LOCUS       NM_000868               4743 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens 5-hydroxytryptamine receptor 2C (HTR2C), transcript
            variant 2, mRNA.
ACCESSION   NM_000868
VERSION     NM_000868.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4743)
  AUTHORS   Kashina,Y.V., Cherednik,I.L., Pokrovsky,V.M. and Polishchuk,S.V.
  TITLE     Association of Serotonin Receptor Gene Polymorphisms with
            Regulatory and Adaptive Capacities of Medical Students
  JOURNAL   Bull Exp Biol Med 175 (4), 424-426 (2023)
   PUBMED   37768455
  REMARK    GeneRIF: Association of Serotonin Receptor Gene Polymorphisms with
            Regulatory and Adaptive Capacities of Medical Students.
REFERENCE   2  (bases 1 to 4743)
  AUTHORS   Konjevod,M., Sreter,K.B., Popovic-Grle,S., Lampalo,M., Tudor,L.,
            Jukic,I., Nedic Erjavec,G., Bingulac-Popovic,J., Safic Stanic,H.,
            Nikolac Perkovic,M., Markeljevic,J., Samarzija,M., Pivac,N. and
            Svob Strac,D.
  TITLE     Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase
            B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in
            Asthma
  JOURNAL   Biomolecules 13 (5), 800 (2023)
   PUBMED   37238670
  REMARK    GeneRIF: Platelet Serotonin (5-HT) Concentration, Platelet
            Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB
            Gene Polymorphisms in Asthma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4743)
  AUTHORS   Jahnsen,J.A. and Uhlen,S.
  TITLE     The N-terminal region of the human 5-HTC receptor has as a
            cleavable signal peptide
  JOURNAL   Eur J Pharmacol 684 (1-3), 44-50 (2012)
   PUBMED   22497996
  REMARK    GeneRIF: predicted signal peptide in the N-terminal tail of the
            5-HT(2C) receptor acts as a cleavable signal peptide
REFERENCE   4  (bases 1 to 4743)
  AUTHORS   Niswender,C.M., Sanders-Bush,E. and Emeson,R.B.
  TITLE     Identification and characterization of RNA editing events within
            the 5-HT2C receptor
  JOURNAL   Ann N Y Acad Sci 861, 38-48 (1998)
   PUBMED   9928237
  REMARK    Review article
REFERENCE   5  (bases 1 to 4743)
  AUTHORS   Burns,C.M., Chu,H., Rueter,S.M., Hutchinson,L.K., Canton,H.,
            Sanders-Bush,E. and Emeson,R.B.
  TITLE     Regulation of serotonin-2C receptor G-protein coupling by RNA
            editing
  JOURNAL   Nature 387 (6630), 303-308 (1997)
   PUBMED   9153397
REFERENCE   6  (bases 1 to 4743)
  AUTHORS   Canton,H., Emeson,R.B., Barker,E.L., Backstrom,J.R., Lu,J.T.,
            Chang,M.S. and Sanders-Bush,E.
  TITLE     Identification, molecular cloning, and distribution of a short
            variant of the 5-hydroxytryptamine2C receptor produced by
            alternative splicing
  JOURNAL   Mol Pharmacol 50 (4), 799-807 (1996)
   PUBMED   8863824
REFERENCE   7  (bases 1 to 4743)
  AUTHORS   Xie,E., Zhu,L., Zhao,L. and Chang,L.S.
  TITLE     The human serotonin 5-HT2C receptor: complete cDNA, genomic
            structure, and alternatively spliced variant
  JOURNAL   Genomics 35 (3), 551-561 (1996)
   PUBMED   8812491
REFERENCE   8  (bases 1 to 4743)
  AUTHORS   Lappalainen,J., Zhang,L., Dean,M., Oz,M., Ozaki,N., Yu,D.H.,
            Virkkunen,M., Weight,F., Linnoila,M. and Goldman,D.
  TITLE     Identification, expression, and pharmacology of a Cys23-Ser23
            substitution in the human 5-HT2c receptor gene (HTR2C)
  JOURNAL   Genomics 27 (2), 274-279 (1995)
   PUBMED   7557992
REFERENCE   9  (bases 1 to 4743)
  AUTHORS   Milatovich,A., Hsieh,C.L., Bonaminio,G., Tecott,L., Julius,D. and
            Francke,U.
  TITLE     Serotonin receptor 1c gene assigned to X chromosome in human (band
            q24) and mouse (bands D-F4)
  JOURNAL   Hum Mol Genet 1 (9), 681-684 (1992)
   PUBMED   1302605
REFERENCE   10 (bases 1 to 4743)
  AUTHORS   Saltzman,A.G., Morse,B., Whitman,M.M., Ivanshchenko,Y., Jaye,M. and
            Felder,S.
  TITLE     Cloning of the human serotonin 5-HT2 and 5-HT1C receptor subtypes
  JOURNAL   Biochem Biophys Res Commun 181 (3), 1469-1478 (1991)
   PUBMED   1722404
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC233299.3, AL590097.17 and
            AL355812.23.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 18, 2020 this sequence version replaced NM_000868.3.
            
            Summary: This gene encodes a seven-transmembrane G-protein-coupled
            receptor. The encoded protein responds to signaling through the
            neurotransmitter serotonin. The mRNA of this gene is subject to
            multiple RNA editing events, where adenosine residues encoded by
            the genome are converted to inosines. RNA editing is predicted to
            alter the structure of the second intracellular loop, thereby
            generating alternate protein forms with decreased ability to
            interact with G proteins. Abnormalities in RNA editing of this gene
            have been detected in victims of suicide that suffer from
            depression. In addition, naturally-occuring variation in the
            promoter and 5' non-coding and coding regions of this gene may show
            statistically-significant association with mental illness and
            behavioral disorders. Alternative splicing results in multiple
            different transcript variants. [provided by RefSeq, Jan 2015].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same isoform (a).
            This variant may undergo RNA editing.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U49516.1, SRR18074969.2853825.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000276198.6/ ENSP00000276198.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            undergoes RNA editing  :: PMID: 9153397, 9928237
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-574               AC233299.3         170506-171079       c
            575-641             AC233299.3         141284-141350       c
            642-755             AC233299.3         28194-28307         c
            756-1069            AC233299.3         23558-23871         c
            1070-1270           AL590097.17        51061-51261         c
            1271-4743           AL355812.23        57841-61313
FEATURES             Location/Qualifiers
     source          1..4743
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq23"
     gene            1..4743
                     /gene="HTR2C"
                     /gene_synonym="5-HT1C; 5-HT2C; 5-HTR2C; 5HTR2C; HTR1C"
                     /note="5-hydroxytryptamine receptor 2C"
                     /db_xref="GeneID:3358"
                     /db_xref="HGNC:HGNC:5295"
                     /db_xref="MIM:312861"
     exon            1..574
                     /gene="HTR2C"
                     /gene_synonym="5-HT1C; 5-HT2C; 5-HTR2C; 5HTR2C; HTR1C"
                     /inference="alignment:Splign:2.1.0"
     exon            575..641
                     /gene="HTR2C"
                     /gene_synonym="5-HT1C; 5-HT2C; 5-HTR2C; 5HTR2C; HTR1C"
                     /inference="alignment:Splign:2.1.0"
     exon            642..755
                     /gene="HTR2C"
                     /gene_synonym="5-HT1C; 5-HT2C; 5-HTR2C; 5HTR2C; HTR1C"
                     /inference="alignment:Splign:2.1.0"
     CDS             721..2097
                     /gene="HTR2C"
                     /gene_synonym="5-HT1C; 5-HT2C; 5-HTR2C; 5HTR2C; HTR1C"
                     /note="isoform a precursor is encoded by transcript
                     variant 2; serotonin 5-HT-2C receptor; 5-hydroxytryptamine
                     receptor 1C; serotonin 5-HT-1C receptor;
                     5-hydroxytryptamine (serotonin) receptor 2C, G
                     protein-coupled"
                     /codon_start=1
                     /product="5-hydroxytryptamine receptor 2C isoform a
                     precursor"
                     /protein_id="NP_000859.2"
                     /db_xref="CCDS:CCDS14564.1"
                     /db_xref="GeneID:3358"
                     /db_xref="HGNC:HGNC:5295"
                     /db_xref="MIM:312861"
                     /translation="MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGG
                     RFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLV
                     GLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPI
                     EHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIG
                     SFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEEN
                     SANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILS
                     VLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKK
                     PPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSV
                     VSERISSV"
     exon            756..1069
                     /gene="HTR2C"
                     /gene_synonym="5-HT1C; 5-HT2C; 5-HTR2C; 5HTR2C; HTR1C"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1270
                     /gene="HTR2C"
                     /gene_synonym="5-HT1C; 5-HT2C; 5-HTR2C; 5HTR2C; HTR1C"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..4743
                     /gene="HTR2C"
                     /gene_synonym="5-HT1C; 5-HT2C; 5-HTR2C; 5HTR2C; HTR1C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4724..4729
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HTR2C"
                     /gene_synonym="5-HT1C; 5-HT2C; 5-HTR2C; 5HTR2C; HTR1C"
                     /note="hexamer: ATTAAA"
     polyA_site      4743
                     /gene="HTR2C"
                     /gene_synonym="5-HT1C; 5-HT2C; 5-HTR2C; 5HTR2C; HTR1C"
                     /note="major polyA site"
ORIGIN      
        1 gaggtaggcg ctctggtgct tgccgaggac gcttccttcc tcagatgcac cgatcttccc
       61 gatactgcct ttggagcggc tagattgcta gccttggctg ctccattggc ctgccttgcc
      121 ccttacctgc cgattgcata tgaactcttc ttctgtctgt acatcgttgt cgtcggagtc
      181 gtcgcgatcg tcgtggcgct cgtgtgatgg ccttcgtccg tttagagtag tgtagttagt
      241 taggggccaa cgaagaagaa agaagacgcg attagtgcag agatgctgga ggtggtcagt
      301 tactaagcta gagtaagata gcggagcgaa aagagccaaa cctagccggg gggcgcacgg
      361 tcacccaaag gaggtcgact cgccggcgct tcctatcgcg ccgagctccc tccattcctc
      421 tccctccgcc gaggcgcgag gttgcggcgc gcagcgcagc gcagctcagc gcaccgactg
      481 ccgcgggctc cgctgggcga ttgcagccga gtccgtttct cgtctagctg ccgccgcggc
      541 gaccgctgcc tggtcttcct cccggacgct agtgggttat cagctaacac ccgcgagcat
      601 ctataacata ggccaactga cgccatcctt caaaaacaac taaaggatga tatgatgaac
      661 ctagcctgtt aatttcgtct tctcaatttt aaactttggt tgcttaagac tgaagcaatc
      721 atggtgaacc tgaggaatgc ggtgcattca ttccttgtgc acctaattgg cctattggtt
      781 tggcaatctg atatttctgt gagcccagta gcagctatag taactgacat tttcaatacc
      841 tccgatggtg gacgcttcaa attcccagac ggggtacaaa actggccagc actttcaatc
      901 gtcatcataa taatcatgac aataggtggc aacatccttg tgatcatggc agtaagcatg
      961 gaaaagaaac tgcacaatgc caccaattac ttcttaatgt ccctagccat tgctgatatg
     1021 ctagtgggac tacttgtcat gcccctgtct ctcctggcaa tcctttatga ttatgtctgg
     1081 ccactaccta gatatttgtg ccccgtctgg atttctttag atgttttatt ttcaacagcg
     1141 tccatcatgc acctctgcgc tatatcgctg gatcggtatg tagcaatacg taatcctatt
     1201 gagcatagcc gtttcaattc gcggactaag gccatcatga agattgctat tgtttgggca
     1261 atttctatag gtgtatcagt tcctatccct gtgattggac tgagggacga agaaaaggtg
     1321 ttcgtgaaca acacgacgtg cgtgctcaac gacccaaatt tcgttcttat tgggtccttc
     1381 gtagctttct tcataccgct gacgattatg gtgattacgt attgcctgac catctacgtt
     1441 ctgcgccgac aagctttgat gttactgcac ggccacaccg aggaaccgcc tggactaagt
     1501 ctggatttcc tgaagtgctg caagaggaat acggccgagg aagagaactc tgcaaaccct
     1561 aaccaagacc agaacgcacg ccgaagaaag aagaaggaga gacgtcctag gggcaccatg
     1621 caggctatca acaatgaaag aaaagcttcg aaagtccttg ggattgtttt ctttgtgttt
     1681 ctgatcatgt ggtgcccatt tttcattacc aatattctgt ctgttctttg tgagaagtcc
     1741 tgtaaccaaa agctcatgga aaagcttctg aatgtgtttg tttggattgg ctatgtttgt
     1801 tcaggaatca atcctctggt gtatactctg ttcaacaaaa tttaccgaag ggcattctcc
     1861 aactatttgc gttgcaatta taaggtagag aaaaagcctc ctgtcaggca gattccaaga
     1921 gttgccgcca ctgctttgtc tgggagggag cttaatgtta acatttatcg gcataccaat
     1981 gaaccggtga tcgagaaagc cagtgacaat gagcccggta tagagatgca agttgagaat
     2041 ttagagttac cagtaaatcc ctccagtgtg gttagcgaaa ggattagcag tgtgtgagaa
     2101 agaacagcac agtcttttcc tacggtacaa gctacatatg taggaaaatt ttcttcttta
     2161 atttttctgt tggtcttaac taatgtaaat attgctgtct gaaaaagtgt ttttacatat
     2221 agctttgcaa ccttgtactt tacaatcatg cctacattag tgagatttag ggttctatat
     2281 ttactgttta taataggtgg agactaactt attttgattg tttgatgaat aaaatgttta
     2341 tttttgctct ccctcccttc tttccttcct tttttccttt cttccttcct ttctctcttt
     2401 cttttgtgca tatggcaacg ttcatgttca tctcaggtgg catttgcagg tgaccagaat
     2461 gaggcacatg acagtggtta tatttcaacc acacctaaat taacaaattc agtggacatt
     2521 tgttctgggt taacagtaaa tatacacttt acattcttgc tctgctcatc tacacatata
     2581 aacacagtaa gataggttct gctttctgat acatctgtca gtgagtcaga ggcagaacct
     2641 agtcttgttg ttcatatagg ggcaaaaatt tgacattgtc agaatgttgt gttggtattt
     2701 actgcaatgt ctgtccctaa acatagtggt attttaacat agcagctggt taaccgggac
     2761 tacagaagtg gaaggataat gagatgtaat acaccaaata gcttttcact tcttaaggac
     2821 agtgttcaaa ttctgattat tacaacaagc aaactgaaat tagtgttttc attctggtcc
     2881 ttagtaaatt cctaattcta tgattaaact gggaaatgag atcccagagt tatttcccaa
     2941 cccaggattc aacatcaatt gggttttgat ctcagcatcc tggaaatttg tgtgcttcac
     3001 acaaagtgaa attagtattt tgagccttat taaaatattt tcttaattat ggtacctctg
     3061 tctataggac ttaatttagc agtccatttt tgagtaaaac ttgtattgga agtatagatg
     3121 gtagaaactt tggaagtttt acttgattaa ggactacaga attgggccct tagaatgtga
     3181 aaaaaaaaag taattaaaaa gacactttta ccgaactcgg gattacagaa acacggagtt
     3241 tccatttgga ttttaaacaa aatttatgtc attttcagat ccttccaaac tctctagtgc
     3301 aggaaaaggc tgcagctaat ttgtgaaagt ggcaagctct tcattgcact gcagttattt
     3361 accagaagtt taaatctttg ttaaaatata gtgttgtgtt acaataagtg ttggccatca
     3421 tttcattcgt gggcctgctg ctctctaaga attcagtagc attttaatag tttctaaacc
     3481 atgaaaagtt ttcaagcatt gctaaagtca ggccattcag tctatgctgt gtgcagagta
     3541 tacaagtgtt tctagtaaca gtatttccat acgtgcccat ttcacacaac tgtggataaa
     3601 ttttggaaga attcatgatg ctagttctta cgcttgacag ttacttacac acctgagaat
     3661 gtgcctctca gtatcttaaa attggttaat gaaaaatctg aatttctaaa acccttggtc
     3721 tgtgttctca acacacagta tagataaatc caatagtctg ccacaagggc agtggaagag
     3781 ctgctgtatt tgaggaaact catacagtct ctatttgatt tgcaacactg ccaaacatca
     3841 gtcaattgct tgagcatgcc caaatataac atgaaagtca agtctacctg ccttgcctgt
     3901 taggtctgtt gaagtgcatg ttaaaataat tatatgaagc agaatgagat gatttaattc
     3961 ttaccgaaat gaaaatggct gaagaaacac agcatgcatt tagcatgagt tctgcacata
     4021 cagatggtgt cctgcatgta tgccatgtat gttgcatgaa tccatcgatt tgtattaatg
     4081 tagggcagaa tagctgatag aagaaggact gaagaaaatc cttcagcaat ccttaaaaag
     4141 accatgcatt cagatctgaa gtagtgtgag tgttagaaaa aactggaaac atctgatttc
     4201 tgaactatca gggcaagctc atagcacatg ttttacaaag aaacaaaata taaatcacag
     4261 atttccaaaa gtactagcaa taagttgaat gataatagct cacagcacat ttgttaatga
     4321 ttcttgtgtc atcaagtagt agtacttaat agtacccaac ctggtaatta tcctcaagtt
     4381 gtgtgctatt cgtaagttct gtgcagtttg gtatgaaaca aatatactca tttggatata
     4441 aatcttaccc ttcaatgtta aatctacaaa cttttataaa tgttttaaag aagtccatgt
     4501 gataattgta aaggtgatga atttaccatc aaacaaatca ttttgatgta ttattatata
     4561 tgtatatctg tgtaagacac gtgcaacaga ctgccttata ttattttctg taattcttct
     4621 cctttgtcaa atggtatttt ttgtgaatgg ttgcaaagtg ttgtcttatt cctaattcct
     4681 gtatgttatc cactacaggt tttatgagac ttcctattaa tttattaaat ttattaaatg
     4741 ttg
//
