LOCUS       NM_001145143            1609 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens 5-hydroxytryptamine receptor 3D (HTR3D), transcript
            variant 1, mRNA.
ACCESSION   NM_001145143
VERSION     NM_001145143.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1609)
  AUTHORS   Tang,F.Y., Ma,L., Tam,P.O.S., Pang,C.P., Tham,C.C. and Chen,L.J.
  TITLE     Genetic Association of the PARL-ABCC5-HTR3D-HTR3C Locus With
            Primary Angle-Closure Glaucoma in Chinese
  JOURNAL   Invest Ophthalmol Vis Sci 58 (10), 4384-4389 (2017)
   PUBMED   28813580
  REMARK    GeneRIF: These findings enrich the allelic spectrum of ABCC5 in
            PACG. We identified no tagging SNP responsible for the association
            of the whole region.
            Erratum:[Invest Ophthalmol Vis Sci. 2017 Sep 1;58(11):4799. doi:
            10.1167/iovs.17-22948a.. PMID: 28973336]
REFERENCE   2  (bases 1 to 1609)
  AUTHORS   Nongpiur,M.E., Khor,C.C., Jia,H., Cornes,B.K., Chen,L.J., Qiao,C.,
            Nair,K.S., Cheng,C.Y., Xu,L., George,R., Tan,D., Abu-Amero,K.,
            Perera,S.A., Ozaki,M., Mizoguchi,T., Kurimoto,Y., Low,S.,
            Tajudin,L.S., Ho,C.L., Tham,C.C., Soto,I., Chew,P.T., Wong,H.T.,
            Shantha,B., Kuroda,M., Osman,E.A., Tang,G., Fan,S., Meng,H.,
            Wang,H., Feng,B., Yong,V.H., Ting,S.M., Li,Y., Wang,Y.X., Li,Z.,
            Lavanya,R., Wu,R.Y., Zheng,Y.F., Su,D.H., Loon,S.C., Yong,V.K.,
            Allingham,R.R., Hauser,M.A., Soumittra,N., Ramprasad,V.L.,
            Waseem,N., Yaakub,A., Chia,K.S., Kumaramanickavel,G., Wong,T.T.,
            How,A.C., Chau,T.N., Simmons,C.P., Bei,J.X., Zeng,Y.X.,
            Bhattacharya,S.S., Zhang,M., Tan,D.T., Teo,Y.Y., Al-Obeidan,S.A.,
            Hon,D.N., Tai,E.S., Saw,S.M., Foster,P.J., Vijaya,L., Jonas,J.B.,
            Wong,T.Y., John,S.W., Pang,C.P., Vithana,E.N., Wang,N. and Aung,T.
  TITLE     ABCC5, a gene that influences the anterior chamber depth, is
            associated with primary angle closure glaucoma
  JOURNAL   PLoS Genet 10 (3), e1004089 (2014)
   PUBMED   24603532
  REMARK    Erratum:[PLoS Genet. 2014 Apr;10(4):e1004352. Yong, Vernon K Y
            [added]]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1609)
  AUTHORS   Ripke,S., Wray,N.R., Lewis,C.M., Hamilton,S.P., Weissman,M.M.,
            Breen,G., Byrne,E.M., Blackwood,D.H., Boomsma,D.I., Cichon,S.,
            Heath,A.C., Holsboer,F., Lucae,S., Madden,P.A., Martin,N.G.,
            McGuffin,P., Muglia,P., Noethen,M.M., Penninx,B.P., Pergadia,M.L.,
            Potash,J.B., Rietschel,M., Lin,D., Muller-Myhsok,B., Shi,J.,
            Steinberg,S., Grabe,H.J., Lichtenstein,P., Magnusson,P.,
            Perlis,R.H., Preisig,M., Smoller,J.W., Stefansson,K., Uher,R.,
            Kutalik,Z., Tansey,K.E., Teumer,A., Viktorin,A., Barnes,M.R.,
            Bettecken,T., Binder,E.B., Breuer,R., Castro,V.M., Churchill,S.E.,
            Coryell,W.H., Craddock,N., Craig,I.W., Czamara,D., De Geus,E.J.,
            Degenhardt,F., Farmer,A.E., Fava,M., Frank,J., Gainer,V.S.,
            Gallagher,P.J., Gordon,S.D., Goryachev,S., Gross,M., Guipponi,M.,
            Henders,A.K., Herms,S., Hickie,I.B., Hoefels,S., Hoogendijk,W.,
            Hottenga,J.J., Iosifescu,D.V., Ising,M., Jones,I., Jones,L.,
            Jung-Ying,T., Knowles,J.A., Kohane,I.S., Kohli,M.A., Korszun,A.,
            Landen,M., Lawson,W.B., Lewis,G., Macintyre,D., Maier,W.,
            Mattheisen,M., McGrath,P.J., McIntosh,A., McLean,A.,
            Middeldorp,C.M., Middleton,L., Montgomery,G.M., Murphy,S.N.,
            Nauck,M., Nolen,W.A., Nyholt,D.R., O'Donovan,M., Oskarsson,H.,
            Pedersen,N., Scheftner,W.A., Schulz,A., Schulze,T.G., Shyn,S.I.,
            Sigurdsson,E., Slager,S.L., Smit,J.H., Stefansson,H., Steffens,M.,
            Thorgeirsson,T., Tozzi,F., Treutlein,J., Uhr,M., van den Oord,E.J.,
            Van Grootheest,G., Volzke,H., Weilburg,J.B., Willemsen,G.,
            Zitman,F.G., Neale,B., Daly,M., Levinson,D.F. and Sullivan,P.F.
  CONSRTM   Major Depressive Disorder Working Group of the Psychiatric GWAS
            Consortium
  TITLE     A mega-analysis of genome-wide association studies for major
            depressive disorder
  JOURNAL   Mol Psychiatry 18 (4), 497-511 (2013)
   PUBMED   22472876
REFERENCE   4  (bases 1 to 1609)
  AUTHORS   Kapeller,J., Moller,D., Lasitschka,F., Autschbach,F., Hovius,R.,
            Rappold,G., Bruss,M., Gershon,M.D. and Niesler,B.
  TITLE     Serotonin receptor diversity in the human colon: Expression of
            serotonin type 3 receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E
  JOURNAL   J Comp Neurol 519 (3), 420-432 (2011)
   PUBMED   21192076
  REMARK    GeneRIF: Data show that 5-HT3C, 5-HT3D, and 5-HT3E subunits are
            coexpressed with 5-HT3A in cell bodies of myenteric neurons, and
            that 5-HT3A and 5-HT3D were expressed in submucosal plexus of the
            human large intestine.
REFERENCE   5  (bases 1 to 1609)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   6  (bases 1 to 1609)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 1609)
  AUTHORS   Schuhmacher,A., Mossner,R., Quednow,B.B., Kuhn,K.U., Wagner,M.,
            Cvetanovska,G., Rujescu,D., Zill,P., Moller,H.J., Rietschel,M.,
            Franke,P., Wolwer,W., Gaebel,W. and Maier,W.
  TITLE     Influence of 5-HT3 receptor subunit genes HTR3A, HTR3B, HTR3C,
            HTR3D and HTR3E on treatment response to antipsychotics in
            schizophrenia
  JOURNAL   Pharmacogenet Genomics 19 (11), 843-851 (2009)
   PUBMED   19794330
  REMARK    GeneRIF: Six functional and coding variants of the subunit genes
            HTR3A, HTR3B as well as the novel HTR3C, HTR3D, and HTR3E subunits
            in the response to haloperidol or risperidone, were assessed.
REFERENCE   8  (bases 1 to 1609)
  AUTHORS   Niesler,B., Walstab,J., Combrink,S., Moller,D., Kapeller,J.,
            Rietdorf,J., Bonisch,H., Gothert,M., Rappold,G. and Bruss,M.
  TITLE     Characterization of the novel human serotonin receptor subunits
            5-HT3C,5-HT3D, and 5-HT3E
  JOURNAL   Mol Pharmacol 72 (1), 8-17 (2007)
   PUBMED   17392525
REFERENCE   9  (bases 1 to 1609)
  AUTHORS   Karnovsky,A.M., Gotow,L.F., McKinley,D.D., Piechan,J.L.,
            Ruble,C.L., Mills,C.J., Schellin,K.A., Slightom,J.L.,
            Fitzgerald,L.R., Benjamin,C.W. and Roberds,S.L.
  TITLE     A cluster of novel serotonin receptor 3-like genes on human
            chromosome 3
  JOURNAL   Gene 319, 137-148 (2003)
   PUBMED   14597179
REFERENCE   10 (bases 1 to 1609)
  AUTHORS   Niesler,B., Frank,B., Kapeller,J. and Rappold,G.A.
  TITLE     Cloning, physical mapping and expression analysis of the human
            5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E
  JOURNAL   Gene 310, 101-111 (2003)
   PUBMED   12801637
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BK001746.1, AC068644.15 and
            AC131235.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: The protein encoded this gene belongs to the ligand-gated
            ion channel receptor superfamily. This gene encodes subunit D of
            the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic
            hormone that functions as a neurotransmitter, a mitogen and a
            hormone. This hormone has been linked to neuropsychiatric
            disorders, including anxiety, depression, and migraine. Serotonin
            receptors causes fast and depolarizing responses in neurons
            following activation. The genes encoding subunits C, D and E of
            this type 3 receptor form a cluster on chromosome 3. Alternatively
            spliced transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Jul 2009].
            
            Transcript Variant: This variant (1) differs in the 5' coding
            region, compared to variant 3, resulting in an isoform (1) that is
            shorter than isoform 3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK001746.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000428798.7/ ENSP00000405409.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1215              BK001746.1         1-1215
            1216-1529           AC068644.15        178375-178688
            1530-1609           AC131235.4         172438-172517       c
FEATURES             Location/Qualifiers
     source          1..1609
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.1"
     gene            1..1609
                     /gene="HTR3D"
                     /gene_synonym="5HT3D"
                     /note="5-hydroxytryptamine receptor 3D"
                     /db_xref="GeneID:200909"
                     /db_xref="HGNC:HGNC:24004"
                     /db_xref="MIM:610122"
     CDS             1..1215
                     /gene="HTR3D"
                     /gene_synonym="5HT3D"
                     /note="isoform 1 is encoded by transcript variant 1;
                     5-hydroxytryptamine receptor 3 subunit D; serotonin
                     5-HT-3D receptor; serotonin receptor 3D;
                     5-hydroxytryptamine (serotonin) receptor 3 family member
                     D; 5-hydroxytryptamine (serotonin) receptor 3D,
                     ionotropic"
                     /codon_start=1
                     /product="5-hydroxytryptamine receptor 3D isoform 1"
                     /protein_id="NP_001138615.1"
                     /db_xref="CCDS:CCDS46966.1"
                     /db_xref="GeneID:200909"
                     /db_xref="HGNC:HGNC:24004"
                     /db_xref="MIM:610122"
                     /translation="MERGWFHGKGFLLGFILHLLLQDSHLQLVTSFLWLNMWNPDECG
                     GIKKSGMATENLWLSDVFIEESVDQTPAGLMASMSIVKATSNTISQCGWSASANWTPS
                     ISPSMDRGERSPSALSPTQVTRAWRRMSRSFQIHHRTSFRTRREWVLLGIQKRTIKVT
                     VATNQYEQAIFHVAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMT
                     VLLGYSVFLLMMNDLLPATSTSSHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIF
                     ITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQKGNKGPGLTPTHLPGVKEPE
                     VSAGQMPGPGEAELTGGSEWTRAQREHEAQKQHSVELWVQFSHAMDALLFRLYLLFMA
                     SSIITVICLWNT"
     exon            1..66
                     /gene="HTR3D"
                     /gene_synonym="5HT3D"
                     /inference="alignment:Splign:2.1.0"
     exon            67..111
                     /gene="HTR3D"
                     /gene_synonym="5HT3D"
                     /inference="alignment:Splign:2.1.0"
     exon            112..197
                     /gene="HTR3D"
                     /gene_synonym="5HT3D"
                     /inference="alignment:Splign:2.1.0"
     exon            198..367
                     /gene="HTR3D"
                     /gene_synonym="5HT3D"
                     /inference="alignment:Splign:2.1.0"
     exon            368..516
                     /gene="HTR3D"
                     /gene_synonym="5HT3D"
                     /inference="alignment:Splign:2.1.0"
     exon            517..769
                     /gene="HTR3D"
                     /gene_synonym="5HT3D"
                     /inference="alignment:Splign:2.1.0"
     exon            770..985
                     /gene="HTR3D"
                     /gene_synonym="5HT3D"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1609
                     /gene="HTR3D"
                     /gene_synonym="5HT3D"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1609
                     /gene="HTR3D"
                     /gene_synonym="5HT3D"
ORIGIN      
        1 atggaaagag gctggttcca tgggaaagga ttcctccttg gcttcatcct ccacctgctg
       61 ctgcaagatt cacaccttca actggtgaca tcgttcctgt ggctaaatat gtggaaccca
      121 gatgaatgcg gaggcatcaa gaagtccggc atggcaactg agaacctatg gctttcagat
      181 gtcttcatcg aggagtctgt ggatcagaca cctgcaggtc tcatggctag tatgtcaata
      241 gtgaaggcca catcaaacac aataagccaa tgtgggtggt cagcatctgc aaactggaca
      301 ccttctattt ccccttccat ggacagaggt gaacgctctc cttcagccct ttcacctaca
      361 caggtaaccc gggcatggag aaggatgtcc aggagctttc aaatacatca cagaacctca
      421 ttcagaacaa ggagggagtg ggtactgctg ggtatccaaa aaagaacaat aaaggtgacc
      481 gtggccacta accagtatga acaagccatc ttccatgtgg ccatcaggcg caggtgcagg
      541 cccagcccct acgtggtaaa ctttctggtg cccagtggca ttctgattgc catcgatgcc
      601 ctcagtttct acctgccact ggaaagtggg aattgtgccc cattcaagat gactgttctg
      661 ctgggctaca gcgtcttcct gctcatgatg aatgacttgc tcccagccac tagcacttca
      721 tcacatgctt cactagtacg tcctcatcca tcaagagacc aaaagcgagg tgtctacttc
      781 gccctgtgcc tgtccctgat ggtgggcagc ctgctggaga ccatcttcat cacccacctg
      841 ctgcacgtgg ccaccaccca gcccctacct ctgcctcggt ggctccactc cctgctgctg
      901 cactgcaccg gccaagggag atgctgtccc actgcgcccc agaagggaaa taagggcccg
      961 ggtctcaccc ccacccacct gcccggtgtg aaggagccag aggtatcagc agggcagatg
     1021 ccaggccctg gggaggcaga gctgacaggg ggctcagaat ggacaagggc ccagcgggaa
     1081 cacgaggccc agaagcagca ctcggtggag ctgtgggtgc agttcagcca cgcgatggac
     1141 gccctgctct tccgcctcta cctgctcttc atggcctcct ccatcatcac cgtcatatgc
     1201 ctctggaaca cctaggcagg tgctcacctg caaacttcag tctggacttc tttttgccag
     1261 agaactccag aaaccagtca ggctctcagt cagccttgtg gccctgtcaa ccgcctcatt
     1321 tttaacccag tcctctgtgt agtttcagac cagacctgaa tagtctccta tgccctccaa
     1381 aagtcgggtc cttgctcctg catgccatca gccccactca gccctcccat acctccctgg
     1441 ctcctcagga ttcaggttcc tagggtacgt ccttgattaa atcaccccaa tatgcccctt
     1501 tgcagaaagt attggctttt ccctgaattc tgttatggta aaaaaaatct tgggattgag
     1561 agtcttcttg cagaaacttc tcagccaaag taaaaaggat tttctctta
//
