LOCUS       NP_000859                458 aa            linear   PRI 12-JUN-2025
DEFINITION  5-hydroxytryptamine receptor 2C isoform a precursor [Homo sapiens].
ACCESSION   NP_000859
VERSION     NP_000859.2
DBSOURCE    REFSEQ: accession NM_000868.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 458)
  AUTHORS   Falzone,M.E. and MacKinnon,R.
  TITLE     The mechanism of Galphaq regulation of PLCbeta3-catalyzed PIP2
            hydrolysis
  JOURNAL   Proc Natl Acad Sci U S A 120 (48), e2315011120 (2023)
   PUBMED   37991948
REFERENCE   2  (residues 1 to 458)
  AUTHORS   Kashina,Y.V., Cherednik,I.L., Pokrovsky,V.M. and Polishchuk,S.V.
  TITLE     Association of Serotonin Receptor Gene Polymorphisms with
            Regulatory and Adaptive Capacities of Medical Students
  JOURNAL   Bull Exp Biol Med 175 (4), 424-426 (2023)
   PUBMED   37768455
  REMARK    GeneRIF: Association of Serotonin Receptor Gene Polymorphisms with
            Regulatory and Adaptive Capacities of Medical Students.
REFERENCE   3  (residues 1 to 458)
  AUTHORS   Jahnsen,J.A. and Uhlen,S.
  TITLE     The N-terminal region of the human 5-HTC receptor has as a
            cleavable signal peptide
  JOURNAL   Eur J Pharmacol 684 (1-3), 44-50 (2012)
   PUBMED   22497996
  REMARK    GeneRIF: predicted signal peptide in the N-terminal tail of the
            5-HT(2C) receptor acts as a cleavable signal peptide
REFERENCE   4  (residues 1 to 458)
  AUTHORS   Niswender,C.M., Sanders-Bush,E. and Emeson,R.B.
  TITLE     Identification and characterization of RNA editing events within
            the 5-HT2C receptor
  JOURNAL   Ann N Y Acad Sci 861, 38-48 (1998)
   PUBMED   9928237
  REMARK    Review article
REFERENCE   5  (residues 1 to 458)
  AUTHORS   Burns,C.M., Chu,H., Rueter,S.M., Hutchinson,L.K., Canton,H.,
            Sanders-Bush,E. and Emeson,R.B.
  TITLE     Regulation of serotonin-2C receptor G-protein coupling by RNA
            editing
  JOURNAL   Nature 387 (6630), 303-308 (1997)
   PUBMED   9153397
REFERENCE   6  (residues 1 to 458)
  AUTHORS   Canton,H., Emeson,R.B., Barker,E.L., Backstrom,J.R., Lu,J.T.,
            Chang,M.S. and Sanders-Bush,E.
  TITLE     Identification, molecular cloning, and distribution of a short
            variant of the 5-hydroxytryptamine2C receptor produced by
            alternative splicing
  JOURNAL   Mol Pharmacol 50 (4), 799-807 (1996)
   PUBMED   8863824
REFERENCE   7  (residues 1 to 458)
  AUTHORS   Xie,E., Zhu,L., Zhao,L. and Chang,L.S.
  TITLE     The human serotonin 5-HT2C receptor: complete cDNA, genomic
            structure, and alternatively spliced variant
  JOURNAL   Genomics 35 (3), 551-561 (1996)
   PUBMED   8812491
REFERENCE   8  (residues 1 to 458)
  AUTHORS   Lappalainen,J., Zhang,L., Dean,M., Oz,M., Ozaki,N., Yu,D.H.,
            Virkkunen,M., Weight,F., Linnoila,M. and Goldman,D.
  TITLE     Identification, expression, and pharmacology of a Cys23-Ser23
            substitution in the human 5-HT2c receptor gene (HTR2C)
  JOURNAL   Genomics 27 (2), 274-279 (1995)
   PUBMED   7557992
REFERENCE   9  (residues 1 to 458)
  AUTHORS   Milatovich,A., Hsieh,C.L., Bonaminio,G., Tecott,L., Julius,D. and
            Francke,U.
  TITLE     Serotonin receptor 1c gene assigned to X chromosome in human (band
            q24) and mouse (bands D-F4)
  JOURNAL   Hum Mol Genet 1 (9), 681-684 (1992)
   PUBMED   1302605
REFERENCE   10 (residues 1 to 458)
  AUTHORS   Saltzman,A.G., Morse,B., Whitman,M.M., Ivanshchenko,Y., Jaye,M. and
            Felder,S.
  TITLE     Cloning of the human serotonin 5-HT2 and 5-HT1C receptor subtypes
  JOURNAL   Biochem Biophys Res Commun 181 (3), 1469-1478 (1991)
   PUBMED   1722404
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC233299.3, AL590097.17 and
            AL355812.23.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 18, 2020 this sequence version replaced NP_000859.1.
            
            Summary: This gene encodes a seven-transmembrane G-protein-coupled
            receptor. The encoded protein responds to signaling through the
            neurotransmitter serotonin. The mRNA of this gene is subject to
            multiple RNA editing events, where adenosine residues encoded by
            the genome are converted to inosines. RNA editing is predicted to
            alter the structure of the second intracellular loop, thereby
            generating alternate protein forms with decreased ability to
            interact with G proteins. Abnormalities in RNA editing of this gene
            have been detected in victims of suicide that suffer from
            depression. In addition, naturally-occuring variation in the
            promoter and 5' non-coding and coding regions of this gene may show
            statistically-significant association with mental illness and
            behavioral disorders. Alternative splicing results in multiple
            different transcript variants. [provided by RefSeq, Jan 2015].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same isoform (a).
            This variant may undergo RNA editing.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U49516.1, SRR18074969.2853825.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000276198.6/ ENSP00000276198.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            undergoes RNA editing  :: PMID: 9153397, 9928237
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq23"
     Protein         1..458
                     /product="5-hydroxytryptamine receptor 2C isoform a
                     precursor"
                     /note="serotonin 5-HT-2C receptor; 5-hydroxytryptamine
                     receptor 1C; serotonin 5-HT-1C receptor;
                     5-hydroxytryptamine (serotonin) receptor 2C, G
                     protein-coupled"
                     /calculated_mol_wt=48336
     sig_peptide     1..32
                     /note="/evidence=ECO:0000269|PubMed:22497996; propagated
                     from UniProtKB/Swiss-Prot (P28335.2)"
                     /calculated_mol_wt=3487
     mat_peptide     33..458
                     /product="5-hydroxytryptamine receptor 2C.
                     /id=PRO_0000068958"
                     /note="propagated from UniProtKB/Swiss-Prot (P28335.2)"
                     /calculated_mol_wt=48336
     Site            39
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (P28335.2)"
     Region          54..385
                     /region_name="7tmA_5-HT2C"
                     /note="serotonin receptor subtype 2C, member of the class
                     A family of seven-transmembrane G protein-coupled
                     receptors; cd15305"
                     /db_xref="CDD:341346"
     Region          55..81
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:341346"
     Site            56..80
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P28335.2)"
     Site            87..111
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P28335.2)"
     Region          88..114
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:341346"
     Region          127..157
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:341346"
     Site            129..151
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P28335.2)"
     Site            order(131,134..135,138..139,207,214..215,218,222,324,
                     327..328,331,334,347,350..351,354,358)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:341346"
     Region          151..153
                     /region_name="DRY motif, important for ligand-induced
                     conformation changes.
                     /evidence=ECO:0000250|UniProtKB:P41595"
                     /note="propagated from UniProtKB/Swiss-Prot (P28335.2)"
     Site            168..189
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P28335.2)"
     Region          169..192
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:341346"
     Site            204
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (P28335.2)"
     Region          211..240
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:341346"
     Site            214..236
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P28335.2)"
     Region          274..301
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P28335.2)"
     Region          304..334
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:341346"
     Site            312..336
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P28335.2)"
     Region          347..372
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:341346"
     Site            348..370
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P28335.2)"
     Region          364..368
                     /region_name="NPxxY motif, important for ligand-induced
                     conformation changes and signaling.
                     /evidence=ECO:0000250|UniProtKB:P41595"
                     /note="propagated from UniProtKB/Swiss-Prot (P28335.2)"
     Region          456..458
                     /region_name="PDZ-binding"
                     /note="propagated from UniProtKB/Swiss-Prot (P28335.2)"
     CDS             1..458
                     /gene="HTR2C"
                     /gene_synonym="5-HT1C; 5-HT2C; 5-HTR2C; 5HTR2C; HTR1C"
                     /coded_by="NM_000868.4:721..2097"
                     /note="isoform a precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS14564.1"
                     /db_xref="GeneID:3358"
                     /db_xref="HGNC:HGNC:5295"
                     /db_xref="MIM:312861"
ORIGIN      
        1 mvnlrnavhs flvhligllv wqsdisvspv aaivtdifnt sdggrfkfpd gvqnwpalsi
       61 viiiimtigg nilvimavsm ekklhnatny flmslaiadm lvgllvmpls llailydyvw
      121 plprylcpvw isldvlfsta simhlcaisl dryvairnpi ehsrfnsrtk aimkiaivwa
      181 isigvsvpip viglrdeekv fvnnttcvln dpnfvligsf vaffipltim vitycltiyv
      241 lrrqalmllh ghteeppgls ldflkcckrn taeeensanp nqdqnarrrk kkerrprgtm
      301 qainnerkas kvlgivffvf limwcpffit nilsvlceks cnqklmekll nvfvwigyvc
      361 sginplvytl fnkiyrrafs nylrcnykve kkppvrqipr vaatalsgre lnvniyrhtn
      421 epviekasdn epgiemqven lelpvnpssv vserissv
//
