LOCUS       NM_014586               7680 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens hormonally up-regulated Neu-associated kinase (HUNK),
            mRNA.
ACCESSION   NM_014586
VERSION     NM_014586.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7680)
  AUTHORS   Jiang,S., Han,X., Liu,T., He,Y., Zhao,Z., Liu,T., Cheng,S.,
            Zhang,J., Duan,L., Liu,Y., Cheng,T., Liu,Y., Ye,Q. and Gao,S.
  TITLE     HUNK inhibits cargo uptake and lysosomal traffic in the caveolar
            pathway via the AGAP3/ARF6
  JOURNAL   Sci Bull (Beijing) 69 (2), 173-178 (2024)
   PUBMED   38071109
  REMARK    GeneRIF: HUNK inhibits cargo uptake and lysosomal traffic in the
            caveolar pathway via the AGAP3/ARF6.
REFERENCE   2  (bases 1 to 7680)
  AUTHORS   Han,X., Jiang,S., Gu,Y., Ding,L., Zhao,E., Cao,D., Wang,X., Wen,Y.,
            Pan,Y., Yan,X., Duan,L., Sun,M., Zhou,T., Liu,Y., Hu,H., Ye,Q. and
            Gao,S.
  TITLE     HUNK inhibits epithelial-mesenchymal transition of CRC via direct
            phosphorylation of GEF-H1 and activating RhoA/LIMK-1/CFL-1
  JOURNAL   Cell Death Dis 14 (5), 327 (2023)
   PUBMED   37193711
  REMARK    GeneRIF: HUNK inhibits epithelial-mesenchymal transition of CRC via
            direct phosphorylation of GEF-H1 and activating RhoA/LIMK-1/CFL-1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7680)
  AUTHORS   Viard,J., Loe-Mie,Y., Daudin,R., Khelfaoui,M., Plancon,C.,
            Boland,A., Tejedor,F., Huganir,R.L., Kim,E., Kinoshita,M., Liu,G.,
            Haucke,V., Moncion,T., Yu,E., Hindie,V., Blehaut,H., Mircher,C.,
            Herault,Y., Deleuze,J.F., Rain,J.C., Simonneau,M. and
            Lepagnol-Bestel,A.M.
  TITLE     Chr21 protein-protein interactions: enrichment in proteins involved
            in intellectual disability, autism, and late-onset Alzheimer's
            disease
  JOURNAL   Life Sci Alliance 5 (12), e202101205 (2022)
   PUBMED   35914814
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7680)
  AUTHORS   Williams,C.B., Phelps-Polirer,K., Dingle,I.P., Williams,C.J.,
            Rhett,M.J., Eblen,S.T., Armeson,K., Hill,E.G. and Yeh,E.S.
  TITLE     HUNK phosphorylates EGFR to regulate breast cancer metastasis
  JOURNAL   Oncogene 39 (5), 1112-1124 (2020)
   PUBMED   31597954
  REMARK    GeneRIF: HUNK phosphorylates EGFR to regulate breast cancer
            metastasis.
            Erratum:[Oncogene. 2021 May;40(20):3635-3636. doi:
            10.1038/s41388-021-01797-3.. PMID: 33958726]
REFERENCE   5  (bases 1 to 7680)
  AUTHORS   Zambrano,J.N., Eblen,S.T., Abt,M., Rhett,J.M., Muise-Helmericks,R.
            and Yeh,E.S.
  TITLE     HUNK Phosphorylates Rubicon to Support Autophagy
  JOURNAL   Int J Mol Sci 20 (22), 5813 (2019)
   PUBMED   31752345
  REMARK    GeneRIF: Rubicon as a novel substrate of HUNK.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7680)
  AUTHORS   Wertheim,G.B., Yang,T.W., Pan,T.C., Ramne,A., Liu,Z., Gardner,H.P.,
            Dugan,K.D., Kristel,P., Kreike,B., van de Vijver,M.J.,
            Cardiff,R.D., Reynolds,C. and Chodosh,L.A.
  TITLE     The Snf1-related kinase, Hunk, is essential for mammary tumor
            metastasis
  JOURNAL   Proc Natl Acad Sci U S A 106 (37), 15855-15860 (2009)
   PUBMED   19717424
  REMARK    GeneRIF: a gene expression signature that distinguishes Hunk-wild
            type from Hunk-deficient tumors predicts clinical outcome in women
            with breast cancer
REFERENCE   7  (bases 1 to 7680)
  AUTHORS   Vasilescu,J., Zweitzig,D.R., Denis,N.J., Smith,J.C., Ethier,M.,
            Haines,D.S. and Figeys,D.
  TITLE     The proteomic reactor facilitates the analysis of affinity-purified
            proteins by mass spectrometry: application for identifying
            ubiquitinated proteins in human cells
  JOURNAL   J Proteome Res 6 (1), 298-305 (2007)
   PUBMED   17203973
REFERENCE   8  (bases 1 to 7680)
  AUTHORS   Korobko,I.V., Zavalishina,L.E., Kiselev,S.L., Raikhlin,N.T. and
            Frank,G.A.
  TITLE     [Proteinkinase MAK-V/Hunk as a possible dianostic and prognostic
            marker of human breast carcinoma]
  JOURNAL   Arkh Patol 66 (5), 6-9 (2004)
   PUBMED   15575376
  REMARK    GeneRIF: Overproduction of MAK-V/Hunk in human breast cancer may be
            used fore more precise molecular typing.
REFERENCE   9  (bases 1 to 7680)
  AUTHORS   Korobko,I.V., Korobko,E.V. and Kiselev,S.L.
  TITLE     The MAK-V protein kinase regulates endocytosis in mouse
  JOURNAL   Mol Gen Genet 264 (4), 411-418 (2000)
   PUBMED   11129044
REFERENCE   10 (bases 1 to 7680)
  AUTHORS   Gardner,H.P., Wertheim,G.B., Ha,S.I., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A., Marquis,S.T. and Chodosh,L.A.
  TITLE     Cloning and characterization of Hunk, a novel mammalian
            SNF1-related protein kinase
  JOURNAL   Genomics 63 (1), 46-59 (2000)
   PUBMED   10662544
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000256.1 and AJ271722.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014586.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ271722.1, SRR1660807.109709.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000270112.7/ ENSP00000270112.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-295               AP000256.1         806-1100
            296-7680            AJ271722.1         1-7385
FEATURES             Location/Qualifiers
     source          1..7680
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.11"
     gene            1..7680
                     /gene="HUNK"
                     /note="hormonally up-regulated Neu-associated kinase"
                     /db_xref="GeneID:30811"
                     /db_xref="HGNC:HGNC:13326"
                     /db_xref="MIM:606532"
     exon            1..916
                     /gene="HUNK"
                     /inference="alignment:Splign:2.1.0"
     CDS             656..2800
                     /gene="HUNK"
                     /EC_number="2.7.11.1"
                     /note="hormonally upregulated neu tumor-associated kinase;
                     hormonally upregulated Neu-associated kinase;
                     serine/threonine protein kinase MAK-V; B19"
                     /codon_start=1
                     /product="hormonally up-regulated neu tumor-associated
                     kinase"
                     /protein_id="NP_055401.1"
                     /db_xref="CCDS:CCDS13610.1"
                     /db_xref="GeneID:30811"
                     /db_xref="HGNC:HGNC:13326"
                     /db_xref="MIM:606532"
                     /translation="MPAAAGDGLLGEPAAPGGGGGAEDAARPAAACEGSFLPAWVSGV
                     PRERLRDFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDT
                     YVTKNLRREGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEE
                     SEARRYIRQLISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSD
                     PFSTQCGSPAYAAPELLARKKYGPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQK
                     MVDKEMNPLPTQLSTGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTY
                     PNRISLEDLSPSVVLHMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGK
                     SDIQDSLCYKTRLYQIEKYRAPKESYEASLDTWTRDLEFHAVQDKKPKEQEKRGDFLH
                     RPFSKKLDKNLPSHKQPSGSLMTQIQNTKALLKDRKASKSSFPDKDSFGCRNIFRKTS
                     DSNCVASSSMEFIPVPPPRTPRIVKKPEPHQPGPGSTGIPHKEDPLMLDMVRSFESVD
                     RDDHVEVLSPSHHYRILNSPVSLARRNSSERTLSPGLPSGSMSPLHTPLHPTLVSFAH
                     EDKNSPPKEEGLCCPPPVPSNGPMQPLGSPNCVKSRGRFPMMGIGQMLRKRHQSLQPS
                     ADRPLEASLPPLQPLAPVNLAFDMADGVKTQC"
     exon            917..1209
                     /gene="HUNK"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1265
                     /gene="HUNK"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1401
                     /gene="HUNK"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1529
                     /gene="HUNK"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1665
                     /gene="HUNK"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1828
                     /gene="HUNK"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1912
                     /gene="HUNK"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..1960
                     /gene="HUNK"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2141
                     /gene="HUNK"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..7680
                     /gene="HUNK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5601..5606
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HUNK"
                     /note="hexamer: AATACA"
     polyA_site      5620
                     /gene="HUNK"
                     /note="major polyA site"
     regulatory      5641..5646
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HUNK"
                     /note="hexamer: GATAAA"
     polyA_site      5661
                     /gene="HUNK"
     regulatory      7661..7666
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HUNK"
                     /note="hexamer: AATAAA"
     polyA_site      7680
                     /gene="HUNK"
ORIGIN      
        1 actagggatt tgaaagtgca cgggctgcgg agtggagctc gcatctgttc ccgccgcccg
       61 cgagcggatt aaatttctgc aaattcaaac tgaatggggc tttcttctgc tgccttccag
      121 agggcgccgg cagcccgccg cgcgcttctc tccggcggga gcggccgccc agcgcacggc
      181 taggagcgat cgcgggagcc cgacccaagc ccgtgcgggc cagacggcgg cggcgaggcg
      241 gaggctgcgg aggcacccgg gctcccggac ccaggcaccc ggaccccggg acccaggcgc
      301 cgccggaccg cgccccaccc cgcgcgcccg agcagggcga ctgtcattag cttcctggac
      361 gggacccggg gcgggatcct ggtgtcctga aaggggcccg ggcgacccta agaggaagaa
      421 cttttggggg cggggtcccc ggtcccgcgt cccctgggca gccgctattg tctacgcgcc
      481 tcgctgggcg gcgcgggggg cgtgatcgcg gcggccccgg gctctgggtg cggagaccca
      541 ggcggggctg ggcccagggc ggcggcggga gaagccgggg aagccgaaga gcctggggag
      601 gaggagctgc gagcgcggga gacgagcagg agccgcgcgg gccgcggcga gcgcgatgcc
      661 ggcggcggcg ggggacgggc tcctggggga gccggcggcg cctgggggcg gcggcggcgc
      721 ggaggacgcg gccaggcccg cggcggcctg cgagggaagt ttcctgcctg cctgggtgag
      781 cggcgtgccc cgcgagcggc tccgcgactt ccagcaccac aagcgcgtgg gcaactacct
      841 catcggcagc aggaagctgg gcgagggctc ctttgccaag gtgcgcgagg ggctgcacgt
      901 gctgaccggg gagaaggtgg ccataaaagt cattgataag aagagagcca aaaaggacac
      961 ctatgtcacc aaaaacctgc ggcgagaggg tcagatccag cagatgatcc gccaccccaa
     1021 tatcactcag ctccttgata ttttagaaac ggaaaacagc tactacctgg tcatggagct
     1081 gtgccctggg ggcaacctga tgcacaagat ctatgagaag aagcggctgg aggagtccga
     1141 agcccgcaga tacatccgac agctcatctc tgccgtagag cacctgcacc gggccggggt
     1201 ggtccacaga gacttgaaga tagagaattt gctactagat gaagacaata atatcaagct
     1261 gattgacttt ggtttgagca actgcgcagg gatcctgggt tactcggatc cgttcagcac
     1321 acagtgtggc agccctgcct acgctgcacc tgaactgctc gccaggaaga aatacggccc
     1381 caaaatcgat gtctggtcca taggtgtgaa catgtatgcc atgttgaccg ggacgctgcc
     1441 tttcacggtg gagcctttca gcctgagggc tttgtaccag aagatggtag acaaagaaat
     1501 gaaccccctc cccactcagc tctccacagg tgccatcagt ttcctgcgct ctctcctgga
     1561 accggatcct gtgaagaggc caaatattca gcaggcactg gcgaatcgct ggcttaatga
     1621 gaattacacg ggcaaagtgc cctgtaatgt cacctatccc aacaggattt ctctggaaga
     1681 tctgagcccg agcgtcgtgc tgcacatgac cgagaagctg ggttacaaga acagcgacgt
     1741 gatcaacact gtgctctcca accgcgcctg ccacatcctg gccatctact tcctcttaaa
     1801 caagaaactg gagcgctatt tgtcagggaa atctgacatc caggacagcc tctgctacaa
     1861 gacccggctc taccagatag aaaagtacag ggcccccaag gagtcctatg aggcctctct
     1921 ggacacctgg acacgagatc ttgaattcca tgccgtgcag gataaaaagc ccaaagaaca
     1981 agaaaaaaga ggggattttc ttcatcgacc attctccaag aagttggaca agaacctgcc
     2041 ctcgcacaaa cagccctcag gctcgcttat gacacagatt cagaacacca aagccctcct
     2101 gaaggaccgg aaggcctcca agtccagctt ccccgacaaa gattcctttg gctgccgcaa
     2161 tattttccgc aaaacctcag attccaattg tgtggcttct tcttccatgg agttcatccc
     2221 cgtgccaccg cccaggaccc cgaggattgt gaagaaaccg gagccccatc agccagggcc
     2281 cggaagcact ggcatccccc acaaggaaga ccccctgatg ctggacatgg tgcgctcctt
     2341 cgagtctgtg gatcgcgacg accacgtaga agtgctgtct ccctctcatc actacaggat
     2401 tctgaactcc ccggtcagct tggctcgcag aaattccagc gagaggacgc tgtccccggg
     2461 tctgccatcc ggaagcatgt cgcctctcca tactcctttg catccaactc tggtctcttt
     2521 tgctcacgaa gataagaaca gccccccaaa agaggagggc ctgtgttgcc cacctccggt
     2581 tcccagcaat ggccccatgc agcctctggg gagccccaat tgtgtgaaaa gccgaggccg
     2641 gttccctatg atgggcatcg gacagatgtt aaggaagcgc catcagagtc tgcagccatc
     2701 tgcagatagg cccctggagg ccagcctgcc cccactgcag cccctagccc ctgtgaacct
     2761 tgcctttgac atggccgatg gggtcaagac ccagtgctaa cttgggccag cggggtttgg
     2821 ggtatctcta gaaaacagca actgaacaga gctccacaca tctgtcaggg tgtgagcact
     2881 ccaaggcctc gcgtggagca tccttagtcc cacctgtagc tgaatccaca gacccaaagc
     2941 ctgcacaacc caacctcgct tagggacccc cagagatgct ggaatcgcta ggagggttgg
     3001 ctccaggggc agccaattcc tatcattcag atcttccttc ctcccaagta ctcaccaacc
     3061 ccttccactt cccacttccc ccaggcttgg ggggaaaaca gggcatgagc cttctggggc
     3121 actcagatta tggactgtta ccagatcttt cttcacgctg tgctacatgt gtgcctctca
     3181 cagcagttgg ccacagttac agggagagaa caatatcaca gtcattcatc caggccacgt
     3241 ttcctctgcg gagtgtagca gccctgcctt tcatagcagg gattacctga aggccagcag
     3301 gagccggggg caggcccagg atcctcagag gaagatggag aggagcttcg gaccaagatc
     3361 aaaccaaaca gtggggaccc caacagaaga gaaagactga aggagacact catttcccaa
     3421 gcaagatttt gatagatttt tgttgttgtt gttgttgaaa catgctaatg attgaattat
     3481 cttttccaaa gatttttttt aaatgtgatg tcggtaaatt gaaataacat aattttttaa
     3541 aacttggatg gagagatgag aagcaattcc accaaactca tgttttcaca ggagggttca
     3601 gtgtggagag caaaaaagct gactgtggtg atttgctgag tgctgtggcc cacaggcagg
     3661 gcaagtctcg gtggccctgt gttcatcctg ttgtttaagg catagccctg atccttctgg
     3721 aaggcataga acacggttac agctggttct gtagaaagag ggaaaagatg attgtgacaa
     3781 ttcagagcat aactcagatg gcgagaaggc agcattatct ctgtgcgatg ctgatttcaa
     3841 gctgcccaca gaactggtgc ggctcagagc tcggcgagtt tgctgggagc tgggagcagg
     3901 cttgcctggc agagaacctg ttcagataca ggccagtttc ttcttcgagg aaagccaagc
     3961 tcctcaaaca gggttcagtc cacgttgtgt tttcacacct ttctccaagg atcgaaccaa
     4021 agatgtgtct ccagtattgt gtctgtgccc ctgtgtgtgt tttgtggaca gccgtgttgt
     4081 ctgactgtat ccagctggca cttgacaggg tgcagtcatt ggtgagaaga atcagaaaaa
     4141 gaagacccat cagcacaggt tggatagggg ttagtgtagg agaccagtta cagaatggcc
     4201 tggagtcttc aacttttgac cggtgcaggt gtgaccagag accacctctg tggccacctc
     4261 agatagtcat ctcagtccaa ggatcccaaa acacaaatct agaattgcaa agccagcctt
     4321 tatttccctg gcaggcagcc ttgccagaag gcagagaggc agttctgaat cattctctca
     4381 ttcaccagtg gtgacatcct tcagtccctc acatctctga cagagcggga cagaatggat
     4441 atttggctga ccttggtgag acctggagct gcctgtttct tccctagggg atcaccacgg
     4501 ctctagggca ttctaggatg aggtcagacc ccttggccat tggtgttatt ttttgtatag
     4561 cttcagactg ggttccagaa cttaccattg aaaacagagc ttttaggcca ggtgtggtgg
     4621 ctcacacctg taatcccagc actttgggag gccgaggcag gtggatcgct tgagctcagg
     4681 agttcgagag cagcctgggc aacatggtga aagcccgtct ctaccgaaaa atacaaaaaa
     4741 aaatagctgg gtgtggtggt acgtgcctgt agtcccagct acttcgggga ctgaggtggg
     4801 aggatcactt gaacctagga ggtcgaggct gcagtgagcc aagatcatgc tactgcactc
     4861 cagcttaggt ggcaaagtga gaccctgtct ccaaaaaaag aaaatagagc tttataagca
     4921 gagagaagaa aataatcatc taagaccatc tctccattcg acatgaagtg taccttttct
     4981 aaagacggtt tccagctgca acggctccac tttgcaggct tgcagggtgt atacctgcgc
     5041 attgggaact tgctggaacc cctgatgcat tttccttgag agcaggggta cttccgcctt
     5101 gccgttagct tgtggagaac gtgcttctta ttcctggcag gcttcaagaa cagctgcaca
     5161 tgtgccgcta actgaccgcg ttgccattgg cgacctggac tctgaactca ggtttattct
     5221 aaacccagtg agaggtgagg gggagtgatg aaaggggatc agctgtattt gtgtgtgtgt
     5281 gtgtgtgtga gcacctgaca aatctatgaa accgagtgaa aggagaaatg ttagattctt
     5341 tattatttta ttatatttat atggaaagct cgactctccc tttggtaagt ccgaagcatg
     5401 ttgtctgttc gaccgtgact gtcttcctca gtctgtgcct gtgattccag tcaccctgta
     5461 gttactgaca gaaattgact ggactgtcat tgtgtgaagt ctaggaggaa atgtccattt
     5521 taattgtatg atttggtcat aagtaaggac tatatttatg tcaccattat tagatatatg
     5581 tacttttgta atgactgtga aatacacttt tccctcacta cgactgcttc tttatttgct
     5641 gataaatctt aaaacaacta agtacgttgc aaataatagt acaggtacca tcttttatgt
     5701 gaagttcttt ttcttttttt gagacagggt cttgctctgt cacccaggct ggagtgcagt
     5761 ggcacaatca cagttcactg cagcctcaac ctctccagat tcaagtgatc ctcccatctc
     5821 agcctcccaa gtagctggga ctacagttgt gcaccacaat gcctagctaa ttttttttgt
     5881 attttgtaga aatggggttt cgccatgttg ctcaggctga tctcaaactc ctgggctcca
     5941 acgatctgcc caccttggcc tcccaaagtg ctgagattac aggcgtgagc cactgtgcct
     6001 ggccttatgt aaagctcttg acctagcatc tgactggaaa caagcgggaa ttgcattggg
     6061 gggcattttc tgggccagtt tccctgcctt attttacctg caataggtgt gcctacaaaa
     6121 gtctttctga catacacact gcaggtggca gttcaagaag aatcaacctt tttcatttgg
     6181 ggatattagg atcttccttg gagactctga aaatggcaca caaagaatgg cagttatgaa
     6241 cgtgacttct agattttgtc cttgtaggag gccttggtca tggatagggg aagagggatg
     6301 atgggatgga atgggagggt gggatctaga tgacctcttg aaattgtccc agttactgct
     6361 tccttcataa ctgttcacaa aacgtttttc atatatacca ccttgtttcc cctgggaagt
     6421 gaggggacga agccttagag ggtgacatag ctagaaagtg gagaagctca ctgttcactg
     6481 tgcaaagccc cagtagtcgg attccgggga aaagaacaag tatctagttt tgatgacaat
     6541 gttttcttgt aagaatccca acactttaga atagaaaagg acctaagatt ctctggctca
     6601 gccccagcct ttctgaagaa gggaaaacta gggacccaga tggtttaagg acaccccaga
     6661 gtccccagat gagctggcat ttgagctggt ctggagcaga gtttctccct caaagaacac
     6721 agagaaatca gagagtggct gccatggtca gagggggatg tcaacaacag atcaagccgt
     6781 catcacaaca ggtatttctg aagttcctgc agggactagg tcttgcattt ttaagtcctt
     6841 ttcaaaactg tgcagcttcc tgaaccttat gctgtttgtc ccatccactc ttgaagctgg
     6901 ggaaagacag ctttctttgg gaactctgtc tttctcagtt gacttcccaa gtaagcagca
     6961 aacccctgga tagccttgtt atctacttta ggtattaaga ggctattggg ttttactaga
     7021 ttaaatcaat aaaacatttc ctatagagcc atatcataca ctgaagcaaa ttcagaaaga
     7081 atgcaaaact gctatctttt gggggagtct ggaagcctgt tggttagtgt atttattttc
     7141 tttgtggggt cttctgtgag ctacaggcac agtaagaata attcagagcg gtactgggag
     7201 ttggttcaat ttcatgtcat cacttttcaa tgaagggagt gcatttcctg agtagtaaat
     7261 gagtatatta tttgtggcag cttttctgtt aagggagctt tccagacatc tggttgcaaa
     7321 gacaaatagg atatatattt gtacttcttc tctgtggaca tgtttttgtg acacacagtt
     7381 atctctagga gttgacgtct gtgggcacta agggactgag gttgggggag aaagctgagg
     7441 aggctttgga agagaaggtg aggagcattt caggatttgc agtccccctc cacatgtatc
     7501 cacatctgag ctggtggtgt tccaataatg aggcatttgg ggcaaccaat tttggaagga
     7561 tagaatagct ttatgtggag caaacttgag gatcaattgg agttgagtgg tttaaaactt
     7621 aaagatggca caggaagctg tatcatttac aggtgaaaaa aataaatggg tctgacttca
//
