LOCUS       NM_002775               2091 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens HtrA serine peptidase 1 (HTRA1), mRNA.
ACCESSION   NM_002775
VERSION     NM_002775.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2091)
  AUTHORS   Sun,Y., Yang,H., Guo,J., Du,J., Han,S. and Yang,X.
  TITLE     Identification of HTRA1, DPT and MXRA5 as potential biomarkers
            associated with osteoarthritis progression and immune infiltration
  JOURNAL   BMC Musculoskelet Disord 25 (1), 647 (2024)
   PUBMED   39148085
  REMARK    GeneRIF: Identification of HTRA1, DPT and MXRA5 as potential
            biomarkers associated with osteoarthritis progression and immune
            infiltration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2091)
  AUTHORS   Beaufort,N., Ingendahl,L., Merdanovic,M., Schmidt,A.,
            Podlesainski,D., Richter,T., Neumann,T., Kuszner,M., Vetter,I.R.,
            Stege,P., Burston,S.G., Filipovic,A., Ruiz-Blanco,Y.B.,
            Bravo-Rodriguez,K., Mieres-Perez,J., Beuck,C., Uebel,S., Zobawa,M.,
            Schillinger,J., Malik,R., Todorov-Volgyi,K., Rey,J., Roberti,A.,
            Hagemeier,B., Wefers,B., Muller,S.A., Wurst,W., Sanchez-Garcia,E.,
            Zimmermann,A., Hu,X.Y., Clausen,T., Huber,R., Lichtenthaler,S.F.,
            Schmuck,C., Giese,M., Kaiser,M., Ehrmann,M. and Dichgans,M.
  TITLE     Rational correction of pathogenic conformational defects in HTRA1
  JOURNAL   Nat Commun 15 (1), 5944 (2024)
   PUBMED   39013852
  REMARK    GeneRIF: Rational correction of pathogenic conformational defects
            in HTRA1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2091)
  AUTHORS   Navneet,S., Ishii,M. and Rohrer,B.
  TITLE     Altered Elastin Turnover, Immune Response, and Age-Related Retinal
            Thinning in a Transgenic Mouse Model With RPE-Specific HTRA1
            Overexpression
  JOURNAL   Invest Ophthalmol Vis Sci 65 (8), 34 (2024)
   PUBMED   39028977
  REMARK    GeneRIF: Altered Elastin Turnover, Immune Response, and Age-Related
            Retinal Thinning in a Transgenic Mouse Model With RPE-Specific
            HTRA1 Overexpression.
REFERENCE   4  (bases 1 to 2091)
  AUTHORS   Shi,H., Yuan,M., Cai,J., Lan,L., Wang,Y., Wang,W., Zhou,J.,
            Wang,B., Yu,W., Dong,Z., Deng,D., Qian,Q., Li,Y., Zhou,X. and
            Liu,J.
  TITLE     HTRA1-driven detachment of type I collagen from endoplasmic
            reticulum contributes to myocardial fibrosis in dilated
            cardiomyopathy
  JOURNAL   J Transl Med 22 (1), 297 (2024)
   PUBMED   38515161
  REMARK    GeneRIF: HTRA1-driven detachment of type I collagen from
            endoplasmic reticulum contributes to myocardial fibrosis in dilated
            cardiomyopathy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2091)
  AUTHORS   Zhao,W., Wu,Y., Wang,S., Zhao,F., Liu,W., Xue,Z., Zhang,L.,
            Wang,J., Han,M., Li,X. and Huang,B.
  TITLE     HTRA1 promotes EMT through the HDAC6/Ac-alpha-tubulin pathway in
            human GBM cells
  JOURNAL   CNS Neurosci Ther 30 (2), e14605 (2024)
   PUBMED   38334007
  REMARK    GeneRIF: HTRA1 promotes EMT through the HDAC6/Ac-alpha-tubulin
            pathway in human GBM cells.
REFERENCE   6  (bases 1 to 2091)
  AUTHORS   Baldi,A., De Luca,A., Morini,M., Battista,T., Felsani,A., Baldi,F.,
            Catricala,C., Amantea,A., Noonan,D.M., Albini,A., Natali,P.G.,
            Lombardi,D. and Paggi,M.G.
  TITLE     The HtrA1 serine protease is down-regulated during human melanoma
            progression and represses growth of metastatic melanoma cells
  JOURNAL   Oncogene 21 (43), 6684-6688 (2002)
   PUBMED   12242667
REFERENCE   7  (bases 1 to 2091)
  AUTHORS   Hu,S.I., Carozza,M., Klein,M., Nantermet,P., Luk,D. and Crowl,R.M.
  TITLE     Human HtrA, an evolutionarily conserved serine protease identified
            as a differentially expressed gene product in osteoarthritic
            cartilage
  JOURNAL   J Biol Chem 273 (51), 34406-34412 (1998)
   PUBMED   9852107
REFERENCE   8  (bases 1 to 2091)
  AUTHORS   Zumbrunn,J. and Trueb,B.
  TITLE     Localization of the gene for a serine protease with IGF-binding
            domain (PRSS11) to human chromosome 10q25.3-q26.2
  JOURNAL   Genomics 45 (2), 461-462 (1997)
   PUBMED   9344681
REFERENCE   9  (bases 1 to 2091)
  AUTHORS   Zumbrunn,J. and Trueb,B.
  TITLE     Primary structure of a putative serine protease specific for
            IGF-binding proteins
  JOURNAL   FEBS Lett 398 (2-3), 187-192 (1996)
   PUBMED   8977104
REFERENCE   10 (bases 1 to 2091)
  AUTHORS   Onodera,O., Nozaki,H. and Fukutake,T.
  TITLE     HTRA1 Disorder
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20437615
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA633502.1 and Y07921.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_002775.4.
            
            Summary: This gene encodes a member of the trypsin family of serine
            proteases. This protein is a secreted enzyme that is proposed to
            regulate the availability of insulin-like growth factors (IGFs) by
            cleaving IGF-binding proteins. It has also been suggested to be a
            regulator of cell growth. Variations in the promoter region of this
            gene are the cause of susceptibility to age-related macular
            degeneration type 7. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031082.1, D87258.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368984.8/ ENSP00000357980.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                DA633502.1         29-94
            67-2091             Y07921.1           5-2029
FEATURES             Location/Qualifiers
     source          1..2091
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.13"
     gene            1..2091
                     /gene="HTRA1"
                     /gene_synonym="ARMD7; CADASIL2; CARASIL; HtrA; L56;
                     ORF480; PRSS11"
                     /note="HtrA serine peptidase 1"
                     /db_xref="GeneID:5654"
                     /db_xref="HGNC:HGNC:9476"
                     /db_xref="MIM:602194"
     exon            1..572
                     /gene="HTRA1"
                     /gene_synonym="ARMD7; CADASIL2; CARASIL; HtrA; L56;
                     ORF480; PRSS11"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1543
                     /gene="HTRA1"
                     /gene_synonym="ARMD7; CADASIL2; CARASIL; HtrA; L56;
                     ORF480; PRSS11"
                     /EC_number="3.4.21.-"
                     /note="IGFBP5-protease; protease, serine, 11 (IGF
                     binding); serine protease HTRA1; high-temperature
                     requirement A serine peptidase 1"
                     /codon_start=1
                     /product="serine protease HTRA1 precursor"
                     /protein_id="NP_002766.1"
                     /db_xref="CCDS:CCDS7630.1"
                     /db_xref="GeneID:5654"
                     /db_xref="HGNC:HGNC:9476"
                     /db_xref="MIM:602194"
                     /translation="MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPA
                     RCPPQPEHCEGGRARDACGCCEVCGAPEGAACGLQEGPCGEGLQCVVPFGVPASATVR
                     RRAQAGLCVCASSEPVCGSDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQGQE
                     DPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTN
                     AHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPG
                     EFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVN
                     LDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTS
                     SKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSD
                     VIKRESTLNMVVRRGNEDIMITVIPEEIDP"
     exon            573..672
                     /gene="HTRA1"
                     /gene_synonym="ARMD7; CADASIL2; CARASIL; HtrA; L56;
                     ORF480; PRSS11"
                     /inference="alignment:Splign:2.1.0"
     exon            673..877
                     /gene="HTRA1"
                     /gene_synonym="ARMD7; CADASIL2; CARASIL; HtrA; L56;
                     ORF480; PRSS11"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1072
                     /gene="HTRA1"
                     /gene_synonym="ARMD7; CADASIL2; CARASIL; HtrA; L56;
                     ORF480; PRSS11"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1105
                     /gene="HTRA1"
                     /gene_synonym="ARMD7; CADASIL2; CARASIL; HtrA; L56;
                     ORF480; PRSS11"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1220
                     /gene="HTRA1"
                     /gene_synonym="ARMD7; CADASIL2; CARASIL; HtrA; L56;
                     ORF480; PRSS11"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1278
                     /gene="HTRA1"
                     /gene_synonym="ARMD7; CADASIL2; CARASIL; HtrA; L56;
                     ORF480; PRSS11"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1374
                     /gene="HTRA1"
                     /gene_synonym="ARMD7; CADASIL2; CARASIL; HtrA; L56;
                     ORF480; PRSS11"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..2091
                     /gene="HTRA1"
                     /gene_synonym="ARMD7; CADASIL2; CARASIL; HtrA; L56;
                     ORF480; PRSS11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2069..2074
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HTRA1"
                     /gene_synonym="ARMD7; CADASIL2; CARASIL; HtrA; L56;
                     ORF480; PRSS11"
                     /note="hexamer: ATTAAA"
     polyA_site      2091
                     /gene="HTRA1"
                     /gene_synonym="ARMD7; CADASIL2; CARASIL; HtrA; L56;
                     ORF480; PRSS11"
                     /note="major polyA site"
ORIGIN      
        1 actcgcaccc gctgcccccg aggccctcct gcactctccc cggcgccgct ctccggccct
       61 cgccctgtcc gccgccaccg ccgccgccgc cagagtcgcc atgcagatcc cgcgcgccgc
      121 tcttctcccg ctgctgctgc tgctgctggc ggcgcccgcc tcggcgcagc tgtcccgggc
      181 cggccgctcg gcgcctttgg ccgccgggtg cccagaccgc tgcgagccgg cgcgctgccc
      241 gccgcagccg gagcactgcg agggcggccg ggcccgggac gcgtgcggct gctgcgaggt
      301 gtgcggcgcg cccgagggcg ccgcgtgcgg cctgcaggag ggcccgtgcg gcgaggggct
      361 gcagtgcgtg gtgcccttcg gggtgccagc ctcggccacg gtgcggcggc gcgcgcaggc
      421 cggcctctgt gtgtgcgcca gcagcgagcc ggtgtgcggc agcgacgcca acacctacgc
      481 caacctgtgc cagctgcgcg ccgccagccg ccgctccgag aggctgcacc ggccgccggt
      541 catcgtcctg cagcgcggag cctgcggcca agggcaggaa gatcccaaca gtttgcgcca
      601 taaatataac tttatcgcgg acgtggtgga gaagatcgcc cctgccgtgg ttcatatcga
      661 attgtttcgc aagcttccgt tttctaaacg agaggtgccg gtggctagtg ggtctgggtt
      721 tattgtgtcg gaagatggac tgatcgtgac aaatgcccac gtggtgacca acaagcaccg
      781 ggtcaaagtt gagctgaaga acggtgccac ttacgaagcc aaaatcaagg atgtggatga
      841 gaaagcagac atcgcactca tcaaaattga ccaccagggc aagctgcctg tcctgctgct
      901 tggccgctcc tcagagctgc ggccgggaga gttcgtggtc gccatcggaa gcccgttttc
      961 ccttcaaaac acagtcacca ccgggatcgt gagcaccacc cagcgaggcg gcaaagagct
     1021 ggggctccgc aactcagaca tggactacat ccagaccgac gccatcatca actatggaaa
     1081 ctcgggaggc ccgttagtaa acctggacgg tgaagtgatt ggaattaaca ctttgaaagt
     1141 gacagctgga atctcctttg caatcccatc tgataagatt aaaaagttcc tcacggagtc
     1201 ccatgaccga caggccaaag gaaaagccat caccaagaag aagtatattg gtatccgaat
     1261 gatgtcactc acgtccagca aagccaaaga gctgaaggac cggcaccggg acttcccaga
     1321 cgtgatctca ggagcgtata taattgaagt aattcctgat accccagcag aagctggtgg
     1381 tctcaaggaa aacgacgtca taatcagcat caatggacag tccgtggtct ccgccaatga
     1441 tgtcagcgac gtcattaaaa gggaaagcac cctgaacatg gtggtccgca ggggtaatga
     1501 agatatcatg atcacagtga ttcccgaaga aattgaccca taggcagagg catgagctgg
     1561 acttcatgtt tccctcaaag actctcccgt ggatgacgga tgaggactct gggctgctgg
     1621 aataggacac tcaagacttt tgactgccat tttgtttgtt cagtggagac tccctggcca
     1681 acagaatcct tcttgatagt ttgcaggcaa aacaaatgta atgttgcaga tccgcaggca
     1741 gaagctctgc ccttctgtat cctatgtatg cagtgtgctt tttcttgcca gcttgggcca
     1801 ttcttgctta gacagtcagc atttgtctcc tcctttaact gagtcatcat cttagtccaa
     1861 ctaatgcagt cgatacaatg cgtagataga agaagcccca cgggagccag gatgggactg
     1921 gtcgtgtttg tgcttttctc caagtcagca cccaaaggtc aatgcacaga gaccccgggt
     1981 gggtgagcgc tggcttctca aacggccgaa gttgcctctt ttaggaatct ctttggaatt
     2041 gggagcacga tgactctgag tttgagctat taaagtactt cttacacatt g
//
