LOCUS       NM_001322209            3386 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens 5-hydroxytryptamine receptor 1F (HTR1F), transcript
            variant 2, mRNA.
ACCESSION   NM_001322209 XM_005264749
VERSION     NM_001322209.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3386)
  AUTHORS   Zhang,S., Chen,H., Zhang,C., Yang,Y., Popov,P., Liu,J., Krumm,B.E.,
            Cao,C., Kim,K., Xiong,Y., Katritch,V., Shoichet,B.K., Jin,J.,
            Fay,J.F. and Roth,B.L.
  TITLE     Inactive and active state structures template selective tools for
            the human 5-HT5A receptor
  JOURNAL   Nat Struct Mol Biol 29 (7), 677-687 (2022)
   PUBMED   35835867
REFERENCE   2  (bases 1 to 3386)
  AUTHORS   Tan,Y., Xu,P., Huang,S., Yang,G., Zhou,F., He,X., Ma,H., Xu,H.E.
            and Jiang,Y.
  TITLE     Structural insights into the ligand binding and Gi coupling of
            serotonin receptor 5-HT5A
  JOURNAL   Cell Discov 8 (1), 50 (2022)
   PUBMED   35610220
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3386)
  AUTHORS   Huang,S., Xu,P., Tan,Y., You,C., Zhang,Y., Jiang,Y. and Xu,H.E.
  TITLE     Structural basis for recognition of anti-migraine drug lasmiditan
            by the serotonin receptor 5-HT1F-G protein complex
  JOURNAL   Cell Res 31 (9), 1036-1038 (2021)
   PUBMED   34239069
REFERENCE   4  (bases 1 to 3386)
  AUTHORS   Dupre,T.V., Jenkins,D.P., Muise-Helmericks,R.C. and
            Schnellmann,R.G.
  TITLE     The 5-hydroxytryptamine receptor 1F stimulates mitochondrial
            biogenesis and angiogenesis in endothelial cells
  JOURNAL   Biochem Pharmacol 169, 113644 (2019)
   PUBMED   31542386
  REMARK    GeneRIF: stimulation of 5-HT1F receptor is involved in
            mitochondrial biogenesis in endothelial cells.
REFERENCE   5  (bases 1 to 3386)
  AUTHORS   Almaca,J., Molina,J., Menegaz,D., Pronin,A.N., Tamayo,A.,
            Slepak,V., Berggren,P.O. and Caicedo,A.
  TITLE     Human Beta Cells Produce and Release Serotonin to Inhibit Glucagon
            Secretion from Alpha Cells
  JOURNAL   Cell Rep 17 (12), 3281-3291 (2016)
   PUBMED   28009296
  REMARK    GeneRIF: Supporting this model, pharmacological activation of
            5-HT1F receptors reduces glucagon secretion and has hypoglycemic
            effects in diabetic mice. Thus, modulation of serotonin signaling
            in the islet represents a drug intervention opportunity
REFERENCE   6  (bases 1 to 3386)
  AUTHORS   Maassen VanDenBrink,A., Vergouwe,M.N., Ophoff,R.A., Naylor,S.L.,
            Dauwerse,H.G., Saxena,P.R., Ferrari,M.D. and Frants,R.R.
  TITLE     Chromosomal localization of the 5-HT1F receptor gene: no evidence
            for involvement in response to sumatriptan in migraine patients
  JOURNAL   Am J Med Genet 77 (5), 415-420 (1998)
   PUBMED   9632173
REFERENCE   7  (bases 1 to 3386)
  AUTHORS   Lovenberg,T.W., Erlander,M.G., Baron,B.M., Racke,M., Slone,A.L.,
            Siegel,B.W., Craft,C.M., Burns,J.E., Danielson,P.E. and
            Sutcliffe,J.G.
  TITLE     Molecular cloning and functional expression of 5-HT1E-like rat and
            human 5-hydroxytryptamine receptor genes
  JOURNAL   Proc Natl Acad Sci U S A 90 (6), 2184-2188 (1993)
   PUBMED   8384716
REFERENCE   8  (bases 1 to 3386)
  AUTHORS   Adham,N., Kao,H.T., Schecter,L.E., Bard,J., Olsen,M., Urquhart,D.,
            Durkin,M., Hartig,P.R., Weinshank,R.L. and Branchek,T.A.
  TITLE     Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1
            receptor subtype coupled to the inhibition of adenylate cyclase
  JOURNAL   Proc Natl Acad Sci U S A 90 (2), 408-412 (1993)
   PUBMED   8380639
REFERENCE   9  (bases 1 to 3386)
  AUTHORS   Amlaiky,N., Ramboz,S., Boschert,U., Plassat,J.L. and Hen,R.
  TITLE     Isolation of a mouse '5HT1E-like' serotonin receptor expressed
            predominantly in hippocampus
  JOURNAL   J Biol Chem 267 (28), 19761-19764 (1992)
   PUBMED   1328180
REFERENCE   10 (bases 1 to 3386)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117513.4, AC119034.2 and AC119733.2.
            
            On Jun 3, 2019 this sequence version replaced NM_001322209.1.
            
            Transcript Variant: Variants 1 through 4 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.199206.1,
                                           SRR1660807.38768.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153307, SAMEA2467145
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319595.7/ ENSP00000322924.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               AC117513.4         148397-148533
            138-254             AC119034.2         28860-28976
            255-3386            AC119733.2         3918-7049
FEATURES             Location/Qualifiers
     source          1..3386
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p11.2-p11.1"
     gene            1..3386
                     /gene="HTR1F"
                     /gene_synonym="5-HT-1F; 5-HT1F; 5HT6; HTR1EL; MR77"
                     /note="5-hydroxytryptamine receptor 1F"
                     /db_xref="GeneID:3355"
                     /db_xref="HGNC:HGNC:5292"
                     /db_xref="MIM:182134"
     exon            1..137
                     /gene="HTR1F"
                     /gene_synonym="5-HT-1F; 5-HT1F; 5HT6; HTR1EL; MR77"
                     /inference="alignment:Splign:2.1.0"
     exon            138..254
                     /gene="HTR1F"
                     /gene_synonym="5-HT-1F; 5-HT1F; 5HT6; HTR1EL; MR77"
                     /inference="alignment:Splign:2.1.0"
     exon            255..3386
                     /gene="HTR1F"
                     /gene_synonym="5-HT-1F; 5-HT1F; 5HT6; HTR1EL; MR77"
                     /inference="alignment:Splign:2.1.0"
     CDS             297..1397
                     /gene="HTR1F"
                     /gene_synonym="5-HT-1F; 5-HT1F; 5HT6; HTR1EL; MR77"
                     /note="5-hydroxytryptamine (serotonin) receptor 1F, G
                     protein-coupled; serotonin receptor 1F"
                     /codon_start=1
                     /product="5-hydroxytryptamine receptor 1F"
                     /protein_id="NP_001309138.1"
                     /db_xref="CCDS:CCDS2920.1"
                     /db_xref="GeneID:3355"
                     /db_xref="HGNC:HGNC:5292"
                     /db_xref="MIM:182134"
                     /translation="MDFLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLV
                     IAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSV
                     DITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLF
                     WRHQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILILYYKIYRAAKTLYHKRQAS
                     RIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEK
                     SWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAW
                     LGYLNSLINPLIYTIFNEDFKKAFQKLVRCRC"
     regulatory      1818..1823
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HTR1F"
                     /gene_synonym="5-HT-1F; 5-HT1F; 5HT6; HTR1EL; MR77"
                     /note="hexamer: AATATA"
     polyA_site      1838
                     /gene="HTR1F"
                     /gene_synonym="5-HT-1F; 5-HT1F; 5HT6; HTR1EL; MR77"
                     /note="major polyA site"
     regulatory      2946..2951
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HTR1F"
                     /gene_synonym="5-HT-1F; 5-HT1F; 5HT6; HTR1EL; MR77"
                     /note="hexamer: AATAAA"
     polyA_site      2972
                     /gene="HTR1F"
                     /gene_synonym="5-HT-1F; 5-HT1F; 5HT6; HTR1EL; MR77"
ORIGIN      
        1 gcagtcagcg tcgcggcccc gaaagctggc gacaggcgct gctgtcttcc cgccccgtgg
       61 ggtcgcccct gccctcccgc gccccggggc tgggggcgcc accttgccag ctccgactgc
      121 tgcagggagc gccaggggag gagtttggga gagaatgaat tggactgtga aactttcatg
      181 aacttctcaa aagaacagga acatgaggag acgaaatggt gatgaaaacc cacaattcaa
      241 tctaccacag tatggtatcc atttttcagc tatattaatc ttttaaaaca aagaaaatgg
      301 atttcttaaa ttcatctgat caaaacttga cctcagagga actgttaaac agaatgccat
      361 ccaaaattct ggtgtccctc actctgtctg ggctggcact gatgacaaca actatcaact
      421 cccttgtgat cgctgcaatt attgtgaccc ggaagctgca ccatccagcc aattatttaa
      481 tttgttccct tgcagtcaca gattttcttg tggctgtcct ggtgatgccc ttcagcattg
      541 tgtatattgt gagagagagc tggattatgg ggcaagtggt ctgtgacatt tggctgagtg
      601 ttgacattac ctgctgcacg tgctccatct tgcatctctc agctatagct ttggatcggt
      661 atcgagcaat cacagatgct gttgagtatg ccaggaaaag gactccaaag catgctggca
      721 ttatgattac aatagtttgg attatatctg tttttatctc tatgcctcct ctattctgga
      781 ggcaccaagg aactagcaga gatgatgaat gcatcatcaa gcacgaccac attgtttcca
      841 ccatttactc aacatttgga gctttctaca tcccactggc attgattttg atcctttact
      901 acaaaatata tagagcagca aagacattat accacaagag acaagcaagt aggattgcaa
      961 aggaggaggt gaatggccaa gtccttttgg agagtggtga gaaaagcact aaatcagttt
     1021 ccacatccta tgtactagaa aagtctttat ctgacccatc aacagacttt gataaaattc
     1081 atagcacagt gagaagtctc aggtctgaat tcaagcatga gaaatcttgg agaaggcaaa
     1141 agatctcagg tacaagagaa cggaaagcag ccactaccct gggattaatc ttgggtgcat
     1201 ttgtaatatg ttggcttcct ttttttgtaa aagaattagt tgttaatgtc tgtgacaaat
     1261 gtaaaatttc tgaagaaatg tccaattttt tggcatggct tgggtatctc aattccctta
     1321 taaatccact gatttacaca atctttaatg aagacttcaa gaaagcattc caaaagcttg
     1381 tgcgatgtcg atgttagttt taaaaatgtt tattattgaa ggatgggggt ttttgagggg
     1441 aggaataact agatgaatgc caaataataa aacacttaag cttttagagg gaaatacatg
     1501 aaaactgcta aattgataag gctataattt atattttaat agcaatgtga atataaaagt
     1561 tattgatcac cactattcta gggtattcaa aattagaaaa taatttatgt aggttataaa
     1621 caatattttg cctatgcaat gttcctaaaa agctaactgg aaaaaatata tatatataca
     1681 atagtaatga cagtgatttt ccatgtttac atcttacaat aattatagag gagttttcaa
     1741 ttaacaacat acctccctcc ataatttcta tctagtccta ctgttttata atataattct
     1801 attattttgt ataagaaaat ataattcacc acaaagtaca catttctcct gtctccattc
     1861 ttgtcccttc tccatcttac cctgagcaaa agggaggggg aaggagcaac tcttacttag
     1921 tgtgactgca gaaaatgtaa aaaagtcaga gcttgaaatt gtccttgtgt ttaggtagca
     1981 aagagtaatc ataaagtggg ttaggtacag caaaataatt caatactgaa cttgtgcata
     2041 tttaatgtat tatgtttgat ataaacttct agaataatat tatcttatcc ttatattatc
     2101 agcatttgaa atcaaagcct taccttagta acaataactc aacaaagggg catgggtgac
     2161 gttgttataa ttgctctctg tttacttagg aatcaaattt aaagcactaa atatcataga
     2221 ttactcacca cagttatact cttaacatct ttttaaaagt ataaaatgta tttcatttct
     2281 gttaataagc tcagttatta actaaattgt ctgtggtatt ttgcacttca gtattttcca
     2341 tacctttgat ttcaacatta tttcccgttt actagacaga atataatgga aatttttaga
     2401 actttccctt tactttaaaa tatttctact tttccaattg gtagaaatga acaggaaaaa
     2461 agactcatat tacactaatt aataaatgta cacacatata tatttttgta attagtcact
     2521 ctactagttc agtgagccaa agcaattcca taagtttttc ttccatattt ataaaaggat
     2581 ttgaaaacaa tagaaccatg agtttgagag gattttattt tatttgaacc agcaaggtca
     2641 tagactacct ttgggaagac ctatcatcaa ccaagatcgt ttgaaaaaca atatatacct
     2701 ttttttaagt tgtacattta tgtgcattgt aaatattcct tcctgatggt gtggttaaga
     2761 gtacattaca tcaattttat gtatatatag atctgtgaca aattactctc aatctaacaa
     2821 acatttacag agttcccatt ttatacaagg cattgagaca tatactagat agaagatata
     2881 cgaaataata aaatacagtt ttttttcctg aatatgttta cagtctaaaa ggagaaacaa
     2941 gaaaaaataa aactataata gaaaagagca aactaaaatc tggcatggaa gttgtttaca
     3001 cagttatgat ggtgcagagg aaaaactgat cgcatcttgt ttagaaaaat cagaaatatt
     3061 tcacaaagaa tgtatctaga acacatgtca aatacacagc actggggcaa gaaaaatgga
     3121 agagcacact ccaggttgtg acaacatcag gatacaaact gcaccatgca agtatttggt
     3181 ggggcatgtt cataaatagc aatgagtttg gcaactattt agagcaatag aggaaaagga
     3241 tattaaaaga aaaattgggc atttttgtgg ctgactttga acgtcagaaa aaagtctaca
     3301 gtcaatttta ttgctgacga tgggtaatca ctgatacttt tagcaaaaat attacaagtt
     3361 tagagcaaat ctaaacaaaa aagaaa
//
