LOCUS       NM_019859               3467 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens 5-hydroxytryptamine receptor 7 (HTR7), transcript
            variant d, mRNA.
ACCESSION   NM_019859
VERSION     NM_019859.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3467)
  AUTHORS   Cinar,V., Hamurcu,Z., Guler,A., Nurdinov,N. and Ozpolat,B.
  TITLE     Serotonin 5-HT7 receptor is a biomarker poor prognostic factor and
            induces proliferation of triple-negative breast cancer cells
            through FOXM1
  JOURNAL   Breast Cancer 29 (6), 1106-1120 (2022)
   PUBMED   36006564
  REMARK    GeneRIF: Serotonin 5-HT7 receptor is a biomarker poor prognostic
            factor and induces proliferation of triple-negative breast cancer
            cells through FOXM1.
REFERENCE   2  (bases 1 to 3467)
  AUTHORS   Huang,S., Xu,P., Shen,D.D., Simon,I.A., Mao,C., Tan,Y., Zhang,H.,
            Harpsoe,K., Li,H., Zhang,Y., You,C., Yu,X., Jiang,Y., Zhang,Y.,
            Gloriam,D.E. and Xu,H.E.
  TITLE     GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed
            by structures of serotonin receptors
  JOURNAL   Mol Cell 82 (14), 2681-2695 (2022)
   PUBMED   35714614
REFERENCE   3  (bases 1 to 3467)
  AUTHORS   Solas,M., Van Dam,D., Janssens,J., Ocariz,U., Vermeiren,Y., De
            Deyn,P.P. and Ramirez,M.J.
  TITLE     5-HT7 receptors in Alzheimer's disease
  JOURNAL   Neurochem Int 150, 105185 (2021)
   PUBMED   34555475
  REMARK    GeneRIF: 5-HT7 receptors in Alzheimer's disease.
REFERENCE   4  (bases 1 to 3467)
  AUTHORS   Cinar,I., Sirin,B., Halici,Z., Palabiyik-Yucelik,S.S., Akpinar,E.
            and Cadirci,E.
  TITLE     5-HT7 receptors as a new target for prostate cancer physiopathology
            and treatment: an experimental study on PC-3 cells and FFPE tissues
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 394 (6), 1205-1213 (2021)
   PUBMED   33528589
  REMARK    GeneRIF: 5-HT7 receptors as a new target for prostate cancer
            physiopathology and treatment: an experimental study on PC-3 cells
            and FFPE tissues.
REFERENCE   5  (bases 1 to 3467)
  AUTHORS   Liu,B., Chu,S., Liu,T., Song,J., Ma,Z., Gu,X. and Xia,T.
  TITLE     Effects of 5-HT7 receptors on circadian rhythm of mice anesthetized
            with isoflurane
  JOURNAL   Chronobiol Int 38 (1), 38-45 (2021)
   PUBMED   33081564
  REMARK    GeneRIF: Effects of 5-HT7 receptors on circadian rhythm of mice
            anesthetized with isoflurane.
REFERENCE   6  (bases 1 to 3467)
  AUTHORS   Heidmann,D.E., Metcalf,M.A., Kohen,R. and Hamblin,M.W.
  TITLE     Four 5-hydroxytryptamine7 (5-HT7) receptor isoforms in human and
            rat produced by alternative splicing: species differences due to
            altered intron-exon organization
  JOURNAL   J Neurochem 68 (4), 1372-1381 (1997)
   PUBMED   9084407
REFERENCE   7  (bases 1 to 3467)
  AUTHORS   Ullmer,C., Schmuck,K., Kalkman,H.O. and Lubbert,H.
  TITLE     Expression of serotonin receptor mRNAs in blood vessels
  JOURNAL   FEBS Lett 370 (3), 215-221 (1995)
   PUBMED   7656980
REFERENCE   8  (bases 1 to 3467)
  AUTHORS   Gelernter,J., Rao,P.A., Pauls,D.L., Hamblin,M.W., Sibley,D.R. and
            Kidd,K.K.
  TITLE     Assignment of the 5HT7 receptor gene (HTR7) to chromosome 10q and
            exclusion of genetic linkage with Tourette syndrome
  JOURNAL   Genomics 26 (2), 207-209 (1995)
   PUBMED   7601444
REFERENCE   9  (bases 1 to 3467)
  AUTHORS   Bard,J.A., Zgombick,J., Adham,N., Vaysse,P., Branchek,T.A. and
            Weinshank,R.L.
  TITLE     Cloning of a novel human serotonin receptor (5-HT7) positively
            linked to adenylate cyclase
  JOURNAL   J Biol Chem 268 (31), 23422-23426 (1993)
   PUBMED   8226867
REFERENCE   10 (bases 1 to 3467)
  AUTHORS   Lovenberg,T.W., Baron,B.M., de Lecea,L., Miller,J.D., Prosser,R.A.,
            Rea,M.A., Foye,P.E., Racke,M., Slone,A.L., Siegel,B.W. et al.
  TITLE     A novel adenylyl cyclase-activating serotonin receptor (5-HT7)
            implicated in the regulation of mammalian circadian rhythms
  JOURNAL   Neuron 11 (3), 449-458 (1993)
   PUBMED   8398139
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL360011.19, BC047526.1,
            U68488.1 and BG108256.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_019859.3.
            
            Summary: The neurotransmitter, serotonin, is thought to play a role
            in various cognitive and behavioral functions. The serotonin
            receptor encoded by this gene belongs to the superfamily of G
            protein-coupled receptors and the gene is a candidate locus for
            involvement in autistic disorder and other neuropsychiatric
            disorders. Three splice variants have been identified which encode
            proteins that differ in the length of their carboxy terminal ends.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (d) results from the inclusion of
            a 98 base pair exon cassette (exon D) at the exon II/exon III
            boundary, as compared to splice variant a. The inclusion of exon D
            results in a protein with a carboxy terminal end 34 amino acids
            longer than the splice variant a protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U68488.1, AK292606.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336152.8/ ENSP00000337949.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               AL360011.19        143855-143979       c
            126-341             BC047526.1         1-216
            342-1859            U68488.1           1-1518
            1860-2008           BG108256.1         98-246
            2009-3467           BC047526.1         1787-3245
FEATURES             Location/Qualifiers
     source          1..3467
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.31"
     gene            1..3467
                     /gene="HTR7"
                     /gene_synonym="5-HT7"
                     /note="5-hydroxytryptamine receptor 7"
                     /db_xref="GeneID:3363"
                     /db_xref="HGNC:HGNC:5302"
                     /db_xref="MIM:182137"
     exon            1..907
                     /gene="HTR7"
                     /gene_synonym="5-HT7"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1663
                     /gene="HTR7"
                     /gene_synonym="5-HT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1761
                     /gene="HTR7"
                     /gene_synonym="5-HT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..3467
                     /gene="HTR7"
                     /gene_synonym="5-HT7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3417..3422
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HTR7"
                     /gene_synonym="5-HT7"
                     /note="hexamer: AATAAA"
     regulatory      3439..3444
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HTR7"
                     /gene_synonym="5-HT7"
                     /note="hexamer: AATAAA"
     polyA_site      3444
                     /gene="HTR7"
                     /gene_synonym="5-HT7"
                     /note="major polyA site"
     polyA_site      3467
                     /gene="HTR7"
                     /gene_synonym="5-HT7"
ORIGIN      
        1 gcactccgca acttctgccg ctgccgcccg ggcgctctcg gcgcagccga gctgctgctg
       61 cgaactgtgg agctgccagc ggagcccagc ccgagctccc tcgactccgc gcgtcccagg
      121 cgtccgtcgg gggccgaagc gcctcccgca gggagtcccc gtgaggccgc gctgccgcgt
      181 tacccgcagc ggccgggggt ccggggagtg cggggctccg agacagagcc aggcgccccc
      241 cagcggtcgg cgcgggcccc atggctgggc cgggcggagc ggaaccggtg aggtgaagcc
      301 ccggggccgg cagccggagg cgcgtggccg gggcgccggc tccatgggca gcggcacacg
      361 gcggcgcgat gatggacgtt aacagcagcg gccgcccgga cctctacggg cacctccgct
      421 ctttccttct gccagaagtg gggcgcgggc tgcccgactt gagccccgac ggtggcgccg
      481 acccggtcgc gggctcctgg gcgccgcacc tgctgagcga ggtgacagcc agcccggcgc
      541 ccacctggga cgcgcccccg gacaatgcct ccggctgtgg ggaacagatc aactacggca
      601 gagtcgagaa agttgtgatc ggctccatcc tgacgctcat cacgctgctg acgatcgcgg
      661 gcaactgcct ggtggtgatc tccgtgtgct tcgtcaagaa gctccgccag ccctccaact
      721 acctgatcgt gtccctggcg ctggccgacc tctcggtggc tgtggcggtc atgcccttcg
      781 tcagcgtcac cgacctcatc gggggcaagt ggatctttgg acactttttc tgtaatgtct
      841 tcatcgccat ggacgtcatg tgctgcacgg cctcgatcat gaccctgtgc gtgatcagca
      901 ttgacaggta ccttgggatc acaaggcccc tcacataccc tgtgaggcag aatgggaaat
      961 gcatggcgaa gatgattctc tccgtctggc ttctctccgc ctccatcacc ttacctccac
     1021 tctttggatg ggctcagaat gtaaatgatg ataaggtgtg cttgatcagc caggactttg
     1081 gctatacgat ttactctacc gcagtggcat tttatatccc catgtccgtc atgcttttca
     1141 tgtactacca gatttacaag gctgccagga agagtgctgc caaacacaag tttcctggct
     1201 tccctcgagt ggagccagac agcgtcatcg ccctgaatgg catagtgaag ctccagaagg
     1261 aggtggaaga gtgtgcaaac ctttcgagac tcctcaagca tgaaaggaaa aacatctcca
     1321 tctttaagcg agaacagaaa gcagccacca ccctggggat catcgtcggg gcctttaccg
     1381 tgtgctggct gccatttttc ctcctctcga cagccagacc cttcatctgt ggcacttcct
     1441 gcagctgcat cccactgtgg gtggagagga catttctgtg gctaggctat gcaaactctc
     1501 tcattaaccc ttttatatat gccttcttca accgggacct gaggaccacc tatcgcagcc
     1561 tgctccagtg ccagtaccgg aatatcaacc ggaagctctc agctgcaggc atgcatgaag
     1621 ccctgaagct tgctgagagg ccagagagac ctgagtttgt gctgagggcc tgcacaagga
     1681 gggtgctgtt gagaccagaa aagaggccac cggtatctgt gtgggtgcta caatctccag
     1741 accatcacaa ttggttagca gacaaaatgc tgactactgt agaaaaaaag gtcatgattc
     1801 atgattgaaa gcagaacaat ggagatgaaa taaacaaggc aaaatagagg tggaaacaga
     1861 aggaagtcat ttgctgagtc tgcagaatgg aatgcagctt ctgtcctttc ttgggatgtc
     1921 taaaacatga caaacagggt gatctgttgt acacactatc ttatgaggga gatggtgact
     1981 tctccttttt tctgtggatc agtgctattg tgtgttctca gtttaagata gcagatcatc
     2041 tcagcagtaa gcacaccaac agaactgagt tccagaaagg aagcagtttc tggtgctttg
     2101 catatgtcca aatccatgca agtgggagaa agttccagtg cacacttccc atgcttctga
     2161 gtctaggcgt tgtggtgaat atgcaggaat cattcatgag acagaatgta ttttgttgta
     2221 tgacagaagg cttttccaag caaactgcgg tgagcgtagt gttgaatatg ttgcatgtcc
     2281 atgttagaaa acagaatcca gtcatcagct aatacaaatg atttcccaga gcagtgtttg
     2341 tttcaagctt ctgtcaaata gtttggcttt tctgcagggt ctctgtgatt tccccaccta
     2401 tgtacttttc tgtgttaact cacttattat ggtataactc aggaacaggt ctcaggatgg
     2461 agagaagcat acaacatgag caaagctttt tctcgtgctc tgaagggtct tgagagggga
     2521 gtgggatgcc ttctgtgagg atttttatcg cagtgaagct caagtggtac ccaactgcgt
     2581 tgtaattaac atgattattg gcatgttttt gactctcatt ttctacaagg ctgcagtggg
     2641 cccacccatg ggctggccca taactgtatg ttatgtggaa gaagtgtggg aatgatgggt
     2701 tttccatgaa atgtgatgct tctggagatg gggcataaac atgttcattc ttgttgagct
     2761 gcattgtgtt aaaccaaatt gtgtgaagcg aggtcacctg gaccactctt gggaaatgct
     2821 tcagaacacc agtctgttcc ttctagagaa tttgtttttg tgttctatgt atcttaaatc
     2881 aaatgtgtgc ctaagcaatt ctgtcctctg attcccaccc ctacccacca aaaaatggta
     2941 gacatgaaag gcaggtgagg aaacagaaaa ggtctctttg cagatatata ttttttaaat
     3001 ggcactatgt agtaattaag agctaaggag acagaaagac agtagatgag aatagaagag
     3061 tacctgtacc tacaagggga aaaatgaatg caattcttta tttgataaga gtgaactgaa
     3121 agagaatatt attttcctac aataaagcaa gctgtcctct cacaggataa agtggaattc
     3181 tgacatggat tatggacttc ttctaactcc cattgacatt gcttcttacc agacatgggg
     3241 aaaagctacc tttcctgaaa ggggaggagg gcactgtcct ttcagacaaa gcttgtacaa
     3301 attcctgaac cgcaaatttg ctgaagtgac cgtatatatt atattcataa tttaaatgat
     3361 tatttatggt cagatacata ttgttaaact tgaaaatgtt ttattacatt acatcaaata
     3421 aagtttattt gtagctgaaa taaagcaacg taagtaacaa tttttaa
//
