LOCUS       NP_062873                479 aa            linear   PRI 27-APR-2025
DEFINITION  5-hydroxytryptamine receptor 7 isoform d [Homo sapiens].
ACCESSION   NP_062873
VERSION     NP_062873.1
DBSOURCE    REFSEQ: accession NM_019859.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 479)
  AUTHORS   Cinar,V., Hamurcu,Z., Guler,A., Nurdinov,N. and Ozpolat,B.
  TITLE     Serotonin 5-HT7 receptor is a biomarker poor prognostic factor and
            induces proliferation of triple-negative breast cancer cells
            through FOXM1
  JOURNAL   Breast Cancer 29 (6), 1106-1120 (2022)
   PUBMED   36006564
  REMARK    GeneRIF: Serotonin 5-HT7 receptor is a biomarker poor prognostic
            factor and induces proliferation of triple-negative breast cancer
            cells through FOXM1.
REFERENCE   2  (residues 1 to 479)
  AUTHORS   Huang,S., Xu,P., Shen,D.D., Simon,I.A., Mao,C., Tan,Y., Zhang,H.,
            Harpsoe,K., Li,H., Zhang,Y., You,C., Yu,X., Jiang,Y., Zhang,Y.,
            Gloriam,D.E. and Xu,H.E.
  TITLE     GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed
            by structures of serotonin receptors
  JOURNAL   Mol Cell 82 (14), 2681-2695 (2022)
   PUBMED   35714614
REFERENCE   3  (residues 1 to 479)
  AUTHORS   Solas,M., Van Dam,D., Janssens,J., Ocariz,U., Vermeiren,Y., De
            Deyn,P.P. and Ramirez,M.J.
  TITLE     5-HT7 receptors in Alzheimer's disease
  JOURNAL   Neurochem Int 150, 105185 (2021)
   PUBMED   34555475
  REMARK    GeneRIF: 5-HT7 receptors in Alzheimer's disease.
REFERENCE   4  (residues 1 to 479)
  AUTHORS   Cinar,I., Sirin,B., Halici,Z., Palabiyik-Yucelik,S.S., Akpinar,E.
            and Cadirci,E.
  TITLE     5-HT7 receptors as a new target for prostate cancer physiopathology
            and treatment: an experimental study on PC-3 cells and FFPE tissues
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 394 (6), 1205-1213 (2021)
   PUBMED   33528589
  REMARK    GeneRIF: 5-HT7 receptors as a new target for prostate cancer
            physiopathology and treatment: an experimental study on PC-3 cells
            and FFPE tissues.
REFERENCE   5  (residues 1 to 479)
  AUTHORS   Liu,B., Chu,S., Liu,T., Song,J., Ma,Z., Gu,X. and Xia,T.
  TITLE     Effects of 5-HT7 receptors on circadian rhythm of mice anesthetized
            with isoflurane
  JOURNAL   Chronobiol Int 38 (1), 38-45 (2021)
   PUBMED   33081564
  REMARK    GeneRIF: Effects of 5-HT7 receptors on circadian rhythm of mice
            anesthetized with isoflurane.
REFERENCE   6  (residues 1 to 479)
  AUTHORS   Heidmann,D.E., Metcalf,M.A., Kohen,R. and Hamblin,M.W.
  TITLE     Four 5-hydroxytryptamine7 (5-HT7) receptor isoforms in human and
            rat produced by alternative splicing: species differences due to
            altered intron-exon organization
  JOURNAL   J Neurochem 68 (4), 1372-1381 (1997)
   PUBMED   9084407
REFERENCE   7  (residues 1 to 479)
  AUTHORS   Ullmer,C., Schmuck,K., Kalkman,H.O. and Lubbert,H.
  TITLE     Expression of serotonin receptor mRNAs in blood vessels
  JOURNAL   FEBS Lett 370 (3), 215-221 (1995)
   PUBMED   7656980
REFERENCE   8  (residues 1 to 479)
  AUTHORS   Gelernter,J., Rao,P.A., Pauls,D.L., Hamblin,M.W., Sibley,D.R. and
            Kidd,K.K.
  TITLE     Assignment of the 5HT7 receptor gene (HTR7) to chromosome 10q and
            exclusion of genetic linkage with Tourette syndrome
  JOURNAL   Genomics 26 (2), 207-209 (1995)
   PUBMED   7601444
REFERENCE   9  (residues 1 to 479)
  AUTHORS   Bard,J.A., Zgombick,J., Adham,N., Vaysse,P., Branchek,T.A. and
            Weinshank,R.L.
  TITLE     Cloning of a novel human serotonin receptor (5-HT7) positively
            linked to adenylate cyclase
  JOURNAL   J Biol Chem 268 (31), 23422-23426 (1993)
   PUBMED   8226867
REFERENCE   10 (residues 1 to 479)
  AUTHORS   Lovenberg,T.W., Baron,B.M., de Lecea,L., Miller,J.D., Prosser,R.A.,
            Rea,M.A., Foye,P.E., Racke,M., Slone,A.L., Siegel,B.W. et al.
  TITLE     A novel adenylyl cyclase-activating serotonin receptor (5-HT7)
            implicated in the regulation of mammalian circadian rhythms
  JOURNAL   Neuron 11 (3), 449-458 (1993)
   PUBMED   8398139
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL360011.19, BC047526.1,
            U68488.1 and BG108256.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: The neurotransmitter, serotonin, is thought to play a role
            in various cognitive and behavioral functions. The serotonin
            receptor encoded by this gene belongs to the superfamily of G
            protein-coupled receptors and the gene is a candidate locus for
            involvement in autistic disorder and other neuropsychiatric
            disorders. Three splice variants have been identified which encode
            proteins that differ in the length of their carboxy terminal ends.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (d) results from the inclusion of
            a 98 base pair exon cassette (exon D) at the exon II/exon III
            boundary, as compared to splice variant a. The inclusion of exon D
            results in a protein with a carboxy terminal end 34 amino acids
            longer than the splice variant a protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U68488.1, AK292606.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336152.8/ ENSP00000337949.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.31"
     Protein         1..479
                     /product="5-hydroxytryptamine receptor 7 isoform d"
                     /note="5-HT-7; 5-HT-X; 5-hydroxytryptamine (serotonin)
                     receptor 7 (adenylate cyclase-coupled)"
                     /calculated_mol_wt=53424
     Site            5
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:22448645; propagated from
                     UniProtKB/Swiss-Prot (P34969.2)"
     Site            66
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:22448645; propagated from
                     UniProtKB/Swiss-Prot (P34969.2)"
     Site            84..108
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P34969.2)"
     Region          97..395
                     /region_name="7tmA_5-HT7"
                     /note="serotonin receptor subtype 7, member of the class A
                     family of seven-transmembrane G protein-coupled receptors;
                     cd15329"
                     /db_xref="CDD:320452"
     Region          116..142
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320452"
     Site            119..140
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P34969.2)"
     Site            153..178
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P34969.2)"
     Region          155..185
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320452"
     Site            order(158..159,162..163,166..167,231,243,247,340,343..344,
                     350,363,366..367,370,374)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:320452"
     Region          197..219
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320452"
     Site            199..219
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P34969.2)"
     Region          236..265
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320452"
     Site            238..260
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P34969.2)"
     Region          320..350
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320452"
     Site            327..352
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P34969.2)"
     Region          363..388
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320452"
     Site            364..387
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P34969.2)"
     CDS             1..479
                     /gene="HTR7"
                     /gene_synonym="5-HT7"
                     /coded_by="NM_019859.4:369..1808"
                     /note="isoform d is encoded by transcript variant d"
                     /db_xref="CCDS:CCDS7408.1"
                     /db_xref="GeneID:3363"
                     /db_xref="HGNC:HGNC:5302"
                     /db_xref="MIM:182137"
ORIGIN      
        1 mmdvnssgrp dlyghlrsfl lpevgrglpd lspdggadpv agswaphlls evtaspaptw
       61 dappdnasgc geqinygrve kvvigsiltl itlltiagnc lvvisvcfvk klrqpsnyli
      121 vslaladlsv avavmpfvsv tdliggkwif ghffcnvfia mdvmcctasi mtlcvisidr
      181 ylgitrplty pvrqngkcma kmilsvwlls asitlpplfg waqnvnddkv clisqdfgyt
      241 iystavafyi pmsvmlfmyy qiykaarksa akhkfpgfpr vepdsvialn givklqkeve
      301 ecanlsrllk herknisifk reqkaattlg iivgaftvcw lpffllstar pficgtscsc
      361 iplwvertfl wlgyanslin pfiyaffnrd lrttyrsllq cqyrninrkl saagmhealk
      421 laerperpef vlractrrvl lrpekrppvs vwvlqspdhh nwladkmltt vekkvmihd
//
