LOCUS       NM_148959               1162 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens HUS1 checkpoint clamp component B (HUS1B), mRNA.
ACCESSION   NM_148959
VERSION     NM_148959.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1162)
  AUTHORS   Li,H., Dai,H., Shi,T., Cheng,X., Sun,M., Chen,K., Wang,M. and
            Wei,Q.
  TITLE     Potentially functional variants in nucleotide excision repair
            pathway genes predict platinum treatment response of Chinese
            ovarian cancer patients
  JOURNAL   Carcinogenesis 41 (9), 1229-1237 (2020)
   PUBMED   32663249
  REMARK    GeneRIF: Potentially functional variants in nucleotide excision
            repair pathway genes predict platinum treatment response of Chinese
            ovarian cancer patients.
REFERENCE   2  (bases 1 to 1162)
  AUTHORS   Rumbajan,J.M., Yamaguchi,Y., Nakabayashi,K., Higashimoto,K.,
            Yatsuki,H., Nishioka,K., Matsuoka,K., Aoki,S., Toda,S., Takeda,S.,
            Seki,H., Hatada,I., Hata,K., Soejima,H. and Joh,K.
  TITLE     The HUS1B promoter is hypomethylated in the placentas of
            low-birth-weight infants
  JOURNAL   Gene 583 (2), 141-146 (2016)
   PUBMED   26911255
  REMARK    GeneRIF: The HUS1B promoter is hypomethylated in the placentas of
            low-birth-weight infants.
REFERENCE   3  (bases 1 to 1162)
  AUTHORS   Lyndaker,A.M., Vasileva,A., Wolgemuth,D.J., Weiss,R.S. and
            Lieberman,H.B.
  TITLE     Clamping down on mammalian meiosis
  JOURNAL   Cell Cycle 12 (19), 3135-3145 (2013)
   PUBMED   24013428
REFERENCE   4  (bases 1 to 1162)
  AUTHORS   Edwards,D.R., Gilbert,J.R., Hicks,J.E., Myers,J.L., Jiang,L.,
            Cummings,A.C., Guo,S., Gallins,P.J., Konidari,I., Caywood,L.,
            Reinhart-Mercer,L., Fuzzell,D., Knebusch,C., Laux,R., Jackson,C.E.,
            Pericak-Vance,M.A., Haines,J.L. and Scott,W.K.
  TITLE     Linkage and association of successful aging to the 6q25 region in
            large Amish kindreds
  JOURNAL   Age (Dordr) 35 (4), 1467-1477 (2013)
   PUBMED   22773346
REFERENCE   5  (bases 1 to 1162)
  AUTHORS   Liu,C.Y., Wu,M.C., Chen,F., Ter-Minassian,M., Asomaning,K.,
            Zhai,R., Wang,Z., Su,L., Heist,R.S., Kulke,M.H., Lin,X., Liu,G. and
            Christiani,D.C.
  TITLE     A Large-scale genetic association study of esophageal
            adenocarcinoma risk
  JOURNAL   Carcinogenesis 31 (7), 1259-1263 (2010)
   PUBMED   20453000
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 1162)
  AUTHORS   Dufault,V.M., Oestreich,A.J., Vroman,B.T. and Karnitz,L.M.
  TITLE     Identification and characterization of RAD9B, a paralog of the RAD9
            checkpoint gene
  JOURNAL   Genomics 82 (6), 644-651 (2003)
   PUBMED   14611806
REFERENCE   7  (bases 1 to 1162)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   8  (bases 1 to 1162)
  AUTHORS   Hopkins,K.M., Wang,X., Berlin,A., Hang,H., Thaker,H.M. and
            Lieberman,H.B.
  TITLE     Expression of mammalian paralogues of HRAD9 and Mrad9 checkpoint
            control genes in normal and cancerous testicular tissue
  JOURNAL   Cancer Res 63 (17), 5291-5298 (2003)
   PUBMED   14500360
REFERENCE   9  (bases 1 to 1162)
  AUTHORS   Hang,H., Zhang,Y., Dunbrack,R.L. Jr., Wang,C. and Lieberman,H.B.
  TITLE     Identification and characterization of a paralog of human cell
            cycle checkpoint gene HUS1
  JOURNAL   Genomics 79 (4), 487-492 (2002)
   PUBMED   11944979
  REMARK    GeneRIF: HUS1B directly interacts with RAD1, but not RAD9 or HUS1,
            whereas HUS1 can bind RAD1, RAD9, and another molecule of HUS1,
            suggesting that HUS1B cannot simply substitute for HUS1 in the
            complex.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL357054.14.
            
            On Jan 14, 2021 this sequence version replaced NM_148959.3.
            
            Summary: The protein encoded by this gene is most closely related
            to HUS1, a component of a cell cycle checkpoint protein complex
            involved in cell cycle arrest in response to DNA damage. This
            protein can interact with the check point protein RAD1 but not with
            RAD9. Overexpression of this protein has been shown to induce cell
            death, which suggests a related but distinct role of this protein,
            as compared to the HUS1. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC101699.1, AF508547.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380907.3/ ENSP00000370293.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1162              AL357054.14        2321-3482           c
FEATURES             Location/Qualifiers
     source          1..1162
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p25.3"
     gene            1..1162
                     /gene="HUS1B"
                     /note="HUS1 checkpoint clamp component B"
                     /db_xref="GeneID:135458"
                     /db_xref="HGNC:HGNC:16485"
                     /db_xref="MIM:609713"
     exon            1..1162
                     /gene="HUS1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..993
                     /gene="HUS1B"
                     /note="hHUS1B; HUS1 checkpoint homolog b"
                     /codon_start=1
                     /product="checkpoint protein HUS1B"
                     /protein_id="NP_683762.2"
                     /db_xref="CCDS:CCDS4470.1"
                     /db_xref="GeneID:135458"
                     /db_xref="HGNC:HGNC:16485"
                     /db_xref="MIM:609713"
                     /translation="MKFRAKITGKGCLELFIHVSGTVARLAKVCVLRVRPDSLCFGPA
                     GSGGLHEARLWCEVRQGAFQQFRMEGVSEDLDEIHLELTAEHLSRAARSAAGASSLKL
                     QLTHKRRPSLTVAVELVSSLGRARSVVHDLPVRVLPRRVWRDCLPPSLRASDASIRLP
                     RWRTLRSIVERMANVGSHVLVEANLSGRMTLSIETEVVSIQSYFKNLGNPPQSAVGVP
                     ENRDLESMVQVRVDNRKLLQFLEGQQIHPTTALCNIWDNTLLQLVLVQEDVSLQYFIP
                     AL"
     regulatory      1143..1148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HUS1B"
                     /note="hexamer: ATTAAA"
     polyA_site      1162
                     /gene="HUS1B"
                     /note="major polyA site"
ORIGIN      
        1 agaacccgca accgcaaccg ggaacccgag tgcctgccta gctggggggc cggagggagg
       61 gcggggaggg cagcgccacg gaccccagcg gaccggaagg gcttgtggca cgcggaatcc
      121 ccctcagagg cccccagctg ccttccctgt ggcatcatga agtttcgcgc caagatcacc
      181 ggcaaaggct gtctagagct gttcattcac gtcagcggca ccgtcgcgag gctagcgaag
      241 gtctgcgtgc tccgcgtgcg ccctgacagc ctgtgcttcg gccccgcggg ttccggcggc
      301 ctccacgagg ccaggctgtg gtgcgaggtg cggcaggggg ccttccagca gtttcgcatg
      361 gaaggtgtct cggaagatct cgatgagatc cacctggagc tgacggcgga gcacctgtcc
      421 cgggcggcga gaagcgcagc gggcgcgtcc tccctgaagc tgcagctgac ccacaagcgc
      481 cgcccctccc tcacggtggc ggtggagctg gtctcgtccc tgggccgcgc tcgcagcgtg
      541 gtgcacgatc tgcccgtgcg ggtgcttccc aggagagtgt ggcgggactg cctgccgccc
      601 agcctgcgcg cctccgacgc gagcatccgc ctgccgcgct ggaggacgct gaggagcatc
      661 gtggagagga tggcgaacgt gggcagtcac gtgctggtgg aagcaaacct cagtggcagg
      721 atgaccctga gtatagagac ggaggtggtg tccattcaaa gttattttaa aaatcttgga
      781 aaccctcccc agtcggctgt gggtgtgcct gaaaacagag acctggagag catggtgcaa
      841 gtgcgggtgg acaatcggaa gcttctgcag tttttggagg gacagcaaat acatcctacg
      901 acggccctgt gcaatatttg ggacaatact cttcttcagc ttgttttggt tcaagaagat
      961 gtctctcttc agtatttcat tcctgccttg taaaaattca gccagcttag attttttttt
     1021 taaggttttg atcttttcaa aactaaaaca gaccctgagt taattgggtt gaaaatttgg
     1081 accttcactg acttatgcag ggcgtatatt ttgttgagcc cttcctcctt tgcaaaattt
     1141 atattaaagc attggtaaaa ca
//
