LOCUS       NM_024012               4555 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens 5-hydroxytryptamine receptor 5A (HTR5A), mRNA.
ACCESSION   NM_024012
VERSION     NM_024012.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4555)
  AUTHORS   Zhang,S., Chen,H., Zhang,C., Yang,Y., Popov,P., Liu,J., Krumm,B.E.,
            Cao,C., Kim,K., Xiong,Y., Katritch,V., Shoichet,B.K., Jin,J.,
            Fay,J.F. and Roth,B.L.
  TITLE     Inactive and active state structures template selective tools for
            the human 5-HT5A receptor
  JOURNAL   Nat Struct Mol Biol 29 (7), 677-687 (2022)
   PUBMED   35835867
REFERENCE   2  (bases 1 to 4555)
  AUTHORS   Tan,Y., Xu,P., Huang,S., Yang,G., Zhou,F., He,X., Ma,H., Xu,H.E.
            and Jiang,Y.
  TITLE     Structural insights into the ligand binding and Gi coupling of
            serotonin receptor 5-HT5A
  JOURNAL   Cell Discov 8 (1), 50 (2022)
   PUBMED   35610220
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4555)
  AUTHORS   Lu,Q., Ding,Y., Li,Y. and Lu,Q.
  TITLE     5-HT receptor agonist Valerenic Acid enhances the innate immunity
            signal and suppresses glioblastoma cell growth and invasion
  JOURNAL   Int J Biol Sci 16 (12), 2104-2115 (2020)
   PUBMED   32549758
  REMARK    GeneRIF: 5-HT receptor agonist Valerenic Acid enhances the innate
            immunity signal and suppresses glioblastoma cell growth and
            invasion.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4555)
  AUTHORS   Guan,F., Lin,H., Chen,G., Li,L., Chen,T., Liu,X., Han,J. and Li,T.
  TITLE     Evaluation of association of common variants in HTR1A and HTR5A
            with schizophrenia and executive function
  JOURNAL   Sci Rep 6, 38048 (2016)
   PUBMED   27897266
  REMARK    GeneRIF: results provide further supportive evidence of the effect
            of HTR1A and HTR5A on the etiology of schizophrenia and suggest
            that the selected genetic variations in HTR5A may be involved in
            impaired executive function.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4555)
  AUTHORS   Kim,Y.G., Chang,H.S., Won,E.S., Ham,B.J. and Lee,M.S.
  TITLE     Serotonin-related polymorphisms in TPH1 and HTR5A genes are not
            associated with escitalopram treatment response in Korean patients
            with major depression
  JOURNAL   Neuropsychobiology 69 (4), 210-219 (2014)
   PUBMED   24903772
  REMARK    GeneRIF: Results suggest that TPH1 218A/C and HTR5A 12A/T
            polymorphisms cannot predict treatment response in major depression
REFERENCE   6  (bases 1 to 4555)
  AUTHORS   Francken,B.J., Josson,K., Lijnen,P., Jurzak,M., Luyten,W.H. and
            Leysen,J.E.
  TITLE     Human 5-hydroxytryptamine(5A) receptors activate coexpressed G(i)
            and G(o) proteins in Spodoptera frugiperda 9 cells
  JOURNAL   Mol Pharmacol 57 (5), 1034-1044 (2000)
   PUBMED   10779389
REFERENCE   7  (bases 1 to 4555)
  AUTHORS   Francken,B.J., Jurzak,M., Vanhauwe,J.F., Luyten,W.H. and
            Leysen,J.E.
  TITLE     The human 5-ht5A receptor couples to Gi/Go proteins and inhibits
            adenylate cyclase in HEK 293 cells
  JOURNAL   Eur J Pharmacol 361 (2-3), 299-309 (1998)
   PUBMED   9865521
REFERENCE   8  (bases 1 to 4555)
  AUTHORS   Schanen,N.C., Scherer,S.W., Tsui,L.C. and Francke,U.
  TITLE     Assignment of the 5-hydroxytryptamine (serotonin) receptor 5A gene
            (HTR5A) to human chromosome band 7q36.1
  JOURNAL   Cytogenet Cell Genet 72 (2-3), 187-188 (1996)
   PUBMED   8978771
REFERENCE   9  (bases 1 to 4555)
  AUTHORS   Rees,S., den Daas,I., Foord,S., Goodson,S., Bull,D., Kilpatrick,G.
            and Lee,M.
  TITLE     Cloning and characterisation of the human 5-HT5A serotonin receptor
  JOURNAL   FEBS Lett 355 (3), 242-246 (1994)
   PUBMED   7988681
  REMARK    GeneRIF: The receptor has been transiently expressed in Cos M6
            cells and exhibits a pharmacological profile closely resembling the
            mouse and rat 5-HT5A receptors with high, specific binding for
            ergotamine and methiothepin.
REFERENCE   10 (bases 1 to 4555)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093726.3, BC112021.1,
            AC092628.3 and BX538209.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 27, 2020 this sequence version replaced NM_024012.3.
            
            Summary: The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT)
            has been implicated in a wide range of psychiatric conditions and
            also has vasoconstrictive and vasodilatory effects. The gene
            described in this record is a member of 5-hydroxytryptamine
            (serotonin) receptor family and encodes a multi-pass membrane
            protein that functions as a receptor for 5-hydroxytryptamine and
            couples to G-proteins. This protein has been shown to function in
            part through the regulation of intracellular Ca2+ mobilization.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK094255.1, SRR1803617.49656.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000287907.3/ ENSP00000287907.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-512               AC093726.3         144674-145185
            513-1725            BC112021.1         1-1213
            1726-1854           AC093726.3         158913-159041
            1855-2686           AC092628.3         1996-2827
            2687-4555           BX538209.1         1-1869
FEATURES             Location/Qualifiers
     source          1..4555
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.2"
     gene            1..4555
                     /gene="HTR5A"
                     /gene_synonym="5-HT5A"
                     /note="5-hydroxytryptamine receptor 5A"
                     /db_xref="GeneID:3361"
                     /db_xref="HGNC:HGNC:5300"
                     /db_xref="MIM:601305"
     exon            1..1317
                     /gene="HTR5A"
                     /gene_synonym="5-HT5A"
                     /inference="alignment:Splign:2.1.0"
     CDS             577..1650
                     /gene="HTR5A"
                     /gene_synonym="5-HT5A"
                     /note="5-HT-5; 5-HT-5A; 5-hydroxytryptamine (serotonin)
                     receptor 5A, G protein-coupled"
                     /codon_start=1
                     /product="5-hydroxytryptamine receptor 5A"
                     /protein_id="NP_076917.1"
                     /db_xref="CCDS:CCDS5936.1"
                     /db_xref="GeneID:3361"
                     /db_xref="HGNC:HGNC:5300"
                     /db_xref="MIM:601305"
                     /translation="MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLIL
                     TLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHEL
                     SGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNV
                     MIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLF
                     VYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWR
                     EQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFN
                     PLIYTAFNKNYNSAFKNFFSRQH"
     exon            1318..4555
                     /gene="HTR5A"
                     /gene_synonym="5-HT5A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2950..2955
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HTR5A"
                     /gene_synonym="5-HT5A"
                     /note="hexamer: ATTATA"
     polyA_site      2972
                     /gene="HTR5A"
                     /gene_synonym="5-HT5A"
                     /note="major polyA site"
     regulatory      4531..4536
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HTR5A"
                     /gene_synonym="5-HT5A"
                     /note="hexamer: AATAAA"
     polyA_site      4555
                     /gene="HTR5A"
                     /gene_synonym="5-HT5A"
ORIGIN      
        1 agcattcgct ctccggagct gcagcctccg aaggggtggc gggggcaaca gggacagaag
       61 gcaggtccca gaaagcaggt tcccccaaaa ctggcttccc tagcacggag ttaaggctgc
      121 agccggctgc ctagagagaa gggtgggcag ggagacaacg cggtgagagc gactgctctg
      181 acgcaccagc ccctctcctg cacccacacg ctgctggccg cccagcttct ccccgatctg
      241 ggagatgctc ggctctgggc ggccaaacag cctttccacc aaggcgagga gccctgggct
      301 cctgacagct taggcgggcc ctggctgcga cacgcagccc ctcgcctctg cttccttagc
      361 ctctgagggc ttcagacctg ccgcgcttgc agccacacca tctccaacgg atgctcacta
      421 gcaggaaatt ggggccaaat tcacaggcac tttccagaaa ctcccccact ggccagaggt
      481 tgcaaacatc cggattggct ctgggcacag tggccgcctt aagtcctcct gaacacccct
      541 tctgcaagta ccccagggcg gtctcctgac ccagagatgg atttacctgt gaacctaacc
      601 tccttttccc tctccacccc ctcccctttg gagaccaacc acagcctcgg caaagacgac
      661 ctgcgcccca gctcgcccct gctctcggtc ttcggagtgc ttattctcac cttgctgggc
      721 tttctggtgg cggcgacgtt cgcctggaac ctgctggtgc tggcgaccat cctccgtgta
      781 cgcaccttcc accgcgtgcc ccacaacctg gtggcatcca tggccgtctc ggatgtcctg
      841 gtggccgcgc tggtcatgcc gctgagcctg gtgcacgagc tgtccgggcg ccgctggcag
      901 ctaggtcgga ggctgtgcca gctttggatc gcgtgcgacg tgctttgctg cacggccagc
      961 atctggaacg tgacggccat agccctggac cgctactggt ccatcacgcg ccacatggaa
     1021 tacacgctcc gcacccgcaa gtgcgtctcc aacgtcatga tcgcgctcac ctgggcactc
     1081 tccgctgtca tctctctggc cccgctgctt tttggctggg gagagacgta ctctgagggc
     1141 agcgaggagt gccaggtaag ccgcgagcct tcctacgccg tgttctccac cgtaggcgcc
     1201 ttctacctgc cgctctgtgt ggtgctcttc gtgtactgga agatctacaa ggctgccaag
     1261 ttccgcgtgg gctccaggaa gaccaatagc gtctcaccca tatccgaagc tgtggaggtg
     1321 aaggactctg ccaaacagcc ccagatggtg ttcacggtcc gccacgccac cgtcaccttc
     1381 cagccagaag gggacacgtg gcgggagcag aaggagcagc gggccgccct catggtgggc
     1441 atcctcattg gcgtgttcgt gctctgctgg atccccttct ttctcaccga gctcatcagt
     1501 cccctctgct cctgtgacat ccccgccatc tggaaaagca tcttcctgtg gcttggctac
     1561 tccaactcct tctttaaccc cctgatctat acggctttca acaagaacta caacagcgcc
     1621 ttcaagaact tcttttctag gcaacactga gggagaggac caggattgaa aaaagtttct
     1681 tcccataatt cagtggaatt cccagttcat ccatttccca tccccaccca acagccatgt
     1741 ggacgggatg aatcctcacc attctccagg gtcatcttca gaactgcact ggcctctttt
     1801 ccacctcctc agtaggaata tgactcctca tagagttacg gtgacatgat gtatctaact
     1861 tatctactat ccctttctct gtgctgacag tcatggtctt tgcccgcaaa gtgtcctttc
     1921 ctccccaaat tcactctggc atggtgatcg acattgtctt aaagaagtca aggcaaataa
     1981 gaaggaggag gtaaaacaat atgggcaggt tgagattgaa tagaaaagaa tgaacaagtc
     2041 atgatgtaga cctctgaggg taggagacca tagttccagg ctttctggca cagtccccat
     2101 ttcaaatatt ctctgtggtc ctagtacata tatcctaata ctgatggggt atgacccaag
     2161 agttgaccac aaaacactgt ctccaaatat attaaagtat atagtcctat ccatgagagc
     2221 agggaatctt agctttaagg ttttgtttgt ggcaaccaca cacgaacata cacacacaca
     2281 cacacacaac tatgaaagag gcaggtgttc tagctagcta gtttactcca aaatgcaatc
     2341 cgttgacatg aaacaggcac tgagggtaac tacttccttt cattttgaag caacagttta
     2401 taaacaggaa agtctactgg tttcatagaa tctgtcagat ttgtttattt gctactggtt
     2461 tcacgcgcgt ggactatatt ccagtgtttc tagtcaaaga cctttatcct caaatcatga
     2521 gattagagta aaacaactgc tgtaaggttg agcatttcat gaccaatgac tatgaaggca
     2581 cattcaccaa acacaggcac tttaagggca tccttgatta atttgctaat tgctattttt
     2641 tgttggtatg tgaattcctg ctaggaggcc gaggctagta ggcaatgaaa aagacagaac
     2701 aatggtaaaa tgcagcccca gtcctctaca aattgacagt ataatttatg aggtgaggca
     2761 gttaagtgat gatgcagcat ttggatgatc atgtaaaacc agtgtcatta cacaaaactt
     2821 aaaaaaaaat cctaggcaat aaaactgcct gtggtctgct atgtctctga ctcttcaaat
     2881 gcatgaatta aagaatgata taataatctc tgaattattg taattcatgt agtatattgt
     2941 atataataaa ttatatcaat taagagttca aacataggaa atttgtgata atttatatgt
     3001 ggtcttggct tgaagtttag tcttgtcttt attgcaaaga ctagctttat caaaagaatg
     3061 tgagcagata aagaaatgtt agacacctgt gaagtcacaa ttaatatgct aaatgcagat
     3121 ctttatgcat tcaagcagat tcattgagaa atttagtgat aagaattgaa gaatttattt
     3181 agaaacgtcc ttagattttt catctgtata tatcacttga agtgctaaac ccacaagtat
     3241 ttaaaataca gactcttcac ttactcaagt tacttttccc cattattact cgaaatcaga
     3301 gagaataaca aatgctattg ttttctagtg ttttgaataa gggaagtgtt tgaataaggg
     3361 aagggaagtg tttgaaaaac cttattaagt accccatggc agagaagaaa aattcagaca
     3421 tgaggagtct ggagaggtaa cactagaatc aagggtaaac gcttaagtct attctacctg
     3481 aaaatccatg tgaaaacttt taatccataa atcgtgagtg tcttactgtt taaaaaagtt
     3541 catactcttc agtaaagcga agcttgagga agatgtgcca catttttctg gtggcttcaa
     3601 acactcccca actctccaag gattctgtat accccagttg gagaacgatg ttattataat
     3661 attaattcaa tctccagctg agggttttat taatgttttc ataagatgga taagcctcat
     3721 tattcttatc actcaatatg tatttaacac ctctcaggtg tcacttaaat tatacattat
     3781 atacaacata ctccacatac actatctaga gcaagaaaca ttccacataa gagaaggaag
     3841 aagtggcaat taatgaatta ttttgcttcc atttcaatag taaaagttgt ttataccctg
     3901 gtaagaaatg tagacattca ttgactttga gtctctacta tgcaaatcaa atatttgtga
     3961 aacactctca tttatgcttg actgctaata ttttatcagg ttagaaattt atatgaatca
     4021 taaacagaag taattgctca aaataactaa ttgtgttccc gtgccagatt gcaacaacca
     4081 cctttattag atggtgcacc tagagaaggc tggagggttt cctgcaagcc ctctctgtag
     4141 ggtgactgag gtgaaccaat ccaaagccct cctttcagct cttgtagaat atgtcgaaca
     4201 aaacgcacag ttctgccctc ctgcctaaag acaaagtaca aaggagataa tcctctcctt
     4261 atgagtgatc ttagccctct tgaggtcact atcagtttta tattttcatt gtgcggtagt
     4321 gaaagacaag tggaagatgt ccctgagtct gtattgacat cagaccatat tgtagggatt
     4381 aattcttgat aaaaaaaaag cttgttattt ctctcttctt ttcatgagga gcatttttgc
     4441 ttccgtgttt gtctgttgga tttgcagttc cctgctcaca gccaaagagg ctgtagagac
     4501 aacactttgc catatttcta ttaaagagaa aataaagatt gagtccacag ctcaa
//
