgt
     2461 aatcttggaa gggaccccaa atacatctgt cagaagccat caatccagaa ggcagatggc
     2521 actgccactg ctcctccccc aaggtctaat catgccgcag aagaagcctc tagtgaggat
     2581 gaggaggaag aggaagtaca ggccatgcag agctttaatt ctacccagca aaatgaaact
     2641 gagcctaatc agcaggttgt tggtacagag gaacgtattc ctattcccct catggattac
     2701 atccttaatg tgatgaaatt tgtggaatct attctgagca acaatacaac agatgaccac
     2761 tgccaggaat ttgtgaatca gaaaggactg ttgcctttgg ttaccatttt gggtcttccc
     2821 aatctgccca ttgactttcc cacatctgct gcctgtcagg ctgttgcagg tgtctgcaaa
     2881 tccatattga cactgtcaca tgaacccaaa gtccttcaag agggtctcct tcagttggac
     2941 tccatcctct cctccctgga gcccttacac cgccccattg aatcccctgg gggctcagtg
     3001 ttgttgcgag aactggcttg cgcaggcaat gttgctgatg ctaccctctc agcccaggcc
     3061 acacctctgc tgcatgcact cactgctgcc catgcctaca tcatgatgtt tgttcatact
     3121 tgcagagttg gacagagtga aattcgttcc atctccgtaa accagtgggg ctctcaattg
     3181 ggtctgagtg ttttgagcaa gctgagccag ttatactgtt ccctggtgtg ggaaagcact
     3241 gtcctcctct ctctgtgtac cccaaacagc ctaccatctg ggtgtgaatt tggccaggca
     3301 gatatgcaga aactggttcc aaaggatgag aaggcaggta cgacccaggg cggaaaaaga
     3361 tcagatgggg aacaggatgg agcagctgga agtatggatg cttctaccca gggcttatta
     3421 gaaggcattg ggctagatgg tgacacattg gctcccatgg agacagatga acctactgct
     3481 tcagactcta agggcaaatc taaaatcaca ccagcaatgg ctgccagaat taagcaaatc
     3541 aagcctttgt tatcagcttc ctccagatta ggccgagcac ttgctgagct atttggactt
     3601 cttgttaaac tttgtgtggg atctcctgtc cgccagagaa ggagccatca tgctgccagc
     3661 accactacag caccgacacc tgccgcgcga tcaacagcct cagctctcac taagctcttg
     3721 actaaggggt tatcttggca gcccccacca tatacaccta ctccccgatt caggctgaca
     3781 ttcttcatct gttcagttgg tttcacatcc ccaatgctgt ttgatgagag gaagtatccc
     3841 taccacctca tgctgcaaaa atttctctgc tccggaggcc acaatgctct ttttgaaact
     3901 ttcaactggg ctctgtccat gggaggtaaa gttcctgttt ctgagggatt ggaacactca
     3961 gacttgcctg atggcacagg agaattccta gatgcctggc ttatgctggt ggagaagatg
     4021 gtgaatccca ccacggtgct tgaatctcca cattcgctgc ctgccaaatt gcctggaggt
     4081 gtccagaact ttccccagtt cagtgcactg cgcttccttg tggtaactca gaaagcagcc
     4141 tttacttgca tcaaaaactt atggaaccgg aaacccctga aggtatatgg tggacgaatg
     4201 gctgaatcga tgctggccat tctatgccac atcctccgag gagaacctgt gattcgagag
     4261 agactaagca aggagaagga ggggtctcga ggagaagagg atacagggca agaggaaggt
     4321 ggctcccgcc gggaacctca agtcaaccag caacaactgc aacagctcat ggacatgggc
     4381 ttcacaaggg aacatgcaat ggaggcactg ttgaacacca gcaccatgga gcaggccaca
     4441 gagtaccttt taacccaccc tcctccaatc atgggaggag ttgttcggga tctcagcatg
     4501 tctgaagagg accagatgat gagagcaatt gctatgtctc tgggacagga tattccaatg
     4561 gatcaaaggg cagagtcacc tgaggaagtt gcttgccgga aggaggaaga ggaacggaaa
     4621 gctcgggaaa agcaggagga ggaagaggct aaatgtctag agaagttcca ggatgctgac
     4681 ccgttggaac aagatgagct ccacactttc acagatacta tgttgccagg ctgcttccac
     4741 cttcttgatg agctgccaga cacagtatac cgtgtgtgtg acctgatcat gacagcaatc
     4801 aaacgtaatg gagcagatta tcgtgacatg attctgaagc aagtagtcaa tcaggtgtgg
     4861 gaagctgctg atgtattgat caaagctgct cttcccctga caacaagtga cacaaaaacc
     4921 gtgtcagagt ggataagtca gatggccaca ctgccccagg cctccaattt ggctactaga
     4981 atcttgcttt taacgctact ttttgaggag ttgaagctac cttgtgcttg ggtggttgaa
     5041 tcaagtggca tccttaatgt cctaatcaaa ctcttggaag tggttcagcc ctgcctccag
     5101 gcagccaagg agcagaagga agtccagacc ccaaagtgga tcacaccagt gttgctcctg
     5161 attgatttct atgaaaagac agccatctcc tcaaaaagga gagcccagat gactaagtac
     5221 ctgcaatcca acagcaacaa ctggcgctgg tttgatgatc gctctgggcg ttggtgtagt
     5281 tacagtgcaa gcaacaatag cactattgat tctgcctgga aatctggaga gacaagcgtg
     5341 cgattcactg caggccgaag aagatacacg gtccaattca ctacaatggt gcaggttaat
     5401 gaggaaacag ggaaccgacg ccctgtgatg ctgactctcc tcagggtacc tcggctgaat
     5461 aaaaattcaa aaaacagcaa tggacaggaa ctagagaaga cgctggaaga aagcaaagaa
     5521 atggatatca aacgtaaaga aaataaaggc aatgataccc ctttggccct agagagtaca
     5581 aacactgaaa aggagacaag cctggaggaa acaaaaatcg gggagatcct gatccagggc
     5641 ttgacagaag atatggtgac tgttttaatc cgggcctgcg tgagcatgct gggagtccct
     5701 gtggacccag atactttgca tgccaccctt cgtctctgtc tgaggctcac ccgggaccac
     5761 aaatatgcca tgatgtttgc agaactgaag agtacccgca tgatcttgaa tttgacccag
     5821 agctcaggct tcaatgggtt tactcccctg gtcacccttc tcttaagaca catcattgag
     5881 gacccctgta cccttcgtca taccatggaa aaggttgttc gctcagcagc tacaagtgga
     5941 gctggtagca ctacctctgg tgttgtgtct ggcagcctcg gctctcggga gatcaactac
     6001 atccttcgtg tccttgggcc agccgcatgc cgcaatccag acatattcac agaagtggcc
     6061 aactgctgta tccgcatcgc ccttcctgcc cctcgaggct caggaactgc ttcagatgat
     6121 gaatttgaga atcttagaat taaaggccct aatgctgtac agctggtgaa gaccacccct
     6181 ttgaagccct cacctctgcc tgtcatccct gatactatca aggaagtgat ctatgatatg
     6241 ctgaatgctc tggctgcata ccatgctcca gaggaagcag ataaatctga tcctaaacct
     6301 ggggttatga cccaagaggt tggccagctc ctgcaagaca tgggtgatga tgtataccag
     6361 cagtaccggt cacttacgcg tcagagcagt gactttgata cgcagtcagg tttttccatt
     6421 aatagtcagg tctttgctgc agatggtgcc tccactgaga cttccgcatc tgggacctcc
     6481 caaggagagg cttcaactcc agaggagtct cgagatggga agaaagataa agaaggggac
     6541 cgggcctctg aggaaggcaa acagaaaggc aagggcagca aacctttaat gcctacctcc
     6601 actatccttc gtcttctggc agagttggtg aggtcctatg ttggtattgc taccctgatt
     6661 gccaactaca gctacactgt gggccagtct gaactgatca aagaggactg cagtgtgcta
     6721 gcttttgttc tggaccacct gctcccacat acccagaatg cagaagacaa ggacacccct
     6781 gccttggccc gcctgttcct cgcaagcctg gctgctgcag ggagtggcac agatgcccag
     6841 gtggccctag tgaatgaagt aaaagcagcc cttggacggg cactggctat ggctgagagt
     6901 acagagaaac atgccaggct tcaggcagtg atgtgtatca tcagtactat catggagtcc
     6961 tgcccctcca cctccagctt ctacagcagt gccacagcga agacccagca caatggcatg
     7021 aacaacatca ttcggctttt cctgaagaag ggactggtta atgacctggc cagagtacct
     7081 cacagcttag acctgtccag tcccaacatg gccaacacag tcaatgctgc tctgaagcct
     7141 ttggaaacac tttcccggat tgtgaaccag cccagtagcc tttttggcag caagagtgct
     7201 tctagcaaga acaagtctga gcaggatgcc caaggagcct ctcaagattc cagtagcaac
     7261 cagcaggacc caggcgagcc tggggaagca gaagtgcagg aggaggatca tgatgtcact
     7321 cagacagagg tggcagatgg ggatatcatg gatggggagg ctgaaaccga ctcagtggtg
     7381 attgctgggc agcctgaggt gctcagttca caagagatgc aggttgagaa tgagctggag
     7441 gacctgatag atgagttgct tgagagggat ggcggatctg ggaacagtac aattatagtg
     7501 agcagaagtg gagaggatga atcacaagag gacgtgctga tggatgaagc tccttccaac
     7561 ctcagccaag cttccacctt gcaggccaac cgagaagatt ccatgaatat cctggaccct
     7621 gaggatgagg aggagcacac tcaggaagag gacagcagtg gcagtaacga ggatgaggat
     7681 gatagtcagg atgaagagga ggaggaggag gaagatgagg aagatgatca ggaggatgat
     7741 gaaggtgaag agggagatga agacgatgac gacgatggct ctgagatgga attggatgag
     7801 gattatcctg atatgaacgc ttctcccttg gtccgatttg agcgctttga ccgggaggat
     7861 gatctcatca ttgagtttga caacatgttc tccagtgcta cagacatccc cccatcccca
     7921 ggaaatatcc ctaccaccca tccactgatg gtgcgccatg cagaccacag ttctctgaca
     7981 ctgggcagtg gctcttcaac aactcgtctc acccagggca tcgggcgcag tcagaggacc
     8041 ctaaggcagc tgacggccaa tactggccac accattcatg ttcactaccc tgggaatcgc
     8101 cagcccaacc ctcctcttat actgcagagg ttgcttggtc cctcagctgc tgctgacatc
     8161 cttcagctga gcagcagcct tcccctacaa agccggggtc gggcccgcct cctggtaggc
     8221 aacgatgacg tccacatcat cgcccgttct gatgatgagc tgctggatga ctttttccat
     8281 gatcagagca cagctaccag ccaagcagga accctgtcca gcatccccac agccctgacc
     8341 cgctggacag aagaatgcaa agttctcgat gctgagagca tgcatgactg tgtttcagtg
     8401 gttaaagtgt ccattgtcaa tcacctggaa ttcctgaggg atgaggagct ggaagaaagg
     8461 cgagagaagc gcaggaaaca actggctgag gaagaaacaa agataactga taaaggcaaa
     8521 gaagataagg agaacaggga tcagagtgca cagtgtactg catctaagtc aaatgactcc
     8581 actgaacaga atctctcaga tgggacgcct atgcctgaca gctacccaac aaccccatct
     8641 tcaactgatg cagctacatc tgagtccaag gagacccttg gcactctgca atcctcacaa
     8701 cagcaaccaa cactcccaac cccaccagct ttgggagagg ttcctcagga gctgcagtct
     8761 ccagctggag aagggggcag ctctacacag ctattgatgc ctgtagagcc agaggaattg
     8821 ggtcccacaa ggccaagtgg ggaagcagaa acaactcaga tggagttatc cccagctccc
     8881 actataacct cactttcccc agagagagct gaggattctg atgcactgac ggctgtcagc
     8941 agtcagctag aaggctctcc tatggataca agcagcctgg cttcctgtac cttagaggag
     9001 gctgtgggtg acacttcagc agctggcagt tctgagcagc ccagagcagg cagctccact
     9061 cctggggatg ccccaccagc tgtggcggaa gtgcaaggca ggagtgatgg gtcaggggaa
     9121 tctgcccagc cacctgagga cagctcccca cctgcatcct ctgagagctc ttccaccaga
     9181 gattctgccg tggccatttc tggagcagat tcccgaggaa tcctagaaga gccgttgcct
     9241 tcaacaagca gtgaagaaga agatcccctt gcgggtatca gtctccctga aggtgtggac
     9301 ccctcttttc tggctgccct gcctgatgac atccgtcggg aagttctaca gaaccagcta
     9361 ggcattcgtc caccaacccg gactgccccc tccacaaata gctcagcgcc tgcagtggtg
     9421 gggaatcctg gtgtgactga agtgagccct gagtttctgg ctgccctgcc tccagccatt
     9481 caggaggaag tactggcaca gcagagagct gagcagcagc gacgagaact agcacagaat
     9541 gccagctcag acacccctat ggaccctgtg accttcatcc agactctgcc ctcagacctg
     9601 cgccgtagtg tcctagagga tatggaggac agtgtgttag ctgtgatgcc acctgacatt
     9661 gcagctgagg ctcaagccct gagacgagag caagaagccc ggcagcgaca gctcatgcat
     9721 gagcgtctgt ttgggcacag tagcacctcc gcactctctg ctattctccg aagcccggct
     9781 ttcaccagtc gcttaagtgg caaccgtggg gtccagtata ctcgccttgc tgtgcagaga
     9841 ggtggcacct tccagatggg gggtagcagc agccataaca ggccttctgg cagtaatgta
     9901 gatactctcc tccgcctccg aggacggctc cttctggacc acgaagccct ttcttgtctc
     9961 ttggtcctac tttttgtgga tgagccaaag ctcaatacta gccgtctaca ccgagtactg
    10021 agaaatctct gctaccatgc ccagacccgc cactgggtca tccgcagtct gctctccatc
    10081 ttgcagcgca gcagtgagag tgagctatgc attgaaacac ccaaactcac tacaagtgag
    10141 gaaaagggca aaaagtcgag caagagctgt gggtcaagta gccatgagaa ccgtcccctg
    10201 gacctgctac acaagatgga gtcaaagagc tccaaccagc tttcctggct ctcagtatcc
    10261 atggatgcag ccctaggctg caggactaat atatttcaga tccagcgttc aggggggcgt
    10321 aaacataccg agaagcatgc aagcggtggc tccaccgtcc acatccatcc ccaagctgct
    10381 cctgttgtct gcagacacgt tttggataca ctcattcaat tggccaaggt atttcccagc
    10441 cacttcacac agcagcggac caaagaaaca aactgtgaga gtgatcggga aaggggcaat
    10501 aaggcctgta gcccatgctc ctcacagtcc tccagcagtg gcatttgcac agacttctgg
    10561 gacttattgg taaaactgga caacatgaat gtcagccgga aaggcaagaa ctccgtgaag
    10621 tcagtgccag tgagcgctgg cggtgagggg gaaacctctc catacagcct cgaggcctct
    10681 ccactggggc agctcatgaa catgttgtca cacccagtca tccgccggag ctctctctta
    10741 actgagaaac tcctcagact cctttctctc atctcaattg ctctcccaga aaacaaggtg
    10801 tcagaagcac aggctaattc tggcagcggt gcttcctcca ccaccactgc cacctcaacc
    10861 acatctacca ccaccaccac tgccgcctcc accacgccca caccccctac tgcacccacc
    10921 cctgtcactt ctgctccagc cctggttgct gccacggcta tttccaccat tgtcgtagct
    10981 gcttcgacca cagtgactac ccccacgact gctaccacta ctgtttcaat ttctcccact
    11041 actaagggca gcaaatctcc agcgaaggtg agtgatgggg gcagcagcag tacagacttt
    11101 aagatggtgt cctctggcct cactgaaaac cagctacagc tctctgtaga ggtgttgaca
    11161 tcccactctt gttctgagga aggcttagag gatgcagcca acgtactact gcagctctcc
    11221 cggggggact ctgggacccg ggacactgtt ctcaagctgc tactgaatgg agcccgccat
    11281 ctgggttata ccctttgtaa acaaataggt accctgctgg ccgagctgcg ggaatacaac
    11341 ctcgagcagc agcggcgagc ccaatgtgaa accctctctc ctgatggcct gcctgaggag
    11401 cagccacaga ccaccaagct gaagggcaaa atgcagagca ggtttgacat ggctgagaat
    11461 gtggtaattg tggcatctca gaagcgacct ttgggtggcc gggagctcca gctgccttct
    11521 atgtccatgt tgacatccaa gacatctacc cagaagttct tcttgagggt actacaggtc
    11581 atcatccagc tccgggacga cacgcgccgg gctaacaaga aagccaagca gacaggcagg
    11641 ctaggttcct ccggtttagg ctcagctagc agcatccagg cagctgttcg gcagctggag
    11701 gctgaggctg atgccattat acaaatggta cgtgagggtc aaagggcgcg gagacagcaa
    11761 caagcagcaa cgtcggagtc tagccagtca gaggcgtctg tccggaggga ggaatcaccc
    11821 atggatgtgg accagccatc tcccagtgct caagatactc aatccattgc ctccgatgga
    11881 accccacagg gggagaagga aaaggaagaa agaccacctg agttacccct gctcagcgag
    11941 cagctgagtt tggacgagct gtgggacatg cttggggagt gtctaaagga actagaggaa
    12001 tcccatgacc agcatgcggt gctagtgcta cagcctgctg tcgaggcctt ctttctggtc
    12061 catgccacag agcgggagag caagcctcct gtccgagaca cccgtgagag ccagctggca
    12121 cacatcaagg acgagcctcc tccactctcc cctgccccct taaccccagc cacgccttcc
    12181 tcccttgacc cattcttctc ccgggagccc tcatctatgc acatctcctc aagcctgccc
    12241 cctgacacac agaagttcct tcgctttgca gagactcacc gcactgtgtt aaaccagatc
    12301 ctacggcagt ccacgaccca ccttgctgat gggccttttg ctgtcctggt agactacatt
    12361 cgtgtcctcg actttgatgt caagcgcaaa tatttccgcc aagagctgga gcgtttagat
    12421 gaggggctcc ggaaagaaga catggctgtg catgtccgtc gtgaccatgt gtttgaagac
    12481 tcctatcgtg agctgcatcg caaatccccc gaagaaatga agaatcgatt gtatatagta
    12541 tttgaaggag aagaagggca ggatgctggt gggctcctgc gggagtggta tatgatcatc
    12601 tctcgagaga tgtttaaccc tatgtatgcc ttgttccgta cctcacctgg tgatcgagtc
    12661 acctacacca tcaatccatc ttcccactgc aaccccaacc acctcagcta cttcaagttt
    12721 gtcggacgca ttgtggccaa agctgtatat gacaaccgtc ttctggagtg ctactttact
    12781 cgatcctttt acaaacacat cttgggcaag tcagtcagat atacagatat ggagagtgaa
    12841 gattaccact tctaccaagg tctggtttat ctgctggaaa atgatgtctc cacactaggc
    12901 tatgacctca ccttcagcac tgaggtccaa gagtttggag tttgtgaagt tcgtgacctc
    12961 aaacccaatg gggccaacat cttggtaaca gaggagaata agaaggagta tgtacacctg
    13021 gtatgccaga tgagaatgac aggagccatc cgcaagcagt tggcggcttt cttagaaggc
    13081 ttctatgaga tcattccaaa gcgcctcatt tccatcttca ctgagcagga gttagagctg
    13141 cttatatcag gactgcccac cattgacatc gatgatctga aatccaacac tgaataccac
    13201 aagtaccagt ccaactctat tcagatccag tggttctgga gagcattgcg ttctttcgat
    13261 caagctgacc gtgccaagtt cctccagttt gtcacaggta cttccaaggt acccctgcaa
    13321 ggctttgctg ccctcgaagg catgaatggc attcagaagt ttcagatcca tcgagatgac
    13381 aggtccacag atcgcctgcc ttcagctcac acatgtttta atcagctgga tctgcctgcc
    13441 tatgagagct ttgagaagct ccgccacatg ctactgttgg ctatccagga gtgctctgaa
    13501 ggctttgggc tggcctaata aggccctgcc caactccgtg gggttttttt taccattgtt
    13561 ggacctgggg aggggggagt taaaaaaaga accagaaaga aattgtcaaa aaccaataaa
    13621 tgaaatccac caactcaccg tgtgtgtccc agctgcccca tcttccccag cgcatacctg
    13681 ttcctcttct cattctctcc ccgccgcctg tttcctcacc ttctctcccc tttccatgcc
    13741 gtccatgatc cccaccccat gtgttttaaa aaggcagtag cctttgcagg gacctgtctg
    13801 tcccaactgt ttgaacagtg tgctcctcag attctgtgtt cagaaggatt tgctgcattg
    13861 agacttgaaa cctttggata ggggaaaaaa ttatatatat atatattttt ttgttctgtt
    13921 tgcatttctt aatttgtgct tggaatgtgt tgatgtgcac agctaatgat tcaatgcgag
    13981 acaagattgg cgtctgtgtt gtggaggttt caaataaaga gcactcttca taactcactt
    14041 ttcacaatgg agtttttttc aaacttaaaa aaaaaaacaa aaaactctta agcacatgct
    14101 aggcatctgg agaaaagatg gattctccag gaaaccatcc ctgccctacc cgcttgccca
    14161 cctgcctcca ccactggtgc aacttcctcc ttcagagtca gtttctgcag tcaggagaga
    14221 tgagcagttc accaggaatt gggggtgggg gcatctgttt ttttttttta gaatgggagc
    14281 tgcacttggg gatggtgatg gtgttagaga ttgcagccca ggacaaagca tcaccttgct
    14341 caaggggaac aaactgcagc aggttgtaca aaacattcag agagctcact tgacccaacc
    14401 gagggtttta cttggtgagc ctttctagta gtcttgagtc tggggctcag ttttagattt
    14461 ttatttcatt aatgtttgtt tatttctaat aaattttaat aagcgagtaa tttaactagg
    14521 tcgccagaag accattattt ttgtttgtct atttttgttg tcgtcactcc ctctctcgtc
    14581 atctgtctgc cagtctgttc acagatcacc ttgtagtccc ttgtggtttt tactccatcc
    14641 agtgcttaaa gctgatctaa ggacttcgat ggttccagcc ttcaaagaaa aaataattta
    14701 ataaaaattt agttagaaaa aataacccca a
//
