LOCUS       NM_130770               1699 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens 5-hydroxytryptamine receptor 3C (HTR3C), mRNA.
ACCESSION   NM_130770
VERSION     NM_130770.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1699)
  AUTHORS   Tang,F.Y., Ma,L., Tam,P.O.S., Pang,C.P., Tham,C.C. and Chen,L.J.
  TITLE     Genetic Association of the PARL-ABCC5-HTR3D-HTR3C Locus With
            Primary Angle-Closure Glaucoma in Chinese
  JOURNAL   Invest Ophthalmol Vis Sci 58 (10), 4384-4389 (2017)
   PUBMED   28813580
  REMARK    GeneRIF: These findings enrich the allelic spectrum of ABCC5 in
            PACG. We identified no tagging SNP responsible for the association
            of the whole region.
            Erratum:[Invest Ophthalmol Vis Sci. 2017 Sep 1;58(11):4799. doi:
            10.1167/iovs.17-22948a.. PMID: 28973336]
REFERENCE   2  (bases 1 to 1699)
  AUTHORS   Nongpiur,M.E., Khor,C.C., Jia,H., Cornes,B.K., Chen,L.J., Qiao,C.,
            Nair,K.S., Cheng,C.Y., Xu,L., George,R., Tan,D., Abu-Amero,K.,
            Perera,S.A., Ozaki,M., Mizoguchi,T., Kurimoto,Y., Low,S.,
            Tajudin,L.S., Ho,C.L., Tham,C.C., Soto,I., Chew,P.T., Wong,H.T.,
            Shantha,B., Kuroda,M., Osman,E.A., Tang,G., Fan,S., Meng,H.,
            Wang,H., Feng,B., Yong,V.H., Ting,S.M., Li,Y., Wang,Y.X., Li,Z.,
            Lavanya,R., Wu,R.Y., Zheng,Y.F., Su,D.H., Loon,S.C., Yong,V.K.,
            Allingham,R.R., Hauser,M.A., Soumittra,N., Ramprasad,V.L.,
            Waseem,N., Yaakub,A., Chia,K.S., Kumaramanickavel,G., Wong,T.T.,
            How,A.C., Chau,T.N., Simmons,C.P., Bei,J.X., Zeng,Y.X.,
            Bhattacharya,S.S., Zhang,M., Tan,D.T., Teo,Y.Y., Al-Obeidan,S.A.,
            Hon,D.N., Tai,E.S., Saw,S.M., Foster,P.J., Vijaya,L., Jonas,J.B.,
            Wong,T.Y., John,S.W., Pang,C.P., Vithana,E.N., Wang,N. and Aung,T.
  TITLE     ABCC5, a gene that influences the anterior chamber depth, is
            associated with primary angle closure glaucoma
  JOURNAL   PLoS Genet 10 (3), e1004089 (2014)
   PUBMED   24603532
  REMARK    Erratum:[PLoS Genet. 2014 Apr;10(4):e1004352. Yong, Vernon K Y
            [added]]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1699)
  AUTHORS   Pud,D., Har-Zahav,G., Laitman,Y., Rubinek,T., Yeheskel,A.,
            Ben-Ami,S., Kaufman,B., Friedman,E., Symon,Z. and Wolf,I.
  TITLE     Association between variants of 5-hydroxytryptamine receptor 3C
            (HTR3C) and chemotherapy-induced symptoms in women receiving
            adjuvant treatment for breast cancer
  JOURNAL   Breast Cancer Res Treat 144 (1), 123-131 (2014)
   PUBMED   24477975
  REMARK    GeneRIF: Our study indicates, for the first time, an association
            between variants of HTR3C and severity of chemotherapy-induced
            symptoms
REFERENCE   4  (bases 1 to 1699)
  AUTHORS   Lennertz,L., Wagner,M., Grabe,H.J., Franke,P.E., Guttenthaler,V.,
            Rampacher,F., Schulze-Rauschenbach,S., Vogeley,A., Benninghoff,J.,
            Ruhrmann,S., Pukrop,R., Klosterkotter,J., Falkai,P., Maier,W. and
            Mossner,R.
  TITLE     5-HT3 receptor influences the washing phenotype and visual
            organization in obsessive-compulsive disorder supporting 5-HT3
            receptor antagonists as novel treatment option
  JOURNAL   Eur Neuropsychopharmacol 24 (1), 86-94 (2014)
   PUBMED   23928294
  REMARK    GeneRIF: The association findings of the HTR3C and the HTR3E
            remained significant after correction for the number of variants
            investigated.
REFERENCE   5  (bases 1 to 1699)
  AUTHORS   Ripke,S., Wray,N.R., Lewis,C.M., Hamilton,S.P., Weissman,M.M.,
            Breen,G., Byrne,E.M., Blackwood,D.H., Boomsma,D.I., Cichon,S.,
            Heath,A.C., Holsboer,F., Lucae,S., Madden,P.A., Martin,N.G.,
            McGuffin,P., Muglia,P., Noethen,M.M., Penninx,B.P., Pergadia,M.L.,
            Potash,J.B., Rietschel,M., Lin,D., Muller-Myhsok,B., Shi,J.,
            Steinberg,S., Grabe,H.J., Lichtenstein,P., Magnusson,P.,
            Perlis,R.H., Preisig,M., Smoller,J.W., Stefansson,K., Uher,R.,
            Kutalik,Z., Tansey,K.E., Teumer,A., Viktorin,A., Barnes,M.R.,
            Bettecken,T., Binder,E.B., Breuer,R., Castro,V.M., Churchill,S.E.,
            Coryell,W.H., Craddock,N., Craig,I.W., Czamara,D., De Geus,E.J.,
            Degenhardt,F., Farmer,A.E., Fava,M., Frank,J., Gainer,V.S.,
            Gallagher,P.J., Gordon,S.D., Goryachev,S., Gross,M., Guipponi,M.,
            Henders,A.K., Herms,S., Hickie,I.B., Hoefels,S., Hoogendijk,W.,
            Hottenga,J.J., Iosifescu,D.V., Ising,M., Jones,I., Jones,L.,
            Jung-Ying,T., Knowles,J.A., Kohane,I.S., Kohli,M.A., Korszun,A.,
            Landen,M., Lawson,W.B., Lewis,G., Macintyre,D., Maier,W.,
            Mattheisen,M., McGrath,P.J., McIntosh,A., McLean,A.,
            Middeldorp,C.M., Middleton,L., Montgomery,G.M., Murphy,S.N.,
            Nauck,M., Nolen,W.A., Nyholt,D.R., O'Donovan,M., Oskarsson,H.,
            Pedersen,N., Scheftner,W.A., Schulz,A., Schulze,T.G., Shyn,S.I.,
            Sigurdsson,E., Slager,S.L., Smit,J.H., Stefansson,H., Steffens,M.,
            Thorgeirsson,T., Tozzi,F., Treutlein,J., Uhr,M., van den Oord,E.J.,
            Van Grootheest,G., Volzke,H., Weilburg,J.B., Willemsen,G.,
            Zitman,F.G., Neale,B., Daly,M., Levinson,D.F. and Sullivan,P.F.
  CONSRTM   Major Depressive Disorder Working Group of the Psychiatric GWAS
            Consortium
  TITLE     A mega-analysis of genome-wide association studies for major
            depressive disorder
  JOURNAL   Mol Psychiatry 18 (4), 497-511 (2013)
   PUBMED   22472876
REFERENCE   6  (bases 1 to 1699)
  AUTHORS   Fasching,P.A., Kollmannsberger,B., Strissel,P.L., Niesler,B.,
            Engel,J., Kreis,H., Lux,M.P., Weihbrecht,S., Lausen,B., Bani,M.R.,
            Beckmann,M.W. and Strick,R.
  TITLE     Polymorphisms in the novel serotonin receptor subunit gene HTR3C
            show different risks for acute chemotherapy-induced vomiting after
            anthracycline chemotherapy
  JOURNAL   J Cancer Res Clin Oncol 134 (10), 1079-1086 (2008)
   PUBMED   18389280
  REMARK    GeneRIF: Polymorphisms in the HTR3C gene could serve as a
            predictive factor for chemotherapy-induced nausea and vomiting in
            patients undergoing moderately emetogenic chemotherapy.
            GeneRIF: Observational study of gene-disease association and
            pharmacogenomic / toxicogenomic. (HuGE Navigator)
REFERENCE   7  (bases 1 to 1699)
  AUTHORS   Niesler,B., Walstab,J., Combrink,S., Moller,D., Kapeller,J.,
            Rietdorf,J., Bonisch,H., Gothert,M., Rappold,G. and Bruss,M.
  TITLE     Characterization of the novel human serotonin receptor subunits
            5-HT3C,5-HT3D, and 5-HT3E
  JOURNAL   Mol Pharmacol 72 (1), 8-17 (2007)
   PUBMED   17392525
REFERENCE   8  (bases 1 to 1699)
  AUTHORS   Peters,J.A., Kelley,S.P., Dunlop,J.I., Kirkness,E.F., Hales,T.G.
            and Lambert,J.J.
  TITLE     The 5-hydroxytryptamine type 3 (5-HT3) receptor reveals a novel
            determinant of single-channel conductance
  JOURNAL   Biochem Soc Trans 32 (Pt3), 547-552 (2004)
   PUBMED   15157181
  REMARK    Review article
REFERENCE   9  (bases 1 to 1699)
  AUTHORS   Karnovsky,A.M., Gotow,L.F., McKinley,D.D., Piechan,J.L.,
            Ruble,C.L., Mills,C.J., Schellin,K.A., Slightom,J.L.,
            Fitzgerald,L.R., Benjamin,C.W. and Roberds,S.L.
  TITLE     A cluster of novel serotonin receptor 3-like genes on human
            chromosome 3
  JOURNAL   Gene 319, 137-148 (2003)
   PUBMED   14597179
REFERENCE   10 (bases 1 to 1699)
  AUTHORS   Niesler,B., Frank,B., Kapeller,J. and Rappold,G.A.
  TITLE     Cloning, physical mapping and expression analysis of the human
            5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E
  JOURNAL   Gene 310, 101-111 (2003)
   PUBMED   12801637
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC131235.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_130770.2.
            
            Summary: The product of this gene belongs to the ligand-gated ion
            channel receptor superfamily. This gene encodes subunit C of the
            type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic
            hormone that functions as a neurotransmitter, a hormone, and a
            mitogen. This receptor causes fast, depolarizing responses in
            neurons after activation. Genes encoding subunits C, D and E form a
            cluster on chromosome 3. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF459285.1, BC131799.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA2142363 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000318351.2/ ENSP00000322617.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               AC131235.4         158660-158760       c
            102-268             AC131235.4         156920-157086       c
            269-313             AC131235.4         156451-156495       c
            314-423             AC131235.4         155521-155630       c
            424-593             AC131235.4         154763-154932       c
            594-754             AC131235.4         153220-153380       c
            755-959             AC131235.4         152167-152371       c
            960-1175            AC131235.4         151764-151979       c
            1176-1699           AC131235.4         151134-151657       c
FEATURES             Location/Qualifiers
     source          1..1699
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.1"
     gene            1..1699
                     /gene="HTR3C"
                     /note="5-hydroxytryptamine receptor 3C"
                     /db_xref="GeneID:170572"
                     /db_xref="HGNC:HGNC:24003"
                     /db_xref="MIM:610121"
     exon            1..101
                     /gene="HTR3C"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1378
                     /gene="HTR3C"
                     /note="5-hydroxytryptamine receptor 3 subunit C; 5-HT3C;
                     5-HT3-C; serotonin receptor 3C; 5-hydroxytryptamine
                     (serotonin) receptor 3, family member C;
                     5-hydroxytryptamine (serotonin) receptor 3C, ionotropic"
                     /codon_start=1
                     /product="5-hydroxytryptamine receptor 3C precursor"
                     /protein_id="NP_570126.2"
                     /db_xref="CCDS:CCDS3250.1"
                     /db_xref="GeneID:170572"
                     /db_xref="HGNC:HGNC:24003"
                     /db_xref="MIM:610121"
                     /translation="MEGGWPARQSALLCLTVSLLLQGRGDAFTINCSGFDQHGVDPAV
                     FQAVFDRKAFRPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINW
                     NPKECVGINKLTVLAENLWLPDIFIVESMDVDQTPSGLTAYISSEGRIKYDKPMRVTS
                     ICNLDIFYFPFDQQNCTFTFSSFLYTVDSMLLGMDKEVWEITDTSRKVIQTQGEWELL
                     GINKATPKMSMGNNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESE
                     NRAPFKITLLLGYNVFLLMMNDLLPASGTPLISVYFALCLSLMVVSLLETVFITYLLH
                     VATTQPPPMPRWLHSLLLHCTSPGRCCPTAPQKGNKGLGLTLTHLPGPKEPGELAGKK
                     LGPRETEPDGGSGWTKTQLMELWVQFSHAMDTLLFRLYLLFMASSILTVIVLWNT"
     exon            102..268
                     /gene="HTR3C"
                     /inference="alignment:Splign:2.1.0"
     exon            269..313
                     /gene="HTR3C"
                     /inference="alignment:Splign:2.1.0"
     exon            314..423
                     /gene="HTR3C"
                     /inference="alignment:Splign:2.1.0"
     exon            424..593
                     /gene="HTR3C"
                     /inference="alignment:Splign:2.1.0"
     exon            594..754
                     /gene="HTR3C"
                     /inference="alignment:Splign:2.1.0"
     exon            755..959
                     /gene="HTR3C"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1175
                     /gene="HTR3C"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1699
                     /gene="HTR3C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1680..1685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HTR3C"
                     /note="hexamer: AATAAA"
     polyA_site      1699
                     /gene="HTR3C"
                     /note="major polyA site"
ORIGIN      
        1 tggtgaatcc ccagagaaga gtccagaaag aagaatggaa ggagggtggc ctgcaaggca
       61 gagtgccctc ctctgcctca ctgtcagtct tctgcttcaa ggaagaggcg acgcttttac
      121 catcaattgc tcaggctttg accagcatgg ggttgaccct gctgtcttcc aagcagtgtt
      181 tgacagaaag gccttccgtc cattcaccaa ctacagcatc cctacccgtg tcaacatctc
      241 cttcaccctg tctgccatcc tgggagtgga tgcacagctc cagctgctga catcattcct
      301 gtggatggat ttggtatggg acaatccttt cattaattgg aacccaaaag agtgtgttgg
      361 catcaataaa ctcacagtat tagctgaaaa cctgtggctc ccagacatct tcatcgtgga
      421 atccatggat gtggatcaga cgccttccgg tctcactgcc tatatcagca gtgaaggtcg
      481 aattaagtat gataagccaa tgagggtgac cagcatctgt aacctggaca tcttctactt
      541 cccttttgac caacagaact gtaccttcac cttcagttct ttcctctaca cagtggacag
      601 catgctgctg ggcatggaca aggaggtgtg ggagatcaca gacacgtctc gcaaagtcat
      661 ccaaacccag ggggagtggg agctcttggg catcaacaag gccaccccaa agatgtccat
      721 gggcaacaac ctatatgacc agatcatgtt ttatgtggcc atcaggcgca ggccaagcct
      781 ctacatcata aacctgctgg tgcccagtag ctttctggtt gccattgatg ccctcagctt
      841 ctacctgcca gcagagagcg agaatcgtgc cccattcaag ataacacttc tgctgggcta
      901 caacgtcttc ctgctcatga tgaatgactt gctccctgcc agtggcaccc ccctcatcag
      961 tgtctacttc gccctgtgcc tgtccctgat ggtggtcagc ctgctggaga ccgtcttcat
     1021 tacctacctg ctgcacgtgg ccaccaccca gcccccaccc atgcctaggt ggcttcactc
     1081 cctgctgctc cactgcacca gcccagggag atgctgtccc actgcgcccc agaagggaaa
     1141 taagggcctg ggtctcaccc tcacccacct gcctggccca aaggagccgg gggagttagc
     1201 agggaagaag ctgggaccca gagagaccga gccagatggg ggctcaggat ggacaaagac
     1261 ccagctaatg gagctgtggg tgcagttcag ccacgcgatg gacaccctgc tcttccgcct
     1321 ctacctgctc ttcatggcct cctccatcct tactgtcatt gtcctctgga acacctaggc
     1381 agacatcccc cctctctggc aaacaacagc ttggagtttc tgctggtctt gggccagccg
     1441 gactcatttt cctaatctta gccacttatc cccagtgact accatgtccc cttctaaatt
     1501 ccaaagactc caacgcagca ctagcaagca ggttcgggac agccctggac gatttcccga
     1561 ccgctgctca ggctgctcat tcctgctcac cctcagtctc cctgagctac cacctaactc
     1621 ctcactccct gatcaatgga agtccaggtc agtggagtct ctccttgatt gatcacccca
     1681 ataaacaact ttccaggaa
//
