LOCUS       NM_001388492           13472 bp    mRNA    linear   PRI 08-FEB-2025
DEFINITION  Homo sapiens huntingtin (HTT), transcript variant 1, mRNA.
ACCESSION   NM_001388492
VERSION     NM_001388492.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13472)
  AUTHORS   Lisowski,P., Lickfett,S., Rybak-Wolf,A., Menacho,C., Le,S.,
            Pentimalli,T.M., Notopoulou,S., Dykstra,W., Oehler,D.,
            Lopez-Calcerrada,S., Mlody,B., Otto,M., Wu,H., Richter,Y., Roth,P.,
            Anand,R., Kulka,L.A.M., Meierhofer,D., Glazar,P., Legnini,I.,
            Telugu,N.S., Hahn,T., Neuendorf,N., Miller,D.C., Boddrich,A.,
            Polzin,A., Mayatepek,E., Diecke,S., Olzscha,H., Kirstein,J.,
            Ugalde,C., Petrakis,S., Cambridge,S., Rajewsky,N., Kuhn,R.,
            Wanker,E.E., Priller,J., Metzger,J.J. and Prigione,A.
  TITLE     Mutant huntingtin impairs neurodevelopment in human brain organoids
            through CHCHD2-mediated neurometabolic failure
  JOURNAL   Nat Commun 15 (1), 7027 (2024)
   PUBMED   39174523
  REMARK    GeneRIF: Mutant huntingtin impairs neurodevelopment in human brain
            organoids through CHCHD2-mediated neurometabolic failure.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13472)
  AUTHORS   Salem,S., Kilgore,M.D., Anwer,M., Maxan,A., Child,D., Bird,T.D.,
            Keene,C.D., Cicchetti,F. and Latimer,C.
  TITLE     Evidence of mutant huntingtin and tau-related pathology within
            neuronal grafts in Huntington's disease cases
  JOURNAL   Neurobiol Dis 198, 106542 (2024)
   PUBMED   38810948
  REMARK    GeneRIF: Evidence of mutant huntingtin and tau-related pathology
            within neuronal grafts in Huntington's disease cases.
REFERENCE   3  (bases 1 to 13472)
  AUTHORS   Torricella,F., Tugarinov,V. and Clore,G.M.
  TITLE     Nucleation of Huntingtin Aggregation Proceeds via Conformational
            Conversion of Pre-Formed, Sparsely-Populated Tetramers
  JOURNAL   Adv Sci (Weinh) 11 (24), e2309217 (2024)
   PUBMED   38476051
  REMARK    GeneRIF: Nucleation of Huntingtin Aggregation Proceeds via
            Conformational Conversion of Pre-Formed, Sparsely-Populated
            Tetramers.
REFERENCE   4  (bases 1 to 13472)
  AUTHORS   Hoschek,F., Natan,J., Wagner,M., Sathasivam,K., Abdelmoez,A., von
            Einem,B., Bates,G.P., Landwehrmeyer,G.B. and Neueder,A.
  TITLE     Huntingtin HTT1a is generated in a CAG repeat-length-dependent
            manner in human tissues
  JOURNAL   Mol Med 30 (1), 36 (2024)
   PUBMED   38459427
  REMARK    GeneRIF: Huntingtin HTT1a is generated in a CAG
            repeat-length-dependent manner in human tissues.
            Erratum:[Mol Med. 2024 Apr 10;30(1):49. doi:
            10.1186/s10020-024-00810-1.. PMID: 38600455]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 13472)
  AUTHORS   Lee,J., Park,E.H., Couture,G., Harvey,I., Garneau,P. and
            Pelletier,J.
  TITLE     An upstream open reading frame impedes translation of the
            huntingtin gene
  JOURNAL   Nucleic Acids Res 30 (23), 5110-5119 (2002)
   PUBMED   12466534
  REMARK    GeneRIF: An upstream open reading frame impedes translation of the
            huntingtin gene
REFERENCE   6  (bases 1 to 13472)
  AUTHORS   Li,X.J., Li,S.H., Sharp,A.H., Nucifora,F.C. Jr., Schilling,G.,
            Lanahan,A., Worley,P., Snyder,S.H. and Ross,C.A.
  TITLE     A huntingtin-associated protein enriched in brain with implications
            for pathology
  JOURNAL   Nature 378 (6555), 398-402 (1995)
   PUBMED   7477378
REFERENCE   7  (bases 1 to 13472)
  AUTHORS   Gutekunst,C.A., Levey,A.I., Heilman,C.J., Whaley,W.L., Yi,H.,
            Nash,N.R., Rees,H.D., Madden,J.J. and Hersch,S.M.
  TITLE     Identification and localization of huntingtin in brain and human
            lymphoblastoid cell lines with anti-fusion protein antibodies
  JOURNAL   Proc Natl Acad Sci U S A 92 (19), 8710-8714 (1995)
   PUBMED   7568002
REFERENCE   8  (bases 1 to 13472)
  AUTHORS   Caron,N.S., Wright,G.E.B. and Hayden,M.R.
  TITLE     Huntington Disease
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301482
REFERENCE   9  (bases 1 to 13472)
  AUTHORS   Klein,C., Lohmann,K., Marras,C. and Munchau,A.
  TITLE     Hereditary Dystonia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301334
REFERENCE   10 (bases 1 to 13472)
  AUTHORS   MacDonald,M.E., Novelletto,A., Lin,C., Tagle,D., Barnes,G.,
            Bates,G., Taylor,S., Allitto,B., Altherr,M., Myers,R. et al.
  TITLE     The Huntington's disease candidate region exhibits many different
            haplotypes
  JOURNAL   Nat Genet 1 (2), 99-103 (1992)
   PUBMED   1302016
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL390059.10.
            
            Summary: Huntingtin is a disease gene linked to Huntington's
            disease, a neurodegenerative disorder characterized by loss of
            striatal neurons. This is thought to be caused by an expanded,
            unstable trinucleotide repeat in the huntingtin gene, which
            translates as a polyglutamine repeat in the protein product. A
            fairly broad range of trinucleotide repeats (9-35) has been
            identified in normal controls, and repeat numbers in excess of 40
            have been described as pathological. The huntingtin locus is large,
            spanning 180 kb and consisting of 67 exons. The huntingtin gene is
            widely expressed and is required for normal development. It is
            expressed as 2 alternatively polyadenylated forms displaying
            different relative abundance in various fetal and adult tissues.
            The larger transcript is approximately 13.7 kb and is expressed
            predominantly in adult and fetal brain whereas the smaller
            transcript of approximately 10.3 kb is more widely expressed. The
            genetic defect leading to Huntington's disease may not necessarily
            eliminate transcription, but may confer a new property on the mRNA
            or alter the function of the protein. One candidate is the
            huntingtin-associated protein-1, highly expressed in brain, which
            has increased affinity for huntingtin protein with expanded
            polyglutamine repeats. This gene contains an upstream open reading
            frame in the 5' UTR that inhibits expression of the huntingtin gene
            product through translational repression. [provided by RefSeq, Jul
            2016].
            
            Sequence Note: This RefSeq contains a CAG-repeat region encoding 21
            Glutamines, and matches the GRCh38 reference genome. The repeat
            region is not associated with Huntington's Disease.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB016794.1, L12392.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355072.11/ ENSP00000347184.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-408               AL390059.10        196533-196940       c
            409-492             AL390059.10        184599-184682       c
            493-613             AL390059.10        172227-172347       c
            614-673             AL390059.10        167738-167797       c
            674-753             AL390059.10        166185-166264       c
            754-892             AL390059.10        164198-164336       c
            893-1034            AL390059.10        156176-156317       c
            1035-1213           AL390059.10        155358-155536       c
            1214-1418           AL390059.10        150189-150393       c
            1419-1466           AL390059.10        148685-148732       c
            1467-1547           AL390059.10        145992-146072       c
            1548-1888           AL390059.10        144017-144357       c
            1889-2012           AL390059.10        141574-141697       c
            2013-2131           AL390059.10        141198-141316       c
            2132-2243           AL390059.10        140224-140335       c
            2244-2381           AL390059.10        139846-139983       c
            2382-2540           AL390059.10        138901-139059       c
            2541-2638           AL390059.10        138710-138807       c
            2639-2778           AL390059.10        137081-137220       c
            2779-2842           AL390059.10        135654-135717       c
            2843-2943           AL390059.10        135295-135395       c
            2944-3090           AL390059.10        130965-131111       c
            3091-3211           AL390059.10        128735-128855       c
            3212-3288           AL390059.10        126393-126469       c
            3289-3440           AL390059.10        124673-124824       c
            3441-3643           AL390059.10        123414-123616       c
            3644-3770           AL390059.10        117202-117328       c
            3771-3898           AL390059.10        114422-114549       c
            3899-4009           AL390059.10        111229-111339       c
            4010-4087           AL390059.10        99224-99301         c
            4088-4311           AL390059.10        98490-98713         c
            4312-4390           AL390059.10        96822-96900         c
            4391-4552           AL390059.10        96514-96675         c
            4553-4608           AL390059.10        94234-94289         c
            4609-4757           AL390059.10        93175-93323         c
            4758-4894           AL390059.10        90970-91106         c
            4895-5011           AL390059.10        89151-89267         c
            5012-5134           AL390059.10        84902-85024         c
            5135-5370           AL390059.10        83735-83970         c
            5371-5513           AL390059.10        82528-82670         c
            5514-5721           AL390059.10        71682-71889         c
            5722-5863           AL390059.10        67473-67614         c
            5864-6043           AL390059.10        64946-65125         c
            6044-6220           AL390059.10        64638-64814         c
            6221-6297           AL390059.10        64264-64340         c
            6298-6436           AL390059.10        62710-62848         c
            6437-6559           AL390059.10        61672-61794         c
            6560-6773           AL390059.10        59479-59692         c
            6774-6919           AL390059.10        58912-59057         c
            6920-7097           AL390059.10        57486-57663         c
            7098-7199           AL390059.10        56410-56511         c
            7200-7387           AL390059.10        53669-53856         c
            7388-7514           AL390059.10        51313-51439         c
            7515-7615           AL390059.10        49134-49234         c
            7616-7770           AL390059.10        48061-48215         c
            7771-7910           AL390059.10        47490-47629         c
            7911-7993           AL390059.10        45878-45960         c
            7994-8124           AL390059.10        42876-43006         c
            8125-8254           AL390059.10        42612-42741         c
            8255-8410           AL390059.10        41579-41734         c
            8411-8601           AL390059.10        38268-38458         c
            8602-8716           AL390059.10        36223-36337         c
            8717-8930           AL390059.10        35843-36056         c
            8931-9036           AL390059.10        35367-35472         c
            9037-9199           AL390059.10        33012-33174         c
            9200-9360           AL390059.10        32643-32803         c
            9361-13472          AL390059.10        27664-31775         c
FEATURES             Location/Qualifiers
     source          1..13472
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..13472
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /note="huntingtin"
                     /db_xref="GeneID:3064"
                     /db_xref="HGNC:HGNC:4851"
                     /db_xref="MIM:613004"
     exon            1..408
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..9574
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /note="isoform 1 is encoded by transcript variant 1;
                     huntington disease protein"
                     /codon_start=1
                     /product="huntingtin isoform 1"
                     /protein_id="NP_001375421.1"
                     /db_xref="CCDS:CCDS43206.1"
                     /db_xref="GeneID:3064"
                     /db_xref="HGNC:HGNC:4851"
                     /db_xref="MIM:613004"
                     /translation="MATLEKLMKAFESLKSFQQQQQQQQQQQQQQQQQQQQQPPPPPP
                     PPPPPQLPQPPPQAQPLLPQPQPPPPPPPPPPGPAVAEEPLHRPKKELSATKKDRVNH
                     CLTICENIVAQSVRNSPEFQKLLGIAMELFLLCSDDAESDVRMVADECLNKVIKALMD
                     SNLPRLQLELYKEIKKNGAPRSLRAALWRFAELAHLVRPQKCRPYLVNLLPCLTRTSK
                     RPEESVQETLAAAVPKIMASFGNFANDNEIKVLLKAFIANLKSSSPTIRRTAAGSAVS
                     ICQHSRRTQYFYSWLLNVLLGLLVPVEDEHSTLLILGVLLTLRYLVPLLQQQVKDTSL
                     KGSFGVTRKEMEVSPSAEQLVQVYELTLHHTQHQDHNVVTGALELLQQLFRTPPPELL
                     QTLTAVGGIGQLTAAKEESGGRSRSGSIVELIAGGGSSCSPVLSRKQKGKVLLGEEEA
                     LEDDSESRSDVSSSALTASVKDEISGELAASSGVSTPGSAGHDIITEQPRSQHTLQAD
                     SVDLASCDLTSSATDGDEEDILSHSSSQVSAVPSDPAMDLNDGTQASSPISDSSQTTT
                     EGPDSAVTPSDSSEIVLDGTDNQYLGLQIGQPQDEDEEATGILPDEASEAFRNSSMAL
                     QQAHLLKNMSHCRQPSDSSVDKFVLRDEATEPGDQENKPCRIKGDIGQSTDDDSAPLV
                     HCVRLLSASFLLTGGKNVLVPDRDVRVSVKALALSCVGAAVALHPESFFSKLYKVPLD
                     TTEYPEEQYVSDILNYIDHGDPQVRGATAILCGTLICSILSRSRFHVGDWMGTIRTLT
                     GNTFSLADCIPLLRKTLKDESSVTCKLACTAVRNCVMSLCSSSYSELGLQLIIDVLTL
                     RNSSYWLVRTELLETLAEIDFRLVSFLEAKAENLHRGAHHYTGLLKLQERVLNNVVIH
                     LLGDEDPRVRHVAAASLIRLVPKLFYKCDQGQADPVVAVARDQSSVYLKLLMHETQPP
                     SHFSVSTITRIYRGYNLLPSITDVTMENNLSRVIAAVSHELITSTTRALTFGCCEALC
                     LLSTAFPVCIWSLGWHCGVPPLSASDESRKSCTVGMATMILTLLSSAWFPLDLSAHQD
                     ALILAGNLLAASAPKSLRSSWASEEEANPAATKQEEVWPALGDRALVPMVEQLFSHLL
                     KVINICAHVLDDVAPGPAIKAALPSLTNPPSLSPIRRKGKEKEPGEQASVPLSPKKGS
                     EASAASRQSDTSGPVTTSKSSSLGSFYHLPSYLKLHDVLKATHANYKVTLDLQNSTEK
                     FGGFLRSALDVLSQILELATLQDIGKCVEEILGYLKSCFSREPMMATVCVQQLLKTLF
                     GTNLASQFDGLSSNPSKSQGRAQRLGSSSVRPGLYHYCFMAPYTHFTQALADASLRNM
                     VQAEQENDTSGWFDVLQKVSTQLKTNLTSVTKNRADKNAIHNHIRLFEPLVIKALKQY
                     TTTTCVQLQKQVLDLLAQLVQLRVNYCLLDSDQVFIGFVLKQFEYIEVGQFRESEAII
                     PNIFFFLVLLSYERYHSKQIIGIPKIIQLCDGIMASGRKAVTHAIPALQPIVHDLFVL
                     RGTNKADAGKELETQKEVVVSMLLRLIQYHQVLEMFILVLQQCHKENEDKWKRLSRQI
                     ADIILPMLAKQQMHIDSHEALGVLNTLFEILAPSSLRPVDMLLRSMFVTPNTMASVST
                     VQLWISGILAILRVLISQSTEDIVLSRIQELSFSPYLISCTVINRLRDGDSTSTLEEH
                     SEGKQIKNLPEETFSRFLLQLVGILLEDIVTKQLKVEMSEQQHTFYCQELGTLLMCLI
                     HIFKSGMFRRITAAATRLFRSDGCGGSFYTLDSLNLRARSMITTHPALVLLWCQILLL
                     VNHTDYRWWAEVQQTPKRHSLSSTKLLSPQMSGEEEDSDLAAKLGMCNREIVRRGALI
                     LFCDYVCQNLHDSEHLTWLIVNHIQDLISLSHEPPVQDFISAVHRNSAASGLFIQAIQ
                     SRCENLSTPTMLKKTLQCLEGIHLSQSGAVLTLYVDRLLCTPFRVLARMVDILACRRV
                     EMLLAANLQSSMAQLPMEELNRIQEYLQSSGLAQRHQRLYSLLDRFRLSTMQDSLSPS
                     PPVSSHPLDGDGHVSLETVSPDKDWYVHLVKSQCWTRSDSALLEGAELVNRIPAEDMN
                     AFMMNSEFNLSLLAPCLSLGMSEISGGQKSALFEAAREVTLARVSGTVQQLPAVHHVF
                     QPELPAEPAAYWSKLNDLFGDAALYQSLPTLARALAQYLVVVSKLPSHLHLPPEKEKD
                     IVKFVVATLEALSWHLIHEQIPLSLDLQAGLDCCCLALQLPGLWSVVSSTEFVTHACS
                     LIYCVHFILEAVAVQPGEQLLSPERRTNTPKAISEEEEEVDPNTQNPKYITAACEMVA
                     EMVESLQSVLALGHKRNSGVPAFLTPLLRNIIISLARLPLVNSYTRVPPLVWKLGWSP
                     KPGGDFGTAFPEIPVEFLQEKEVFKEFIYRINTLGWTSRTQFEETWATLLGVLVTQPL
                     VMEQEESPPEEDTERTQINVLAVQAITSLVLSAMTVPVAGNPAVSCLEQQPRNKPLKA
                     LDTRFGRKLSIIRGIVEQEIQAMVSKRENIATHHLYQAWDPVPSLSPATTGALISHEK
                     LLLQINPERELGSMSYKLGQVSIHSVWLGNSITPLREEEWDEEEEEEADAPAPSSPPT
                     SPVNSRKHRAGVDIHSCSQFLLELYSRWILPSSSARRTPAILISEVVRSLLVVSDLFT
                     ERNQFELMYVTLTELRRVHPSEDEILAQYLVPATCKAAAVLGMDKAVAEPVSRLLEST
                     LRSSHLPSRVGALHGVLYVLECDLLDDTAKQLIPVISDYLLSNLKGIAHCVNIHSQQH
                     VLVMCATAFYLIENYPLDVGPEFSASIIQMCGVMLSGSEESTPSIIYHCALRGLERLL
                     LSEQLSRLDAESLVKLSVDRVNVHSPHRAMAALGLMLTCMYTGKEKVSPGRTSDPNPA
                     APDSESVIVAMERVSVLFDRIRKGFPCEARVVARILPQFLDDFFPPQDIMNKVIGEFL
                     SNQQPYPQFMATVVYKVFQTLHSTGQSSMVRDWVMLSLSNFTQRAPVAMATWSLSCFF
                     VSASTSPWVAAILPHVISRMGKLEQVDVNLFCLVATDFYRHQIEEELDRRAFQSVLEV
                     VAAPGSPYHRLLTCLRNVHKVTTC"
     exon            409..492
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            493..613
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            614..673
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            674..753
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            754..892
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1034
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1213
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1418
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1466
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1547
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1888
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..2012
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2131
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..2243
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            2244..2381
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            2382..2540
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            2541..2638
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            2639..2778
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            2779..2842
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            2843..2943
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            2944..3090
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            3091..3211
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            3212..3288
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            3289..3440
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            3441..3643
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            3644..3770
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            3771..3898
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            3899..4009
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            4010..4087
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            4088..4311
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            4312..4390
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            4391..4552
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            4553..4608
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            4609..4757
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            4758..4894
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            4895..5011
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            5012..5134
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            5135..5370
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            5371..5513
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            5514..5721
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            5722..5863
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            5864..6043
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            6044..6220
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            6221..6297
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            6298..6436
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            6437..6559
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            6560..6773
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            6774..6919
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            6920..7097
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            7098..7199
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            7200..7387
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            7388..7514
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            7515..7615
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            7616..7770
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            7771..7910
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            7911..7993
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            7994..8124
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            8125..8254
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            8255..8410
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            8411..8601
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            8602..8716
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            8717..8930
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            8931..9036
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            9037..9199
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            9200..9360
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     exon            9361..13472
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10150..10155
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /note="hexamer: AGTAAA"
     polyA_site      10174
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /note="major polyA site"
     regulatory      13449..13454
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /note="hexamer: ATTAAA"
     polyA_site      13472
                     /gene="HTT"
                     /gene_synonym="HD; IT15; LOMARS"
                     /note="major polyA site"
ORIGIN      
        1 gctgccggga cgggtccaag atggacggcc gctcaggttc tgcttttacc tgcggcccag
       61 agccccattc attgccccgg tgctgagcgg cgccgcgagt cggcccgagg cctccgggga
      121 ctgccgtgcc gggcgggaga ccgccatggc gaccctggaa aagctgatga aggccttcga
      181 gtccctcaag tccttccagc agcagcagca gcagcagcag cagcagcagc agcagcagca
      241 gcagcagcag cagcaacagc cgccaccgcc gccgccgccg ccgccgcctc ctcagcttcc
      301 tcagccgccg ccgcaggcac agccgctgct gcctcagccg cagccgcccc cgccgccgcc
      361 cccgccgcca cccggcccgg ctgtggctga ggagccgctg caccgaccaa agaaagaact
      421 ttcagctacc aagaaagacc gtgtgaatca ttgtctgaca atatgtgaaa acatagtggc
      481 acagtctgtc agaaattctc cagaatttca gaaacttctg ggcatcgcta tggaactttt
      541 tctgctgtgc agtgatgacg cagagtcaga tgtcaggatg gtggctgacg aatgcctcaa
      601 caaagttatc aaagctttga tggattctaa tcttccaagg ttacagctcg agctctataa
      661 ggaaattaaa aagaatggtg cccctcggag tttgcgtgct gccctgtgga ggtttgctga
      721 gctggctcac ctggttcggc ctcagaaatg caggccttac ctggtgaacc ttctgccgtg
      781 cctgactcga acaagcaaga gacccgaaga atcagtccag gagaccttgg ctgcagctgt
      841 tcccaaaatt atggcttctt ttggcaattt tgcaaatgac aatgaaatta aggttttgtt
      901 aaaggccttc atagcgaacc tgaagtcaag ctcccccacc attcggcgga cagcggctgg
      961 atcagcagtg agcatctgcc agcactcaag aaggacacaa tatttctata gttggctact
     1021 aaatgtgctc ttaggcttac tcgttcctgt cgaggatgaa cactccactc tgctgattct
     1081 tggcgtgctg ctcaccctga ggtatttggt gcccttgctg cagcagcagg tcaaggacac
     1141 aagcctgaaa ggcagcttcg gagtgacaag gaaagaaatg gaagtctctc cttctgcaga
     1201 gcagcttgtc caggtttatg aactgacgtt acatcataca cagcaccaag accacaatgt
     1261 tgtgaccgga gccctggagc tgttgcagca gctcttcaga acgcctccac ccgagcttct
     1321 gcaaaccctg accgcagtcg ggggcattgg gcagctcacc gctgctaagg aggagtctgg
     1381 tggccgaagc cgtagtggga gtattgtgga acttatagct ggagggggtt cctcatgcag
     1441 ccctgtcctt tcaagaaaac aaaaaggcaa agtgctctta ggagaagaag aagccttgga
     1501 ggatgactct gaatcgagat cggatgtcag cagctctgcc ttaacagcct cagtgaagga
     1561 tgagatcagt ggagagctgg ctgcttcttc aggggtttcc actccagggt cagcaggtca
     1621 tgacatcatc acagaacagc cacggtcaca gcacacactg caggcggact cagtggatct
     1681 ggccagctgt gacttgacaa gctctgccac tgatggggat gaggaggata tcttgagcca
     1741 cagctccagc caggtcagcg ccgtcccatc tgaccctgcc atggacctga atgatgggac
     1801 ccaggcctcg tcgcccatca gcgacagctc ccagaccacc accgaagggc ctgattcagc
     1861 tgttacccct tcagacagtt ctgaaattgt gttagacggt accgacaacc agtatttggg
     1921 cctgcagatt ggacagcccc aggatgaaga tgaggaagcc acaggtattc ttcctgatga
     1981 agcctcggag gccttcagga actcttccat ggcccttcaa caggcacatt tattgaaaaa
     2041 catgagtcac tgcaggcagc cttctgacag cagtgttgat aaatttgtgt tgagagatga
     2101 agctactgaa ccgggtgatc aagaaaacaa gccttgccgc atcaaaggtg acattggaca
     2161 gtccactgat gatgactctg cacctcttgt ccattgtgtc cgccttttat ctgcttcgtt
     2221 tttgctaaca gggggaaaaa atgtgctggt tccggacagg gatgtgaggg tcagcgtgaa
     2281 ggccctggcc ctcagctgtg tgggagcagc tgtggccctc cacccggaat ctttcttcag
     2341 caaactctat aaagttcctc ttgacaccac ggaataccct gaggaacagt atgtctcaga
     2401 catcttgaac tacatcgatc atggagaccc acaggttcga ggagccactg ccattctctg
     2461 tgggaccctc atctgctcca tcctcagcag gtcccgcttc cacgtgggag attggatggg
     2521 caccattaga accctcacag gaaatacatt ttctttggcg gattgcattc ctttgctgcg
     2581 gaaaacactg aaggatgagt cttctgttac ttgcaagtta gcttgtacag ctgtgaggaa
     2641 ctgtgtcatg agtctctgca gcagcagcta cagtgagtta ggactgcagc tgatcatcga
     2701 tgtgctgact ctgaggaaca gttcctattg gctggtgagg acagagcttc tggaaaccct
     2761 tgcagagatt gacttcaggc tggtgagctt tttggaggca aaagcagaaa acttacacag
     2821 aggggctcat cattatacag ggcttttaaa actgcaagaa cgagtgctca ataatgttgt
     2881 catccatttg cttggagatg aagaccccag ggtgcgacat gttgccgcag catcactaat
     2941 taggcttgtc ccaaagctgt tttataaatg tgaccaagga caagctgatc cagtagtggc
     3001 cgtggcaaga gatcaaagca gtgtttacct gaaacttctc atgcatgaga cgcagcctcc
     3061 atctcatttc tccgtcagca caataaccag aatatataga ggctataacc tactaccaag
     3121 cataacagac gtcactatgg aaaataacct ttcaagagtt attgcagcag tttctcatga
     3181 actaatcaca tcaaccacca gagcactcac atttggatgc tgtgaagctt tgtgtcttct
     3241 ttccactgcc ttcccagttt gcatttggag tttaggttgg cactgtggag tgcctccact
     3301 gagtgcctca gatgagtcta ggaagagctg taccgttggg atggccacaa tgattctgac
     3361 cctgctctcg tcagcttggt tcccattgga tctctcagcc catcaagatg ctttgatttt
     3421 ggccggaaac ttgcttgcag ccagtgctcc caaatctctg agaagttcat gggcctctga
     3481 agaagaagcc aacccagcag ccaccaagca agaggaggtc tggccagccc tgggggaccg
     3541 ggccctggtg cccatggtgg agcagctctt ctctcacctg ctgaaggtga ttaacatttg
     3601 tgcccacgtc ctggatgacg tggctcctgg acccgcaata aaggcagcct tgccttctct
     3661 aacaaacccc ccttctctaa gtcccatccg acgaaagggg aaggagaaag aaccaggaga
     3721 acaagcatct gtaccgttga gtcccaagaa aggcagtgag gccagtgcag cttctagaca
     3781 atctgatacc tcaggtcctg ttacaacaag taaatcctca tcactgggga gtttctatca
     3841 tcttccttca tacctcaaac tgcatgatgt cctgaaagct acacacgcta actacaaggt
     3901 cacgctggat cttcagaaca gcacggaaaa gtttggaggg tttctccgct cagccttgga
     3961 tgttctttct cagatactag agctggccac actgcaggac attgggaagt gtgttgaaga
     4021 gatcctagga tacctgaaat cctgctttag tcgagaacca atgatggcaa ctgtttgtgt
     4081 tcaacaattg ttgaagactc tctttggcac aaacttggcc tcccagtttg atggcttatc
     4141 ttccaacccc agcaagtcac aaggccgagc acagcgcctt ggctcctcca gtgtgaggcc
     4201 aggcttgtac cactactgct tcatggcccc gtacacccac ttcacccagg ccctcgctga
     4261 cgccagcctg aggaacatgg tgcaggcgga gcaggagaac gacacctcgg gatggtttga
     4321 tgtcctccag aaagtgtcta cccagttgaa gacaaacctc acgagtgtca caaagaaccg
     4381 tgcagataag aatgctattc ataatcacat tcgtttgttt gaacctcttg ttataaaagc
     4441 tttaaaacag tacacgacta caacatgtgt gcagttacag aagcaggttt tagatttgct
     4501 ggcgcagctg gttcagttac gggttaatta ctgtcttctg gattcagatc aggtgtttat
     4561 tggctttgta ttgaaacagt ttgaatacat tgaagtgggc cagttcaggg aatcagaggc
     4621 aatcattcca aacatctttt tcttcttggt attactatct tatgaacgct atcattcaaa
     4681 acagatcatt ggaattccta aaatcattca gctctgtgat ggcatcatgg ccagtggaag
     4741 gaaggctgtg acacatgcca taccggctct gcagcccata gtccacgacc tctttgtatt
     4801 aagaggaaca aataaagctg atgcaggaaa agagcttgaa acccaaaaag aggtggtggt
     4861 gtcaatgtta ctgagactca tccagtacca tcaggtgttg gagatgttca ttcttgtcct
     4921 gcagcagtgc cacaaggaga atgaagacaa gtggaagcga ctgtctcgac agatagctga
     4981 catcatcctc ccaatgttag ccaaacagca gatgcacatt gactctcatg aagcccttgg
     5041 agtgttaaat acattatttg agattttggc cccttcctcc ctccgtccgg tagacatgct
     5101 tttacggagt atgttcgtca ctccaaacac aatggcgtcc gtgagcactg ttcaactgtg
     5161 gatatcggga attctggcca ttttgagggt tctgatttcc cagtcaactg aagatattgt
     5221 tctttctcgt attcaggagc tctccttctc tccgtattta atctcctgta cagtaattaa
     5281 taggttaaga gatggggaca gtacttcaac gctagaagaa cacagtgaag ggaaacaaat
     5341 aaagaatttg ccagaagaaa cattttcaag gtttctatta caactggttg gtattctttt
     5401 agaagacatt gttacaaaac agctgaaggt ggaaatgagt gagcagcaac atactttcta
     5461 ttgccaggaa ctaggcacac tgctaatgtg tctgatccac atcttcaagt ctggaatgtt
     5521 ccggagaatc acagcagctg ccactaggct gttccgcagt gatggctgtg gcggcagttt
     5581 ctacaccctg gacagcttga acttgcgggc tcgttccatg atcaccaccc acccggccct
     5641 ggtgctgctc tggtgtcaga tactgctgct tgtcaaccac accgactacc gctggtgggc
     5701 agaagtgcag cagaccccga aaagacacag tctgtccagc acaaagttac ttagtcccca
     5761 gatgtctgga gaagaggagg attctgactt ggcagccaaa cttggaatgt gcaatagaga
     5821 aatagtacga agaggggctc tcattctctt ctgtgattat gtctgtcaga acctccatga
     5881 ctccgagcac ttaacgtggc tcattgtaaa tcacattcaa gatctgatca gcctttccca
     5941 cgagcctcca gtacaggact tcatcagtgc cgttcatcgg aactctgctg ccagcggcct
     6001 gttcatccag gcaattcagt ctcgttgtga aaacctttca actccaacca tgctgaagaa
     6061 aactcttcag tgcttggagg ggatccatct cagccagtcg ggagctgtgc tcacgctgta
     6121 tgtggacagg cttctgtgca cccctttccg tgtgctggct cgcatggtcg acatccttgc
     6181 ttgtcgccgg gtagaaatgc ttctggctgc aaatttacag agcagcatgg cccagttgcc
     6241 aatggaagaa ctcaacagaa tccaggaata ccttcagagc agcgggctcg ctcagagaca
     6301 ccaaaggctc tattccctgc tggacaggtt tcgtctctcc accatgcaag actcacttag
     6361 tccctctcct ccagtctctt cccacccgct ggacggggat gggcacgtgt cactggaaac
     6421 agtgagtccg gacaaagact ggtacgttca tcttgtcaaa tcccagtgtt ggaccaggtc
     6481 agattctgca ctgctggaag gtgcagagct ggtgaatcgg attcctgctg aagatatgaa
     6541 tgccttcatg atgaactcgg agttcaacct aagcctgcta gctccatgct taagcctagg
     6601 gatgagtgaa atttctggtg gccagaagag tgcccttttt gaagcagccc gtgaggtgac
     6661 tctggcccgt gtgagcggca ccgtgcagca gctccctgct gtccatcatg tcttccagcc
     6721 cgagctgcct gcagagccgg cggcctactg gagcaagttg aatgatctgt ttggggatgc
     6781 tgcactgtat cagtccctgc ccactctggc ccgggccctg gcacagtacc tggtggtggt
     6841 ctccaaactg cccagtcatt tgcaccttcc tcctgagaaa gagaaggaca ttgtgaaatt
     6901 cgtggtggca acccttgagg ccctgtcctg gcatttgatc catgagcaga tcccgctgag
     6961 tctggatctc caggcagggc tggactgctg ctgcctggcc ctgcagctgc ctggcctctg
     7021 gagcgtggtc tcctccacag agtttgtgac ccacgcctgc tccctcatct actgtgtgca
     7081 cttcatcctg gaggccgttg cagtgcagcc tggagagcag cttcttagtc cagaaagaag
     7141 gacaaatacc ccaaaagcca tcagcgagga ggaggaggaa gtagatccaa acacacagaa
     7201 tcctaagtat atcactgcag cctgtgagat ggtggcagaa atggtggagt ctctgcagtc
     7261 ggtgttggcc ttgggtcata aaaggaatag cggcgtgccg gcgtttctca cgccattgct
     7321 aaggaacatc atcatcagcc tggcccgcct gccccttgtc aacagctaca cacgtgtgcc
     7381 cccactggtg tggaagcttg gatggtcacc caaaccggga ggggattttg gcacagcatt
     7441 ccctgagatc cccgtggagt tcctccagga aaaggaagtc tttaaggagt tcatctaccg
     7501 catcaacaca ctaggctgga ccagtcgtac tcagtttgaa gaaacttggg ccaccctcct
     7561 tggtgtcctg gtgacgcagc ccctcgtgat ggagcaggag gagagcccac cagaagaaga
     7621 cacagagagg acccagatca acgtcctggc cgtgcaggcc atcacctcac tggtgctcag
     7681 tgcaatgact gtgcctgtgg ccggcaaccc agctgtaagc tgcttggagc agcagccccg
     7741 gaacaagcct ctgaaagctc tcgacaccag gtttgggagg aagctgagca ttatcagagg
     7801 gattgtggag caagagattc aagcaatggt ttcaaagaga gagaatattg ccacccatca
     7861 tttatatcag gcatgggatc ctgtcccttc tctgtctccg gctactacag gtgccctcat
     7921 cagccacgag aagctgctgc tacagatcaa ccccgagcgg gagctgggga gcatgagcta
     7981 caaactcggc caggtgtcca tacactccgt gtggctgggg aacagcatca cacccctgag
     8041 ggaggaggaa tgggacgagg aagaggagga ggaggccgac gcccctgcac cttcgtcacc
     8101 acccacgtct ccagtcaact ccaggaaaca ccgggctgga gttgacatcc actcctgttc
     8161 gcagtttttg cttgagttgt acagccgctg gatcctgccg tccagctcag ccaggaggac
     8221 cccggccatc ctgatcagtg aggtggtcag atcccttcta gtggtctcag acttgttcac
     8281 cgagcgcaac cagtttgagc tgatgtatgt gacgctgaca gaactgcgaa gggtgcaccc
     8341 ttcagaagac gagatcctcg ctcagtacct ggtgcctgcc acctgcaagg cagctgccgt
     8401 ccttgggatg gacaaggccg tggcggagcc tgtcagccgc ctgctggaga gcacgctcag
     8461 gagcagccac ctgcccagca gggttggagc cctgcacggc gtcctctatg tgctggagtg
     8521 cgacctgctg gacgacactg ccaagcagct catcccggtc atcagcgact atctcctctc
     8581 caacctgaaa gggatcgccc actgcgtgaa cattcacagc cagcagcacg tactggtcat
     8641 gtgtgccact gcgttttacc tcattgagaa ctatcctctg gacgtagggc cggaattttc
     8701 agcatcaata atacagatgt gtggggtgat gctgtctgga agtgaggagt ccaccccctc
     8761 catcatttac cactgtgccc tcagaggcct ggagcgcctc ctgctctctg agcagctctc
     8821 ccgcctggat gcagaatcgc tggtcaagct gagtgtggac agagtgaacg tgcacagccc
     8881 gcaccgggcc atggcggctc tgggcctgat gctcacctgc atgtacacag gaaaggagaa
     8941 agtcagtccg ggtagaactt cagaccctaa tcctgcagcc cccgacagcg agtcagtgat
     9001 tgttgctatg gagcgggtat ctgttctttt tgataggatc aggaaaggct ttccttgtga
     9061 agccagagtg gtggccagga tcctgcccca gtttctagac gacttcttcc caccccagga
     9121 catcatgaac aaagtcatcg gagagtttct gtccaaccag cagccatacc cccagttcat
     9181 ggccaccgtg gtgtataagg tgtttcagac tctgcacagc accgggcagt cgtccatggt
     9241 ccgggactgg gtcatgctgt ccctctccaa cttcacgcag agggccccgg tcgccatggc
     9301 cacgtggagc ctctcctgct tctttgtcag cgcgtccacc agcccgtggg tcgcggcgat
     9361 cctcccacat gtcatcagca ggatgggcaa gctggagcag gtggacgtga accttttctg
     9421 cctggtcgcc acagacttct acagacacca gatagaggag gagctcgacc gcagggcctt
     9481 ccagtctgtg cttgaggtgg ttgcagcccc aggaagccca tatcaccggc tgctgacttg
     9541 tttacgaaat gtccacaagg tcaccacctg ctgagcgcca tggtgggaga gactgtgagg
     9601 cggcagctgg ggccggagcc tttggaagtc tgcgcccttg tgccctgcct ccaccgagcc
     9661 agcttggtcc ctatgggctt ccgcacatgc cgcgggcggc caggcaacgt gcgtgtctct
     9721 gccatgtggc agaagtgctc tttgtggcag tggccaggca gggagtgtct gcagtcctgg
     9781 tggggctgag cctgaggcct tccagaaagc aggagcagct gtgctgcacc ccatgtgggt
     9841 gaccaggtcc tttctcctga tagtcacctg ctggttgttg ccaggttgca gctgctcttg
     9901 catctgggcc agaagtcctc cctcctgcag gctggctgtt ggcccctctg ctgtcctgca
     9961 gtagaaggtg ccgtgagcag gctttgggaa cactggcctg ggtctccctg gtggggtgtg
    10021 catgccacgc cccgtgtctg gatgcacaga tgccatggcc tgtgctgggc cagtggctgg
    10081 gggtgctaga cacccggcac cattctccct tctctctttt cttctcagga tttaaaattt
    10141 aattatatca gtaaagagat taattttaac gtaactcttt ctatgcccgt gtaaagtatg
    10201 tgaatcgcaa ggcctgtgct gcatgcgaca gcgtccgggg tggtggacag ggcccccggc
    10261 cacgctccct ctcctgtagc cactggcata gccctcctga gcacccgctg acatttccgt
    10321 tgtacatgtt cctgtttatg cattcacaag gtgactggga tgtagagagg cgttagtggg
    10381 caggtggcca cagcaggact gaggacaggc ccccattatc ctaggggtgc gctcacctgc
    10441 agcccctcct cctcgggcac agacgactgt cgttctccac ccaccagtca gggacagcag
    10501 cctccctgtc actcagctga gaaggccagc cctccctggc tgtgagcagc ctccactgtg
    10561 tccagagaca tgggcctccc actcctgttc cttgctagcc ctggggtggc gtctgcctag
    10621 gagctggctg gcaggtgttg ggacctgctg ctccatggat gcatgcccta agagtgtcac
    10681 tgagctgtgt tttgtctgag cctctctcgg tcaacagcaa agcttggtgt cttggcactg
    10741 ttagtgacag agcccagcat cccttctgcc cccgttccag ctgacatctt gcacggtgac
    10801 cccttttagt caggagagtg cagatctgtg ctcatcggag actgccccac ggccctgtca
    10861 gagccgccac tcctatcccc aggccaggtc cctggaccag cctcctgttt gcaggcccag
    10921 aggagccaag tcattaaaat ggaagtggat tctggatggc cgggctgctg ctgatgtagg
    10981 agctggattt gggagctctg cttgccgact ggctgtgaga cgaggcaggg gctctgcttc
    11041 ctcagcccta gaggcgagcc aggcaaggtt ggcgactgtc atgtggcttg gtttggtcat
    11101 gcccgtcgat gttttgggta ttgaatgtgg taagtggagg aaatgttgga actctgtgca
    11161 ggtgctgcct tgagaccccc aagcttccac ctgtccctct cctatgtggc agctggggag
    11221 cagctgagat gtggacttgt atgctgccca catacgtgag ggggagctga aagggagccc
    11281 ctcctctgag cagcctctgc caggcctgta tgaggctttt cccaccagct cccaacagag
    11341 gcctccccca gccaggacca cctcgtcctc gtggcggggc agcaggagcg gtagaaaggg
    11401 gtccgatgtt tgaggaggcc cttaagggaa gctactgaat tataacacgt aagaaaatca
    11461 ccattccgta ttggttgggg gctcctgttt ctcatcctag ctttttcctg gaaagcccgc
    11521 tagaaggttt gggaacgagg ggaaagttct cagaactgtt ggctgctccc cacccgcctc
    11581 ccgcctcccc cgcaggttat gtcagcagct ctgagacagc agtatcacag gccagatgtt
    11641 gttcctggct agatgtttac atttgtaaga aataacactg tgaatgtaaa acagagccat
    11701 tcccttggaa tgcatatcgc tgggctcaac atagagtttg tcttcctctt gtttacgacg
    11761 tgatctaaac cagtccttag caaggggctc agaacacccc gctctggcag taggtgtccc
    11821 ccacccccaa agacctgcct gtgtgctccg gagatgaata tgagctcatt agtaaaaatg
    11881 acttcaccca cgcatataca taaagtatcc atgcatgtgc atatagacac atctataatt
    11941 ttacacacac acctctcaag acggagatgc atggcctcta agagtgcccg tgtcggttct
    12001 tcctggaagt tgactttcct tagacccgcc aggtcaagtt agccgcgtga cggacatcca
    12061 ggcgtgggac gtggtcaggg cagggctcat tcattgccca ctaggatccc actggcgaag
    12121 atggtctcca tatcagctct ctgcagaagg gaggaagact ttatcatgtt cctaaaaatc
    12181 tgtggcaagc acccatcgta ttatccaaat tttgttgcaa atgtgattaa tttggttgtc
    12241 aagttttggg ggtgggctgt ggggagattg cttttgtttt cctgctggta atatcgggaa
    12301 agattttaat gaaaccaggg tagaattgtt tggcaatgca ctgaagcgtg tttctttccc
    12361 aaaatgtgcc tcccttccgc tgcgggccca gctgagtcta tgtaggtgat gtttccagct
    12421 gccaagtgct ctttgttact gtccaccctc atttctgcca gcgcatgtgt cctttcaagg
    12481 ggaaaatgtg aagctgaacc ccctccagac acccagaatg tagcatctga gaaggccctg
    12541 tgccctaaag gacacccctc gcccccatct tcatggaggg ggtcatttca gagccctcgg
    12601 agccaatgaa cagctcctcc tcttggagct gagatgagcc ccacgtggag ctcgggacgg
    12661 atagtagaca gcaataactc ggtgtgtggc cgcctggcag gtggaacttc ctcccgttgc
    12721 ggggtggagt gaggttagtt ctgtgtgtct ggtgggtgga gtcaggcttc tcttgctacc
    12781 tgtgagcatc cttcccagca gacatcctca tcgggctttg tccctccccc gcttcctccc
    12841 tctgcgggga ggacccggga ccacagctgc tggccagggt agacttggag ctgtcctcca
    12901 gaggggtcac gtgtaggagt gagaagaagg aagatcttga gagctgctga gggaccttgg
    12961 agagctcagg atggctcaga cgaggacact cgcttgccgg gcctgggcct cctgggaagg
    13021 agggagctgc tcagaatgcc gcatgacaac tgaaggcaac ctggaaggtt caggggccgc
    13081 tcttccccca tgtgcctgtc acgctctggt gcagtcaaag gaacgccttc ccctcagttg
    13141 tttctaagag cagagtctcc cgctgcaatc tgggtggtaa ctgccagcct tggaggatcg
    13201 tggccaacgt ggacctgcct acggagggtg ggctctgacc caagtggggc ctccttgtcc
    13261 aggtctcact gctttgcacc gtggtcagag ggactgtcag ctgagcttga gctcccctgg
    13321 agccagcagg gctgtgatgg gcgagtcccg gagccccacc cagacctgaa tgcttctgag
    13381 agcaaaggga aggactgacg agagatgtat atttaatttt ttaactgctg caaacattgt
    13441 acatccaaat taaaggaaaa aaatggaaac ca
//
