LOCUS       NM_001363563            4515 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens 5-hydroxytryptamine receptor 3B (HTR3B), transcript
            variant 2, mRNA.
ACCESSION   NM_001363563 XM_011543063
VERSION     NM_001363563.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4515)
  AUTHORS   Wang,L., Wang,M., Zhao,C., Jian,J. and Qiao,D.
  TITLE     Association of HTR3B gene polymorphisms with depression and its
            executive dysfunction: a case-control study
  JOURNAL   BMC Psychiatry 23 (1), 128 (2023)
   PUBMED   36849934
  REMARK    GeneRIF: Association of HTR3B gene polymorphisms with depression
            and its executive dysfunction: a case-control study.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4515)
  AUTHORS   Zhang,X. and Sun,Y.
  TITLE     The Predictive Role of ADRA2A rs1800544 and HTR3B rs3758987
            Polymorphisms in Motion Sickness Susceptibility
  JOURNAL   Int J Environ Res Public Health 18 (24), 13163 (2021)
   PUBMED   34948773
  REMARK    GeneRIF: The Predictive Role of ADRA2A rs1800544 and HTR3B
            rs3758987 Polymorphisms in Motion Sickness Susceptibility.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4515)
  AUTHORS   Yan,T., Su,J., Zhou,L. and Zhang,L.
  TITLE     Polymorphisms of 5-hydroxytryptamine receptor type 3B gene and
            clinical characteristics for vomiting after breast surgery in
            chinese han female population
  JOURNAL   J Clin Pharm Ther 46 (4), 936-941 (2021)
   PUBMED   33605481
  REMARK    GeneRIF: Polymorphisms of 5-hydroxytryptamine receptor type 3B gene
            and clinical characteristics for vomiting after breast surgery in
            chinese han female population.
REFERENCE   4  (bases 1 to 4515)
  AUTHORS   Han,H., Liu,Q., Yang,Z., Wang,M., Ma,Y., Cao,L., Cui,W., Yuan,W.,
            Payne,T.J., Li,L. and Li,M.D.
  TITLE     Association and cis-mQTL analysis of variants in serotonergic genes
            associated with nicotine dependence in Chinese Han smokers
  JOURNAL   Transl Psychiatry 8 (1), 243 (2018)
   PUBMED   30405098
  REMARK    GeneRIF: rs1176744 in HTR3B, and one major haplotype, T-T-A-G,
            formed by rs3758987, rs4938056, rs1176744, and rs2276305 in HTR3B,
            are significantly associated with nicotine dependence in Chinese
            Han male smokers.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4515)
  AUTHORS   Farhat,K., Waheed,A., Pasha,A.K. and Ismail,M.
  TITLE     Association of anti-emetic efficacy of Ondansetron with 18792A>G
            polymorphism in a drug target gene 5-HT3B in Pakistani population
  JOURNAL   J Pak Med Assoc 68 (5), 733-736 (2018)
   PUBMED   29885172
  REMARK    GeneRIF: No association of anti-emetic efficacy of ondansetron with
            18792A>G polymorphism in the target gene of 5-hydroxytryptamine
            type 3 subtype B was found.
REFERENCE   6  (bases 1 to 4515)
  AUTHORS   Gutierrez,B., Arranz,M.J., Huezo-Diaz,P., Dempster,D.,
            Matthiasson,P., Travis,M., Munro,J., Osborne,S. and Kerwin,R.W.
  TITLE     Novel mutations in 5-HT3A and 5-HT3B receptor genes not associated
            with clozapine response
  JOURNAL   Schizophr Res 58 (1), 93-97 (2002)
   PUBMED   12363396
  REMARK    GeneRIF: Observational study of gene-environment interaction and
            pharmacogenomic / toxicogenomic. (HuGE Navigator)
REFERENCE   7  (bases 1 to 4515)
  AUTHORS   Boyd,G.W., Low,P., Dunlop,J.I., Robertson,L.A., Vardy,A.,
            Lambert,J.J., Peters,J.A. and Connolly,C.N.
  TITLE     Assembly and cell surface expression of homomeric and heteromeric
            5-HT3 receptors: the role of oligomerization and chaperone proteins
  JOURNAL   Mol Cell Neurosci 21 (1), 38-50 (2002)
   PUBMED   12359150
REFERENCE   8  (bases 1 to 4515)
  AUTHORS   Dubin,A.E., Huvar,R., D'Andrea,M.R., Pyati,J., Zhu,J.Y., Joy,K.C.,
            Wilson,S.J., Galindo,J.E., Glass,C.A., Luo,L., Jackson,M.R.,
            Lovenberg,T.W. and Erlander,M.G.
  TITLE     The pharmacological and functional characteristics of the serotonin
            5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor
            subunit
  JOURNAL   J Biol Chem 274 (43), 30799-30810 (1999)
   PUBMED   10521471
REFERENCE   9  (bases 1 to 4515)
  AUTHORS   Davies,P.A., Pistis,M., Hanna,M.C., Peters,J.A., Lambert,J.J.,
            Hales,T.G. and Kirkness,E.F.
  TITLE     The 5-HT3B subunit is a major determinant of serotonin-receptor
            function
  JOURNAL   Nature 397 (6717), 359-363 (1999)
   PUBMED   9950429
REFERENCE   10 (bases 1 to 4515)
  AUTHORS   Miyake,A., Mochizuki,S., Takemoto,Y. and Akuzawa,S.
  TITLE     Molecular cloning of human 5-hydroxytryptamine3 receptor:
            heterogeneity in distribution and function among species
  JOURNAL   Mol Pharmacol 48 (3), 407-416 (1995)
   PUBMED   7565620
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001874.4.
            
            On Feb 11, 2021 this sequence version replaced NM_001363563.1.
            
            Summary: The product of this gene belongs to the ligand-gated ion
            channel receptor superfamily. This gene encodes subunit B of the
            type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic
            hormone that functions as a neurotransmitter, a hormone, and a
            mitogen. This receptor causes fast, depolarizing responses in
            neurons after activation. It is not functional as a homomeric
            complex, but a pentaheteromeric complex with subunit A (HTR3A)
            displays the full functional features of this receptor. [provided
            by RefSeq, Aug 2011].
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.148354.1,
                                           SRR1803611.201911.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-460               AP001874.4         40842-41301
            461-505             AP001874.4         63230-63274
            506-615             AP001874.4         63604-63713
            616-785             AP001874.4         64135-64304
            786-943             AP001874.4         64782-64939
            944-1154            AP001874.4         74828-75038
            1155-1337           AP001874.4         76419-76601
            1338-4515           AP001874.4         77748-80925
FEATURES             Location/Qualifiers
     source          1..4515
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.2"
     gene            1..4515
                     /gene="HTR3B"
                     /gene_synonym="5-HT3B"
                     /note="5-hydroxytryptamine receptor 3B"
                     /db_xref="GeneID:9177"
                     /db_xref="HGNC:HGNC:5298"
                     /db_xref="MIM:604654"
     exon            1..460
                     /gene="HTR3B"
                     /gene_synonym="5-HT3B"
                     /inference="alignment:Splign:2.1.0"
     CDS             281..1573
                     /gene="HTR3B"
                     /gene_synonym="5-HT3B"
                     /note="isoform 2 is encoded by transcript variant 2;
                     5-hydroxytryptamine 3 receptor B subunit; serotonin-gated
                     ion channel subunit; 5-hydroxytryptamine (serotonin)
                     receptor 3B, ionotropic"
                     /codon_start=1
                     /product="5-hydroxytryptamine receptor 3B isoform 2"
                     /protein_id="NP_001350492.1"
                     /db_xref="CCDS:CCDS86249.1"
                     /db_xref="GeneID:9177"
                     /db_xref="HGNC:HGNC:5298"
                     /db_xref="MIM:604654"
                     /translation="MIVYFPGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTK
                     ATTVYLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAI
                     WAPDIIINEFVDIERYPDLPYVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSL
                     TFKSILHTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSSTYSILQSSAGGFAQI
                     QFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVN
                     MSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLVKFLHDEQRGGQEQPFLCLRGD
                     TDADRPRVEPRAQRAVVTESSLYGEHLAQPGTLKEVWSQLQSISNYLQTQDQTDQQEA
                     EWLVLLSRFDRLLFQSYLFMLGIYTITLCSLWALWGGV"
     exon            461..505
                     /gene="HTR3B"
                     /gene_synonym="5-HT3B"
                     /inference="alignment:Splign:2.1.0"
     exon            506..615
                     /gene="HTR3B"
                     /gene_synonym="5-HT3B"
                     /inference="alignment:Splign:2.1.0"
     exon            616..785
                     /gene="HTR3B"
                     /gene_synonym="5-HT3B"
                     /inference="alignment:Splign:2.1.0"
     exon            786..943
                     /gene="HTR3B"
                     /gene_synonym="5-HT3B"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1154
                     /gene="HTR3B"
                     /gene_synonym="5-HT3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1337
                     /gene="HTR3B"
                     /gene_synonym="5-HT3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..4515
                     /gene="HTR3B"
                     /gene_synonym="5-HT3B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4486..4491
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HTR3B"
                     /gene_synonym="5-HT3B"
                     /note="hexamer: AATAAA"
     polyA_site      4515
                     /gene="HTR3B"
                     /gene_synonym="5-HT3B"
                     /note="major polyA site"
ORIGIN      
        1 attctgtctc caaaatgcaa gattgttgta aaatggaatt gtaggtacag ttttccaacc
       61 ttggagatgg cgttgattta cttgttttta caatgaggtt tctccattgg gcacttaggc
      121 catcagctta ctttaagcat ttgccaaagg ccccaccagc tggctgtgaa ttgatgcaga
      181 ttttggtgag ctgaaagcta tattctagta aaagccaccg agtcctgaac agtctgaaac
      241 ctcctaaaga aaccaagctc ctcttacttt tatcttcaca atgatagttt attttccagg
      301 aattctagcc acagatacac atcatcccca ggattctgct ctgtatcatc tcagcaagca
      361 gctattacag aaatatcata aagaagtgag acctgtttac aactggacca aggccaccac
      421 agtctacctg gacctgttcg tccatgctat attggatgtg gatgcagaga atcaaatatt
      481 aaagacaagt gtatggtacc aagaggtctg gaatgatgaa tttttatcct ggaactccag
      541 catgtttgat gagattagag agatctccct acctctaagt gccatctggg cccccgatat
      601 catcatcaat gagtttgtgg acattgaaag ataccctgac cttccctatg tttatgtgaa
      661 ctcatctggg accattgaga actataagcc catccaggtg gtctctgcgt gcagtttaga
      721 gacatatgct tttccatttg atgtccagaa ttgcagcctg accttcaaga gcattctgca
      781 tacagtggaa gacgtagacc tggcctttct gaggagccca gaagacattc agcatgacaa
      841 aaaggcgttt ttgaatgaca gtgagtggga acttctatct gtgtcctcca catacagcat
      901 cctgcagagc agcgctggag gatttgcaca gattcagttt aatgtggtga tgcgcaggca
      961 ccccctggtc tatgtcgtga gtctgctgat tcctagcatc tttctcatgc tggtggacct
     1021 ggggagcttc tacctgccac ccaactgccg agccaggatt gtgttcaaga ccagtgtgct
     1081 ggtgggctac accgtcttca gggtcaacat gtccaaccag gtgccacgga gtgtagggag
     1141 cacccctctg attgggcact tcttcaccat ctgcatggcc ttcttggttc tcagcttagc
     1201 taagtccatc gtgttggtca aattcctcca tgatgagcag cgtggtggac aggagcagcc
     1261 cttcttgtgc cttcgagggg acaccgatgc tgacaggcct agagtggaac ccagggccca
     1321 acgtgctgtg gtaacagagt cctcgctgta tggagagcac ctggcccagc caggaaccct
     1381 gaaggaagtc tggtcgcagc ttcaatctat cagcaactac ctccaaactc aggaccagac
     1441 agaccaacag gaggcagagt ggctggtcct cctgtcccgc tttgaccgac tgctcttcca
     1501 aagctacctt ttcatgctgg ggatctacac catcactctg tgctccctct gggcactgtg
     1561 gggcggcgtg tgaagactga agtgttcttc agtaattgtg ctggcactta ggagagagag
     1621 gagggggaat aatagtgggt taaaaagctt tctgggtcgg gtgtggtggt tcttgcctat
     1681 agtcccagtg ctttgggagg ccatagcagg aggattgctt gagcccagga gttcgagacc
     1741 agccagagca acatagtgag accacatctc taccagtaaa taaataaata aataaataaa
     1801 taaataaata aataaatagc tgggcatagt ggctcatgcc tgtactctca gctacttggg
     1861 aggttgaggt gggaggattg cttgagccca ggatttcaag gctgcagtga gccatgattg
     1921 caccactgca ccccagcctg ggtgacagag caagaccctg tctcaaaaaa aataaaataa
     1981 aaggctttct gccttcattg cctctccatt gagtccagct tcatacacct aatagtctgc
     2041 tgtgtgaccc aaggatcata tgttcatgaa aatgtataaa cagtatgagt atacagtaaa
     2101 aaagtaaact ttccttctta tcccagtcca ctcacccaaa gcaaccactg ttagtaattt
     2161 cttccagaag atttctaggc acacacatgc atctatgtat ggttaagcag ttttttaaaa
     2221 agtgtaagat agctccatct tccagccctg ccttggccat ttattcagtc acccattcaa
     2281 caaaaccttt attgagtatt aagtcctagg cattatgtta ggcacaccag agaatacaaa
     2341 ataagtcagc acaggttatt attcacttgt tgtgattccc atggtcaacc tggtaccaac
     2401 caaccagagc ataaaattcc tgccatatcc ctcaccttct gaggctcttg ttaccacttc
     2461 ccagctaagt ccactgcctc caccctcttc ctgtgcccct tcagcagtgc atccccactg
     2521 gagagaaccc aggtgccaag gcttcttttt ttttttttga ggcagagtct tgctctgtca
     2581 ccagattgga gtgcagtggt gcaatcttgg ctcactgtaa cctccacctc ccgggttcaa
     2641 gcaattcccc tgcctcagcc tcccgagtag ctggaactac aggtgcatgc caccacaccc
     2701 agctaatttt ctgtatttta gtagcaggtg ccaaggcttc taagcccagt ctagcacatc
     2761 atttagtcca cacacaaggg gcaatgcatg gagtgggagg acaggcatag ttcacggtcc
     2821 tttgcttcaa ggaagttata atccactgtc cctgaactag tcagctagga aatactacac
     2881 actaagttgc tttaagagag atttattttc tcaccagtct ggaagctaga agcctaagat
     2941 caaggtgcaa acagggtggg tggctttctt ctgagccctg tccttggctt gcaggttgct
     3001 gacttcttgc tttgttttca catgaccttt cctctgtgca tgctcatgtc tgtgtccaga
     3061 ttttctcttc taacaagggc accagtgttg ttggtttagg gtccatccta gtgacctctt
     3121 ttaaccttaa tcactttttt caaggcccta tgttcaaaca gtcatattct gagtactagg
     3181 ggttaggatg tcaacatatg aattttgggg agtgggcagc agacaaaggg gacatatttc
     3241 agcccataac actagtgatt ccggaggttt agcaagtcca gattctgcag agtaggctgg
     3301 caggctggag acctgctgac agtcttaacg ctgtcagtag aagacacaaa agtccaaaag
     3361 ctgtttgcta gaaacttttt ccagcactaa aattgccttt agaaaaatct gcccccctcc
     3421 atccccccaa agaaaaagaa tttaaattca aacagccttt acctgcatct tccctctctc
     3481 attacctccc agttagtgct cagcgccaat tgtccatgaa attccactgc tgctgttaat
     3541 gaaatgagga acataagaag tttgtgaaca ggaagtgtcc atgcaaacct ccacctgttt
     3601 ccttcctcac ttcctacttt ctactgctgg cctcctctgc tttgacgtgc tcagttaggc
     3661 atcacggtcc tgatgtcacc ttagcttgcc atccatgtcg attctggctt tctccacttc
     3721 ctcctccagt taacagagga ggaaaggagg aaaaggcctg aggtgaactc ctcactgtgg
     3781 ggtctctctc cttcccaact atgtcttaga gaaagcacca gtgtcagagt caggagtcct
     3841 gatgattacg gtcctggctc tgccattacc tagccagggg acctctgtga gcttaacttc
     3901 tcagacttca acttacctta tttgaaattg gggctgttta tatttgctct acccctatca
     3961 aagagttatg aggatcaaaa tgaaaaaatg tattgaacaa tgctttgaaa agtaaataat
     4021 ggggcgtggt ggctcacgcc tataatccca acactttggg aggctgaggt gggtggatta
     4081 cctgaggtca ggagtttgag accagcctga ccaacatgga gaaaccctgt ctctactaaa
     4141 aatacaaaat tagccaggcg tggtggcaca tgcctgtaat cccacctact cggggggctg
     4201 aggcaggaga atcgcttgaa cccaggaggt ggaggttgcg gtgagccgag atcgtgccat
     4261 tgcactccag cccgggcaac aagagctaaa ctctatctca aaaaaaaaaa aaagtttaaa
     4321 gtgctttggg aagggggagg gatagcatta gaagatatac ctaatgttaa tgggtgcagc
     4381 acagcaacgt ggcacgtgta tacatatgta acaaacctgc acgttgtgca catgtaccct
     4441 aaaacttaaa gtataattta aaaaaaagta aataatgcat cacaaaataa agataagacc
     4501 tgcttgctat caaca
//
