LOCUS       NM_053044               2539 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens HtrA serine peptidase 3 (HTRA3), transcript variant 1,
            mRNA.
ACCESSION   NM_053044
VERSION     NM_053044.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2539)
  AUTHORS   Chen,Y., Yang,J., Jin,H., Wen,W., Xu,Y., Zhang,X. and Wang,Y.
  TITLE     HtrA3: a promising prognostic biomarker and therapeutic target for
            head and neck squamous cell carcinoma
  JOURNAL   PeerJ 11, e16237 (2023)
   PUBMED   37842043
  REMARK    GeneRIF: HtrA3: a promising prognostic biomarker and therapeutic
            target for head and neck squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2539)
  AUTHORS   Xu,Q., Wang,J., Wang,J., Zhu,Y., Chen,B., Guo,R., Qian,Y., Yuan,H.
            and Liu,F.
  TITLE     A Pan-Cancer Analysis to Provide Insight into the Immunological
            Role and Prognostic Value of HTRA3
  JOURNAL   Crit Rev Eukaryot Gene Expr 33 (8), 57-75 (2023)
   PUBMED   37606164
  REMARK    GeneRIF: A Pan-Cancer Analysis to Provide Insight into the
            Immunological Role and Prognostic Value of HTRA3.
REFERENCE   3  (bases 1 to 2539)
  AUTHORS   Pan,J., Xie,Y., Li,H., Li,X., Chen,J., Liu,X., Zhou,J., Tang,X.,
            He,Z., Peng,Z., Zhang,H., Li,Y., Xiang,X., Yuan,Y. and Zhang,D.
  TITLE     mmu-lncRNA 121686/hsa-lncRNA 520657 induced by METTL3 drive the
            progression of AKI by targeting miR-328-5p/HtrA3 signaling axis
  JOURNAL   Mol Ther 30 (12), 3694-3713 (2022)
   PUBMED   35869629
  REMARK    GeneRIF: mmu-lncRNA 121686/hsa-lncRNA 520657 induced by METTL3
            drive the progression of AKI by targeting miR-328-5p/HtrA3
            signaling axis.
REFERENCE   4  (bases 1 to 2539)
  AUTHORS   Huang,W. and Zhang,S.
  TITLE     Study on the Correlation between the Levels of HtrA3 and TGF-beta2
            in Late Pregnancy and Preeclampsia
  JOURNAL   J Healthc Eng 2022, 4453646 (2022)
   PUBMED   35035835
  REMARK    GeneRIF: Study on the Correlation between the Levels of HtrA3 and
            TGF-beta2 in Late Pregnancy and Preeclampsia.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2539)
  AUTHORS   Gong,Q., Shen,Z.M., Sheng,Z., Jiang,S. and Ge,S.L.
  TITLE     Hsa-miR-494-3p attenuates gene HtrA3 transcription to increase
            inflammatory response in hypoxia/reoxygenation HK2 Cells
  JOURNAL   Sci Rep 11 (1), 1665 (2021)
   PUBMED   33462352
  REMARK    GeneRIF: Hsa-miR-494-3p attenuates gene HtrA3 transcription to
            increase inflammatory response in hypoxia/reoxygenation HK2 Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2539)
  AUTHORS   Runyon,S.T., Zhang,Y., Appleton,B.A., Sazinsky,S.L., Wu,P., Pan,B.,
            Wiesmann,C., Skelton,N.J. and Sidhu,S.S.
  TITLE     Structural and functional analysis of the PDZ domains of human
            HtrA1 and HtrA3
  JOURNAL   Protein Sci 16 (11), 2454-2471 (2007)
   PUBMED   17962403
  REMARK    GeneRIF: Structural and functional analysis of the PDZ domains of
            human HtrA1 and HtrA3
REFERENCE   7  (bases 1 to 2539)
  AUTHORS   Bowden,M.A., Di Nezza-Cossens,L.A., Jobling,T., Salamonsen,L.A. and
            Nie,G.
  TITLE     Serine proteases HTRA1 and HTRA3 are down-regulated with increasing
            grades of human endometrial cancer
  JOURNAL   Gynecol Oncol 103 (1), 253-260 (2006)
   PUBMED   16650464
  REMARK    GeneRIF: RT-PCR analysis showed a significant reduction of HTRA1
            and HTRA3 mRNA in endometrial cancer compared to normal
            endometrium. HTRA1 and HTRA3 protein showed a similar pattern of
            expression in EC tissue.
REFERENCE   8  (bases 1 to 2539)
  AUTHORS   Nie,G., Li,Y., Hale,K., Okada,H., Manuelpillai,U., Wallace,E.M. and
            Salamonsen,L.A.
  TITLE     Serine peptidase HTRA3 is closely associated with human placental
            development and is elevated in pregnancy serum
  JOURNAL   Biol Reprod 74 (2), 366-374 (2006)
   PUBMED   16251496
  REMARK    GeneRIF: Upregulation of HTRA3 expression in association with
            placental development was revealed by a significant elevation of
            this protein in the maternal serum during the first trimester
REFERENCE   9  (bases 1 to 2539)
  AUTHORS   De Luca,A., De Falco,M., Severino,A., Campioni,M., Santini,D.,
            Baldi,F., Paggi,M.G. and Baldi,A.
  TITLE     Distribution of the serine protease HtrA1 in normal human tissues
  JOURNAL   J Histochem Cytochem 51 (10), 1279-1284 (2003)
   PUBMED   14500695
REFERENCE   10 (bases 1 to 2539)
  AUTHORS   Nie,G.Y., Hampton,A., Li,Y., Findlay,J.K. and Salamonsen,L.A.
  TITLE     Identification and cloning of two isoforms of human
            high-temperature requirement factor A3 (HtrA3), characterization of
            its genomic structure and comparison of its tissue distribution
            with HtrA1 and HtrA2
  JOURNAL   Biochem J 371 (Pt 1), 39-48 (2003)
   PUBMED   12513693
  REMARK    GeneRIF: We cloned the full-length sequences of two forms (long and
            short) of human HtrA3 mRNA, located the gene on chromosome 4p16.1,
            determined its genomic structure and revealed how the two mRNA
            variants are produced through alternative splicing
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113611.3 and BC035717.1.
            
            On Nov 23, 2018 this sequence version replaced NM_053044.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279870.1338.1, BC034390.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307358.7/ ENSP00000303766.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC113611.3         8904-8914
            12-2539             BC035717.1         1-2528
FEATURES             Location/Qualifiers
     source          1..2539
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.1"
     gene            1..2539
                     /gene="HTRA3"
                     /gene_synonym="Prsp; Tasp"
                     /note="HtrA serine peptidase 3"
                     /db_xref="GeneID:94031"
                     /db_xref="HGNC:HGNC:30406"
                     /db_xref="MIM:608785"
     exon            1..600
                     /gene="HTRA3"
                     /gene_synonym="Prsp; Tasp"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..1577
                     /gene="HTRA3"
                     /gene_synonym="Prsp; Tasp"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; pregnancy-related serine protease; serine
                     protease HTRA3; probable serine protease HTRA3;
                     high-temperature requirement factor A3"
                     /codon_start=1
                     /product="serine protease HTRA3 isoform 1 precursor"
                     /protein_id="NP_444272.1"
                     /db_xref="CCDS:CCDS3400.1"
                     /db_xref="GeneID:94031"
                     /db_xref="HGNC:HGNC:30406"
                     /db_xref="MIM:608785"
                     /translation="MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYV
                     PDLCNCCLVCAASEGEPCGGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCA
                     LQAASRRALQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELF
                     LRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEAT
                     IKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVST
                     AQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPS
                     DRITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVA
                     PNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEVRRGNDDLLFSIAPE
                     VVM"
     exon            601..700
                     /gene="HTRA3"
                     /gene_synonym="Prsp; Tasp"
                     /inference="alignment:Splign:2.1.0"
     exon            701..923
                     /gene="HTRA3"
                     /gene_synonym="Prsp; Tasp"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1118
                     /gene="HTRA3"
                     /gene_synonym="Prsp; Tasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1151
                     /gene="HTRA3"
                     /gene_synonym="Prsp; Tasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1266
                     /gene="HTRA3"
                     /gene_synonym="Prsp; Tasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1315
                     /gene="HTRA3"
                     /gene_synonym="Prsp; Tasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1411
                     /gene="HTRA3"
                     /gene_synonym="Prsp; Tasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..2539
                     /gene="HTRA3"
                     /gene_synonym="Prsp; Tasp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2521..2526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HTRA3"
                     /gene_synonym="Prsp; Tasp"
                     /note="hexamer: AATAAA"
     polyA_site      2539
                     /gene="HTRA3"
                     /gene_synonym="Prsp; Tasp"
                     /note="major polyA site"
ORIGIN      
        1 gtcaggctgg agggagctgg tccctgcgct ccctgcgccc tggggatgcc cctgccgccc
       61 tgacgcccgc cagcctgagc caccggcgca tgtgaccgcg cgtccgcccc agtcccatcc
      121 gtaggcgccc ggcgcccggc cccgcagcgg cctcgttgtc cccgccggcc cccgcccggt
      181 ctcccgcgct gccacccgcc gccggccctg ccgccatgca ggcgcgagcg ctgctcctgg
      241 ccgcgttggc cgcgctggcg ctggcccggg agccccctgc ggcgccgtgt cccgcgcgct
      301 gcgacgtgtc gcggtgtccc agcccccgct gccccggcgg ctacgtgccc gacctctgca
      361 actgctgcct ggtgtgcgcc gccagcgagg gcgagccctg tggcggccct ctggactcgc
      421 cttgcggcga gagcctggag tgcgtgcgcg gcctatgccg ctgccgctgg tcgcacgccg
      481 tgtgtggcac cgacgggcac acctatgcca acgtgtgcgc gctgcaggcg gccagccgcc
      541 gcgcgctgca gctctccggg acgcccgtgc gccagctgca gaagggcgcc tgcccgttgg
      601 gtctccacca gctgagcagc ccgcgctaca agttcaactt cattgctgac gtggtggaga
      661 agatcgcacc agccgtggtc cacatagagc tcttcctgag acacccgctg tttggccgca
      721 acgtgcccct gtccagcggt tctggcttca tcatgtcaga ggccggcctg atcatcacca
      781 atgcccacgt ggtgtccagc aacagtgctg ccccgggcag gcagcagctc aaggtgcagc
      841 tacagaatgg ggactcctat gaggccacca tcaaagacat cgacaagaag tcggacattg
      901 ccaccatcaa gatccatccc aagaaaaagc tccctgtgtt gttgctgggt cactcggccg
      961 acctgcggcc tggggagttt gtggtggcca tcggcagtcc cttcgcccta cagaacacag
     1021 tgacaacggg catcgtcagc actgcccagc gggagggcag ggagctgggc ctccgggact
     1081 ccgacatgga ctacatccag acggatgcca tcatcaacta cgggaactcc gggggaccac
     1141 tggtgaacct ggatggcgag gtcattggca tcaacacgct caaggtcacg gctggcatct
     1201 cctttgccat cccctcagac cgcatcacac ggttcctcac agagttccaa gacaagcaga
     1261 tcaaagactg gaagaagcgc ttcatcggca tacggatgcg gacgatcaca ccaagcctgg
     1321 tggatgagct gaaggccagc aacccggact tcccagaggt cagcagtgga atttatgtgc
     1381 aagaggttgc gccgaattca ccttctcaga gaggcggcat ccaagatggt gacatcatcg
     1441 tcaaggtcaa cgggcgtcct ctagtggact cgagtgagct gcaggaggcc gtgctgaccg
     1501 agtctcctct cctactggag gtgcggcggg ggaacgacga cctcctcttc agcatcgcac
     1561 ctgaggtggt catgtgaggg gcgcattcct ccagcgccaa gcgtcagagc ctgcagacaa
     1621 cggagggcag cgcccccccg agatcaggac gaaggaccac cgtcggtcct cagcagggcg
     1681 gcagcctcct cctggctgtc cggggcagag cggaggctgg gcttggccag gggcccgaat
     1741 ttccgcctgg ggagtgttgg atccacatcc cggtgccggg gagggaagcc caacatcccc
     1801 ttgtacagat gatcctgaaa gtcacttcca agttctccgg atattcacaa aactgccttc
     1861 catggaggtc ccctcctctc ctagcttccc gcctctgccc ctgtgaacac ccatctgcag
     1921 tatcccctgc tcctgcccct cctactgcag gtctgggctg ccaagcttct tcccccctga
     1981 caaacgccca cctgacctga ggccccagct tccctctgcc ctaggactta ccaagctgta
     2041 gggccagggc tgctgcctgc cagcctgggg tccctggagg acaggtcaca tctgatccct
     2101 ttggggtgcg ggggtggggt ccagcccaga gcaggcactg agtgaatgcc ccctggctgc
     2161 ggagctgagc cccgccctgc catgaggttt tcctccccag gcaggcagga ggccgcgggg
     2221 agcacgtgga aagttggctg ctgcctgggg aagcttctcc tccccaaggc ggccatgggg
     2281 cagcctgcag aggacagtgg acgtggagct gcggggtgtg aggactgagc cggcttcccc
     2341 ttcccacgca gctctgggat gcagcagccg ctcgcatgga agtgccgccc agaggcatgc
     2401 aggctgctgg gcaccacccc ctcatccagg gaacgagtgt gtctcaaggg gcatttgtga
     2461 gctttgctgt aaatggattc ccagtgttgc ttgtactgta tgtttctcta ctgtatggaa
     2521 aataaagttt acaagcaca
//
