LOCUS       NM_000871               3800 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens 5-hydroxytryptamine receptor 6 (HTR6), mRNA.
ACCESSION   NM_000871
VERSION     NM_000871.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3800)
  AUTHORS   Chechekhin,V.I., Ivanova,A.M., Kulebyakin,K.Y., Antropova,Y.G.,
            Karagyaur,M.N., Skryabina,M.N., Chechekhina,E.S., Basalova,N.A.,
            Grigorieva,O.A., Sysoeva,V.Y., Kalinina,N.I., Tkachuk,V.A. and
            Tyurin-Kuzmin,P.A.
  TITLE     Peripheral 5-HT/HTR6 axis is responsible for obesity-associated
            hypertension
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (2), 119651 (2024)
   PUBMED   38086448
  REMARK    GeneRIF: Peripheral 5-HT/HTR6 axis is responsible for
            obesity-associated hypertension.
REFERENCE   2  (bases 1 to 3800)
  AUTHORS   Pei,Y., Wen,X., Guo,S.C., Yang,Z.S., Zhang,R., Xiao,P. and Sun,J.P.
  TITLE     Structural insight into the selective agonist ST1936 binding of
            serotonin receptor 5-HT6
  JOURNAL   Biochem Biophys Res Commun 671, 327-334 (2023)
   PUBMED   37327704
REFERENCE   3  (bases 1 to 3800)
  AUTHORS   He,L., Zhao,Q., Qi,J., Wang,Y., Han,W., Chen,Z., Cong,Y. and
            Wang,S.
  TITLE     Structural insights into constitutive activity of 5-HT6 receptor
  JOURNAL   Proc Natl Acad Sci U S A 120 (14), e2209917120 (2023)
   PUBMED   36989299
REFERENCE   4  (bases 1 to 3800)
  AUTHORS   Huang,S., Xu,P., Shen,D.D., Simon,I.A., Mao,C., Tan,Y., Zhang,H.,
            Harpsoe,K., Li,H., Zhang,Y., You,C., Yu,X., Jiang,Y., Zhang,Y.,
            Gloriam,D.E. and Xu,H.E.
  TITLE     GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed
            by structures of serotonin receptors
  JOURNAL   Mol Cell 82 (14), 2681-2695 (2022)
   PUBMED   35714614
REFERENCE   5  (bases 1 to 3800)
  AUTHORS   Zhang,W., Li,L., Li,J., Yu,H., Zheng,F., Yan,B., Cai,W., Chen,Y.,
            Yin,L., Tang,D., Xu,Y. and Dai,Y.
  TITLE     Systematic Analysis of Neurotransmitter Receptors in Human Breast
            Cancer Reveals a Strong Association With Outcome and Uncovers HTR6
            as a Survival-Associated Gene Potentially Regulating the Immune
            Microenvironment
  JOURNAL   Front Immunol 13, 756928 (2022)
   PUBMED   35359970
  REMARK    GeneRIF: Systematic Analysis of Neurotransmitter Receptors in Human
            Breast Cancer Reveals a Strong Association With Outcome and
            Uncovers HTR6 as a Survival-Associated Gene Potentially Regulating
            the Immune Microenvironment.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3800)
  AUTHORS   Lambe,E.K., Fillman,S.G., Webster,M.J. and Shannon Weickert,C.
  TITLE     Serotonin receptor expression in human prefrontal cortex: balancing
            excitation and inhibition across postnatal development
  JOURNAL   PLoS One 6 (7), e22799 (2011)
   PUBMED   21829518
REFERENCE   7  (bases 1 to 3800)
  AUTHORS   Masellis,M., Basile,V.S., Meltzer,H.Y., Lieberman,J.A., Sevy,S.,
            Goldman,D.A., Hamblin,M.W., Macciardi,F.M. and Kennedy,J.L.
  TITLE     Lack of association between the T-->C 267 serotonin 5-HT6 receptor
            gene (HTR6) polymorphism and prediction of response to clozapine in
            schizophrenia
  JOURNAL   Schizophr Res 47 (1), 49-58 (2001)
   PUBMED   11163544
  REMARK    GeneRIF: Observational study of gene-environment interaction and
            pharmacogenomic / toxicogenomic. (HuGE Navigator)
REFERENCE   8  (bases 1 to 3800)
  AUTHORS   Chiu,H.J., Wang,Y.C., Liou,J.H., Chao,C.H., Lee,H., Tsai,K.Y. and
            Liu,W.C.
  TITLE     Serotonin 6 receptor polymorphism in schizophrenia: frequency, age
            at onset and cognitive function
  JOURNAL   Neuropsychobiology 43 (3), 113-116 (2001)
   PUBMED   11287786
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 3800)
  AUTHORS   Comings,D.E., Gade-Andavolu,R., Gonzalez,N., Wu,S., Muhleman,D.,
            Blake,H., Mann,M.B., Dietz,G., Saucier,G. and MacMurray,J.P.
  TITLE     A multivariate analysis of 59 candidate genes in personality
            traits: the temperament and character inventory
  JOURNAL   Clin Genet 58 (5), 375-385 (2000)
   PUBMED   11140838
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   10 (bases 1 to 3800)
  AUTHORS   Kohen,R., Metcalf,M.A., Khan,N., Druck,T., Huebner,K.,
            Lachowicz,J.E., Meltzer,H.Y., Sibley,D.R., Roth,B.L. and
            Hamblin,M.W.
  TITLE     Cloning, characterization, and chromosomal localization of a human
            5-HT6 serotonin receptor
  JOURNAL   J Neurochem 66 (1), 47-56 (1996)
   PUBMED   8522988
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031727.43, L41147.1 and
            AF007141.1.
            
            On Nov 23, 2018 this sequence version replaced NM_000871.2.
            
            Summary: This gene encodes a protein that belongs to the
            seven-transmembrane G protein-coupled receptor family of proteins.
            The encoded protein couples with the Gs alpha subunit and
            stimulates adenylate cyclase to activate the cyclic AMP-dependent
            signaling pathway. This receptor is thought to regulate cholinergic
            neuronal transmission in the brain. Several antidepressants and
            antipsychotic drugs have a high affinity for this receptor.
            [provided by RefSeq, Aug 2013].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L41147.1, BC074995.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000289753.2/ ENSP00000289753.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-412               AL031727.43        93278-93689
            413-698             L41147.1           1-286
            699-699             AL031727.43        93976-93976
            700-2396            L41147.1           288-1984
            2397-2685           AF007141.1         194-482
            2686-3306           AL031727.43        108255-108875
            3307-3800           AF007141.1         1104-1597
FEATURES             Location/Qualifiers
     source          1..3800
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.13"
     gene            1..3800
                     /gene="HTR6"
                     /gene_synonym="5-HT6; 5-HT6R"
                     /note="5-hydroxytryptamine receptor 6"
                     /db_xref="GeneID:3362"
                     /db_xref="HGNC:HGNC:5301"
                     /db_xref="MIM:601109"
     exon            1..1593
                     /gene="HTR6"
                     /gene_synonym="5-HT6; 5-HT6R"
                     /inference="alignment:Splign:2.1.0"
     CDS             880..2202
                     /gene="HTR6"
                     /gene_synonym="5-HT6; 5-HT6R"
                     /note="serotonin receptor 6; 5-hydroxytryptamine
                     (serotonin) receptor 6, G protein-coupled"
                     /codon_start=1
                     /product="5-hydroxytryptamine receptor 6"
                     /protein_id="NP_000862.1"
                     /db_xref="CCDS:CCDS197.1"
                     /db_xref="GeneID:3362"
                     /db_xref="HGNC:HGNC:5301"
                     /db_xref="MIM:601109"
                     /translation="MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAAN
                     SLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLW
                     TAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFL
                     PLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQ
                     AVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGM
                     FFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRF
                     LPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGL
                     RLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN"
     exon            1594..1752
                     /gene="HTR6"
                     /gene_synonym="5-HT6; 5-HT6R"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..3800
                     /gene="HTR6"
                     /gene_synonym="5-HT6; 5-HT6R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3780..3785
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HTR6"
                     /gene_synonym="5-HT6; 5-HT6R"
                     /note="hexamer: AATAAA"
     polyA_site      3800
                     /gene="HTR6"
                     /gene_synonym="5-HT6; 5-HT6R"
                     /note="major polyA site"
ORIGIN      
        1 gcacccggcc tctcctccgc gcgtgcgggc ccctcgcggc gcctcccggg ctcgggagac
       61 ccggtcccgc cgcccgcccg gcccgcggcc gcctcttcct ctcgcagccc cgcggcgctt
      121 gccgcagtcg caggcggcgg agcagccaga gcgccccagg taccagtgcg ggcgggagac
      181 ggaggcgacc ctgctgccgg gtggggaggg ggcgccgcgc ggccgctgcc ctcctcttcc
      241 cgcggggcct ggcggccccg gcgaaccccc gcgccgcaca ggccgtgtgc gccggatccc
      301 ggtgcctccg cgccagctga gacctgcctt tcccaggggc ggctttgctc cggcccctag
      361 gcccccgccc tggtacccca cacgcccacc ggccgcgggg agcctgctcc ggcccgagag
      421 cgcccattca cccccctcac ccacctcccc gcgttcccac ttccccgcac tctgacccgg
      481 ccggacgccc ctcccctatc ttgccgcccg ccccctccag ggggctctgc tcccacccca
      541 gggagcccat ccgacctctg cttgacttcc cgccgcttcc ttcaggggcc tcggctcatc
      601 gggtgcccct ccccaaactt ccaacccgtt tgctccagga gttcctgccc catccccgag
      661 ggcgcccaaa tagccacact gtgtcctcct gtagtcgctg ccccctgacc tagcgcgacc
      721 cagcgccccc gcccatgtcc ccccactcac ctcccccggg gggcgtggtg agtcgcggtc
      781 tgttctcacg gacggtcccc gtccagcctg cgcttcgccg gggccctcat ctgctttccc
      841 gccaccctat cactcccttg ccgtccaccc tcggtcctca tggtcccaga gccgggccca
      901 accgccaata gcaccccggc ctggggggca gggccgccgt cggccccggg gggcagcggc
      961 tgggtggcgg ccgcgctgtg cgtggtcatc gcgctgacgg cggcggccaa ctcgctgctg
     1021 atcgcgctca tctgcactca gcccgcgctg cgcaacacgt ccaacttctt cctggtgtcg
     1081 ctcttcacgt ctgacctgat ggtggggctg gtggtgatgc cgccggccat gctgaacgcg
     1141 ctgtacgggc gctgggtgct ggcgcgcggc ctctgcctgc tctggaccgc cttcgacgtg
     1201 atgtgctgca gcgcctccat cctcaacctc tgcctcatca gcctggaccg ctacctgctc
     1261 atcctctcgc cgctgcgcta caagctgcgc atgacgcccc tgcgtgccct ggccctagtc
     1321 ctgggcgcct ggagcctcgc cgctctcgcc tccttcctgc ccctgctgct gggctggcac
     1381 gagctgggcc acgcacggcc acccgtccct ggccagtgcc gcctgctggc cagcctgcct
     1441 tttgtccttg tggcgtcggg cctcaccttc ttcctgccct cgggtgccat atgcttcacc
     1501 tactgcagga tcctgctagc tgcccgcaag caggccgtgc aggtggcctc cctcaccacc
     1561 ggcatggcca gtcaggcctc ggagacgctg caggtgccca ggaccccacg cccaggggtg
     1621 gagtctgctg acagcaggcg tctagccacg aagcacagca ggaaggccct gaaggccagc
     1681 ctgacgctgg gcatcctgct gggcatgttc tttgtgacct ggttgccctt ctttgtggcc
     1741 aacatagtcc aggccgtgtg cgactgcatc tccccaggcc tcttcgatgt cctcacatgg
     1801 ctgggttact gtaacagcac catgaacccc atcatctacc cactcttcat gcgggacttc
     1861 aagcgggcgc tgggcaggtt cctgccatgt ccacgctgtc cccgggagcg ccaggccagc
     1921 ctggcctcgc catcactgcg cacctctcac agcggccccc ggcccggcct tagcctacag
     1981 caggtgctgc cgctgcccct gccgccggac tcagattcgg actcagacgc aggctcaggc
     2041 ggctcctcgg gcctgcggct cacggcccag ctgctgcttc ctggcgaggc cacccaggac
     2101 cccccgctgc ccaccagggc cgctgccgcc gtcaatttct tcaacatcga ccccgcggag
     2161 cccgagctgc ggccgcatcc acttggcatc cccacgaact gacccgggct tggggctggc
     2221 caatggggag ctggattgag cagaacccag accctgagtc cttgggccag ctcttggcta
     2281 agaccaggag gctgcaagtc tcctagaagc cctctgagct ccagaggggt gcgcagagct
     2341 gaccccctgc tgccatctcc aggcccctta cctgcaggga tcatagctga ctcagatatc
     2401 gtgttctgaa ggatgctcca ctgttgagtg taacttgtgt gtgcagagga tgggctggag
     2461 gactctggat gttggggaga aggacctctt ggttcaggtt aggatgaaaa caatcatgac
     2521 ctttgcccat tctgtcaggc tggacgggag ggaatgcccc cacctgcagg catggattaa
     2581 tgctgggctg aaccccttgc tactcacagt gtagtccatg gacaatcggc attgccgtca
     2641 cctttgggag tttgtgaaaa atgcacatct ctgcccctgc ccagacctgc tgagtcagaa
     2701 ctgcatgtta ccaagatccc aggtgaatca tgtgcccatt acagtttgag atgtgctgcc
     2761 ttagatcatc tttaaccctc agaatgattt gctggatggt ttttggacct gtcagtctcc
     2821 cctccctggt atatatgtgg cagcagctgc acctgggagg caggcaggca tgcatgtggg
     2881 cctctgctct accacctatg agctctgggg cctgacacga gttatttaac ctctccgagc
     2941 ctcggttatc ccatgtgtaa ggtagagaaa tgatgcctat cttgcaggtt gtcttgagaa
     3001 ttaagacaat gtgtgcccag cacccagtac acggtcagtt aattggtacg ttctgttgtt
     3061 acgacccccg gctatccagc cccctggcct ctccggctgt gtgtcaggaa gggctctttg
     3121 ctcccgttgt tctctttcca tttgcctccc cctcttcagc cctggcctag cctcccaaag
     3181 cctgactctg gttccccaac tccctgttct ggctcctggg tggggacccc atctctcagg
     3241 gaccctccca gctcccaagc tgctgccctg cctttcctgg gggcaaaagg ggcaggtggc
     3301 agtttctttt tcagcctcag aactggtttt cctcaatcct ggggggtcct tggacctaga
     3361 agggaacaac tgatggggat aaacccagcc ccttgcccac ctgcctctgg ccttccctgg
     3421 ggtcagtgag agaaatggga atggtagcta cttgggtcag cagagtagag tcaaagagct
     3481 gttcctggtg tgaggtgggg cccacgaggc aggcaggtgg actctggcac aggggccttg
     3541 gtttctgggg gcagggggtt ggggaactct tggtcgccag tttacctgcc ataggtccct
     3601 tttcagccct gcctccccca agttccatca acacaaactc ccagggggtc ctccatgcct
     3661 ggcctggccc tctccttggt gctgatgaga cacaactctg gccccggcgg ctggcctctg
     3721 aggggccatg gtgcttgcgg ggcttcccct atcccccagg tctgcccaag gggactctca
     3781 ataaactcta gctgaaggca
//
