LOCUS       NM_006028               4406 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens 5-hydroxytryptamine receptor 3B (HTR3B), transcript
            variant 1, mRNA.
ACCESSION   NM_006028
VERSION     NM_006028.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4406)
  AUTHORS   Wang,L., Wang,M., Zhao,C., Jian,J. and Qiao,D.
  TITLE     Association of HTR3B gene polymorphisms with depression and its
            executive dysfunction: a case-control study
  JOURNAL   BMC Psychiatry 23 (1), 128 (2023)
   PUBMED   36849934
  REMARK    GeneRIF: Association of HTR3B gene polymorphisms with depression
            and its executive dysfunction: a case-control study.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4406)
  AUTHORS   Zhang,X. and Sun,Y.
  TITLE     The Predictive Role of ADRA2A rs1800544 and HTR3B rs3758987
            Polymorphisms in Motion Sickness Susceptibility
  JOURNAL   Int J Environ Res Public Health 18 (24), 13163 (2021)
   PUBMED   34948773
  REMARK    GeneRIF: The Predictive Role of ADRA2A rs1800544 and HTR3B
            rs3758987 Polymorphisms in Motion Sickness Susceptibility.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4406)
  AUTHORS   Yan,T., Su,J., Zhou,L. and Zhang,L.
  TITLE     Polymorphisms of 5-hydroxytryptamine receptor type 3B gene and
            clinical characteristics for vomiting after breast surgery in
            chinese han female population
  JOURNAL   J Clin Pharm Ther 46 (4), 936-941 (2021)
   PUBMED   33605481
  REMARK    GeneRIF: Polymorphisms of 5-hydroxytryptamine receptor type 3B gene
            and clinical characteristics for vomiting after breast surgery in
            chinese han female population.
REFERENCE   4  (bases 1 to 4406)
  AUTHORS   Han,H., Liu,Q., Yang,Z., Wang,M., Ma,Y., Cao,L., Cui,W., Yuan,W.,
            Payne,T.J., Li,L. and Li,M.D.
  TITLE     Association and cis-mQTL analysis of variants in serotonergic genes
            associated with nicotine dependence in Chinese Han smokers
  JOURNAL   Transl Psychiatry 8 (1), 243 (2018)
   PUBMED   30405098
  REMARK    GeneRIF: rs1176744 in HTR3B, and one major haplotype, T-T-A-G,
            formed by rs3758987, rs4938056, rs1176744, and rs2276305 in HTR3B,
            are significantly associated with nicotine dependence in Chinese
            Han male smokers.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4406)
  AUTHORS   Farhat,K., Waheed,A., Pasha,A.K. and Ismail,M.
  TITLE     Association of anti-emetic efficacy of Ondansetron with 18792A>G
            polymorphism in a drug target gene 5-HT3B in Pakistani population
  JOURNAL   J Pak Med Assoc 68 (5), 733-736 (2018)
   PUBMED   29885172
  REMARK    GeneRIF: No association of anti-emetic efficacy of ondansetron with
            18792A>G polymorphism in the target gene of 5-hydroxytryptamine
            type 3 subtype B was found.
REFERENCE   6  (bases 1 to 4406)
  AUTHORS   Gutierrez,B., Arranz,M.J., Huezo-Diaz,P., Dempster,D.,
            Matthiasson,P., Travis,M., Munro,J., Osborne,S. and Kerwin,R.W.
  TITLE     Novel mutations in 5-HT3A and 5-HT3B receptor genes not associated
            with clozapine response
  JOURNAL   Schizophr Res 58 (1), 93-97 (2002)
   PUBMED   12363396
  REMARK    GeneRIF: Observational study of gene-environment interaction and
            pharmacogenomic / toxicogenomic. (HuGE Navigator)
REFERENCE   7  (bases 1 to 4406)
  AUTHORS   Boyd,G.W., Low,P., Dunlop,J.I., Robertson,L.A., Vardy,A.,
            Lambert,J.J., Peters,J.A. and Connolly,C.N.
  TITLE     Assembly and cell surface expression of homomeric and heteromeric
            5-HT3 receptors: the role of oligomerization and chaperone proteins
  JOURNAL   Mol Cell Neurosci 21 (1), 38-50 (2002)
   PUBMED   12359150
REFERENCE   8  (bases 1 to 4406)
  AUTHORS   Dubin,A.E., Huvar,R., D'Andrea,M.R., Pyati,J., Zhu,J.Y., Joy,K.C.,
            Wilson,S.J., Galindo,J.E., Glass,C.A., Luo,L., Jackson,M.R.,
            Lovenberg,T.W. and Erlander,M.G.
  TITLE     The pharmacological and functional characteristics of the serotonin
            5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor
            subunit
  JOURNAL   J Biol Chem 274 (43), 30799-30810 (1999)
   PUBMED   10521471
REFERENCE   9  (bases 1 to 4406)
  AUTHORS   Davies,P.A., Pistis,M., Hanna,M.C., Peters,J.A., Lambert,J.J.,
            Hales,T.G. and Kirkness,E.F.
  TITLE     The 5-HT3B subunit is a major determinant of serotonin-receptor
            function
  JOURNAL   Nature 397 (6717), 359-363 (1999)
   PUBMED   9950429
REFERENCE   10 (bases 1 to 4406)
  AUTHORS   Miyake,A., Mochizuki,S., Takemoto,Y. and Akuzawa,S.
  TITLE     Molecular cloning of human 5-hydroxytryptamine3 receptor:
            heterogeneity in distribution and function among species
  JOURNAL   Mol Pharmacol 48 (3), 407-416 (1995)
   PUBMED   7565620
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001874.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 11, 2021 this sequence version replaced NM_006028.4.
            
            Summary: The product of this gene belongs to the ligand-gated ion
            channel receptor superfamily. This gene encodes subunit B of the
            type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic
            hormone that functions as a neurotransmitter, a hormone, and a
            mitogen. This receptor causes fast, depolarizing responses in
            neurons after activation. It is not functional as a homomeric
            complex, but a pentaheteromeric complex with subunit A (HTR3A)
            displays the full functional features of this receptor. [provided
            by RefSeq, Aug 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK314268.1, AF169255.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000260191.8/ ENSP00000260191.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               AP001874.4         36642-36831
            191-351             AP001874.4         41141-41301
            352-396             AP001874.4         63230-63274
            397-506             AP001874.4         63604-63713
            507-676             AP001874.4         64135-64304
            677-834             AP001874.4         64782-64939
            835-1045            AP001874.4         74828-75038
            1046-1228           AP001874.4         76419-76601
            1229-4406           AP001874.4         77748-80925
FEATURES             Location/Qualifiers
     source          1..4406
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.2"
     gene            1..4406
                     /gene="HTR3B"
                     /gene_synonym="5-HT3B"
                     /note="5-hydroxytryptamine receptor 3B"
                     /db_xref="GeneID:9177"
                     /db_xref="HGNC:HGNC:5298"
                     /db_xref="MIM:604654"
     exon            1..190
                     /gene="HTR3B"
                     /gene_synonym="5-HT3B"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..1464
                     /gene="HTR3B"
                     /gene_synonym="5-HT3B"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; 5-hydroxytryptamine 3 receptor B subunit;
                     serotonin-gated ion channel subunit; 5-hydroxytryptamine
                     (serotonin) receptor 3B, ionotropic"
                     /codon_start=1
                     /product="5-hydroxytryptamine receptor 3B isoform 1
                     precursor"
                     /protein_id="NP_006019.1"
                     /db_xref="CCDS:CCDS8364.1"
                     /db_xref="GeneID:9177"
                     /db_xref="HGNC:HGNC:5298"
                     /db_xref="MIM:604654"
                     /translation="MLSSVMAPLWACILVAAGILATDTHHPQDSALYHLSKQLLQKYH
                     KEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDE
                     IREISLPLSAIWAPDIIINEFVDIERYPDLPYVYVNSSGTIENYKPIQVVSACSLETY
                     AFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSSTYSI
                     LQSSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTS
                     VLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLVKFLHDEQRGG
                     QEQPFLCLRGDTDADRPRVEPRAQRAVVTESSLYGEHLAQPGTLKEVWSQLQSISNYL
                     QTQDQTDQQEAEWLVLLSRFDRLLFQSYLFMLGIYTITLCSLWALWGGV"
     exon            191..351
                     /gene="HTR3B"
                     /gene_synonym="5-HT3B"
                     /inference="alignment:Splign:2.1.0"
     exon            352..396
                     /gene="HTR3B"
                     /gene_synonym="5-HT3B"
                     /inference="alignment:Splign:2.1.0"
     exon            397..506
                     /gene="HTR3B"
                     /gene_synonym="5-HT3B"
                     /inference="alignment:Splign:2.1.0"
     exon            507..676
                     /gene="HTR3B"
                     /gene_synonym="5-HT3B"
                     /inference="alignment:Splign:2.1.0"
     exon            677..834
                     /gene="HTR3B"
                     /gene_synonym="5-HT3B"
                     /inference="alignment:Splign:2.1.0"
     exon            835..1045
                     /gene="HTR3B"
                     /gene_synonym="5-HT3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1228
                     /gene="HTR3B"
                     /gene_synonym="5-HT3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..4406
                     /gene="HTR3B"
                     /gene_synonym="5-HT3B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4377..4382
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HTR3B"
                     /gene_synonym="5-HT3B"
                     /note="hexamer: AATAAA"
     polyA_site      4406
                     /gene="HTR3B"
                     /gene_synonym="5-HT3B"
                     /note="major polyA site"
ORIGIN      
        1 agcaccagta aggatagcat caactggcaa acggagaagg aggagaacag agtggagagg
       61 aaccctgtta ggagaaattg agcggcattc catctggtag gcaagtttgc atttctcctt
      121 tttgggatct gcccaggaat gttgtcaagt gtaatggctc ccctgtgggc ctgcatcctg
      181 gtggctgcag gaattctagc cacagataca catcatcccc aggattctgc tctgtatcat
      241 ctcagcaagc agctattaca gaaatatcat aaagaagtga gacctgttta caactggacc
      301 aaggccacca cagtctacct ggacctgttc gtccatgcta tattggatgt ggatgcagag
      361 aatcaaatat taaagacaag tgtatggtac caagaggtct ggaatgatga atttttatcc
      421 tggaactcca gcatgtttga tgagattaga gagatctccc tacctctaag tgccatctgg
      481 gcccccgata tcatcatcaa tgagtttgtg gacattgaaa gataccctga ccttccctat
      541 gtttatgtga actcatctgg gaccattgag aactataagc ccatccaggt ggtctctgcg
      601 tgcagtttag agacatatgc ttttccattt gatgtccaga attgcagcct gaccttcaag
      661 agcattctgc atacagtgga agacgtagac ctggcctttc tgaggagccc agaagacatt
      721 cagcatgaca aaaaggcgtt tttgaatgac agtgagtggg aacttctatc tgtgtcctcc
      781 acatacagca tcctgcagag cagcgctgga ggatttgcac agattcagtt taatgtggtg
      841 atgcgcaggc accccctggt ctatgtcgtg agtctgctga ttcctagcat ctttctcatg
      901 ctggtggacc tggggagctt ctacctgcca cccaactgcc gagccaggat tgtgttcaag
      961 accagtgtgc tggtgggcta caccgtcttc agggtcaaca tgtccaacca ggtgccacgg
     1021 agtgtaggga gcacccctct gattgggcac ttcttcacca tctgcatggc cttcttggtt
     1081 ctcagcttag ctaagtccat cgtgttggtc aaattcctcc atgatgagca gcgtggtgga
     1141 caggagcagc ccttcttgtg ccttcgaggg gacaccgatg ctgacaggcc tagagtggaa
     1201 cccagggccc aacgtgctgt ggtaacagag tcctcgctgt atggagagca cctggcccag
     1261 ccaggaaccc tgaaggaagt ctggtcgcag cttcaatcta tcagcaacta cctccaaact
     1321 caggaccaga cagaccaaca ggaggcagag tggctggtcc tcctgtcccg ctttgaccga
     1381 ctgctcttcc aaagctacct tttcatgctg gggatctaca ccatcactct gtgctccctc
     1441 tgggcactgt ggggcggcgt gtgaagactg aagtgttctt cagtaattgt gctggcactt
     1501 aggagagaga ggagggggaa taatagtggg ttaaaaagct ttctgggtcg ggtgtggtgg
     1561 ttcttgccta tagtcccagt gctttgggag gccatagcag gaggattgct tgagcccagg
     1621 agttcgagac cagccagagc aacatagtga gaccacatct ctaccagtaa ataaataaat
     1681 aaataaataa ataaataaat aaataaatag ctgggcatag tggctcatgc ctgtactctc
     1741 agctacttgg gaggttgagg tgggaggatt gcttgagccc aggatttcaa ggctgcagtg
     1801 agccatgatt gcaccactgc accccagcct gggtgacaga gcaagaccct gtctcaaaaa
     1861 aaataaaata aaaggctttc tgccttcatt gcctctccat tgagtccagc ttcatacacc
     1921 taatagtctg ctgtgtgacc caaggatcat atgttcatga aaatgtataa acagtatgag
     1981 tatacagtaa aaaagtaaac tttccttctt atcccagtcc actcacccaa agcaaccact
     2041 gttagtaatt tcttccagaa gatttctagg cacacacatg catctatgta tggttaagca
     2101 gttttttaaa aagtgtaaga tagctccatc ttccagccct gccttggcca tttattcagt
     2161 cacccattca acaaaacctt tattgagtat taagtcctag gcattatgtt aggcacacca
     2221 gagaatacaa aataagtcag cacaggttat tattcacttg ttgtgattcc catggtcaac
     2281 ctggtaccaa ccaaccagag cataaaattc ctgccatatc cctcaccttc tgaggctctt
     2341 gttaccactt cccagctaag tccactgcct ccaccctctt cctgtgcccc ttcagcagtg
     2401 catccccact ggagagaacc caggtgccaa ggcttctttt tttttttttg aggcagagtc
     2461 ttgctctgtc accagattgg agtgcagtgg tgcaatcttg gctcactgta acctccacct
     2521 cccgggttca agcaattccc ctgcctcagc ctcccgagta gctggaacta caggtgcatg
     2581 ccaccacacc cagctaattt tctgtatttt agtagcaggt gccaaggctt ctaagcccag
     2641 tctagcacat catttagtcc acacacaagg ggcaatgcat ggagtgggag gacaggcata
     2701 gttcacggtc ctttgcttca aggaagttat aatccactgt ccctgaacta gtcagctagg
     2761 aaatactaca cactaagttg ctttaagaga gatttatttt ctcaccagtc tggaagctag
     2821 aagcctaaga tcaaggtgca aacagggtgg gtggctttct tctgagccct gtccttggct
     2881 tgcaggttgc tgacttcttg ctttgttttc acatgacctt tcctctgtgc atgctcatgt
     2941 ctgtgtccag attttctctt ctaacaaggg caccagtgtt gttggtttag ggtccatcct
     3001 agtgacctct tttaacctta atcacttttt tcaaggccct atgttcaaac agtcatattc
     3061 tgagtactag gggttaggat gtcaacatat gaattttggg gagtgggcag cagacaaagg
     3121 ggacatattt cagcccataa cactagtgat tccggaggtt tagcaagtcc agattctgca
     3181 gagtaggctg gcaggctgga gacctgctga cagtcttaac gctgtcagta gaagacacaa
     3241 aagtccaaaa gctgtttgct agaaactttt tccagcacta aaattgcctt tagaaaaatc
     3301 tgcccccctc catcccccca aagaaaaaga atttaaattc aaacagcctt tacctgcatc
     3361 ttccctctct cattacctcc cagttagtgc tcagcgccaa ttgtccatga aattccactg
     3421 ctgctgttaa tgaaatgagg aacataagaa gtttgtgaac aggaagtgtc catgcaaacc
     3481 tccacctgtt tccttcctca cttcctactt tctactgctg gcctcctctg ctttgacgtg
     3541 ctcagttagg catcacggtc ctgatgtcac cttagcttgc catccatgtc gattctggct
     3601 ttctccactt cctcctccag ttaacagagg aggaaaggag gaaaaggcct gaggtgaact
     3661 cctcactgtg gggtctctct ccttcccaac tatgtcttag agaaagcacc agtgtcagag
     3721 tcaggagtcc tgatgattac ggtcctggct ctgccattac ctagccaggg gacctctgtg
     3781 agcttaactt ctcagacttc aacttacctt atttgaaatt ggggctgttt atatttgctc
     3841 tacccctatc aaagagttat gaggatcaaa atgaaaaaat gtattgaaca atgctttgaa
     3901 aagtaaataa tggggcgtgg tggctcacgc ctataatccc aacactttgg gaggctgagg
     3961 tgggtggatt acctgaggtc aggagtttga gaccagcctg accaacatgg agaaaccctg
     4021 tctctactaa aaatacaaaa ttagccaggc gtggtggcac atgcctgtaa tcccacctac
     4081 tcggggggct gaggcaggag aatcgcttga acccaggagg tggaggttgc ggtgagccga
     4141 gatcgtgcca ttgcactcca gcccgggcaa caagagctaa actctatctc aaaaaaaaaa
     4201 aaaagtttaa agtgctttgg gaagggggag ggatagcatt agaagatata cctaatgtta
     4261 atgggtgcag cacagcaacg tggcacgtgt atacatatgt aacaaacctg cacgttgtgc
     4321 acatgtaccc taaaacttaa agtataattt aaaaaaaagt aaataatgca tcacaaaata
     4381 aagataagac ctgcttgcta tcaaca
//
