LOCUS       NM_000872               3369 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens 5-hydroxytryptamine receptor 7 (HTR7), transcript
            variant a, mRNA.
ACCESSION   NM_000872
VERSION     NM_000872.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3369)
  AUTHORS   Cinar,V., Hamurcu,Z., Guler,A., Nurdinov,N. and Ozpolat,B.
  TITLE     Serotonin 5-HT7 receptor is a biomarker poor prognostic factor and
            induces proliferation of triple-negative breast cancer cells
            through FOXM1
  JOURNAL   Breast Cancer 29 (6), 1106-1120 (2022)
   PUBMED   36006564
  REMARK    GeneRIF: Serotonin 5-HT7 receptor is a biomarker poor prognostic
            factor and induces proliferation of triple-negative breast cancer
            cells through FOXM1.
REFERENCE   2  (bases 1 to 3369)
  AUTHORS   Huang,S., Xu,P., Shen,D.D., Simon,I.A., Mao,C., Tan,Y., Zhang,H.,
            Harpsoe,K., Li,H., Zhang,Y., You,C., Yu,X., Jiang,Y., Zhang,Y.,
            Gloriam,D.E. and Xu,H.E.
  TITLE     GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed
            by structures of serotonin receptors
  JOURNAL   Mol Cell 82 (14), 2681-2695 (2022)
   PUBMED   35714614
REFERENCE   3  (bases 1 to 3369)
  AUTHORS   Solas,M., Van Dam,D., Janssens,J., Ocariz,U., Vermeiren,Y., De
            Deyn,P.P. and Ramirez,M.J.
  TITLE     5-HT7 receptors in Alzheimer's disease
  JOURNAL   Neurochem Int 150, 105185 (2021)
   PUBMED   34555475
  REMARK    GeneRIF: 5-HT7 receptors in Alzheimer's disease.
REFERENCE   4  (bases 1 to 3369)
  AUTHORS   Cinar,I., Sirin,B., Halici,Z., Palabiyik-Yucelik,S.S., Akpinar,E.
            and Cadirci,E.
  TITLE     5-HT7 receptors as a new target for prostate cancer physiopathology
            and treatment: an experimental study on PC-3 cells and FFPE tissues
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 394 (6), 1205-1213 (2021)
   PUBMED   33528589
  REMARK    GeneRIF: 5-HT7 receptors as a new target for prostate cancer
            physiopathology and treatment: an experimental study on PC-3 cells
            and FFPE tissues.
REFERENCE   5  (bases 1 to 3369)
  AUTHORS   Liu,B., Chu,S., Liu,T., Song,J., Ma,Z., Gu,X. and Xia,T.
  TITLE     Effects of 5-HT7 receptors on circadian rhythm of mice anesthetized
            with isoflurane
  JOURNAL   Chronobiol Int 38 (1), 38-45 (2021)
   PUBMED   33081564
  REMARK    GeneRIF: Effects of 5-HT7 receptors on circadian rhythm of mice
            anesthetized with isoflurane.
REFERENCE   6  (bases 1 to 3369)
  AUTHORS   Heidmann,D.E., Metcalf,M.A., Kohen,R. and Hamblin,M.W.
  TITLE     Four 5-hydroxytryptamine7 (5-HT7) receptor isoforms in human and
            rat produced by alternative splicing: species differences due to
            altered intron-exon organization
  JOURNAL   J Neurochem 68 (4), 1372-1381 (1997)
   PUBMED   9084407
REFERENCE   7  (bases 1 to 3369)
  AUTHORS   Ullmer,C., Schmuck,K., Kalkman,H.O. and Lubbert,H.
  TITLE     Expression of serotonin receptor mRNAs in blood vessels
  JOURNAL   FEBS Lett 370 (3), 215-221 (1995)
   PUBMED   7656980
REFERENCE   8  (bases 1 to 3369)
  AUTHORS   Gelernter,J., Rao,P.A., Pauls,D.L., Hamblin,M.W., Sibley,D.R. and
            Kidd,K.K.
  TITLE     Assignment of the 5HT7 receptor gene (HTR7) to chromosome 10q and
            exclusion of genetic linkage with Tourette syndrome
  JOURNAL   Genomics 26 (2), 207-209 (1995)
   PUBMED   7601444
REFERENCE   9  (bases 1 to 3369)
  AUTHORS   Bard,J.A., Zgombick,J., Adham,N., Vaysse,P., Branchek,T.A. and
            Weinshank,R.L.
  TITLE     Cloning of a novel human serotonin receptor (5-HT7) positively
            linked to adenylate cyclase
  JOURNAL   J Biol Chem 268 (31), 23422-23426 (1993)
   PUBMED   8226867
REFERENCE   10 (bases 1 to 3369)
  AUTHORS   Lovenberg,T.W., Baron,B.M., de Lecea,L., Miller,J.D., Prosser,R.A.,
            Rea,M.A., Foye,P.E., Racke,M., Slone,A.L., Siegel,B.W. et al.
  TITLE     A novel adenylyl cyclase-activating serotonin receptor (5-HT7)
            implicated in the regulation of mammalian circadian rhythms
  JOURNAL   Neuron 11 (3), 449-458 (1993)
   PUBMED   8398139
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL360011.19, BC047526.1 and
            BG108256.1.
            
            On Jun 1, 2019 this sequence version replaced NM_000872.4.
            
            Summary: The neurotransmitter, serotonin, is thought to play a role
            in various cognitive and behavioral functions. The serotonin
            receptor encoded by this gene belongs to the superfamily of G
            protein-coupled receptors and the gene is a candidate locus for
            involvement in autistic disorder and other neuropsychiatric
            disorders. Three splice variants have been identified which encode
            proteins that differ in the length of their carboxy terminal ends.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (a) results from the alternative
            usage of the first of two tandemly arranged splice donor sites at
            the 5' end of intron 2, which causes the protein to have a 13 amino
            acid longer carboxy tail relative to isoform b.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047526.1, SRR1803611.160486.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               AL360011.19        143855-143979       c
            126-1876            BC047526.1         1-1751
            1877-1910           BG108256.1         213-246
            1911-3369           BC047526.1         1787-3245
FEATURES             Location/Qualifiers
     source          1..3369
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.31"
     gene            1..3369
                     /gene="HTR7"
                     /gene_synonym="5-HT7"
                     /note="5-hydroxytryptamine receptor 7"
                     /db_xref="GeneID:3363"
                     /db_xref="HGNC:HGNC:5302"
                     /db_xref="MIM:182137"
     exon            1..907
                     /gene="HTR7"
                     /gene_synonym="5-HT7"
                     /inference="alignment:Splign:2.1.0"
     CDS             369..1706
                     /gene="HTR7"
                     /gene_synonym="5-HT7"
                     /note="isoform a is encoded by transcript variant a;
                     5-HT-7; 5-HT-X; 5-hydroxytryptamine (serotonin) receptor 7
                     (adenylate cyclase-coupled)"
                     /codon_start=1
                     /product="5-hydroxytryptamine receptor 7 isoform a"
                     /protein_id="NP_000863.1"
                     /db_xref="CCDS:CCDS7409.1"
                     /db_xref="GeneID:3363"
                     /db_xref="HGNC:HGNC:5302"
                     /db_xref="MIM:182137"
                     /translation="MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSW
                     APHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLV
                     VISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIA
                     MDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPL
                     FGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFP
                     GFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVG
                     AFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLR
                     TTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLQNADYCRKKGHDS"
     exon            908..1663
                     /gene="HTR7"
                     /gene_synonym="5-HT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..3369
                     /gene="HTR7"
                     /gene_synonym="5-HT7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3319..3324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HTR7"
                     /gene_synonym="5-HT7"
                     /note="hexamer: AATAAA"
     regulatory      3341..3346
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HTR7"
                     /gene_synonym="5-HT7"
                     /note="hexamer: AATAAA"
     polyA_site      3346
                     /gene="HTR7"
                     /gene_synonym="5-HT7"
                     /note="major polyA site"
     polyA_site      3369
                     /gene="HTR7"
                     /gene_synonym="5-HT7"
ORIGIN      
        1 gcactccgca acttctgccg ctgccgcccg ggcgctctcg gcgcagccga gctgctgctg
       61 cgaactgtgg agctgccagc ggagcccagc ccgagctccc tcgactccgc gcgtcccagg
      121 cgtccgtcgg gggccgaagc gcctcccgca gggagtcccc gtgaggccgc gctgccgcgt
      181 tacccgcagc ggccgggggt ccggggagtg cggggctccg agacagagcc aggcgccccc
      241 cagcggtcgg cgcgggcccc atggctgggc cgggcggagc ggaaccggtg aggtgaagcc
      301 ccggggccgg cagccggagg cgcgtggccg gggcgccggc tccatgggca gcggcacacg
      361 gcggcgcgat gatggacgtt aacagcagcg gccgcccgga cctctacggg cacctccgct
      421 ctttccttct gccagaagtg gggcgcgggc tgcccgactt gagccccgac ggtggcgccg
      481 acccggtcgc gggctcctgg gcgccgcacc tgctgagcga ggtgacagcc agcccggcgc
      541 ccacctggga cgcgcccccg gacaatgcct ccggctgtgg ggaacagatc aactacggca
      601 gagtcgagaa agttgtgatc ggctccatcc tgacgctcat cacgctgctg acgatcgcgg
      661 gcaactgcct ggtggtgatc tccgtgtgct tcgtcaagaa gctccgccag ccctccaact
      721 acctgatcgt gtccctggcg ctggccgacc tctcggtggc tgtggcggtc atgcccttcg
      781 tcagcgtcac cgacctcatc gggggcaagt ggatctttgg acactttttc tgtaatgtct
      841 tcatcgccat ggacgtcatg tgctgcacgg cctcgatcat gaccctgtgc gtgatcagca
      901 ttgacaggta ccttgggatc acaaggcccc tcacataccc tgtgaggcag aatgggaaat
      961 gcatggcgaa gatgattctc tccgtctggc ttctctccgc ctccatcacc ttacctccac
     1021 tctttggatg ggctcagaat gtaaatgatg ataaggtgtg cttgatcagc caggactttg
     1081 gctatacgat ttactctacc gcagtggcat tttatatccc catgtccgtc atgcttttca
     1141 tgtactacca gatttacaag gctgccagga agagtgctgc caaacacaag tttcctggct
     1201 tccctcgagt ggagccagac agcgtcatcg ccctgaatgg catagtgaag ctccagaagg
     1261 aggtggaaga gtgtgcaaac ctttcgagac tcctcaagca tgaaaggaaa aacatctcca
     1321 tctttaagcg agaacagaaa gcagccacca ccctggggat catcgtcggg gcctttaccg
     1381 tgtgctggct gccatttttc ctcctctcga cagccagacc cttcatctgt ggcacttcct
     1441 gcagctgcat cccactgtgg gtggagagga catttctgtg gctaggctat gcaaactctc
     1501 tcattaaccc ttttatatat gccttcttca accgggacct gaggaccacc tatcgcagcc
     1561 tgctccagtg ccagtaccgg aatatcaacc ggaagctctc agctgcaggc atgcatgaag
     1621 ccctgaagct tgctgagagg ccagagagac ctgagtttgt gctacaaaat gctgactact
     1681 gtagaaaaaa aggtcatgat tcatgattga aagcagaaca atggagatga aataaacaag
     1741 gcaaaataga ggtggaaaca gaaggaagtc atttgctgag tctgcagaat ggaatgcagc
     1801 ttctgtcctt tcttgggatg tctaaaacat gacaaacagg gtgatctgtt gtacacacta
     1861 tcttatgagg gagatggtga cttctccttt tttctgtgga tcagtgctat tgtgtgttct
     1921 cagtttaaga tagcagatca tctcagcagt aagcacacca acagaactga gttccagaaa
     1981 ggaagcagtt tctggtgctt tgcatatgtc caaatccatg caagtgggag aaagttccag
     2041 tgcacacttc ccatgcttct gagtctaggc gttgtggtga atatgcagga atcattcatg
     2101 agacagaatg tattttgttg tatgacagaa ggcttttcca agcaaactgc ggtgagcgta
     2161 gtgttgaata tgttgcatgt ccatgttaga aaacagaatc cagtcatcag ctaatacaaa
     2221 tgatttccca gagcagtgtt tgtttcaagc ttctgtcaaa tagtttggct tttctgcagg
     2281 gtctctgtga tttccccacc tatgtacttt tctgtgttaa ctcacttatt atggtataac
     2341 tcaggaacag gtctcaggat ggagagaagc atacaacatg agcaaagctt tttctcgtgc
     2401 tctgaagggt cttgagaggg gagtgggatg ccttctgtga ggatttttat cgcagtgaag
     2461 ctcaagtggt acccaactgc gttgtaatta acatgattat tggcatgttt ttgactctca
     2521 ttttctacaa ggctgcagtg ggcccaccca tgggctggcc cataactgta tgttatgtgg
     2581 aagaagtgtg ggaatgatgg gttttccatg aaatgtgatg cttctggaga tggggcataa
     2641 acatgttcat tcttgttgag ctgcattgtg ttaaaccaaa ttgtgtgaag cgaggtcacc
     2701 tggaccactc ttgggaaatg cttcagaaca ccagtctgtt ccttctagag aatttgtttt
     2761 tgtgttctat gtatcttaaa tcaaatgtgt gcctaagcaa ttctgtcctc tgattcccac
     2821 ccctacccac caaaaaatgg tagacatgaa aggcaggtga ggaaacagaa aaggtctctt
     2881 tgcagatata tattttttaa atggcactat gtagtaatta agagctaagg agacagaaag
     2941 acagtagatg agaatagaag agtacctgta cctacaaggg gaaaaatgaa tgcaattctt
     3001 tatttgataa gagtgaactg aaagagaata ttattttcct acaataaagc aagctgtcct
     3061 ctcacaggat aaagtggaat tctgacatgg attatggact tcttctaact cccattgaca
     3121 ttgcttctta ccagacatgg ggaaaagcta cctttcctga aaggggagga gggcactgtc
     3181 ctttcagaca aagcttgtac aaattcctga accgcaaatt tgctgaagtg accgtatata
     3241 ttatattcat aatttaaatg attatttatg gtcagataca tattgttaaa cttgaaaatg
     3301 ttttattaca ttacatcaaa taaagtttat ttgtagctga aataaagcaa cgtaagtaac
     3361 aatttttaa
//
