LOCUS       NM_000621               5415 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens 5-hydroxytryptamine receptor 2A (HTR2A), transcript
            variant 1, mRNA.
ACCESSION   NM_000621
VERSION     NM_000621.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5415)
  AUTHORS   Kossatz,E., Diez-Alarcia,R., Gaitonde,S.A., Ramon-Duaso,C.,
            Stepniewski,T.M., Aranda-Garcia,D., Muneta-Arrate,I., Tepaz,E.,
            Saen-Oon,S., Soliva,R., Shahraki,A., Moreira,D., Brea,J.,
            Loza,M.I., de la Torre,R., Kolb,P., Bouvier,M., Meana,J.J.,
            Robledo,P. and Selent,J.
  TITLE     G protein-specific mechanisms in the serotonin 5-HT2A receptor
            regulate psychosis-related effects and memory deficits
  JOURNAL   Nat Commun 15 (1), 4307 (2024)
   PUBMED   38811567
  REMARK    GeneRIF: G protein-specific mechanisms in the serotonin 5-HT2A
            receptor regulate psychosis-related effects and memory deficits.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5415)
  AUTHORS   Xiang,C., Hong,S.M., Zhao,B., Pi,H., Du,F., Lu,X., Tang,Y.,
            Shen,N., Yang,C. and Wang,R.
  TITLE     Fibroblast expression of neurotransmitter receptor HTR2A associates
            with inflammation in rheumatoid arthritis joint
  JOURNAL   Clin Exp Med 24 (1), 84 (2024)
   PUBMED   38662111
  REMARK    GeneRIF: Fibroblast expression of neurotransmitter receptor HTR2A
            associates with inflammation in rheumatoid arthritis joint.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5415)
  AUTHORS   Pang,J.Y., Wang,Y.P., Teng,H.M., He,J., Luo,R., Feng,S.M., Yue,W.H.
            and Li,H.F.
  TITLE     Interaction between HTR2A rs3125 and negative life events in
            suicide attempts among patients with major depressive disorder: a
            cross-sectional study
  JOURNAL   BMC Psychiatry 24 (1), 249 (2024)
   PUBMED   38565988
  REMARK    GeneRIF: Interaction between HTR2A rs3125 and negative life events
            in suicide attempts among patients with major depressive disorder:
            a cross-sectional study.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5415)
  AUTHORS   Abdolsamadi,M., Rasouli,S., Alizadeh Severi,A., Khirehgesh,M.R.,
            Safari,F., Mahdieh,N., Khazaie,H., Soleymani,B. and Akbari,B.
  TITLE     The Association Between the 5-Hydroxytryptamine Receptor 2A Gene
            Variants rs6311 and rs6313 and Obstructive Sleep Apnea in the
            Iranian Kurdish Population
  JOURNAL   Genet Test Mol Biomarkers 28 (4), 159-164 (2024)
   PUBMED   38657123
  REMARK    GeneRIF: The Association Between the 5-Hydroxytryptamine Receptor
            2A Gene Variants rs6311 and rs6313 and Obstructive Sleep Apnea in
            the Iranian Kurdish Population.
REFERENCE   5  (bases 1 to 5415)
  AUTHORS   Obermanns,J., Meiser,H., Hoberg,S., Vesterager,C.S., Schulz,F.,
            Juckel,G. and Emons,B.
  TITLE     Genetic variation of the 5-HT1A rs6295, 5-HT2A rs6311, and CNR1
            rs1049353 and an altered endocannabinoid system in depressed
            patients
  JOURNAL   Brain Behav 13 (12), e3323 (2023)
   PUBMED   37984468
  REMARK    GeneRIF: Genetic variation of the 5-HT1A rs6295, 5-HT2A rs6311, and
            CNR1 rs1049353 and an altered endocannabinoid system in depressed
            patients.
REFERENCE   6  (bases 1 to 5415)
  AUTHORS   Stam,N.J., Van Huizen,F., Van Alebeek,C., Brands,J., Dijkema,R.,
            Tonnaer,J.A. and Olijve,W.
  TITLE     Genomic organization, coding sequence and functional expression of
            human 5-HT2 and 5-HT1A receptor genes
  JOURNAL   Eur J Pharmacol 227 (2), 153-162 (1992)
   PUBMED   1330647
REFERENCE   7  (bases 1 to 5415)
  AUTHORS   Chen,K., Yang,W., Grimsby,J. and Shih,J.C.
  TITLE     The human 5-HT2 receptor is encoded by a multiple intron-exon gene
  JOURNAL   Brain Res Mol Brain Res 14 (1-2), 20-26 (1992)
   PUBMED   1323014
REFERENCE   8  (bases 1 to 5415)
  AUTHORS   Saltzman,A.G., Morse,B., Whitman,M.M., Ivanshchenko,Y., Jaye,M. and
            Felder,S.
  TITLE     Cloning of the human serotonin 5-HT2 and 5-HT1C receptor subtypes
  JOURNAL   Biochem Biophys Res Commun 181 (3), 1469-1478 (1991)
   PUBMED   1722404
REFERENCE   9  (bases 1 to 5415)
  AUTHORS   Sparkes,R.S., Lan,N., Klisak,I., Mohandas,T., Diep,A., Kojis,T.,
            Heinzmann,C. and Shih,J.C.
  TITLE     Assignment of a serotonin 5HT-2 receptor gene (HTR2) to human
            chromosome 13q14-q21 and mouse chromosome 14
  JOURNAL   Genomics 9 (3), 461-465 (1991)
   PUBMED   2032718
REFERENCE   10 (bases 1 to 5415)
  AUTHORS   Hsieh,C.L., Bowcock,A.M., Farrer,L.A., Hebert,J.M., Huang,K.N.,
            Cavalli-Sforza,L.L., Julius,D. and Francke,U.
  TITLE     The serotonin receptor subtype 2 locus HTR2 is on human chromosome
            13 near genes for esterase D and retinoblastoma-1 and on mouse
            chromosome 14
  JOURNAL   Somat Cell Mol Genet 16 (6), 567-574 (1990)
   PUBMED   1980030
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL160397.17 and AL136958.9.
            
            On Mar 13, 2020 this sequence version replaced NM_000621.4.
            
            Summary: This gene encodes one of the receptors for serotonin, a
            neurotransmitter with many roles. Mutations in this gene are
            associated with susceptibility to schizophrenia and
            obsessive-compulsive disorder, and are also associated with
            response to the antidepressant citalopram in patients with major
            depressive disorder (MDD). MDD patients who also have a mutation in
            intron 2 of this gene show a significantly reduced response to
            citalopram as this antidepressant downregulates expression of this
            gene. Multiple transcript variants encoding different isoforms have
            been found for this gene. [provided by RefSeq, Sep 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK314132.1, SRR14372080.1096257.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2144335
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000542664.4/ ENSP00000437737.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-380               AL160397.17        46031-46410         c
            381-1120            AL160397.17        44852-45591         c
            1121-1321           AL160397.17        41747-41947         c
            1322-5415           AL136958.9         87120-91213         c
FEATURES             Location/Qualifiers
     source          1..5415
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.2"
     gene            1..5415
                     /gene="HTR2A"
                     /gene_synonym="5-HT2A; HTR2"
                     /note="5-hydroxytryptamine receptor 2A"
                     /db_xref="GeneID:3356"
                     /db_xref="HGNC:HGNC:5293"
                     /db_xref="MIM:182135"
     exon            1..380
                     /gene="HTR2A"
                     /gene_synonym="5-HT2A; HTR2"
                     /inference="alignment:Splign:2.1.0"
     exon            381..1120
                     /gene="HTR2A"
                     /gene_synonym="5-HT2A; HTR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             709..2124
                     /gene="HTR2A"
                     /gene_synonym="5-HT2A; HTR2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serotonin 5-HT-2A receptor; 5-HT2 receptor;
                     5-hydroxytryptamine (serotonin) receptor 2A, G
                     protein-coupled"
                     /codon_start=1
                     /product="5-hydroxytryptamine receptor 2A isoform 1"
                     /protein_id="NP_000612.1"
                     /db_xref="CCDS:CCDS9405.1"
                     /db_xref="GeneID:3356"
                     /db_xref="HGNC:HGNC:5293"
                     /db_xref="MIM:182135"
                     /translation="MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFN
                     WTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLE
                     KKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFST
                     ASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDD
                     SKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRA
                     KLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVV
                     MWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFS
                     RYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGK
                     QHSEEASKDNSDGVNEKVSCV"
     exon            1121..1321
                     /gene="HTR2A"
                     /gene_synonym="5-HT2A; HTR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..5415
                     /gene="HTR2A"
                     /gene_synonym="5-HT2A; HTR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5393..5398
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HTR2A"
                     /gene_synonym="5-HT2A; HTR2"
                     /note="hexamer: AATAAA"
     polyA_site      5415
                     /gene="HTR2A"
                     /gene_synonym="5-HT2A; HTR2"
                     /note="major polyA site"
ORIGIN      
        1 agagagctac tccattcccg tggaaaccag gagtcccttg gtgcagacag ctcttcctac
       61 tttcccatgc agttcttttg tgcgactttg aggggctcgt gaatgatttc taaatgtgtg
      121 cctgctgagg cgagccgcac agggagggag gaacccagcc gagccgtgcc agaggaagcc
      181 aacaggatcc tagcagtgcg ggagctggct cagctcttgc atgcagtttt tgaagtcagc
      241 aaaacagaaa ccaaattact atcatattat gctggtggaa gatcaagaag aggggactct
      301 acaccagttt aattactgtg agagatgcag cgagtcacag aataacaaat gtatctcatg
      361 tgtggaccct gaagacaaat gacatttatc ttcccgagcg ctcaaaaaaa accctgcaac
      421 ctctatgcta aaagttcatt ctgctttttt gtcctcggtt tggtgagaaa ataataaaac
      481 caaacagtgg actctcctaa aattgtgaat gaagaaaact tacagccacc acagttcagt
      541 tctttaacta tcattgtaat aatggaagac aaaaatccag ccccgggaga acagcatgta
      601 caccagcctc agtgttacag agtgtgggta catcaaggtg aatggtgagc agaaactata
      661 acctgttagt ccttctacac ctcatctgct acaagttctg gcttagacat ggatattctt
      721 tgtgaagaaa atacttcttt gagctcaact acgaactccc taatgcaatt aaatgatgac
      781 accaggctct acagtaatga ctttaactcc ggagaagcta acacttctga tgcatttaac
      841 tggacagtcg actctgaaaa tcgaaccaac ctttcctgtg aagggtgcct ctcaccgtcg
      901 tgtctctcct tacttcatct ccaggaaaaa aactggtctg ctttactgac agccgtagtg
      961 attattctaa ctattgctgg aaacatactc gtcatcatgg cagtgtccct agagaaaaag
     1021 ctgcagaatg ccaccaacta tttcctgatg tcacttgcca tagctgatat gctgctgggt
     1081 ttccttgtca tgcccgtgtc catgttaacc atcctgtatg ggtaccggtg gcctctgccg
     1141 agcaagcttt gtgcagtctg gatttacctg gacgtgctct tctccacggc ctccatcatg
     1201 cacctctgcg ccatctcgct ggaccgctac gtcgccatcc agaatcccat ccaccacagc
     1261 cgcttcaact ccagaactaa ggcatttctg aaaatcattg ctgtttggac catatcagta
     1321 ggtatatcca tgccaatacc agtctttggg ctacaggacg attcgaaggt ctttaaggag
     1381 gggagttgct tactcgccga tgataacttt gtcctgatcg gctcttttgt gtcatttttc
     1441 attcccttaa ccatcatggt gatcacctac tttctaacta tcaagtcact ccagaaagaa
     1501 gctactttgt gtgtaagtga tcttggcaca cgggccaaat tagcttcttt cagcttcctc
     1561 cctcagagtt ctttgtcttc agaaaagctc ttccagcggt cgatccatag ggagccaggg
     1621 tcctacacag gcaggaggac tatgcagtcc atcagcaatg agcaaaaggc atgcaaggtg
     1681 ctgggcatcg tcttcttcct gtttgtggtg atgtggtgcc ctttcttcat cacaaacatc
     1741 atggccgtca tctgcaaaga gtcctgcaat gaggatgtca ttggggccct gctcaatgtg
     1801 tttgtttgga tcggttatct ctcttcagca gtcaacccac tagtctacac actgttcaac
     1861 aagacctata ggtcagcctt ttcacggtat attcagtgtc agtacaagga aaacaaaaaa
     1921 ccattgcagt taattttagt gaacacaata ccggctttgg cctacaagtc tagccaactt
     1981 caaatgggac aaaaaaagaa ttcaaagcaa gatgccaaga caacagataa tgactgctca
     2041 atggttgctc taggaaagca gcattctgaa gaggcttcta aagacaatag cgacggagtg
     2101 aatgaaaagg tgagctgtgt gtgataggct agttgccgtg gcaactgtgg aaggcacact
     2161 gagcaagttt tcacctatct ggaaaaaaaa aaatatgaga ttggaaaaaa ttagacaagt
     2221 ctagtggaac caacgatcat atctgtatgc ctcattttat tctgtcaatg aaaagcgggg
     2281 ttcaatgcta caaaatgtgt gcttggaaaa tgttctgaca gcatttcagc tgtgagcttt
     2341 ctgatactta tttataacat tgtaaatgat atgtctttaa aatgattcac ttttattgta
     2401 taattatgaa gccctaagta aatctaaatt aacttctatt ttcaagtgga aaccttgctg
     2461 ctatgctgtt cattgatgac atgggattga gttggttacc tattgctgta aataaaaata
     2521 gctataaata gtgaaaattt tattgaatat aatggcctct taaaaattat ctttaaaact
     2581 tactatggta tatattttga aaggagaaaa aaaaagccac taaggtcagt gttataaaat
     2641 ctgtattgct aagataatta aatgaaatac ttgacaacat ttttcattcc tgctttttca
     2701 tagataccat tttgaaatat tcacaaggtt gctggcattt gctgcatttc aagttaattc
     2761 tcagaagtga aaaagacttc aaatgttatt caataactat tgctgctttc tcttctactt
     2821 cttgtgcttt actctgaatt tccagtgtgg tcttgtttaa tatttgttcc tctaggtaaa
     2881 ctagcaaaag gatgatttaa cattaccaaa tgcctttcta gcaattgctt ctctaaaaca
     2941 gcactatcga ggtatttggt aacttgctgt gaaatgactg catcatgcat gcactctttt
     3001 gagcagtaaa tgtatattga tgtaactgtg tcaggattga ggatgaactc aggtttccgg
     3061 ctactgacag tggtagagtc ctaggacatc tctgtaaaaa gcaggtgact ttcctatgac
     3121 actcatcagg taaactgatg ctttcagatc catcggttta tactatttat taaaaccatt
     3181 ctgcttggtt ccacaatcat ctattgagtg tacatttatg tgtgaagcaa atttctagat
     3241 atgagaaata taaaaataat taaaacaaaa tccttgcctt caaacgaaat ggctcggcca
     3301 ggcacggagg ctcgtgcatg taatcctagc actttgggag gctgagatgg gaggatcact
     3361 tgaggccaag agtttgagac caacctgggt aacaaagtga gacctccctg tctctacaaa
     3421 aaaaatcaaa aaattatctg atccttgtgg cacacaactg tggtcccagc tacaggggag
     3481 gctgagacgc aaggatcact tgagcccaga agctcaaggc tgcagtgagc caagttcaca
     3541 ccactgccat ttcctcctgg gcaacagagt gagaccctat cacaaaaaaa aagaaagaaa
     3601 aaaagaaaat gactaaactg aaatggtctt agtcaaaaaa tatatacaga cttattttta
     3661 gaatcatttc aacttatttc cttcttacct ggttcagaaa caagtttgtt tcaactgtga
     3721 gagtagtttt aaaaataagt tttcctgatt ggttaccaat aaacaccaaa caaataaagg
     3781 agggggaaaa tatcacttga ggcttaacat tgcaattaat ttagaaatac gcacctcaat
     3841 ctcaagccag tttataacta ccatagtttt gagcaaaatt tttcttctat ttctccaaaa
     3901 actcactcat ttcagtatta ctcattgaca ctgggctccc taatagaaaa gcagatatta
     3961 taatatttca ttgaaatggt tactaaagag aaaaagagat taacaacagt taatccacct
     4021 tgatattata acactcaagg ttaaattgca tgttgttatt agaatcaatg ttatatatat
     4081 gattacaatg ctgaagcatt tctattgaat gagaaatagt gtttgcccta aacctttggg
     4141 aaaaaaatac agatttgaaa actaaagaat gtgggaagtg tcattgtgta atttggaaat
     4201 gcataaaatt ctcattatgt cctcatagat atgttgaaag atggttcact gtttcaaaga
     4261 tagaatgtat aatatgctgc tagtaccaag gctgcatttg aactgaacta ctccttatga
     4321 tataccatac taactgatga aaatataaat gttaaaatgt ctccactcta atgtattttg
     4381 ccttcacttg taactctgca catttcatta tatattaggg aaaagattac agattctacc
     4441 cccatatact caatcttgat cagaatgtac attaatgttg cctgatagat gtcttttgac
     4501 tacctatata ttacaaatgt gtatgtgttt ttttcttcca taagtatcta ttcaagtgta
     4561 tactgtatag gcaaatgtgt agctgtatat atgtacagac atgttctcat gcactttatt
     4621 caatatttat atatttatat ggacgaaaag caagtcaatg aaaacactca gtatatacac
     4681 atgtgtgcat gtttgtatca tgtttattta aatgtgaatt catgttctaa tatttctatg
     4741 accttccatt gctgcaaagc agattaaagt gtaacaaaaa tatcagctct ttaaataaac
     4801 tggaaattaa tctaattttg tggaagaact ttaagacaag tctatgagga tggcgaaaac
     4861 aatggtccac atatatagtt tcttgatcct aaataaaatg gtacctttgg gccctttgtt
     4921 tagtctggca attttctgac tactatggct ttttaaacag actcacacct aagtgaaaca
     4981 cagttgtcaa atgatttatg gatctgtgat taaaggattc acttttaatg aatactatta
     5041 aaacggagta acaaaccttg ctctacttta agttgaatga tagattcctc tatattcaaa
     5101 aaaaagcaat taactgccat aattagggaa aactgtttaa agcatactgc atttacttgg
     5161 ccacagcgcc atctcatggt aattttttaa agtgctaccg tagccaaatt gaactaagtc
     5221 actgtactgc tttcagcaaa gggtgctcct cccatttgtg catcaatgag acatatttat
     5281 aaagtgctaa attattctgt gccatatgta acaaatacag tgaagattat tttatgaact
     5341 tattttaatc aaggcgatgc taaaagtttt caagaaagga taaataactg taaataaagt
     5401 agactcaaaa atgaa
//
